Moving on from GWAS: Functional Studies on the G6PC2 Gene Implicated in the Regulation of Fasting Blood Glucose
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Title
Moving on from GWAS: Functional Studies on the G6PC2 Gene Implicated in the Regulation of Fasting Blood Glucose
Authors
Keywords
Islet, Glucose, Glucose-6-phosphatase, Insulin, Secretion, Mouse, Genome-wide association studies, GWAS, <em class=EmphasisTypeItalic >G6PC2</em> gene, Fasting blood glucose, Functional studies
Journal
Current Diabetes Reports
Volume 13, Issue 6, Pages 768-777
Publisher
Springer Nature
Online
2013-10-21
DOI
10.1007/s11892-013-0422-8
References
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Note: Only part of the references are listed.- Multiple functional polymorphisms in the G6PC2 gene contribute to the association with higher fasting plasma glucose levels
- (2013) D. A. Baerenwald et al. DIABETOLOGIA
- Genome wide association studies for diabetes: perspective on results and challenges
- (2013) JM Torres et al. PEDIATRIC DIABETES
- Large Scale Meta-Analyses of Fasting Plasma Glucose Raising Variants in GCK, GCKR, MTNR1B and G6PC2 and Their Impacts on Type 2 Diabetes Mellitus Risk
- (2013) Haoran Wang et al. PLoS One
- Recent progress in the use of genetics to understand links between type 2 diabetes and related metabolic traits
- (2013) Hanieh Yaghootkar et al. GENOME BIOLOGY
- Mechanisms of insulin resistance in obesity
- (2013) Jianping Ye Frontiers of Medicine
- A Systematic Review of Oxidative Stress and Safety of Antioxidants in Diabetes: Focus on Islets and Their Defense
- (2013) Udayakumar Karunakaran et al. Diabetes & Metabolism Journal
- Endoplasmic Reticulum Stress and Type 2 Diabetes
- (2012) Sung Hoon Back et al. Annual Review of Biochemistry
- A Systems Genetics Approach Identifies Genes and Pathways for Type 2 Diabetes in Human Islets
- (2012) Jalal Taneera et al. Cell Metabolism
- From Mice to Humans
- (2012) Fiona McMurray et al. Current Diabetes Reports
- G6PC2: A Negative Regulator of Basal Glucose-Stimulated Insulin Secretion
- (2012) L. D. Pound et al. DIABETES
- Phosphofructo-2-kinase/Fructose-2,6-bisphosphatase Modulates Oscillations of Pancreatic Islet Metabolism
- (2012) Matthew J. Merrins et al. PLoS One
- Islet-enriched gene expression and glucose-induced insulin secretion in human and mouse islets
- (2011) C. Dai et al. DIABETOLOGIA
- Understanding type 1 diabetes through genetics: advances and prospects
- (2011) Constantin Polychronakos et al. NATURE REVIEWS GENETICS
- Piecing together the FTO jigsaw
- (2011) Timothy M Frayling et al. GENOME BIOLOGY
- Metabolic Oscillations in Pancreatic Islets Depend on the Intracellular Ca2+ Level but Not Ca2+ Oscillations
- (2010) Matthew J. Merrins et al. BIOPHYSICAL JOURNAL
- From Genetic Association to Molecular Mechanism
- (2010) Martijn van de Bunt et al. Current Diabetes Reports
- Molecular Function of TCF7L2: Consequences of TCF7L2 Splicing for Molecular Function and Risk for Type 2 Diabetes
- (2010) Ola Hansson et al. Current Diabetes Reports
- Detailed Physiologic Characterization Reveals Diverse Mechanisms for Novel Genetic Loci Regulating Glucose and Insulin Metabolism in Humans
- (2010) E. Ingelsson et al. DIABETES
- Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study: Common Genetic Variants in GCK and TCF7L2 Are Associated With Fasting and Postchallenge Glucose Levels in Pregnancy and With the New Consensus Definition of Gestational Diabetes Mellitus From the International Association of Diabetes and Pregnancy Study Groups
- (2010) R. M. Freathy et al. DIABETES
- Genetic and Functional Assessment of the Role of the rs13431652-A and rs573225-A Alleles in the G6PC2 Promoter That Are Strongly Associated With Elevated Fasting Glucose Levels
- (2010) N. Bouatia-Naji et al. DIABETES
- Common Variants at 10 Genomic Loci Influence Hemoglobin A1C Levels via Glycemic and Nonglycemic Pathways
- (2010) N. Soranzo et al. DIABETES
- The Impact of Genetic Variation in theG6PC2Gene on Insulin Secretion Depends on Glycemia
- (2010) Martin Heni et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: a collaborative meta-analysis of 102 prospective studies
- (2010) The Emerging Risk Factors Collaboration LANCET
- New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
- (2010) Josée Dupuis et al. NATURE GENETICS
- Effects of GCK, GCKR, G6PC2 and MTNR1B Variants on Glucose Metabolism and Insulin Secretion
- (2010) Cheng Hu et al. PLoS One
- Common Polymorphisms in MTNR1B, G6PC2 and GCK Are Associated with Increased Fasting Plasma Glucose and Impaired Beta-Cell Function in Chinese Subjects
- (2010) Claudia Ha Ting Tam et al. PLoS One
- Additive Effects of Genetic Variation in GCK and G6PC2 on Insulin Secretion and Fasting Glucose
- (2009) Xia Li et al. DIABETES
- Minimal Contribution of Fasting Hyperglycemia to the Incidence of Type 2 Diabetes in Subjects With Normal 2-h Plasma Glucose
- (2009) M. A. Abdul-Ghani et al. DIABETES CARE
- Plasma Glucose Concentration and Prediction of Future Risk of Type 2 Diabetes
- (2009) M. A. Abdul-Ghani et al. DIABETES CARE
- Mutations in G6PC2 do not contribute to monogenic forms of early infancy diabetes and beta cell dysfunction
- (2009) A. Bonnefond et al. DIABETOLOGIA
- A variant in the G6PC2/ABCB11 locus is associated with increased fasting plasma glucose, increased basal hepatic glucose production and increased insulin release after oral and intravenous glucose loads
- (2009) C. S. Rose et al. DIABETOLOGIA
- Combined effects of single-nucleotide polymorphisms in GCK, GCKR, G6PC2 and MTNR1B on fasting plasma glucose and type 2 diabetes risk
- (2009) E. Reiling et al. DIABETOLOGIA
- Update on mutations in glucokinase (GCK), which cause maturity-onset diabetes of the young, permanent neonatal diabetes, and hyperinsulinemic hypoglycemia
- (2009) Kara K. Osbak et al. HUMAN MUTATION
- Glucose-6-phosphatase Catalytic Subunit Gene Family
- (2009) John C. Hutton et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Assessing the potential of glucokinase activators in diabetes therapy
- (2009) Franz M. Matschinsky NATURE REVIEWS DRUG DISCOVERY
- Towards a genome-wide reconstruction of cis-regulatory networks in the human genome
- (2009) Katharine R. Cecchini et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- Metabolic cycling in control of glucose-stimulated insulin secretion
- (2008) Mette V. Jensen et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Molecular Physiology of Mammalian Glucokinase
- (2008) P. B. Iynedjian CELLULAR AND MOLECULAR LIFE SCIENCES
- Identification of novel IGRP epitopes targeted in type 1 diabetes patients
- (2008) Irene Jarchum et al. CLINICAL IMMUNOLOGY
- A Single-Nucleotide Polymorphism in a Methylatable Foxa2 Binding Site of the G6PC2 Promoter Is Associated With Insulin Secretion In Vivo and Increased Promoter Activity In Vitro
- (2008) C. Dos Santos et al. DIABETES
- A genetic variant of G6PC2 is associated with type 2 diabetes and fasting plasma glucose level in the Chinese population
- (2008) C. Hu et al. DIABETOLOGIA
- The glucose-6-phosphate transporter is a phosphate-linked antiporter deficient in glycogen storage disease type Ib and Ic
- (2008) Shih-Yin Chen et al. FASEB JOURNAL
- Variants in MTNR1B influence fasting glucose levels
- (2008) Inga Prokopenko et al. NATURE GENETICS
- A Polymorphism Within the G6PC2 Gene Is Associated with Fasting Plasma Glucose Levels
- (2008) N. Bouatia-Naji et al. SCIENCE
- Splicing fidelity, enhancers, and disease
- (2007) Amanda et al. Frontiers in Bioscience-Landmark
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