Article
Multidisciplinary Sciences
Ganghua Yang, Zhengyang Lu, Fandi Meng, Yong Wan, Lei Zhang, Qinhong Xu, Zheng Wang
Summary: This study aimed to investigate the biological function and diagnostic and prognostic value of miR-141 in gallbladder cancer (GBC). The results showed that miR-141 was highly expressed in GBC cells but lowly expressed in normal tissues. Elevated plasma miR-141 expression was also detected in GBC patients and could serve as a more valuable diagnostic biomarker for GBC. Moreover, high plasma miR-141 expression was closely associated with tumor invasion, lymph node metastasis, and advanced pathological TNM stage, and it was also an independent prognostic factor for predicting poorer survival in GBC patients. These findings suggest that miR-141 may be a potential biomarker for diagnosis, prognosis, and treatment of GBC.
SCIENTIFIC REPORTS
(2022)
Review
Medicine, General & Internal
Xiangyu Chu, Dan Wei, Xinxin Liu, Di Long, Xiaodong Tian, Yinmo Yang
Summary: Pancreatic cancer is a highly aggressive malignancy with a poor prognosis. Aberrant expression of microRNAs (miRNAs) is often associated with the initiation, progression, and metastasis of pancreatic cancer. This review discusses the potential of integrating miRNAs into the treatment of pancreatic cancer and offers insights for the development of precision medicine.
CHINESE MEDICAL JOURNAL
(2022)
Review
Endocrinology & Metabolism
Jingyu Song, Jiaxin Wang, Kang Liu, Wenchao Xu, Taotao Sun, Jihong Liu
Summary: Erectile dysfunction, a common male sexual dysfunction disease, is predicted to affect 322 million individuals worldwide by 2025. The pathogenesis of ED is complex and current treatments options are limited. Recent studies have highlighted the significant role of miRNAs in ED, suggesting their potential as therapeutic targets for the disease.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Cell Biology
Cassandra Barone, Xin Qi
Summary: Motor Neuron Diseases (MND) are neurological disorders characterized by a loss of motor neurons resulting in decreased physical capabilities. Current research aims to hinder disease progression by understanding the causes of motor neuron death, particularly focusing on metabolic malfunction as a potential therapeutic target. This review highlights the importance of a cohesive system involving both neurons and skeletal muscle tissue and proposes potential metabolic deficits as targets for future intervention.
Review
Cell Biology
Omkar Suhas Vinchure, Ritu Kulshreshtha
Summary: miR-490, a well-studied miRNA, is associated with the pathogenesis of various diseases, particularly showing potential in cancer diagnosis and prognosis. Multiple epigenetic and posttranscriptional mechanisms tightly regulate the levels of miR-490, with its targets involving cancer-related genes that impact various cancer hallmarks.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Review
Immunology
Zhen Gui, Yan Zhang, Aihua Zhang, Weiwei Xia, Zhanjun Jia
Summary: CARMA3 is a scaffold protein widely expressed in non-hematopoietic cells that can activate NF-κB by forming a complex. It mediates different receptor-dependent signaling pathways and its dysregulation is associated with various diseases. Recent studies have demonstrated its involvement in cancer and non-cancerous diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Oncology
Valentina Doldi, Rihan El Bezawy, Nadia Zaffaroni
Summary: Prostate cancer is a common and deadly tumor in men, with high heterogeneity making individual patient management challenging. microRNAs are crucial in determining prostate cancer response to radiation and drug therapy, potentially serving as novel therapeutic targets or tools for improving treatment response.
Review
Cell Biology
Wen (Jess) Li, Yunfei Wang, Ruifang Liu, Andrea L. Kasinski, Haifa Shen, Frank J. Slack, Dean G. Tang
Summary: The majority of treatment-naive tumors contain a subpopulation of cancer cells with stem cell properties, known as cancer cell stem cells (CSCs). These CSCs, along with induced cancer cell plasticity, play fundamental roles in tumor progression, therapy resistance, and relapse. The stemness of CSCs is regulated by genetic factors and epigenetic mechanisms.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Vivek Kumar, Archana Pandey, Arisha Arora, Priyanka Gautam, Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan
Summary: This study aimed to evaluate the therapeutic and diagnostic potential of microRNA (miRNA) in the management of epithelial ovarian cancer (EOC). Expression analysis and functional enrichment revealed the association of miRNA with the disease and involvement of target genes in cancer progression pathways. miRNA-205 and miRNA-34a were found to be significantly downregulated and upregulated, respectively, in EOC, and showed significant negative correlation with their target genes. The combined miRNA-target gene panel exhibited higher diagnostic value in predicting the risk of EOC.
DNA AND CELL BIOLOGY
(2023)
Review
Cell Biology
Yuying Zhang, Jingyan Luo, Weikang Yang, Wen-Chu Ye
Summary: Circular RNAs (circRNAs) are highly stable, conserved, and abundantly expressed in various organs and tissues. Abnormal circRNA expression has been found in CRC patients' blood/serum, cells, CRC tissues, and exosomes, and circRNAs play crucial roles in the development of CRC by acting as microRNA sponges, RNA-binding protein sponges, regulators of gene splicing and transcription, and protein/peptide translators. These characteristics make circRNAs potential markers for CRC diagnosis and prognosis, potential therapeutic targets, and circRNA-based therapies. However, further studies are needed to improve the understanding of the roles and biological mechanisms of circRNAs in CRC development.
CELL DEATH & DISEASE
(2023)
Article
Chemistry, Multidisciplinary
Paco Lopez-Cuevas, Can Xu, Charlotte E. Severn, Tiah C. L. Oates, Stephen J. Cross, Ashley M. Toye, Stephen Mann, Paul Martin
Summary: This study demonstrates that silencing or knocking out a specific immune cell-expressed miRNA, microRNA-223 (miR223), can reduce cancer progression. By using miniature artificial protocells (PCs) to deliver anti-inflammatory miRNAs, the interactions between immune cells and cancer cells are altered, resulting in reduced tumor burden.
Article
Oncology
Axel Stang, Hauke Weilert, Michael J. Lipp, Karl J. Oldhafer, Joerg D. Hoheisel, Chaoyang Zhang, Andrea S. Bauer
Summary: Several cancer-related pathways were found to be affected by the deregulated miRNAs identified in blood samples from patients with colorectal cancer (CRC). The study revealed 179 CRC-associated miRNAs of differential abundance, with the majority specifically predicting metastatic CRC. Further confirmation is needed for the identified biomarker and therapeutic candidates in clinical relevance.
MOLECULAR ONCOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Manzar Alam, Sabeeha Ali, Sarfraz Ahmed, Abdelbaset Mohamed Elasbali, Mohd Adnan, Asimul Islam, Md Imtaiyaz Hassan, Dharmendra Kumar Yadav
Summary: Ursolic acid (UA) is a pentacyclic triterpenoid with various pharmacological effects, showing potential therapeutic benefits for cancer and diabetic neuropathy diseases. Structural modifications have resulted in UA derivatives with increased potency, bioavailability, and water solubility.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Nutrition & Dietetics
Seung-Hyeok Park, Minsun Kim, Somi Lee, Woojin Jung, Bonglee Kim
Summary: Cervical cancer is the fourth most common cancer among women worldwide, and natural products play an important role in its treatment, with various mechanisms. Research has found that multiple natural products have inhibitory effects against cervical cancer, with some demonstrating significant multi-effects.
Review
Medicine, Research & Experimental
Hua Gan, Yuhe Lei, Naijun Yuan, Kairui Tang, Wenzhi Hao, Qingyu Ma, Mansi Wu, Xuan Zhou, Xiaojuan Li, Junqing Huang, Lijuan Deng, Jiaxu Chen
Summary: circRNAs play a crucial role in the development of depression by regulating the expression of target genes and impacting behavioral symptoms. Current research is exploring the potential therapeutic role of circRNAs in depression, which may offer insight into the development of new treatment options.
BIOMEDICINE & PHARMACOTHERAPY
(2021)