The Role of Sodium Channels in Painful Diabetic and Idiopathic Neuropathy

Reactive metabolites as a cause of late diabetic complications: Figure 1

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Fentanyl produces an anti-hyperalgesic effect through the suppression of sodium channels in mice with painful diabetic neuropathy

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Regulating excitability of peripheral afferents: emerging ion channel targets

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The G1662S NaV1.8 mutation in small fibre neuropathy: impaired inactivation underlying DRG neuron hyperexcitability

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Small-Fiber Neuropathy Nav1.8 Mutation Shifts Activation to Hyperpolarized Potentials and Increases Excitability of Dorsal Root Ganglion Neurons

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An animal model of oxaliplatin-induced cold allodynia reveals a crucial role for Nav1.6 in peripheral pain pathways

(2013) Jennifer R. Deuis et al.   PAIN

Methylglyoxal Evokes Pain by Stimulating TRPA1

(2013) David A. Andersson et al.   PLoS One

Functional profiles of SCN9A variants in dorsal root ganglion neurons and superior cervical ganglion neurons correlate with autonomic symptoms in small fibre neuropathy

(2012) Chongyang Han et al.   BRAIN

Reduced conduction failure of the main axon of polymodal nociceptive C-fibres contributes to painful diabetic neuropathy in rats

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Small nerve fibres, small hands and small feet: a new syndrome of pain, dysautonomia and acromesomelia in a kindred with a novel NaV1.7 mutation

(2012) Janneke G. J. Hoeijmakers et al.   BRAIN

Gabapentin reduces allodynia and hyperalgesia in painful diabetic neuropathy rats by decreasing expression level of Nav1.7 and p-ERK1/2 in DRG neurons

(2012) Jun-Long Zhang et al.   BRAIN RESEARCH

Small fibre neuropathy

(2012) Giuseppe Lauria et al.   CURRENT OPINION IN NEUROLOGY

Ciguatoxins activate specific cold pain pathways to elicit burning pain from cooling

(2012) Irina Vetter et al.   EMBO JOURNAL

Altered Distribution of Juxtaparanodal Kv1.2 Subunits Mediates Peripheral Nerve Hyperexcitability in Type 2 Diabetes Mellitus

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Expression of Nav1.7 in DRG Neurons Extends from Peripheral Terminals in the Skin to Central Preterminal Branches and Terminals in the Dorsal Horn

(2012) Joel A Black et al.   Molecular Pain

Small-fibre neuropathies—advances in diagnosis, pathophysiology and management

(2012) Janneke G. Hoeijmakers et al.   Nature Reviews Neurology

Nav1.7-related small fiber neuropathy: Impaired slow-inactivation and DRG neuron hyperexcitability

(2012) C. Han et al.   NEUROLOGY

Gain-of-function Nav1.8 mutations in painful neuropathy

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Distinct Nav1.7-dependent pain sensations require different sets of sensory and sympathetic neurons

(2012) Michael S. Minett et al.   Nature Communications

Structural modelling and mutant cycle analysis predict pharmacoresponsiveness of a Nav1.7 mutant channel

(2012) Yang Yang et al.   Nature Communications

Gain of function NaV1.7 mutations in idiopathic small fiber neuropathy

(2011) Catharina G. Faber et al.   ANNALS OF NEUROLOGY

A modified score to identify and discriminate neuropathic pain: a study on the German version of the neuropathic pain symptom inventory (NPSI)

(2011) Claudia Sommer et al.   BMC Neurology

Prevalence and Characteristics of Painful Diabetic Neuropathy in a Large Community-Based Diabetic Population in the U.K.

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Characterisation of glyoxalase I in a streptozocin-induced mouse model of diabetes with painful and insensate neuropathy

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Vector-mediated release of GABA attenuates pain-related behaviors and reduces NaV1.7 in DRG neurons

(2011) Munmun Chattopadhyay et al.   EUROPEAN JOURNAL OF PAIN

Genetic basis of pain variability: recent advances

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Physiological interactions between Nav1.7 and Nav1.8 sodium channels: a computer simulation study

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Type 2 diabetes across generations: from pathophysiology to prevention and management

(2011) Christopher J Nolan et al.   LANCET

Intra- and Interfamily Phenotypic Diversity in Pain Syndromes Associated with a Gain-of-Function Variant of NaV1.7

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Treatment of Nav1.7-mediated pain in inherited erythromelalgia using a novel sodium channel blocker

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Practice Guidelines for Chronic Pain Management

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EFNS guidelines on the pharmacological treatment of neuropathic pain: 2010 revision

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Sodium channel blockers for neuropathic pain

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European Federation of Neurological Societies/Peripheral Nerve Society Guideline on the use of skin biopsy in the diagnosis of small fiber neuropathy. Report of a joint task force of the European Federation of Neurological Societies and the Peripheral Ner

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Intraepidermal nerve fiber density at the distal leg: a worldwide normative reference study

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A Glial Signal Consisting of Gliomedin and NrCAM Clusters Axonal Na+ Channels during the Formation of Nodes of Ranvier

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Quantitative sensory testing in the German Research Network on Neuropathic Pain (DFNS): Somatosensory abnormalities in 1236 patients with different neuropathic pain syndromes

(2010) C. Maier et al.   PAIN

Treatment-induced diabetic neuropathy: A reversible painful autonomic neuropathy

(2009) Christopher H. Gibbons et al.   ANNALS OF NEUROLOGY

Activation of neurokinin 3 receptor increases Nav1.9 current in enteric neurons

(2009) Carine Copel et al.   JOURNAL OF PHYSIOLOGY-LONDON

Neuropathic pain is associated with increased nodal persistent Na+ currents in human diabetic neuropathy

(2009) Sonoko Misawa et al.   JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM

Diagnosis, natural history, and management of Charcot–Marie–Tooth disease

(2009) Davide Pareyson et al.   LANCET NEUROLOGY

Conduction Failures in Rabbit Saphenous Nerve Unmyelinated Fibers

(2009) Zhi-Ru Zhu et al.   NEUROSIGNALS

The diagnostic criteria for small fibre neuropathy: from symptoms to neuropathology

(2008) G. Devigili et al.   BRAIN

Early diabetic neuropathy: thermal thresholds and intraepidermal nerve fibre density in patients with normal nerve conduction studies

(2008) S. Løseth et al.   JOURNAL OF NEUROLOGY

Continuous  -Opioid Receptor Activation Reduces Neuronal Voltage-Gated Sodium Channel (NaV1.7) Levels through Activation of Protein Kinase C in Painful Diabetic Neuropathy

(2008) M. Chattopadhyay et al.   JOURNAL OF NEUROSCIENCE

Neuropathic pain: Are there distinct subtypes depending on the aetiology or anatomical lesion?

(2008) N. Attal et al.   PAIN

The Cell and Molecular Basis of Mechanical, Cold, and Inflammatory Pain

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Painful Diabetic Neuropathy: Epidemiology, Natural History, Early Diagnosis, and Treatment Options

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