Article
Immunology
Sophie Servais, Frederic Baron, Chantal Lechanteur, Laurence Seidel, Etienne Baudoux, Alexandra Briquet, Dominik Selleslag, Johan Maertens, Xavier Poire, Wilfried Schroyens, Carlos Graux, Ann De Becker, Pierre Zachee, Aurelie Ory, Julie Herman, Tessa Kerre, Yves Beguin
Summary: BM-derived MSC from a third-party donor appeared to improve hematological function after alloHCT, but comparative studies are needed to confirm these results.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Medicine, Research & Experimental
Rupali Sani Kumar, Neena Goyal
Summary: Hematopoietic stem cells provide a continuous supply of all immune cells through proliferation and differentiation decisions, with these decisions being controlled by the local bone marrow environment and long-range signals. Female longevity seems to depend on the major female sex hormone, estrogen, under homeostasis and disease conditions. Estrogen has effects on HSC, immune cells, and bone biology, with Estradiol (E2) being extensively investigated while the effects of other estrogens such as E1, E3, and E4 are starting to be understood. The clinical effects of estrogen as hormone therapy on HSC and immune cells are also discussed.
Review
Immunology
Jicui Li, Manyu Luo, Bing Li, Yan Lou, Yuexin Zhu, Xue Bai, Baichao Sun, Xuehong Lu, Ping Luo
Summary: Lupus nephritis (LN) is a significant cause of acute and chronic renal diseases, characterized by abnormal activation of immune responses and dysregulation of inflammatory signaling pathways. Mesenchymal stem cells (MSCs) have immunomodulatory properties and can suppress the proliferation and functions of immune cells, contributing to the improvement of LN pathology and restoration of kidney function in lupus mice and LN patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biology
Almut S. Eisele, Jason Cosgrove, Aurelie Magniez, Emilie Tubeuf, Sabrina Tenreira Bento, Cecile Conrad, Fanny Cayrac, Tamar Tak, Anne-Marie Lyne, Jos Urbanus, Leila Perie
Summary: This study used cellular barcoding to trace the differentiation of mouse hematopoietic stem and progenitor cells (HSPCs) after exposure to EPO. The researchers found that EPO can directly act on multipotent progenitor cells (MPP) and modulate fate by remodeling the clonal composition of the MPP pool.
Editorial Material
Immunology
Vasileios Oikonomou, Michail S. Lionakis
Summary: Extrathymic MHCII(+)Rorc(+) Aire-expressing cells that resemble type 3 innate lymphoid cells (ILC3s) can internalize C. albicans and present its antigens, leading to the development of Candida-specific T(H)17 cells.
Article
Immunology
Fen Zhang, Linxiao Fan, Qiuhong Liu, Shima Tang, Sainan Zhang, Lanlan Xiao, Lingjian Zhang, Qian Li, Nueraili Maihemuti, Lanjuan Li
Summary: MenSCs treatment can alleviate autoimmune hepatitis by inhibiting macrophages and M1 polarization in the liver tissue.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cell Biology
Vadim I. Chechekhin, Konstantin Yu. Kulebyakin, Romesh I. Kokaev, Pyotr A. Tyurin-Kuzmin
Summary: Adipose tissue relies on the regulation of multipotent mesenchymal stromal cells (MSCs), which serve as both precursors for new adipocytes and key paracrine regulators of adipose tissue homeostasis. The activity of MSCs is tightly controlled, regulating aspects such as proliferation, differentiation, and signal molecule production through modulation of hormonal sensitivity.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Cell Biology
Michal Szymoniuk, Jakub Litak, Leon Sakwa, Aleksandra Dryla, Wojciech Zezulinski, Wojciech Czyzewski, Piotr Kamieniak, Tomasz Blicharski
Summary: Spinal Cord Injury (SCI) is a common neurological disorder that causes permanent disability in most patients. Stem Cell Therapy (SCT) shows promise in regenerating the injured spinal cord through the use of various types of stem cells. Understanding the pathogenesis of SCI and the molecular mechanisms of stem cell action can improve the efficacy of SCT and lead to the development of new therapeutic approaches.
Review
Cell Biology
Asterios S. Tsiftsoglou
Summary: Erythropoietin (EPO) is a glycoprotein hormone that acts as a growth factor for red blood cell production and also plays a role in tissue regeneration. It activates specific signaling pathways in multipotent stem cells, leading to bone remodeling, angiogenesis, and the secretion of trophic factors. EPO is clinically used in the treatment of anemias associated with chronic renal failure, making it a valuable agent in regenerative medicine for treating tissue disorders.
Review
Cell & Tissue Engineering
Hesham Soliman, Marine Theret, Wilder Scott, Lesley Hill, Tully Michael Underhill, Boris Hinz, Fabio M. Rossi
Summary: MSCs are essential for the development, maintenance, function, and regeneration of most tissues. They play a crucial role in responding to injury, promoting regeneration through secretion of trophic factors and ECM molecules, and contributing to fibrotic reparative processes. Through fate mapping and single cell omics, tissue-specific MSC identities and functions are being elucidated, providing unprecedented insights into the secret lives of tissue-resident MSCs.
Review
Biochemistry & Molecular Biology
Lina N. Zaripova, Angela Midgley, Stephen E. Christmas, Michael W. Beresford, Clare Pain, Eileen M. Baildam, Rachel A. Oldershaw
Summary: Mesenchymal stem cells (MSCs) have potential as immunosuppressants for treating autoimmune and autoinflammatory diseases. They can reduce inflammation and promote tissue regeneration. However, during the inflammatory process, MSCs become impaired and lose their immunomodulatory activity. Despite challenges and risks, MSCs show promise in the treatment of severe diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Diana Klein
Summary: Studies have shown the presence of mesenchymal stem cells (MSCs) in the lungs, which may play a role in regulating lung tissue repair and inflammation. However, the true function of tissue-resident MSCs in the lungs and the identification of their niche remain challenging. Future research directions include unraveling the localization of MSCs, controlling their signaling pathways, and exploring the therapeutic benefits of manipulating these cells directly within their endogenous niche.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Article
Immunology
Ehud Even-Or, Yael Dinur Schejter, Adeeb NaserEddin, Irina Zaidman, Bella Shadur, Polina Stepensky
Summary: Autoimmune cytopenia (AIC) is a challenging complication after hematopoietic stem cell transplantation (HSCT) in pediatric patients with nonmalignant diseases. The etiology of post-HSCT AIC is poorly understood, and the treatment response can vary. A relatively high prevalence of AIC is seen in patients with osteopetrosis, possibly due to difficult engraftment and high rates of mixed chimerism. Novel treatment modalities are needed for better management of severe and refractory cases.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Ida Pastore, Emma Assi, Moufida Ben Nasr, Andrea Mario Bolla, Anna Maestroni, Vera Usuelli, Cristian Loretelli, Andy Joe Seelam, Ahmed Abdelsalam, Gian Vincenzo Zuccotti, Francesca D'Addio, Paolo Fiorina
Summary: Although progress has been made in understanding the pathophysiological mechanisms of T1D, the quest for effective therapeutic options is ongoing. Promising results have been seen with HSC-based approaches and teplizumab, but more research is needed to establish their long-term efficacy and safety. Genetically engineered HSCs hold potential as a novel biologic therapy for T1D and other autoimmune/immune-related disorders, with studies in murine models and humanized mouse models showing accelerated translational potentials.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Amelie Bonaud, Julia P. Lemos, Marion Espeli, Karl Balabanian
Summary: This review explores the bone marrow niches in mice that support hematopoietic cells, focusing on the roles of multipotent progenitors and plasma cells. The chemokine CXCL12/CXCR4 signaling axis is highlighted for its importance in these processes. The question of whether multipotent progenitors and plasma cells are neighbors or roommates within the bone marrow is raised for further exploration.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Yanjia Li, Baoyong Yan, Hepeng Wang, Heng Li, Quanhai Li, Dong Zhao, Yana Chen, Ye Zhang, Wenxia Li, Jun Zhang, Shanfeng Wang, Jie Shen, Yunxiang Li, Edward Guindi, Yong Zhao
Article
Medicine, General & Internal
Elias Delgado, Marcos Perez-Basterrechea, Beatriz Suarez-Alvarez, Huimin Zhou, Eva Martinez Revuelta, Jose Maria Garcia-Gala, Silvia Perez, Maria Alvarez-Viejo, Edelmiro Menendez, Carlos Lopez-Larrea, Ruifeng Tang, Zhenlong Zhu, Wei Hu, Thomas Moss, Edward Guindi, Jesus Otero, Yong Zhao
Article
Cell & Tissue Engineering
Yong Zhao, Zhaoshun Jiang, Elias Delgado, Heng Li, Huimin Zhou, Wei Hu, Marcos Perez-Basterrechea, Anna Janostakova, Qidong Tan, Jing Wang, Mao Mao, Zhaohui Yin, Ye Zhang, Ying Li, Quanhai Li, Jing Zhou, Yunxiang Li, Eva Martinez Revuelta, Jose Maria Garcia-Gala, Honglan Wang, Silvia Perez-Lopez, Maria Alvarez-Viejo, Edelmiro Menendez, Thomas Moss, Edward Guindi, Jesus Otero
STEM CELLS TRANSLATIONAL MEDICINE
(2017)
Article
Medicine, General & Internal
Yong Zhao, Zhaoshun Jiang, Tingbao Zhao, Mingliang Ye, Chengjin Hu, Zhaohui Yin, Heng Li, Ye Zhang, Yalin Diao, Yunxiang Li, Yingjian Chen, Xiaoming Sun, Mary Beth Fisk, Randal Skidgel, Mark Holterman, Bellur Prabhakar, Theodore Mazzone
Article
Medicine, General & Internal
Yong Zhao, Zhaoshun Jiang, Tingbao Zhao, Mingliang Ye, Chengjin Hu, Huimin Zhou, Zhaohui Yin, Yana Chen, Ye Zhang, Shanfeng Wang, Jie Shen, Hatim Thaker, Summit Jain, Yunxiang Li, Yalin Diao, Yingjian Chen, Xiaoming Sun, Mary Beth Fisk, Heng Li
Article
Immunology
Wei Hu, Xiang Song, Haibo Yu, Jingyu Sun, Yong Zhao
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Xiang Song, Wei Hu, Haibo Yu, Honglan Wang, Yelu Zhao, Robert Korngold, Yong Zhao
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Cell Biology
Haibo Yu, Wei Hu, Xiang Song, Yong Zhao
Article
Biochemistry & Molecular Biology
Haibo Yu, Wei Hu, Xiang Song, Dante Descalzi-Montoya, Zheng Yang, Robert Korngold, Yong Zhao
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Review
Biochemistry & Molecular Biology
Wei Hu, Xiang Song, Haibo Yu, Jingyu Sun, Yong Zhao
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Haibo Yu, Wei Hu, Xiang Song, Yong Zhao
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Haibo Yu, Wei Hu, Xiang Song, Yong Zhao
MOLECULAR BIOLOGY REPORTS
(2020)
Article
Biochemical Research Methods
Xiang Song, Wei Hu, Haibo Yu, Laura Zhao, Yeqian Zhao, Xin Zhao, Hai-Hui Xue, Yong Zhao
Summary: ACE2 receptor is expressed at low or negligible levels on most human peripheral blood-derived immune cells and platelets, but upregulated on activated macrophages. Alveolar macrophages, as frontline immune cells, may be directly targeted by SARS-CoV-2 infection.
Article
Multidisciplinary Sciences
Wei Hu, Xiang Song, Haibo Yu, Jingyu Sun, Yong Zhao
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2020)