Article
Biochemistry & Molecular Biology
Hui Chiu, Eric D. Hoopfer, Maeve L. Coughlan, David J. Anderson
Summary: This passage discusses the function and gender differences of three cell types that regulate aggression in Drosophila, as well as how these circuits affect the aggressive behaviors of male and female flies from the appetitive phase to the consummatory phase. The strength of the connection between monomorphic and dimorphic behaviors is increased by social isolation, indicating a possible locus for isolation-dependent enhancement of aggression.
Article
Genetics & Heredity
Grace T. Hansen, Debora R. Sobreira, Zachary T. Weber, Alexis G. Thornburg, Ivy Aneas, Li Zhang, Noboru J. Sakabe, Amelia C. Joslin, Gabriela A. Haddad, Sophie M. Strobel, Samantha Laber, Farhath Sultana, Faezeh Sahebdel, Kohinoor Khan, Yang I. Li, Melina Claussnitzer, Liang Ye, Ricardo A. Battaglino, Marcelo A. Nobrega
Summary: The study identifies genes and enhancers associated with WHRadjBMI in women, with a focus on variants within Alu retrotransposons. The gene SNX10 plays a role in adipocyte differentiation and diet-induced adipose expansion in female mice.
Article
Neurosciences
Esther Serrano-Saiz, Yoh Isogai
Summary: Single-cell transcriptomics has revealed a variety of neural cell types in the brain, and there is a pressing need to understand their functional roles in circuits and behavior. This review focuses on the molecular profiling of cell types involved in social behaviors in mice, highlighting key roles of sensory and downstream neurons in sexually dimorphic behaviors, and proposes using multimodal criteria to define cell types for a better understanding of circuits.
CURRENT OPINION IN NEUROBIOLOGY
(2021)
Article
Multidisciplinary Sciences
Li-Fei Luo, Zi-Sheng Xu, Dan-Yang Li, Zhen Hu, Ze-Xia Gao
Summary: Sexual size dimorphism is widespread in fish species, but the regulatory mechanisms underlying growth differences between females and males are still not well understood. In this study, RNA-seq analysis was performed on four fish species with significant growth differences. Differentially expressed genes were identified in the brain and muscle of each species, and their expression levels were validated by qRT-PCR. These comparative transcriptome profiles provide fundamental information for further studies on the commonalities of sexually size dimorphic fish in regulating growth differences.
Review
Endocrinology & Metabolism
Rosa Isela Ortiz-Huidobro, Myrian Velasco, Carlos Larque, Rene Escalona, Marcia Hiriart
Summary: The rise in obesity, particularly among women, is linked to insulin resistance in adipose tissue, a critical factor in metabolic diseases. Understanding the sexual dimorphism in molecular mechanisms of insulin actions is essential for developing targeted therapeutic strategies and public health policies to address obesity and diabetes.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Rodanthi Lyraki, Andreas Schedl
Summary: Many adrenocortical diseases are more common in women than in men, although the reasons for this sex bias are still unknown. Recent studies in mice involving gonadectomy and sex hormone replacement experiments have provided insights into the molecular basis of sexual dimorphism in the adrenal cortex. It has been shown that gonadal hormones influence various aspects of adrenal physiology, from tissue turnover to steroidogenesis and X-zone dynamics. Understanding adrenal cortex sexual dimorphism and the mechanisms by which sex hormones influence adrenal homeostasis is expected to contribute to the development of personalized and novel therapeutic approaches in the future.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Muxian Zhang, Yunqiang Zhou, Yiru Jiang, Zhancheng Lu, Xiaoxia Xiao, Jinhuan Ning, Hao Sun, Xian Zhang, Hong Luo, Dan Can, Jinsheng Lu, Huaxi Xu, Yun-wu Zhang
Summary: The study compared sexual dimorphism in gene expression across primary neurons, astrocytes, and microglia derived from neonatal mouse brains, revealing different levels of sexually dimorphic genes in these primary cells, with enrichment in immune-related pathways. The sexually dimorphic genes were predominantly located on the Y chromosome, and overexpression of Eif2s3y specifically affected synaptic transmission in male neurons and caused autism-like behaviors in male mice, providing new insights into sex differences in neurological disorders.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Zhen Xu, Jiajia Shi, Yu Zhang, Yuhan Liu, Junzheng Zhao, Qian Chen, Chenglin Song, Shuhui Geng, Wei Xie, Feizhen Wu, Yun Bai, Yang Yang, Xiajun Li
Summary: Zfp57 plays important roles in both maternal and zygotic functions in mouse, regulating the allelic expression and DNA methylation imprinting of imprinted genes. Loss of Zfp57 results in the loss of DNA methylation imprint at multiple imprinting control regions, with maternal Zfp57 being essential for maintaining DNA methylation at a subset of imprinted regions. Zfp57 also has sexually dimorphic effects on allelic expression switch and expression level changes of imprinted genes in mouse embryos.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
James J. Wilmouth, Julie Olabe, Diana Garcia-Garcia, Cecily Lucas, Rachel Guiton, Florence Roucher-Boulez, Damien Dufour, Christelle Damon-Soubeyrand, Isabelle Sahut-Barnola, Jean-Christophe Pointud, Yoan Renaud, Adrien Levasseur, Igor Tauveron, Anne-Marie Lefrancois-Martinez, Antoine Martinez, Pierre Val
Summary: Adrenocortical carcinomas (ACCs) are more common in women than in men, but the reasons for this difference are not well understood. Researchers found that in mouse adrenal cortex, inactivation of Znrf3 leads to sexually dimorphic tumor progression, with females developing metastatic carcinomas while males experiencing regression of adrenal hyperplasia. This difference in phenotype is due to androgen-dependent induction of senescence, recruitment, and differentiation of highly phagocytic macrophages in male knockouts that clear out senescent cells. Conversely, in females, macrophage recruitment is delayed and dampened, allowing for aggressive tumor progression.
Article
Multidisciplinary Sciences
Tom W. Andrew, Lauren S. Koepke, Yuting Wang, Michael Lopez, Holly Steininger, Danielle Struck, Tatiana Boyko, Thomas H. Ambrosi, Xinming Tong, Yuxi Sun, Gunsagar S. Gulati, Matthew P. Murphy, Owen Marecic, Ruth Telvin, Katharina Schallmoser, Dirk Strunk, Jun Seita, Stuart B. Goodman, Fan Yang, Michael T. Longaker, George P. Yang, Charles K. F. Chan
Summary: This study investigates the regulation of bone-related sexually dimorphic traits at the stem cell level. The researchers find that estrogen signaling directly controls skeletal stem cells (SSCs) in female mice, but not in male mice. They also demonstrate that estrogen is necessary for the self-renewal and differentiation of SSCs, and suggest a potential clinical strategy for bone healing using localized estrogen hormone therapy.
NATURE COMMUNICATIONS
(2022)
Article
Green & Sustainable Science & Technology
Matthew L. McLean, D. Nicolas Espinoza
Summary: Viable Enhanced Geothermal Systems require access to large reservoir volumes at high temperatures and sufficient permeability for large production flow rates. However, working fluid injection may decrease recoverable heat energy. This study provides novel numerical simulations of a multi-fracture EGS that considers fracture aperture and its impact on fluid flow and heat recovery. The simulations investigate the reservoir behavior and propose strategies to minimize the severity of thermal short-circuiting.
Article
Medicine, Research & Experimental
Isabella M. Salamone, Mattia Quattrocelli, David Y. Barefield, Patrick G. Page, Ibrahim Tahtah, Michele Hadhazy, Garima Tomar, Elizabeth M. McNally
Summary: Weekly glucocorticoid exposure produces different effects on skeletal muscle performance in male and female mice. Male muscles show enhanced response to weekly glucocorticoids, while female muscles exhibit significant upregulation of lipid metabolism genes.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Cell Biology
Evan A. Bordt, Lydia L. Shook, Caroline Atyeo, Krista M. Pullen, Rose M. De Guzman, Marie-Charlotte Meinsohn, Maeva Chauvin, Stephanie Fischinger, Laura J. Yockey, Kaitlyn James, Rosiane Lima, Lael M. Yonker, Alessio Fasano, Sara Brigida, Lisa M. Bebell, Drucilla J. Roberts, David Pepin, Jun R. Huh, Staci D. Bilbo, Jonathan Z. Li, Anjali Kaimal, Danny J. Schust, Kathryn J. Gray, Douglas Lauffenburger, Galit Alter, Andrea G. Edlow
Summary: There is a persistent bias toward higher prevalence and increased severity of COVID-19 in males. After infection with SARS-CoV-2, pregnant women with male fetuses show altered placental antibody transfer, interferon responses, and protein expression patterns. This study demonstrates a fetal sex-specific immune response to SARS-CoV-2 in pregnant women.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Cell Biology
Samantha R. Friedrich, Alexander A. Nevue, Abraao L. P. Andrade, Tarciso A. F. Velho, Claudio V. Mello
Summary: This study reveals the transcriptomic changes underlying the development of extreme neuroanatomical sex difference, including sex-differential gene expression and related developmental processes in the robust nucleus of the arcopallium (RA). Male and female birds show different developmental characteristics in terms of cell and axonal growth, synapse assembly, energy metabolism, as well as transcriptional repression, hormone and immune signaling. Transcription factor binding site analysis supports the activation of pro-apoptotic regulatory networks in female birds. The extensive and sex-specific transcriptomic reorganization of RA provides insights into potential drivers of sexually dimorphic neurodevelopment.
Review
Behavioral Sciences
Elora Midavaine, Jerome Cote, Serge Marchand, Philippe Sarret
Summary: Chronic pain is a major global health issue with limited pharmacological treatment options available. Sex-specific differences in pain conditions are increasingly recognized, highlighting the importance of developing gender-specific pain medications. Research on sexually dimorphic pain responses is vital for advancing pain management strategies.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Mathematical & Computational Biology
Justin M. Fear, Michelle N. Arbeitman, Matthew P. Salomon, Justin E. Dalton, John Tower, Sergey V. Nuzhdin, Lauren M. McIntyre
BMC SYSTEMS BIOLOGY
(2015)
Article
Genetics & Heredity
Nicole R. Newell, Felicia N. New, Justin E. Dalton, Lauren M. McIntyre, Michelle N. Arbeitman
G3-GENES GENOMES GENETICS
(2016)
Article
Genetics & Heredity
Michelle N. Arbeitman, Felicia N. New, Justin M. Fear, Tiffany S. Howard, Justin E. Dalton, Rita M. Graze
G3-GENES GENOMES GENETICS
(2016)
Article
Biotechnology & Applied Microbiology
Justin E. Dalton, Tanvi S. Kacheria, Simon R. V. Knott, Matthew S. Lebo, Allison Nishitani, Laura E. Sanders, Emma J. Stirling, Ari Winbush, Michelle N. Arbeitman
Article
Biotechnology & Applied Microbiology
Peter L. Chang, Joseph P. Dunham, Sergey V. Nuzhdin, Michelle N. Arbeitman
Article
Biotechnology & Applied Microbiology
Justin E. Dalton, Justin M. Fear, Simon Knott, Bruce S. Baker, Lauren M. McIntyre, Michelle N. Arbeitman
Article
Genetics & Heredity
John P. Masly, Justin E. Dalton, Sudeep Srivastava, Liang Chen, Michelle N. Arbeitman
Article
Genetics & Heredity
Michelle N. Arbeitman, Artyom Kopp, Mark L. Siegal, Mark Van Doren
Article
Multidisciplinary Sciences
Amanda Thomas, Pei-Jung Lee, Justin E. Dalton, Krystle J. Nomie, Loredana Stoica, Mauro Costa-Mattioli, Peter Chang, Sergey Nuzhdin, Michelle N. Arbeitman, Herman A. Dierick
Article
Genetics & Heredity
Ari Winbush, Danielle Reed, Peter L. Chang, Sergey V. Nuzhdin, Lisa C. Lyons, Michelle N. Arbeitman
G3-GENES GENOMES GENETICS
(2012)
Article
Genetics & Heredity
Michelle N. Arbeitman, Artyom Kopp, Mark L. Siegal, Mark Van Doren
G3-GENES GENOMES GENETICS
(2014)
Article
Biochemistry & Molecular Biology
Kohtaro Tanaka, Olga Barmina, Laura E. Sanders, Michelle N. Arbeitman, Artyom Kopp
Article
Biology
Daniel Stribling, Peter L. Chang, Justin E. Dalton, Christopher A. Conow, Malcolm Rosenthal, Eileen Hebets, Rita M. Graze, Michelle N. Arbeitman
Summary: The study aimed to lay the groundwork for comparative transcriptomics of sex differences in the brains of wolf spiders, a non-model organism of the phylum Euarthopoda, through generating transcriptomes and analyzing gene expression. Short read transcript sequencing and de novo transcriptome assembly were performed to examine sex-differential gene expression in male and female subadult and mature wolf spiders.
BMC RESEARCH NOTES
(2021)
Article
Biology
Colleen M. Palmateer, Catherina Artikis, Savannah G. Brovero, Benjamin Friedman, Alexis Gresham, Michelle N. Arbeitman
Summary: Reproductive behaviors in Drosophila melanogaster are controlled by fruitless neurons. Single-cell RNA sequencing on pupal neurons revealed sex-specific gene expression patterns, with over 113 distinct clusters identified. Marker gene analyses showed enrichment of specific functional groups, including circadian clock neurons, mushroom body Kenyon cells, neurotransmitter-producing neurons, and those expressing doublesex. The presence of both male and female neurons in most clusters suggests common gene expression programs, with sex-specific differences overlaying these programs to generate diverse behaviors.
Article
Genetics & Heredity
Surjyendu Ray, Ruei-Ying Tzeng, Lisa M. DiCarlo, Joseph L. Bundy, Cynthia Vied, Gary Tyson, Richard Nowakowski, Michelle N. Arbeitman
G3-GENES GENOMES GENETICS
(2016)
