Article
Cell Biology
Mohsen A. Bakooshli, Yu Xin Wang, Elena Monti, Shiqi Su, Peggy Kraft, Minas Nalbandian, Ludmila Alexandrova, Joshua R. Wheeler, Hannes Vogel, Helen M. Blau
Summary: This study discovered that inhibition of the enzyme 15-hydroxyprostaglandin dehydrogenase (15-PGDH) can promote motor axon regeneration and neuromuscular synapse formation, leading to an acceleration in recovery of strength. In aged mice, inhibition of 15-PGDH increased motor neuron viability and restored neuromuscular junctions and function, resulting in a marked increase in muscle strength. The findings suggest that inhibiting 15-PGDH may be a therapeutic strategy for improving strength in cases of acute or chronic denervation due to injury, disease, or aging.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
John M. Lawler, Jeffrey M. Hord, Pat Ryan, Dylan Holly, Mariana Janini Gomes, Dinah Rodriguez, Vinicius Guzzoni, Erika Garcia-Villatoro, Chase Green, Yang Lee, Sarah Little, Marcela Garcia, Lorrie Hill, Mary-Catherine Brooks, Matthew S. Lawler, Nicolette Keys, Amin Mohajeri, Khaled Y. Kamal
Summary: Insufficient stress response and elevated oxidative stress can lead to skeletal muscle atrophy during mechanical unloading. The inhibition of Nox2 has been found to play a crucial role in attenuating muscle fiber atrophy by preserving HSP70, Nrf2, and sarcolemmal nNOS during unloading.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Critical Care Medicine
Sumika Osa, Yuki Enoki, Taichi Miyajima, Masahiro Akiyama, Yukio Fujiwara, Kazuaki Taguchi, Yun-Gi Kim, Kazuaki Matsumoto
Summary: This study verified the association between skeletal muscle atrophy induced by sciatic denervation (DN) and poor prognosis after CLP-induced sepsis. The results showed that the DN group had a lower survival rate, higher bacterial count in the blood, and increased kidney damage markers in comparison to the sham group. Additionally, skeletal muscle atrophy led to alterations in cytokine levels and the accumulation of nitrative stress.
Article
Nutrition & Dietetics
Yuki Yamauchi, Farhana Ferdousi, Satoshi Fukumitsu, Hiroko Isoda
Summary: The study found that Maslinic acid has the potential to prevent denervated muscle atrophy and enhance muscle strength, possibly through regulating various biological processes and signaling pathways. Therefore, this compound may serve as a new dietary ingredient for the treatment and prevention of muscle atrophy.
Article
Biochemistry & Molecular Biology
Suresh Govatati, Prahalathan Pichavaram, Arul M. Mani, Raj Kumar, Deepti Sharma, Ari Dienel, Sunita Meena, Michelle A. Puchowicz, Edwards A. Park, Gadiparthi N. Rao
Summary: The study revealed the significant role of 12/15-LOX in high-fat diet-induced weight gain by influencing lipid synthesis and transport, leading to white adipose tissue expansion and increased weight. Modulation of 12/15-LOX metabolism could serve as a potential therapeutic target for weight gain and obesity.
Article
Biochemistry & Molecular Biology
Riyaz Mohamed, Jennifer C. Sullivan
Summary: This study found that males have delayed recovery of renal function and more severe renal cell death and inflammation after ischemia-reperfusion injury compared to females. Enhanced activation of 12/15 LOX contributes to impaired renal recovery and this mechanism is more significant in males.
MOLECULAR MEDICINE
(2023)
Article
Medicine, Research & Experimental
Zongqi You, Xinying Huang, Yaoxian Xiang, Junxi Dai, Lei Xu, Junjian Jiang, Jianguang Xu
Summary: This study investigated the role of NLRP3 inflammasome activation in denervated muscle and found that its activation leads to pyroptosis, proteolysis, and apoptosis, resulting in muscle atrophy. Inhibition of NLRP3 activation can effectively alleviate muscle atrophy, suggesting the potential involvement of NLRP3 inflammasome in the pathogenesis of neuromuscular diseases.
Review
Cell Biology
Kazumi Takaishi, Hiroyuki Kinoshita, Shingo Kawashima, Shinji Kawahito
Summary: This article discusses the critical role of superoxide in vascular redox signaling and the physiological and pathophysiological functions of NOX in vascular smooth muscle cells. NOX is associated with cardiovascular diseases such as hypertension and diabetes, and is regulated by various stimulants.
Article
Neurosciences
Wenjing Ma, Yong Cai, Yuntian Shen, Xin Chen, Lilei Zhang, Yanan Ji, Zehao Chen, Jianwei Zhu, Xiaoming Yang, Hualin Sun
Summary: The study reveals the potential role of HDAC4 in denervation-induced muscle atrophy, with its inhibition showing promise in alleviating muscle loss and enhancing the expression of key proteins associated with muscle health. This suggests that HDAC4 inhibitors may serve as a potential treatment for neurogenic muscle atrophy.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Neurosciences
Anahita Shahraz, Jannis Wissfeld, Aurelien Ginolhac, Mona Mathews, Lasse Sinkkonen, Harald Neumann
Summary: The study showed that mice deficient in NOX-2 exhibited attenuated loss of dopaminergic neurons in the substantia nigra pars compacta and a decreased inflammatory response after repeated systemic challenge with LPS. This suggests that NOX-2 may play a role in inflammatory neurodegeneration in this region of the brain.
Article
Physiology
Xiaoming Yang, Ming Li, Yanan Ji, Yinghao Lin, Lai Xu, Xiaosong Gu, Hualin Sun, Wei Wang, Yuntian Shen, Hua Liu, Jianwei Zhu
Summary: Peripheral nerve injury can cause skeletal muscle atrophy and dysfunction. Transcription factors play a key role in this process. The current study identified differentially expressed transcription factors that are mainly involved in immune response, providing insights into the regulatory mechanisms and potential therapeutic targets for muscle atrophy following peripheral nerve injury.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yuta Ozaki, Koji Ohashi, Naoya Otaka, Hayato Ogawa, Hiroshi Kawanishi, Tomonobu Takikawa, Lixin Fang, Minako Tatsumi, Mikito Takefuji, Takashi Enomoto, Mohamed Darwish, Yoko Iijima, Takatoshi Iijima, Toyoaki Murohara, Noriyuki Ouchi
Summary: Neuron-derived neurotrophic factor (NDNF) prevents skeletal muscle atrophy by reducing the expression of ubiquitin E3 ligases. Injections of NDNF increase muscle weight and reverse the decrease in myotube diameter caused by DEX stimulation. Therefore, NDNF could be a potential therapeutic target for muscle atrophy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Biology
Marianne E. Emmert, Parul Aggarwal, Kritton Shay-Winkler, Se-Jin Lee, Qingnian Goh, Roger Cornwall
Summary: Neonatal brachial plexus injury (NBPI) leads to muscle contractures, and the study reveals sex dimorphism in the regulation of neonatal longitudinal muscle growth and contractures. It provides insights into finding potential muscle-specific therapeutic targets for contracture prevention and highlights the importance of sex as a biological variable in the pathophysiology of neuromuscular disorders.
Article
Biochemistry & Molecular Biology
Mototada Shichiri, Noriko Ishida, Yoshinori Aoki, Taisuke Koike, Yoshihisa Hagihara
Summary: The arachidonate-derived metabolite produced by stress-activated leukocyte 12/15-lipoxygenase is elevated in plasma and upregulates central norepinephrine release, resulting in enhanced struggle behavior observed in the tail suspension test. Tocotrienols and geranylgeraniol can reduce stress-induced metabolite production and suppress struggle behavior. The study proposes 12/15-lipoxygenase as a potential therapeutic target for the treatment of emotional arousal in stress-related mental disorders.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Lisa A. Walter, Lauren P. Blake, Yann S. Gallot, Charles J. Arends, Randall S. Sozio, Stephen M. Onifer, Kyle R. Bohnert
Summary: This study investigates the molecular mechanisms controlling skeletal muscle atrophy following denervation. It shows that transection of the sciatic nerve leads to significant skeletal muscle atrophy in rats, while having little effect on the neuromuscular junction. The study also reveals the activation of the unfolded protein response in denervated skeletal muscle, with ATF4 and ATF6 elevated in the cytoplasm and XBP1 elevated in the nuclei. These findings suggest a potential role of the unfolded protein response and XBP1 in maintaining skeletal muscle and the neuromuscular junction after peripheral nerve injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Correction
Biochemistry & Molecular Biology
Siew Chin Chan, Chih-Wei Tung, Chia-Wei Lin, Yun-Shiuan Tung, Po-Min Wu, Pei-Hsun Cheng, Chuan-Mu Chen, Shang-Hsun Yang
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Suyuan Liu, Meiling Tan, Jiangxue Cai, Chenxuan Li, Miaoxin Yang, Xiaoxiao Sun, Bin He
Summary: This study reveals that the antibiotic doxycycline effectively inhibits NLRP3 inflammasome activation by targeting mitochondrial translation and mtDNA synthesis, offering potential for the treatment of NLRP3-related diseases.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Hao Liu, Nana Li, Ge Kuang, Xia Gong, Ting Wang, Jun Hu, Hui Du, Minxuan Zhong, Jiashi Guo, Yao Xie, Yang Xiang, Shengwang Wu, Yiling Yuan, Xinru Yin, Jingyuan Wan, Ke Li
Summary: Protectin D1 (PTD1) improves hepatic steatosis, inflammation and fibrosis in a NASH mouse model by inhibiting the activation of TLR4 downstream signaling pathway, possibly through upregulation of IRAK-M expression, suggesting a potential new treatment for NASH.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)