BDNF Regulates Atypical PKC at Spinal Synapses to Initiate and Maintain a Centralized Chronic Pain State

Prkcz null mice show normal learning and memory

(2013) Anna M. Lee et al.   NATURE

PKM-ζ is not required for hippocampal synaptic plasticity, learning and memory

(2013) Lenora J. Volk et al.   NATURE

Morphine hyperalgesia gated through microglia-mediated disruption of neuronal Cl− homeostasis

(2013) Francesco Ferrini et al.   NATURE NEUROSCIENCE

Contribution of PKMζ-dependent and independent amplification to components of experimental neuropathic pain

(2012) Tamara King et al.   PAIN

Identification of a low–molecular weight TrkB antagonist with anxiolytic and antidepressant activity in mice

(2011) Maxime Cazorla et al.   JOURNAL OF CLINICAL INVESTIGATION

Nerve growth factor enhances the excitability of rat sensory neurons through activation of the atypical protein kinase C isoform, PKMζ

(2011) Y. H. Zhang et al.   JOURNAL OF NEUROPHYSIOLOGY

Spinal Protein Kinase M   Underlies the Maintenance Mechanism of Persistent Nociceptive Sensitization

(2011) M. N. Asiedu et al.   JOURNAL OF NEUROSCIENCE

PKMξ is Essential for Spinal Plasticity Underlying the Maintenance of Persistent Pain

(2011) Andre Laferrière et al.   Molecular Pain

Long-Term Potentiation in Spinal Nociceptive Pathways as a Novel Target for Pain Therapy

(2011) Ruth Ruscheweyh et al.   Molecular Pain

Specific Involvement of Atypical PKCξ/PKMξ in Spinal Persistent Nociceptive Processing following Peripheral Inflammation in Rat

(2011) Fabien Marchand et al.   Molecular Pain

Temporary disruption of fear-potentiated startle following PKMζ inhibition in the amygdala

(2011) Ryan G Parsons et al.   NATURE NEUROSCIENCE

BDNF Facilitates L-LTP Maintenance in the Absence of Protein Synthesis through PKMζ

(2011) Fan Mei et al.   PLoS One

Enhancement of Consolidated Long-Term Memory by Overexpression of Protein Kinase M  in the Neocortex

(2011) R. Shema et al.   SCIENCE

Brain-derived neurotrophic factor contributes to spinal long-term potentiation and mechanical hypersensitivity by activation of spinal microglia in rat

(2010) Li-Jun Zhou et al.   BRAIN BEHAVIOR AND IMMUNITY

Translational Control Mechanisms in Long-lasting Synaptic Plasticity and Memory

(2010) Christos Gkogkas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

How does PKMζ maintain long-term memory?

(2010) Todd C. Sacktor   NATURE REVIEWS NEUROSCIENCE

Central sensitization: Implications for the diagnosis and treatment of pain

(2010) Clifford J. Woolf   PAIN

Alleviating Neuropathic Pain Hypersensitivity by Inhibiting PKM  in the Anterior Cingulate Cortex

(2010) X.-Y. Li et al.   SCIENCE

TORC-Specific Phosphorylation of Mammalian Target of Rapamycin (mTOR): Phospho-Ser2481 Is a Marker for Intact mTOR Signaling Complex 2

(2009) J. Copp et al.   CANCER RESEARCH

Positive AMPA Receptor Modulation Rapidly Stimulates BDNF Release and Increases Dendritic mRNA Translation

(2009) H. Jourdi et al.   JOURNAL OF NEUROSCIENCE

P2X4-Receptor-Mediated Synthesis and Release of Brain-Derived Neurotrophic Factor in Microglia Is Dependent on Calcium and p38-Mitogen-Activated Protein Kinase Activation

(2009) T. Trang et al.   JOURNAL OF NEUROSCIENCE

Central Sensitization: A Generator of Pain Hypersensitivity by Central Neural Plasticity

(2009) Alban Latremoliere et al.   JOURNAL OF PAIN

Synaptotagmin-IV modulates synaptic function and long-term potentiation by regulating BDNF release

(2009) Camin Dean et al.   NATURE NEUROSCIENCE

Critical role of nociceptor plasticity in chronic pain

(2009) David B. Reichling et al.   TRENDS IN NEUROSCIENCES

Distinct Role of Long 3′ UTR BDNF mRNA in Spine Morphology and Synaptic Plasticity in Hippocampal Neurons

(2008) Juan Ji An et al.   CELL

BDNF induces late-phase LTP of C-fiber evoked field potentials in rat spinal dorsal horn

(2008) Li-Jun Zhou et al.   EXPERIMENTAL NEUROLOGY

Role of the brain-derived neurotrophic factor at glutamatergic synapses

(2007) A L Carvalho et al.   BRITISH JOURNAL OF PHARMACOLOGY

BDNF: A key regulator for protein synthesis-dependent LTP and long-term memory?

(2007) Yuan Lu et al.   NEUROBIOLOGY OF LEARNING AND MEMORY