Article
Electrochemistry
Ayhan Altun, Roxana-Mihaela Apetrei, Pinar Camurlu
Summary: Biosensing devices for urea detection have been extensively studied due to the importance of analyzing urea levels in biological fluids. The use of specific electrochemical methods and bio-materials have shown promising results for accurate urea detection, potentially playing a crucial role in clinical diagnostics.
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2021)
Article
Chemistry, Analytical
Baha Ondes, Fatma Akpinar, Murat Uygun, Mihrican Muti, Deniz Aktas Uygun
Summary: A highly stable urea biosensor was prepared by immobilizing urease enzyme onto nanoparticles, showing a detection limit of 0.77 mu M and a linear concentration range of 0.01 mM-500 mM. The biosensor system exhibited high repeatability and retained a certain level of activity after long-term storage. Interference from common interferents was found to be negligible, and the biosensor was proven suitable for detecting urea in artificial human serum.
MICROCHEMICAL JOURNAL
(2021)
Article
Multidisciplinary Sciences
Tuser T. Biswas, Junchun Yu, Vincent A. Nierstrasz
Summary: In this study, tyrosinase enzyme was digitally printed on plasma pretreated polyamide-6,6 fabric using sustainable technologies. Ink containing carboxymethyl cellulose was found to be the most suitable viscosity modifier for the enzyme. The printed enzyme on the fabric surface retained a high level of activity even after multiple rinsing cycles. The printed fabrics showed more stable enzyme activity compared to the ink solution for at least 60 days. This research demonstrates the potential applications of tyrosinase printed synthetic fabrics in various fields.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Muhammad Asif Ahmad Khushaini, Nur Hidayah Azeman, Ahmad Ghadafi Ismail, Chin-Hoong Teh, Muhammad Mat Salleh, Ahmad Ashrif A. Bakar, Tg Hasnan Tg Abdul Aziz, Ahmad Rifqi Md Zain
Summary: This study utilized the RS mechanism, formed by electrochemical redox-reactions, and a novel organic molecule, BOBzBT(2), to modify the SPE electrode for creatinine sensing. By optimizing the concentration of BOBzBT(2) during CV measurements, the sensor's sensitivity was enhanced, showing potential for practical application in detecting creatinine levels.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Multidisciplinary
Juliana Chawich, Walid M. Hassen, Amanpreet Singh, Daniela T. Marquez, Maria C. DeRosa, Jan J. Dubowski
Summary: This work demonstrates the potential of polymer brushes (PBs) grown on GaAs substrates as a promising platform for the detection of Legionella pneumophila (Lp). PBs significantly improve antibody immobilization and show enhanced detection capability compared to conventional biosensing architectures.
Article
Engineering, Environmental
Salhah D. Al-Qahtani, Hanan K. Alzahrani, Omer A. Azher, Zeid O. Owidah, Matokah Abualnaja, Turki M. Habeebullah, Nashwa M. El-Metwaly
Summary: A high-sensitivity viscose fabric was developed for colorimetric recognition of urea in fluids using co-encapsulated calcium alginate nanoparticles. Extracted anthocyanin from red-cabbage and urease enzyme were studied for their role in the fabrication of a biosensor on fabrics. The colorimetric changes of the fabric were monitored with increasing urea concentration, showing a shift in absorbance spectra and color variations.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2021)
Article
Multidisciplinary Sciences
Fan Jiang, Lei Wang, Nana Jin, Jing Yuan, Yanbin Li, Jianhan Lin
Summary: An electrochemical biosensor combining magnetic grid based bacterial separation and enzymatic catalysis based signal amplification was developed for Salmonella detection. The sensor was able to detect 50 CFU/mL Salmonella typhimurium in 1 hour.
Review
Microbiology
Ashish Kumar, Vinita Verma, Vimal Kumar Dubey, Alok Srivastava, Sanjay Kumar Garg, Vijay Pal Singh, Pankaj Kumar Arora
Summary: Fungal lipases are important industrial enzymes with numerous applications in various fields. They are carboxylic acid esterases belonging to the serine hydrolase family, and can be easily extracted and purified from fungi. Fungal lipases have applications in hydrolyzing fats and oils, as well as in synthetic reactions such as esterification and interesterification. They are affected by factors such as carbon source, nitrogen source, temperature, pH, metal ions, surfactants, and moisture content. Immobilizing fungal lipases onto different carriers improves their catalytic activities and efficiencies, making them suitable as biocatalysts in industries.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Environmental Sciences
Hui Han, Xuejiao Wu, Nanthi Bolan, M. B. Kirkham, Jianjun Yang, Zhaojin Chen
Summary: The study demonstrated that urease-producing and metal-immobilizing bacteria combined with sheep manure can effectively reduce the uptake of Cd by wheat. This is achieved by increasing soil urease activity and altering the bacterial community structure to enhance wheat's resistance to Cd toxicity.
Article
Chemistry, Physical
Zhiyong Zhao, Michael Zharnikov
Summary: This study presents an alternative approach for immobilizing thiolated single-stranded DNA (ssDNA) using bioinert, porous polyethylene glycol (PEG) films as a 3D template. The immobilization process was successful and resulted in high hybridization efficiency, selectivity, and sensitivity of the resulting DNA sensor. The findings highlight the potential of PEG films as a promising platform for highly selective ssDNA sensing.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2023)
Article
Chemistry, Applied
A. de Athayde Moncorvo Collado, S. B. Socias, F. Gonzalez-Lizarraga, D. Ploper, E. Vera Pingitore, R. N. Chehin, S. Chaves
Summary: A biocatalyst for the hydrolysis of urea in wines and alcoholic beverages was created, which exhibited remarkable urease activity and maintained its activity even after repeated uses. This research provides a platform for designing and developing other biocatalysts for the food industry.
Review
Engineering, Electrical & Electronic
Yaping Dong, Yiqun Liu, Jicheng Lv, Li Yang, Yue Cui
Summary: Kidney disease is a leading cause of death worldwide, and creatinine serves as a key biomarker for it. Amperometric biosensors have gained attention for their rapid, sensitive, and selective detection capabilities. The miniaturized and portable nature of these biosensors makes them popular for various settings. This review explores the development of amperometric biosensing for creatinine, including mechanisms, materials, applications, and commercial status, and can be a valuable resource for future creatinine biosensor development and practical applications in kidney patients.
IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT
(2023)
Article
Chemistry, Multidisciplinary
Satish Kasturi, Yunji Eom, Sri Ramulu Torati, CheolGi Kim
Summary: A novel high-resolution electrochemical biosensor based on rGO/Au was developed for the detection of miRNA-122, showing superior analytical performance and stability. The sensor demonstrated linear response to various concentrations of miRNA-122 by anchoring probe DNA and recognizing the target molecule.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2021)
Review
Chemistry, Multidisciplinary
Saptashwa Datta, R. Veena, Melvin S. Samuel, Ethiraj Selvarajan
Summary: This review article discusses the immobilization methods of laccases, nanomaterials used for immobilization, and applications for the detection and degradation of pollutants.
ENVIRONMENTAL CHEMISTRY LETTERS
(2021)
Article
Chemistry, Analytical
Chunli Wan, Aoxuan Qu, Min Li, Rui Tang, Liya Fu, Xiang Liu, Panxin Wang, Changyong Wu
Summary: In this study, a rapid targeted identification and analysis method of antibiotic resistance genes (ARGs) was established using an electrochemical sensor modified with a sulfhydryl single-stranded DNA probe. The sensor showed good detection performance for ARGs encoding beta-lactam hydrolase, with a linear detection range of 6.3-900.0 ng/mL and high specificity for different types of DNA mismatches. The accurate identification and analysis of ARGs could still be maintained after 30 days of storage at 4 degrees C.
ANALYTICAL CHEMISTRY
(2022)
Review
Genetics & Heredity
Esra Bozgeyik, Ibrahim Bozgeyik
Summary: Scientists used to believe that only mutations in protein-coding genes were responsible for cancer. However, the discovery of non-coding RNAs has changed this understanding and revealed that non-coding RNA molecules play a significant role in cancer biology. The unstable nature of non-coding RNAs in the laboratory presents challenges for accurate analysis, making variation analysis crucial for understanding their impact on cancer biology.
Article
Dentistry, Oral Surgery & Medicine
Bilal Ege, Esra Bozgeyik, Seyma Bayazit, Ibrahim Bozgeyik, Zozan Erdogmus, Mahmut Koparal
Summary: The aim of this study was to investigate the effects of hypoxia-associated signaling in odontogenic cysts. The expression levels of genes involved in the signaling pathway were determined. The results showed that odontogenic cysts had lower PTEN expression and higher expression levels of PIK3CA, HIF1A, and HIF1A-AS1.
ARCHIVES OF ORAL BIOLOGY
(2023)
Article
Genetics & Heredity
Ibrahim Bozgeyik, Miray Ege, Ebru Temiz, Berna Erdal, Ismail Koyuncu, Cengiz Temiz, Esra Bozgeyik, Mahfuz Elmastas
Summary: The management of gastric cancer is challenging due to drug resistance and recurrence. Green-synthesized zinc oxide nanoparticles (ZnO-NPs) derived from natural resources show promise as therapeutic agents for anticancer treatment. In this study, we conducted a facile green synthesis of TP-ZnO-NPs using Teucrium polium herb extract and investigated their anticancer activities on gastric cancer cells. The results suggest that TP-ZnO-NPs have significant antiproliferative and anticancer effects on HGC-27 gastric cancer cells, making them a novel and promising agent for future gastric cancer therapeutics.
Article
Optics
Abbad Al Baroot, Khaled A. Elsayed, Shamsuddeen A. Haladu, Saminu Musa Magami, Muidh Alheshibri, Filiz Ercan, Emre Cevik, Sultan Akhtar, Abdullah A. Manda, T. S. Kayed, Nafala A. Altamimi, Aamerah A. Alsanea, Amal L. Al-Otaibi
Summary: This study reports the synthesis and characterization of SnO2/CNT nanocomposites and their photocatalytic performance for the degradation of methylene blue dye. The results show that the SnO2/CNT nanocomposites exhibit high photocatalytic activity and rapid removal of the dye under UV irradiation. The findings provide an effective method for the potential application of SnO2/CNT nanocomposites in wastewater treatment for the removal of various dyes.
OPTICS AND LASER TECHNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Emre Cevik, Mohammed A. Gondal, Noha Alqahtani, M. Hassan
Summary: The power performance of bio-electrochemical fuel cells (BEFCs) is mainly dependent on the energy harvesting ability of the anode material. In this study, a novel anode utilizing indium tin oxide (ITO) modified by chromium oxide quantum dots (CQDs) was designed, resulting in improved optical properties of the photoanode. The optimization of CQDs and green algae (Alg) film led to enhanced power generation performance, with the BEFC cell exhibiting a photocurrent generation of 120 mA cm(-2) and a maximum power density of 7 W m(-2) under continuous light illumination.
BIOTECHNOLOGY AND BIOENGINEERING
(2023)
Article
Integrative & Complementary Medicine
Onder Yumrutas, Ibrahim Bozgeyik
Summary: This study aimed to determine the antiproliferative and apoptosis induction activities of methanol extract of Inula graveolens (IGME) in the human cervical cancer cell line (HeLa). IGME exhibited antiproliferative effect and induced apoptosis in the HeLa cells, while reducing intracellular ROS levels and IL-6, IL-8 expression levels. Thus, IGME has potential anticancer activity.
BOLETIN LATINOAMERICANO Y DEL CARIBE DE PLANTAS MEDICINALES Y AROMATICAS
(2023)
Article
Biochemistry & Molecular Biology
Hasan Aydin, Suleyman Akocak, Nebih Lolak, Onder Yumrutas, Ugur Uslu, Ibrahim Bozgeyik, Fatih Uckardes, Selami Gunal, Onur Ceylan
Summary: In our study, we synthesized and tested the cytotoxic, antifungal, and larvicidal activities of bis-sulfonamide Schiff base derivatives. Among the 16 compounds tested, A1B2, A1B4, A4B2, A4B3, and A4B4 showed cytotoxic activity against lung cancer cells. A2B1 and A2B2 exhibited the strongest antifungal activity against all tested fungi, while A1B1 had the highest larvicidal effect. These results suggest that these bis-substituted compounds could be promising pharmacophores for various diseases.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Ameerah N. Alqarni, Emre Cevik, M. A. Almessiere, A. Baykal, M. A. Gondal, M. Hassan, Ayhan Bozkurt, Arfa Iqbal, Sarah M. Asiri, Y. Slimani
Summary: This study presents a simple and cost-effective method to synthesize bismuth-doped spinel ferrites nanoparticles Co-Ni/Bi for high-performance electrode fabrication. The cyclic performance of the supercapacitor is highly improved by Bi-doped spinel ferrite nanoparticles, showing a superior specific capacitance and advantageous cyclic stabilities. Moreover, the same electrode exhibits a high energy density at a certain power density.
JOURNAL OF PHYSICS AND CHEMISTRY OF SOLIDS
(2023)
Article
Biochemistry & Molecular Biology
Esra Bozgeyik, Haydar Bagis, Ibrahim Bozgeyik, Sayad Kocahan
Summary: In this study, the researchers identified a long non-coding RNA called PACER that plays a crucial role in regulating necroptotic cell death. They found that PACER is involved in the control of necroptosis and that its tumor promoter activity may contribute to the lack of necroptotic death signal in cancer cells.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Pathology
Esra Bozgeyik, Bilal Ege, Zozan Erdogmus, Ibrahim Bozgeyik, Mahmut Koparal, Seyma Bayazit, Muhammed Yusuf Kurt
Summary: The gene expression levels of inflammation-related long non-coding RNAs were investigated in radicular cysts, and their possible roles in the development of radicular cysts were shown. The expression levels of PACER and THRIL were found to be significantly elevated in radicular cyst tissues, while MALAT1, ANRIL, and NEAT1 expression levels were not significantly altered. Therefore, long non-coding RNAs PACER and THRIL seem to have significant pathophysiological roles in inflammation and might be involved in the development and formation of radicular cysts.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Chemistry, Analytical
Mehmet Senel
Summary: With the increasing number of patients suffering from Parkinson's disease, the measurement of drug levels in patient body fluids, particularly for clozapine, has become significantly important. There is a growing demand for a cost-effective platform that can analyze biofluids in real-time and in small volumes. This study aims to measure the level of clozapine using a portable potentiostat and a practical approach. The designed sensor showed good performance in terms of linearity, detection limit, reproducibility, and reusability. It was able to detect clozapine in real samples within a wide range of concentrations.
Article
Nanoscience & Nanotechnology
Emre Cevik, Talal F. Qahtan, Sarah M. Asiri, Ayhan Bozkurt
Summary: An intercalation-type Zn-doped Zn-V@Mo-V (ZMV) cathode material is reported, which provides prolonged cycle stability and high storage capacity, addressing the problem of metal oxide cathode dissolution.
ACS APPLIED NANO MATERIALS
(2023)
Article
Chemistry, Analytical
Tahani M. Alfareed, Atheel Almofleh, Sarah M. Asiri, Jwaher M. AlGhamdi, Emre Cevik
Summary: In this work, a highly sensitive and selective non-enzymatic glucose biosensor using a novel MoCo nanocomposite was reported. The MoCo nanocomposite, composed of CoOOH nanospheres decorated MoO3 nanobelts, exhibited superior sensing properties due to improved electron transfer capability and large surface area. The biosensor achieved an excellent linear range of 0.001-1.0 mM with a corresponding amperometric current response from the GCE/MoCo/Nafion electrode. The biosensing electrode showed a linear regression coefficient (R2 = 0.9959) and a limit of detection (LOD) of 56µM (S/N = 3). Remarkable selectivity against glucose in the presence of different interfering substances and long-term stability of 30 days with negligible decay in the amperometric current response were achieved.
MICROCHEMICAL JOURNAL
(2023)
Review
Pathology
Esra Bozgeyik, Ibrahim Bozgeyik
Summary: Cell death was traditionally classified into two types, necrosis and apoptosis. However, recent studies have identified new cell death pathways that are distinct from necrosis and apoptosis. The development of natural-based anticancer drugs that target these non-canonical cell death mechanisms is of great interest due to the resistance and adverse effects associated with apoptosis-targeting drugs in cancer therapy.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Dermatology
Yusuf Ozay, Ebru Gokalp Ozkorkmaz, Meltem Kumas-Kulualp, Sevda Guzel Kara, Zuhal Yildirim, Cosar Uzun, Ayla Celik, Yusuf Camlica, Ibrahim Bozgeyik, Gizem Guler, Nurten Erdal, Onder Yumrutas, Bahar Tasdelen, Ahmet Kahraman
Summary: The aim of this study was to investigate the wound healing potential of Salvia huberi Hedge on excision and incision wound models in diabetic rats. The results showed that Salvia huberi ointments promoted the healing process in diabetic rats with both excisional and incisional wounds, indicating its potential as a potent healing agent.
JOURNAL OF WOUND CARE
(2023)
Article
Materials Science, Multidisciplinary
Honggyun Kim, Jamal Aziz, Vijay D. Chavan, Deok-kee Kim
Summary: Silicon nitride films were prepared using plasma enhanced chemical vapor deposition with different trap densities induced by adjusting the RF power ratio. It was found that the film's trap density was lowest under compressive stress and increased under tensile stress. This study has significant implications for the formation of durable nitride films in various electronic and optoelectronic applications.
CURRENT APPLIED PHYSICS
(2024)
Article
Materials Science, Multidisciplinary
Qiang Yu, Huwei Zhao, Yue Zhao
Summary: Zinc oxide thin films and Al-doped zinc oxide films were prepared and characterized in this study. The addition of Al ions was found to change the growth orientation, increase the grain size, and enhance the absorption intensity in the visible light region. Furthermore, the addition of Al ions also increased the forward current in the heterojunction.
CURRENT APPLIED PHYSICS
(2024)
Article
Materials Science, Multidisciplinary
Sang Woo Lee, Min Sun Park, Sangwon Wi, So Yeon Lim, Yeseul Lee, Jin-Seok Chung, Sang Mo Yang
Summary: In this study, we investigated the dynamics of domain switching in pristine and fatigued BiFeO3 capacitors through experimental observations and measurements. The results showed that the switching in the pristine capacitors was dominantly driven by domain growth, while the fatigued capacitors exhibited two different switching dynamics, in which nucleation played a critical role.
CURRENT APPLIED PHYSICS
(2024)
Article
Materials Science, Multidisciplinary
Boshi Wang, Tianyi Wang, Yufang Liu, Kun Yu
Summary: In this paper, a tunable and anisotropic perfect absorber composed of anisotropic black phosphorus (BP) and isotropic graphene is proposed. The structure exhibits high absorption and strong anisotropic plasma response. The resonance characteristics can be effectively controlled by adjusting geometric parameters and doping levels, offering potential applications.
CURRENT APPLIED PHYSICS
(2024)
Article
Materials Science, Multidisciplinary
Xiaolan Liu, Chunyang Li, Tonghui Yang, Naiqiang Yin, Gangling Zhao
Summary: Water drop triboelectric nanogenerators (WD-TENGs) can harvest energy from raindrops and improve the output performance of TENGs.
CURRENT APPLIED PHYSICS
(2024)
