Article
Engineering, Electrical & Electronic
Agnes Beate Bussmann, Claudia Patricia Durasiewicz, Sebastian Heinrich Alexander Kibler, Christian Klaus Wald
Summary: This study presents the design, fabrication, and experimental evaluation of three piezoelectric microfluidic devices for implant automation: a diaphragm pump, a normally closed valve, and a normally open valve. All devices are made of titanium, minimizing the risk of artefacts in medical imaging. They have similar form factors and use the same actuation method, demonstrating outstanding fluidic performance.
SENSORS AND ACTUATORS A-PHYSICAL
(2021)
Article
Biochemical Research Methods
Hiroki Sano, Yutaka Kazoe, Ryoichi Ohta, Hisashi Shimizu, Kyojiro Morikawa, Takehiko Kitamori
Summary: In this study, a nanofluidic analytical system integrated with multiple nanochannel open/close valves was developed. The system successfully accomplished fluid operations such as sample injection, pL-level aliquot sampling, and flow switching by opening/closing specific valves. The study is expected to significantly improve the usability of nanofluidic analytical devices and enable the realization of complex analytical techniques such as single-cell proteomics.
Article
Engineering, Electrical & Electronic
Tuo Ma, Yousu Wang, Shixin Sun, Tingrui Pan, Baoqing Li, Jiaru Chu
Summary: In this article, a size-tunable droplet microfluidic system with an on-chip microfluidic peristaltic pump is developed, allowing for the fine-tuning of droplet size and frequency without changing the microfluidic chip design. The system has a small dead volume and minimal reagent waste, showing potential for encapsulation and precise analysis in small-volume samples.
SENSORS AND ACTUATORS A-PHYSICAL
(2022)
Article
Energy & Fuels
Xuling Liu, Wensi Zuo, Huafeng Song, Tingdong Shang, Haiwei Dong, Liangwen Wang, Jinggan Shao, Songjing Li
Summary: In this study, a compact, rapid, and portable off-chip microvalve with a high-speed electromagnetic switch actuator and PDMS valve body was designed for the miniaturization and integration of external pneumatic systems for microfluidic chips. Mathematical models and simulations were used to analyze the control capability of the microvalve, and the testing results demonstrated its suitability for most applications in pneumatic microfluidic chips.
Article
Nanoscience & Nanotechnology
Sebastian Bohm, Hai Binh Phi, Ayaka Moriyama, Erich Runge, Steffen Strehle, Jorg Konig, Christian Cierpka, Lars Dittrich
Summary: A multistage optimization method is developed to create efficient Tesla valves at low flow rates. The method uses topological optimization based on the finite element method, resulting in compact valve structures that can be directly used in microfluidic systems.
MICROSYSTEMS & NANOENGINEERING
(2022)
Article
Engineering, Electrical & Electronic
Valeria Nico, Eric Dalton
Summary: Microfluidic technology has grown rapidly in recent years, with limitations in pumps for high-end electronics and biomedical devices. A novel magnetic shuttle pump technology and numerical model were proposed to address this issue, showing promising results in achieving required pressure and flow characteristics through simulations and experiments.
SENSORS AND ACTUATORS A-PHYSICAL
(2021)
Article
Nanoscience & Nanotechnology
Seung-Ryeol Lee, Youngtaek Kim, Suryong Kim, Jiho Kim, Seonghyuk Park, Stephen Rhee, Dohyun Park, Byungjun Lee, Kyusuk Baek, Ho-Young Kim, Noo Li Jeon
Summary: This study presents a novel injection-molded plastic array 3D universal culture platform (U-IMPACT) that offers a versatile solution for various biological applications. The platform allows for cocultures of different cell types, as well as the cultivation of spheroids and tissues. By utilizing capillary action, the platform enables stable multichannel patterning without the need for modification. Experimental results demonstrate its potential in creating 3D tumor microenvironments and culturing neurospheres.
MICROSYSTEMS & NANOENGINEERING
(2022)
Article
Chemistry, Analytical
Adam Shebindu, Himali Somaweera, Zachary Estlack, Jungtae Kim, Jungkyu Kim
Summary: This study introduces a programmable microfluidic platform (PMP) combined with isotachophoresis (ITP) for fully automated optimization of multiple analytes. By utilizing lifting-gate microvalve technology, a two-dimensional microvalve array was designed and fabricated to seamlessly integrate with an ITP chip for automated buffer selection and repetitive ITP procedures. The optimal buffer combination of 40mM borate and 100mM Tris-HCl successfully preconcentrated all analytes during a single ITP run.
Article
Biochemical Research Methods
Md Ehtashamul Haque, Alvaro J. J. Conde, William N. N. MacPherson, Stephen R. R. Knight, Richard M. M. Carter, Maiwenn Kersaudy-Kerhoas
Summary: A finger-actuated blood lysate preparation device based on acoustofluidic micromixer is developed for effective red blood cell lysis, which has potential applications in various blood-based diagnostic tests. The device features innovative design and user-friendly operation, offering opportunities for the development of low-cost microfluidic-based diagnostics.
Article
Biochemical Research Methods
Hyungkook Jeon, Taehong Kwon, Junghyo Yoon, Jongyoon Han
Summary: This paper presents a deformation-free and mass-producible plastic spiral inertial microfluidic device for high-throughput cell separation applications. The plastic spiral device shows similar performance to PDMS devices in blood separation and CHO cell retention. Furthermore, a multiplexed plastic spiral unit achieves ultra-high-throughput cell clarification with high efficiency, which could have a significant impact on biomanufacturing.
Article
Materials Science, Multidisciplinary
Zhichang Du, Gangnan Zhao, Anyang Wang, Wei Sun, Shengli Mi
Summary: The paper introduces a microfluidic contact lens that integrates a microchannel and a micropump to achieve drug release through the mechanical action of blinking. Experimental results demonstrate the controllability of liquid release and the good flexibility, light transmittance, and biocompatibility of the microfluidic contact lens. The liquid exchange between the eye and the contact lens provides potential for personalized medicine.
ACS APPLIED POLYMER MATERIALS
(2022)
Article
Biology
Tudor Petreus, Elaine Cadogan, Gareth Hughes, Aaron Smith, Venkatesh Pilla Reddy, Alan Lau, Mark James O'Connor, Susan Critchlow, Marianne Ashford, Lenka Oplustil O'Connor
Summary: Petreus et al. introduce a novel tumour-on-chip microfluidic system that mimics pharmacokinetic profiles of compounds on 3D tumour spheroids to evaluate their response to treatments, successfully predicting efficacy from in vivo studies and guiding drug dose and schedules for optimal efficacy while reducing the need for animal studies.
COMMUNICATIONS BIOLOGY
(2021)
Article
Biochemical Research Methods
Tengbao Xie, Ping Wang, Lei Wu, Bangyong Sun, Qiang Zhao, Gang Li
Summary: The study introduces a simple system for sample discretization, using water-soluble film and a syringe to rapidly partition samples, which can be applied in digital PCR and other fields such as single-cell analysis and diagnostics.
Review
Engineering, Aerospace
Yimeng Zhao, Xuefei Lv, Xiaoqiong Li, Nino Rcheulishvili, Yu Chen, Zhe Li, Yulin Deng
Summary: The use of the space environment for life science research is significant, but there are limitations in complex manipulation and research models. Microfluidic chips integrate traditional lab functions into micron-scale chips with low energy consumption, high throughput, and automation. They can overcome challenges in space environments, limited experimental resources, and unmanned operation. Microfluidic chips enable long-term experiments and remote data recording and transmission. Microfluidic actuation and control are crucial for conducting research with microfluidic chips.
SPACE: SCIENCE & TECHNOLOGY
(2023)
Article
Biochemical Research Methods
Jinrong Shen, Jihong Zheng, Zhenqing Li, Yourong Liu, Fengxiang Jing, Xinjun Wan, Yoshinori Yamaguchi, Songlin Zhuang
Summary: The study introduces an effective technique for the absolute quantification of target nucleic acids, with self-developed software controlling functional units to achieve high-resolution one-time gene chip imaging, speeding up the lab-to-application process.
Article
Materials Science, Multidisciplinary
Honggyun Kim, Jamal Aziz, Vijay D. Chavan, Deok-kee Kim
Summary: Silicon nitride films were prepared using plasma enhanced chemical vapor deposition with different trap densities induced by adjusting the RF power ratio. It was found that the film's trap density was lowest under compressive stress and increased under tensile stress. This study has significant implications for the formation of durable nitride films in various electronic and optoelectronic applications.
CURRENT APPLIED PHYSICS
(2024)
Article
Materials Science, Multidisciplinary
Qiang Yu, Huwei Zhao, Yue Zhao
Summary: Zinc oxide thin films and Al-doped zinc oxide films were prepared and characterized in this study. The addition of Al ions was found to change the growth orientation, increase the grain size, and enhance the absorption intensity in the visible light region. Furthermore, the addition of Al ions also increased the forward current in the heterojunction.
CURRENT APPLIED PHYSICS
(2024)
Article
Materials Science, Multidisciplinary
Sang Woo Lee, Min Sun Park, Sangwon Wi, So Yeon Lim, Yeseul Lee, Jin-Seok Chung, Sang Mo Yang
Summary: In this study, we investigated the dynamics of domain switching in pristine and fatigued BiFeO3 capacitors through experimental observations and measurements. The results showed that the switching in the pristine capacitors was dominantly driven by domain growth, while the fatigued capacitors exhibited two different switching dynamics, in which nucleation played a critical role.
CURRENT APPLIED PHYSICS
(2024)
Article
Materials Science, Multidisciplinary
Boshi Wang, Tianyi Wang, Yufang Liu, Kun Yu
Summary: In this paper, a tunable and anisotropic perfect absorber composed of anisotropic black phosphorus (BP) and isotropic graphene is proposed. The structure exhibits high absorption and strong anisotropic plasma response. The resonance characteristics can be effectively controlled by adjusting geometric parameters and doping levels, offering potential applications.
CURRENT APPLIED PHYSICS
(2024)
Article
Materials Science, Multidisciplinary
Xiaolan Liu, Chunyang Li, Tonghui Yang, Naiqiang Yin, Gangling Zhao
Summary: Water drop triboelectric nanogenerators (WD-TENGs) can harvest energy from raindrops and improve the output performance of TENGs.
CURRENT APPLIED PHYSICS
(2024)
