Article
Pharmacology & Pharmacy
Liulin Wang, Xuerui Wang, Gang Li, Shanshan Zhou, Rui Wang, Qi Long, Min Wang, Liang Li, Hai Huang, Yuanming Ba
Summary: Emodin has protective effects on renal fibrosis by regulating the miR-490-3p/HMGA2 signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Zhenglei Xu, Zeming Chen, Minsi Peng, Zhuliang Zhang, Weixiang Luo, Ruiyue Shi, Lisheng Wang, Yingcai Hong
Summary: Pancreatic cancer is difficult to treat, and the main reasons for poor prognosis are cell invasion and migration. In this study, researchers found that miR-490-5p is abnormally low-expressed in pancreatic cancer and downregulation of miR-490-5p enhances the viability, migration, and invasion of pancreatic cancer cells. Additionally, miR-490-5p regulates the protein expression of MMP2, MMP9, and N-cadherin, and upregulates the protein expression of E-cadherin. The expression of MAGI2-AS3 is also associated with cell viability, migration, and invasion in pancreatic cancer. The study reveals that miR-490-5p plays an anti-cancer role in pancreatic cancer by targeting MAGI2-AS3 and regulating EMT.
Review
Biochemistry & Molecular Biology
Malgorzata Guz, Witold Jeleniewicz, Marek Cybulski
Summary: The role of non-coding RNAs (ncRNAs) in cancer is undeniable. Aberrant expression of ncRNAs, including circular RNAs (circRNAs) and microRNAs (miRNAs), is involved in the molecular mechanisms of carcinogenesis. CircRNAs, as a part of the competing endogenous RNA (ceRNAs) network, play a central role in regulating the accessibility of miRNAs to their mRNA targets. The imbalance between circRNAs and miRNAs is crucial in various pathologies, including cancer. This review focuses on the interaction between circRNAs and miR-141, a well-known member of the miR-200 family, in malignant transformation, highlighting the biological role of circRNA/miR-141/mRNA networks as a potential target for future anti-cancer therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pathology
Wen Bi, Jingjing Li, Mengqiu Xiong, Bei Pan, Zhongqiu Zhang, Lubanga Nasifu, Bangshun He, Ping Wang
Summary: MicroRNA-27a (miR-27a) is abnormally expressed in cancer patients and can serve as a potential diagnostic and prognostic biomarker. It is a valuable diagnostic biomarker in serum/plasma and can predict poor prognosis in cancer patients. However, its diagnostic value is slightly reduced in tumor tissue samples.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Review
Oncology
Sara Raji, Mehrdad Sahranavard, Mahdi Mottaghi, Amirhossein Sahebkar
Summary: In this study, a systematic review and meta-analysis were conducted to evaluate the prognostic and diagnostic value of miR-212 in cancer. The results showed that high levels of miR-212 were associated with poor prognosis in pancreatic ductal adenocarcinoma (PDAC), while low levels of miR-212 were associated with poor prognosis in other cancers. Additionally, miR-212 demonstrated excellent diagnostic performance and was associated with certain patient characteristics.
CANCER CELL INTERNATIONAL
(2022)
Article
Endocrinology & Metabolism
Chen-Kai Chou, Shun-Yu Chi, Yi-Yung Hung, Yi-Chien Yang, Hung-Chun Fu, Jia-He Wang, Chueh-Chen Chen, Hong-Yo Kang
Summary: The study revealed that dysregulated expression of miR-146b and androgen receptor (AR) played critical roles in the tumorigenesis of papillary thyroid carcinoma (PTC). It was confirmed that miR-146b expression was significantly inversely correlated with AR expression. Further experiments showed that AR might bind to the androgen receptor element on the promoter region of miR-146b, leading to repression of miR-146b expression and reduction of PTC tumor aggressiveness. PTC patients with low AR/high miR-146b expression were associated with advanced tumor characteristics.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Biochemistry & Molecular Biology
Yuto Hozaka, Yoshiaki Kita, Ryutaro Yasudome, Takako Tanaka, Masumi Wada, Tetsuya Idichi, Kan Tanabe, Shunichi Asai, Shogo Moriya, Hiroko Toda, Shinichiro Mori, Hiroshi Kurahara, Takao Ohtsuka, Naohiko Seki
Summary: In this study, a novel miRNA expression signature of colorectal cancer was established based on RNA-sequencing, revealing the tumor-suppressive role of miR-490-3p and its regulation of multiple oncogenic targets in CRC cells. The expression levels of IRAK1, FUT1, and GPRIN2, among the targets identified, significantly predicted the 5-year overall survival of colorectal cancer patients, highlighting the potential prognostic value of these miRNA-regulated genes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Li Zuo, Xiaoli Li, Hailong Zhu, Anqi Li, Yonggang Wang
Summary: Detection of miR-181a in circulating tumor cells (CTCs) of ovarian cancer patients may allow for early diagnosis and prognostic evaluation. MiR-181a could be involved in the development and progression of ovarian cancer as an oncogene. The expression of miR-181a in CTCs captured by EpCAM liposome magnetic beads (Ep-LMBs) correlates with clinical characteristics of ovarian cancer.
Article
Medicine, General & Internal
Dengke Fu, Yang Chen, Dongkui Xu
Summary: The study found that circulating miR-449a levels were significantly decreased in CRC patients compared to healthy controls, and low miR-449a levels were significantly associated with CEA and CA19-9 levels as well as a lower 5-year overall survival rate. Low circulating miR-449a levels were also identified as an independent risk factor for CRC.
Article
Reproductive Biology
Jun Li, Huiran Yue, Wenzhi Li, Guohua Zhu, Tingting Zhu, Ruifang Chen, Xin Lu
Summary: The study identified differential expression of miR-25 and miR-142 in LVSI-positive and LVSI-negative ovarian cancer tumors. High miR-25 expression was associated with better PFS and OS, while high miR-142 expression was linked to reduced OS. Patients with low miR-25 expression and high miR-142 expression benefited significantly from bevacizumab treatment.
JOURNAL OF OVARIAN RESEARCH
(2021)
Article
Pathology
Kai Zhang, Yan-Yan Wang, Yao Xu, Li Zhang, Jiang Zhu, Peng-Chao Si, Ya-Wen Wang, Rong Ma
Summary: The study identified six upregulated miRNAs and a two-miRNA panel in the blood as potential biomarkers for the diagnosis and prognosis of breast cancer. The two-miRNA panel showed a better diagnostic performance than individual miRNAs, with high sensitivity and specificity. The high expression of these miRNAs was also associated with poor prognosis in breast cancer.
PATHOLOGY RESEARCH AND PRACTICE
(2021)
Review
Biochemistry & Molecular Biology
Phuong T. B. Ho, Ian M. Clark, Linh T. T. Le
Summary: MicroRNAs (miRNAs) are endogenous non-coding RNAs that regulate gene expression and hold promise as biomarkers for diagnosis and prognosis of diseases. This review discusses the intracellular and extracellular trafficking of miRNAs, their role as potential biomarkers, measurement methods, available panels for clinical use, and their potential as therapeutics.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Genetics & Heredity
Yu Shi, Zihao Liu, Qun Lin, Qing Luo, Yinghuan Cen, Juanmei Li, Xiaolin Fang, Chang Gong
Summary: The study of miRNA in cancer has made significant advancements, with research showing that miRNA can be dysregulated in different types of cancers and act as either tumor promoters or tumor suppressors. Studies have also revealed that miRNA may serve as novel tools and targets for therapeutic attempts, and the development of miRNA delivery systems has accelerated the preclinical implications of miRNA in cancer treatment.
Article
Multidisciplinary Sciences
Min Liu, Fei Mo, Xiaohan Song, Yun He, Yan Yuan, Jiaoyan Yan, Ye Yang, Jian Huang, Shu Zhang
Summary: The study utilized comprehensive bioinformatics analysis and experimental validation to identify hsa-miR-21-5p as significantly up-regulated in breast cancer tissues, cells, and exosomes. Further investigations confirmed the diagnostic value of plasma exosomal hsa-miR-21-5p in distinguishing healthy individuals from breast cancer patients, with a sensitivity of 86.7% and specificity of 93.3%.
Article
Multidisciplinary Sciences
Ganghua Yang, Zhengyang Lu, Fandi Meng, Yong Wan, Lei Zhang, Qinhong Xu, Zheng Wang
Summary: This study aimed to investigate the biological function and diagnostic and prognostic value of miR-141 in gallbladder cancer (GBC). The results showed that miR-141 was highly expressed in GBC cells but lowly expressed in normal tissues. Elevated plasma miR-141 expression was also detected in GBC patients and could serve as a more valuable diagnostic biomarker for GBC. Moreover, high plasma miR-141 expression was closely associated with tumor invasion, lymph node metastasis, and advanced pathological TNM stage, and it was also an independent prognostic factor for predicting poorer survival in GBC patients. These findings suggest that miR-141 may be a potential biomarker for diagnosis, prognosis, and treatment of GBC.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Rahul Agrawal, Ankita Garg, Prit Benny Malgulwar, Vikas Sharma, Chitra Sarkar, Ritu Kulshreshtha
INTERNATIONAL JOURNAL OF CANCER
(2018)
Article
Cell Biology
Anubha Shukla, Srishti Srivastava, Jayant Darokar, Ritu Kulshreshtha
Summary: The study found that MED30 is overexpressed in GBM tissues and cell lines, induced by factors in the tumor microenvironment, and positively correlated with p53 and HIF1 alpha levels in GBM tissues. MED30 promotes cell proliferation and reduces migration capabilities in GBM cell lines, and also confers sensitivity to temozolomide and modulates p53 levels in vitro. Overall, the results suggest that MED30 may play a role in GBM pathogenesis and could be a potential diagnostic and therapeutic target, urging further exploration of its interactome and target networks.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Omkar Suhas Vinchure, Kurt Whittemore, Deependra Kushwah, Maria A. Blasco, Ritu Kulshreshtha
Summary: miR-490 targets multiple genes to regulate telomere maintenance in GBM, exerting tumor suppressive effects, impacting stemness and senescence, activating DNA damage response, and potentially holding therapeutic significance in GBM treatment.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Oncology
Sonam Takkar, Vikas Sharma, Sourabh Ghosh, Ashish Suri, Chitra Sarkar, Ritu Kulshreshtha
Summary: This study identified miR-196a as a hypoxia-inducible and hypoxia-inducible factor (HIF)-regulated miRNA that plays an oncogenic role in GBM. It was significantly up-regulated in TCGA-GBM, CGGA glioma and Indian GBM patient cohorts. miR-196a overexpression promoted cellular proliferation, migration, spheroid and colony formation, and inhibited apoptosis, while inhibition of miR-196a yielded opposite results, suggesting an oncogenic role.
Review
Cell Biology
Garima Yadav, Ritu Kulshreshtha
Summary: Recent studies have highlighted the significance of long noncoding RNAs (lncRNAs) in GBM metastasis, showing potential as diagnostic/prognostic biomarkers and therapeutic targets. The intricate network of lncRNA/miRNA/protein plays a crucial role in regulating metastasis-associated genes, offering insights into potential therapeutic strategies for GBM treatment.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Srishti Srivastava, Hima Makala, Vikas Sharma, Vaishali Suri, Chitra Sarkar, Ritu Kulshreshtha
Summary: This study reveals the overexpression of a subunit of the mediator complex, MED12, in glioblastoma and shows its role in promoting tumor cell proliferation, migration, and inhibiting apoptosis. The study also identifies MED12 as an important mediator of the VDR signaling pathway and highlights its potential as a therapeutic target for glioblastoma.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Materials Science, Biomaterials
Indranil Mondal, Syeda Warisul Fatima, Swati Priya, Sagar Sengupta, Sunil Kumar Khare, Ritu Kulshreshtha
Summary: A novel nanostructure called TGNFs has been developed for efficient delivery of anti-miR-210 to glioblastoma cells, resulting in decreased proliferation and migration and increased apoptosis. This method shows potential as a delivery agent in miRNA inhibition therapy.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Review
Cell Biology
Srishti Srivastava, Ritu Kulshreshtha
Summary: Transcriptional dysregulation is central to many diseases, with MED12 playing a critical role as a master regulator of the mediator complex involved in transcription. Mutations or differential expression of MED12 are associated with various human disorders and cancers, making it an attractive novel therapeutic target.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Chemistry, Inorganic & Nuclear
Priyaranjan Kumar, Indranil Mondal, Ritu Kulshreshtha, Ashis K. Patra
DALTON TRANSACTIONS
(2020)