Article
Biochemistry & Molecular Biology
Jae-Ryoung Park, Yoon-Hee Jang, Eun-Gyeong Kim, Sang-Sun Hur, Kyung-Min Kim, Deyong Ren
Summary: In this study, QTLs and candidate genes related to rice plant height regulation were identified, which can provide information and foundation for marker-assisted selection and breeding.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Agronomy
Yu Wang, Quanyi Sun, Jianhua Zhao, Taixuan Liu, Haibo Du, Wenfeng Shan, Keting Wu, Xiang Xue, Chao Yang, Jun Liu, Zongxiang Chen, Keming Hu, Zhiming Feng, Shimin Zuo
Summary: This study identified a QTL for sheath blight resistance in rice and further fine-mapped it to a specific region. Functional analysis suggested that this QTL might enhance resistance to sheath blight through the activation of secondary metabolites biosynthesis and ROS scavenging system. Field trials demonstrated that this QTL conferred stable resistance and significantly reduced yield losses. These findings will contribute to the isolation of the QTL and its utilization in rice breeding programs against sheath blight.
THEORETICAL AND APPLIED GENETICS
(2023)
Review
Endocrinology & Metabolism
Jessica L. Harding, Pandora L. Wander, Xinge Zhang, Xia Li, Suvi Karuranga, Hongzhi Chen, Hong Sun, Yuting Xie, Richard A. Oram, Dianna J. Magliano, Zhiguang Zhou, Alicia J. Jenkins, Ronald C. W. Ma
Summary: This systematic review demonstrates that the incidence of adult-onset type 1 diabetes (T1D) is significant and emphasizes the urgent need to distinguish T1D from T2D in adults to better understand and address the true burden of T1D in adults.
Review
Endocrinology & Metabolism
Jessica L. Harding, Pandora L. Wander, Xinge Zhang, Xia Li, Suvi Karuranga, Hongzhi Chen, Hong Sun, Yuting Xie, Richard A. Oram, Dianna J. Magliano, Zhiguang Zhou, Alicia J. Jenkins, Ronald C. W. Ma
Summary: The incidence of adult-onset type 1 diabetes is lowest in Asian countries and highest in Nordic countries, with higher rates in men than women. It is unclear whether the incidence decreases with increasing age or changes over time. This study highlights the need to better distinguish type 1 diabetes from type 2 diabetes in adults to address the true burden of type 1 diabetes in adults.
Article
Plant Sciences
Hye Rang Park, Jeong Hyun Seo, Beom Kyu Kang, Jun Hoi Kim, Su Vin Heo, Man Soo Choi, Jee Yeon Ko, Choon Song Kim
Summary: This study identified QTLs and potential candidate genes associated with high soybean protein content. The identified genes may affect protein accumulation during seed development and sucrose and oil metabolism. These findings can aid in the development of soybean lines with increased protein content through marker-assisted selection.
Article
Plant Sciences
Rama Harinath Reddy Dadu, Ido Bar, Rebecca Ford, Prabhakaran Sambasivam, Janine Croser, Federico Ribalta, Sukhjiwan Kaur, Shimna Sudheesh, Dorin Gupta
Summary: This study identified major quantitative trait loci (QTL) regions on linkage group 5 and another QTL on LG2 that are associated with Ascochyta lentis resistance in lentils. The QTL regions contain putative candidate genes potentially involved in defense responses to fungal infection, which could aid in marker-assisted resistance selection in lentil breeding programs.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Forestry
Suyun Wei, Guo Yang, Yonghua Yang, Tongming Yin
Summary: This study conducted a large-scale field trial on the progeny of Salix suchowensis and analyzed the genetic factors underlying plant growth. The results showed that stem height and ground diameter were controlled by four quantitative trait loci, with two of them exerting a pleiotropic effect. The pleiotropic effect was found to result from the co-localization of genes with independent effects on stem height and ground diameter. Furthermore, the study revealed that height and circumference growth involve different tissue activities.
Article
Agronomy
Zhenqi Shao, Jiabiao Shao, Xiaobo Huo, Wenlong Li, Youbin Kong, Hui Du, Xihuan Li, Caiying Zhang
Summary: This study identified closely associated SNPs and genes related to seed size and shape in soybean. These findings are important for understanding the genetic basis of soybean yield and breeding improvements.
THEORETICAL AND APPLIED GENETICS
(2022)
Article
Agriculture, Multidisciplinary
Zhang Xi-juan, Lai Yong-cai, Meng Ying, Tang Ao, Dong Wen-jun, Liu You-hong, Liu Kai, Wang Li-zhi, Yang Xian-li, Wang Wen-long, Ding Guo-hua, Jiang Hui, Ren Yang, Jiang Shu-kun
Summary: Rice direct seeding is an important technology that can save labor and water, conserve environmental resources, and reduce greenhouse gas emissions. This study identified key genes associated with mesocotyl elongation in rice using a mapping population and detected multiple quantitative trait loci (QTLs) across different chromosomes. The investigation also identified a specific gene, LOC_Os03g50550, as a strong candidate for controlling mesocotyl elongation. These findings contribute to our understanding of the genetic mechanisms underlying rice's mesocotyl elongation and can help accelerate breeding programs for direct-seeded rice varieties.
JOURNAL OF INTEGRATIVE AGRICULTURE
(2023)
Article
Plant Sciences
Jianqin Xu, Xiaoxin Qin, Huaqing Zhu, Fanjun Chen, Xiuyi Fu, Futong Yu
Summary: Iron (Fe) deficiency is a major stress in crop production. This study used maize inbred lines to investigate the physiological mechanism underlying Fe deficiency tolerance and identified several candidate genes associated with Fe deficiency tolerance. The findings provide insights into the response to Fe deficiency stress in maize.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Biotechnology & Applied Microbiology
Fenglei Sun, Yanlong Yang, Penglong Wang, Jun Ma, Xiongming Du
Summary: This study provides insights into the genetic basis of cotton yield under drought conditions and identifies potential candidate genes for breeding high-yield cotton varieties.
Article
Agronomy
Thomas Bergmann, Jan Menkhaus, Wanzhi Ye, Markus Schemmel, Mario Hasler, Steffen Rietz, Gunhild Leckband, Daguang Cai
Summary: Novel QTLs and candidate genes for Sclerotinia-resistance were identified in a wild Brassica species, B. villosa, providing a new genetic source for improving oilseed rape resistance to SSR.
THEORETICAL AND APPLIED GENETICS
(2023)
Article
Biochemical Research Methods
Jing Chen, Lindsey J. Leach, Zewei Luo
Summary: Mapping quantitative trait loci (QTL) in autotetraploid species is a timely and challenging task. Two papers by Wu and his colleagues proposed statistical methods for QTL mapping in these species, but have been criticized for fundamental conceptual errors from statistical and genetic perspectives.
BRIEFINGS IN BIOINFORMATICS
(2021)
Article
Plant Sciences
Xiaohui Song, Guozhong Zhu, Sen Hou, Yamei Ren, Muhammad Waqas Amjid, Weixi Li, Wangzhen Guo
Summary: Genome-wide association analysis was conducted on fiber quality parameters in cotton, identifying 67 stable quantitative trait loci (QTLs) related to fiber length, strength, and micronaire. Transcriptome analysis revealed candidate genes involved in crucial processes like sugar metabolism and cytoskeleton organization, providing new insights for improving fiber quality in cotton.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Plant Sciences
Guozhong Zhu, Sen Hou, Xiaohui Song, Xing Wang, Wei Wang, Quanjia Chen, Wangzhen Guo
Summary: This study identified numerous QTLs and candidate genes associated with yield-related traits in cotton through phenotype data analysis and genetic analysis under multiple field environments. LP and SI were identified as more suitable traits for genetic improvement, while GN and BW had lower heritability estimates. Additionally, NET genes related to fiber development stages and stable QTL regions were discovered, providing insights into the regulatory mechanisms of yield components in cotton.
Article
Endocrinology & Metabolism
Xiaoyu He, Qiaohong Lai, Cai Chen, Na Li, Fei Sun, Wenting Huang, Shu Zhang, Qilin Yu, Ping Yang, Fei Xiong, Zhishui Chen, Quan Gong, Boxu Ren, Jianping Weng, Decio L. Eizirik, Zhiguang Zhou, Cong-Yi Wang
Review
Biochemistry & Molecular Biology
Jing Zhang, Longmin Chen, Fei Xiong, Shu Zhang, Kun Huang, Ziyun Zhang, Cong-Yi Wang
MOLECULAR IMMUNOLOGY
(2019)
Review
Cell Biology
Na Li, Furong Liu, Ping Yang, Fei Xiong, Qilin Yu, Jinxiu Li, Zhiguang Zhou, Shu Zhang, Cong-Yi Wang
Article
Cell Biology
Faxi Wang, Fei Sun, Jiahui Luo, Tiantian Yue, Longmin Chen, Haifeng Zhou, Jing Zhang, Chunliang Yang, Xi Luo, Qing Zhou, He Zhu, Jinxiu Li, Ping Yang, Fei Xiong, Qilin Yu, Huilan Zhang, Wanguang Zhang, Aimin Xu, Zhiguang Zhou, Qianjin Lu, Decio L. Eizirik, Shu Zhang, Cong-Yi Wang
CELL DEATH & DISEASE
(2019)
Article
Cell Biology
Lei Zhang, Yi Wang, Guorao Wu, Lizong Rao, Yanqiu Wei, Huihui Yue, Ting Yuan, Ping Yang, Fei Xiong, Shu Zhang, Qing Zhou, Zhishui Chen, Jinxiu Li, Bi-Wen Mo, Huilan Zhang, Weining Xiong, Cong-Yi Wang
CELL PROLIFERATION
(2020)
Article
Endocrinology & Metabolism
Jing Zhang, Longmin Chen, Faxi Wang, Yuan Zou, Jingyi Li, Jiahui Luo, Faheem Khan, Fei Sun, Yang Li, Jing Liu, Zhishui Chen, Shu Zhang, Fei Xiong, Qilin Yu, Jinxiu Li, Kun Huang, Bao-Ling Adam, Zhiguang Zhou, Decio L. Eizirik, Ping Yang, Cong-Yi Wang
Letter
Medicine, General & Internal
Huilan Zhang, Peng Zhou, Yanqiu Wei, Huihui Yue, Yi Wang, Ming Hu, Shu Zhang, Tanze Cao, Chengqing Yang, Ming Li, Guangyun Guo, Xianxiang Chen, Ying Chen, Mei Lei, Huiguo Liu, Jianping Zhao, Peng Peng, Cong-Yi Wang, Ronghui Du
ANNALS OF INTERNAL MEDICINE
(2020)
Review
Immunology
Fei Sun, Jia-Hui Luo, Tian-Tian Yue, Fa-Xi Wang, Chun-Liang Yang, Shu Zhang, Xin-Qiang Wang, Cong-Yi Wang
Summary: Hydrogen sulphide (H2S) is a recently identified gaseous mediator with important roles in neuronal activity and immune regulation, affecting macrophage function through modulation of inflammatory pathways and promotion of mitochondrial biogenesis.
Article
Cell Biology
Chun-Liang Yang, Fei Sun, Fa-Xi Wang, Shan-Jie Rong, Tian-Tian Yue, Jia-Hui Luo, Qing Zhou, Cong-Yi Wang, Shi-Wei Liu
Summary: Type 1 diabetes is an autoimmune disease with viral infections playing a critical role in its initiation. Interferon regulatory factors have a significant impact on T1D pathogenesis.
CELLULAR IMMUNOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Shan Jie Rong, Chun Liang Yang, Fa Xi Wang, Fei Sun, Jia Hui Luo, Tian Tian Yue, Ping Yang, Qilin Yu, Shu Zhang, Cong-Yi Wang
Summary: Macrophages play important roles in immune response, tissue homeostasis, and disease development. FoxO1, a member of the forkhead box transcription factor family, regulates macrophage functions including phagocytosis, migration, differentiation, and inflammatory activation. Macrophages also reciprocally modulate FoxO1 activity through post-translational modifications.
BIOMED RESEARCH INTERNATIONAL
(2022)
Review
Biochemistry & Molecular Biology
Fei Sun, Chun-Liang Yang, Fa-Xi Wang, Shan-Jie Rong, Jia-Hui Luo, Wan-Ying Lu, Tian-Tian Yue, Cong-Yi Wang, Shi-Wei Liu
Summary: Type 1 diabetes (T1D) is a chronic autoimmune disorder caused by a breakdown of self-tolerance and unrestrained immune response against beta cells. Pancreatic draining lymph nodes (PLNs) play a crucial role in amplifying the immune response and affecting T1D progression. Intervention strategies for T1D should focus on cutting off harmful signals, modulating immune activation in PLNs, and blocking the detrimental effects of PLNs on pancreatic islets.
CELL AND BIOSCIENCE
(2023)
Article
Multidisciplinary Sciences
Leike Zhang, Xuefang Peng, Qingxing Wang, Jin Li, Shouming Lv, Shuo Han, Lingyu Zhang, Heng Ding, Cong-Yi Wang, Gengfu Xiao, Xuguang Du, Ke Peng, Hao Li, Wei Liu
Summary: Severe fever with thrombocytopenia syndrome virus (SFTSV) is a tick-borne bunyavirus with a high fatality rate. C-C motif chemokine receptor 2 (CCR2) was identified as the host receptor for SFTSV, and its knockout reduced viral binding and infection. CCR2 enhanced SFTSV binding through direct binding to SFTSV glycoprotein N (Gn), and individuals with higher CCR2 surface expression showed stronger SFTSV binding and replication. CCR2 is a potential target for developing anti-SFTSV therapeutics.
Meeting Abstract
Immunology
C. -Y. Wang
EUROPEAN JOURNAL OF IMMUNOLOGY
(2019)
Article
Oncology
Lei Zhang, Yi Wang, Nuruliarizki Shinta Pandupuspitasari, Guorao Wu, Xudong Xiang, Quan Gong, Weining Xiong, Cong-Yi Wang, Ping Yang, Boxu Ren
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2017)
Review
Respiratory System
Lei Zhang, Yi Wang, Guorao Wu, Weining Xiong, Weikuan Gu, Cong-Yi Wang
RESPIRATORY RESEARCH
(2018)
