Article
Cardiac & Cardiovascular Systems
Ricardo A. Albertini, Juan C. Nicolas, Virginia Actis Dato, Dario G. Ferrer, Maria E. Tinti, Raul H. Capra, Gustavo A. Chiabrando
Summary: This study found that the expression of LRP1 on the surface of circulating monocytes is reduced in asymptomatic individuals with atherosclerosis, indicating its association with the development of the disease.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Anand Rohatgi, Marit Westerterp, Arnold von Eckardstein, Alan Remaley, Kerry-Anne Rye
Summary: Low high-density lipoprotein cholesterol (HDL-C) is associated with adverse lifestyle choices, cardiovascular diseases, inflammatory disorders, and other conditions. Therapeutic strategies targeting HDL-C levels have not been successful, and future focus should be on optimizing HDL function for better outcomes.
Article
Cardiac & Cardiovascular Systems
Congzhuo Jia, Josephine L. C. Anderson, Eke G. Gruppen, Yu Lei, Stephan J. L. Bakker, Robin P. F. Dullaart, Uwe J. F. Tietge
Summary: The study found that in the general population, high-density lipoprotein anti-inflammatory capacity is inversely associated with first cardiovascular events, independent of HDL cholesterol and cholesterol efflux capacity.
Review
Hematology
Christian M. Madsen, Anette Varbo, Borge G. Nordestgaard
Summary: Recent studies have suggested that extremely high levels of HDL cholesterol are associated with increased mortality, indicating that HDL may have harmful effects in some instances. Furthermore, observational and genetic studies have shown that HDL might be linked to the development of major noncardiovascular diseases.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Hematology
Jiahuan Chen, Huanyu Zhang, Linquan Li, Xinwei Zhang, Dazhong Zhao, Lingyu Wang, Jiaqi Wang, Ping Yang, Huan Sun, Kun Liu, Weiwei Chen, Lin Li, Feng Lin, Zhanjun Li, Y. Eugene Chen, Jifeng Zhang, Daxin Pang, Hongsheng Ouyang, Yuquan He, Jianglin Fan, Xiaochun Tang
Summary: In this study, Lp-PLA(2) knockout rabbits were generated using the CRISPR/Cas9 system to investigate the role of Lp-PLA(2) in blood lipid regulation and atherosclerosis. The results showed that Lp-PLA(2) deficiency reduced plasma lipid levels and protected against cholesterol-induced atherosclerosis in rabbits. Furthermore, Lp-PLA(2) deficiency impaired cholesterol biosynthesis and inhibited the adhesion between monocytes and endothelial cells.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Hematology
Vishal Kothari, Jingjing Tang, Yi He, Farah Kramer, Jenny E. Kanter, Karin E. Bornfeldt
Summary: The study reveals a crucial role for ADAM17 in regulating the anti-inflammatory and proinflammatory effects of HDL in macrophages, as cholesterol enrichment in ADAM17-deficient macrophages can prevent inflammatory responses induced by HDL. This highlights the importance of ADAM17 in maintaining cholesterol efflux in macrophages and modulating their immune functions.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Laura Canclini, Amir Mohammad Malvandi, Patrizia Uboldi, Najoua Jabnati, Liliana Grigore, Alberto Zambon, Andrea Baragetti, Alberico Luigi Catapano
Summary: This study aimed to investigate the interaction between PCSK9 and LDL, and found that PCSK9 interacts with a subfraction of LDL, with a binding percentage ranging from 2% to 30%, which is not correlated with plasma or LDL cholesterol levels. The association of PCSK9 with LDL appears to be sensitive to high salt concentrations. FPLC and iodixanol gradient ultracentrifugation are identified as the most suitable methods for studying this association.
Review
Nutrition & Dietetics
Patrick S. S. Elliott, Soraeya S. S. Kharaty, Catherine M. M. Phillips
Summary: Plant-based diets (PBDs) are negatively associated with lipid, lipoprotein, and inflammatory biomarkers of cardiovascular disease (CVD). PBDs are associated with favorable lipid and lipoprotein profiles and decreased low-grade inflammation. PBD interventions have greater effects compared to habitual dietary patterns.
Review
Biochemistry & Molecular Biology
Patricia Richter, Anca Cardoneanu, Ciprian Rezus, Alexandra Maria Burlui, Elena Rezus
Summary: Cardiovascular diseases are a leading cause of high mortality in SLE patients, and traditional risk factors are insufficient in predicting their risk. Inflammation has been found to play a crucial role in the development of atherosclerosis in SLE, highlighting the need for new biomarkers to assess subclinical CVD risk.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Hematology
Ayea El-Ghazali, Sneha Deodhar, Suzanne Saldanha, Brooke Smyth, Mark Izbrand, Anamika Gangwar, Mandana Pahlavani, Anand Rohatgi
Summary: Cholesterol efflux capacity (CEC) is a clinically relevant cardiovascular biomarker inversely associated with atherosclerotic cardiovascular disease events. Extreme high and low CEC are persistent and robust phenotypes, showing significant differences in CEC patterns across the size distribution of molecules. Further studies are needed to determine specific molecular species linked to CEC in a size-specific manner.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Review
Geriatrics & Gerontology
Yongzheng Lu, Xiaolin Cui, Li Zhang, Xu Wang, Yanyan Xu, Zhen Qin, Gangqiong Liu, Qiguang Wang, Kang Tian, Khoon S. Lim, Chris J. Charles, Jinying Zhang, Junnan Tang
Summary: Dyslipidemia increases the risk of atherosclerosis, and lipoproteins play a significant role in its development. Understanding lipoprotein function can help predict risk and provide novel treatment approaches for atherosclerosis.
Article
Biochemistry & Molecular Biology
Pradeep Kumar Kopparapu, Meghshree Deshmukh, Zhicheng Hu, Majd Mohammad, Marco Maugeri, Friedrich Goetz, Hadi Valadi, Tao Jin
Summary: Staphylococcal aureus extracellular vesicles can induce inflammatory responses in host cells, with lipidated lipoproteins (Lpp) playing a crucial role in this activity while cell wall anchoring of surface proteins does not contribute to immune stimulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Petri Kresanov, Juha Mykkanen, Markku Ahotupa, Mika Ala-Korpela, Markus Juonala, Jari Kaikkonen, Mika Kahonen, Terho Lehtimaki, Tommi Vasankari, Jorma Viikari, Olli T. Raitakari
Summary: The study found that oxidized HDL lipids were not significantly associated with lipoprotein subclass lipid concentrations and composition after adjusting for certain factors, while oxidized LDL lipids were associated with multiple markers of lipoprotein subclass lipid concentrations and composition. Additionally, HDL and LDL subclass measures, such as phospholipid and triglyceride composition, were directly associated with oxidized LDL lipids, while cholesterol ester and free cholesterol composition in HDL and LDL were inversely associated. These results suggest that LDL oxidation may play a role in atherogenesis.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Laura A. Bosmans, Claudia M. van Tiel, Suzanne A. B. M. Aarts, Lisa Willemsen, Jeroen Baardman, Bram W. van Os, Myrthe den Toom, Linda Beckers, David J. Ahern, Johannes H. M. Levels, Aldo Jongejan, Perry D. Moerland, Sanne G. S. Verberk, Jan van den Bossche, Menno M. P. J. de Winther, Christian Weber, Dorothee Atzler, Claudia Monaco, Norbert Gerdes, Annelie Shami, Esther Lutgens
Summary: This study investigates the role of CD40 in atherosclerosis and shows that inhibiting CD40 signaling can reduce atherosclerosis. The researchers used myeloid-specific CD40-deficient mice and found that the absence of CD40 in myeloid cells reduces atherosclerosis and systemic inflammation by preventing pro-inflammatory macrophage polarization.
CARDIOVASCULAR RESEARCH
(2023)
Review
Cardiac & Cardiovascular Systems
MacRae F. Linton, Patricia G. Yancey, Huan Tao, Sean S. Davies
Summary: Epidemiologic studies have shown that HDL-C levels are inversely related to ASCVD, suggesting that HDL-C is a major risk factor for ASCVD. However, clinical trials have questioned the role of HDL-C in mediating ASCVD risk. Progress in understanding the composition of HDL particles has revealed that HDL-C levels do not necessarily reflect HDL function. HDL has been found to have antiatherogenic functions, such as reverse cholesterol transport and suppression of inflammation, but its oxidative modifications can lead to dysfunction and inflammation.
CIRCULATION RESEARCH
(2023)
Article
Rheumatology
Robert Winchester, Jon T. Giles, Simona Nativ, Kendall Downer, Hui-Zhu Zhang, Ayse Bag-Ozbek, Afshin Zartoshti, Sabahat Bokhari, Joan M. Bathon
ARTHRITIS & RHEUMATOLOGY
(2016)
Article
Rheumatology
Laura Geraldino-Pardilla, Afshin Zartoshti, Ayse Bag Ozbek, Jon T. Giles, Richard Weinberg, Mona Kinkhabwala, Sabahat Bokhari, Joan M. Bathon
ARTHRITIS & RHEUMATOLOGY
(2018)
Editorial Material
Pediatrics
Hana Niebur, Javeed Akhter, Erjola Balliu, Rachel Boykan, Maribeth Chitkara, Ayse Bag-Ozbek, Marian Kim, Ruba K. Azzam, Joseph Hageman
PEDIATRICS IN REVIEW
(2014)
Review
Rheumatology
Ahmed Aly Elghawy, Maria Skopis, James Davis, Ayse Bag-Ozbek
RHEUMATOLOGY INTERNATIONAL
(2020)
Review
Rheumatology
Maria Skopis, Ahmed Aly Elghawy, Barbara Pociurko, Kei Shing Oh, Ayse Bag-Ozbek
Summary: Pyoderma gangrenosum is a skin disease characterized by painful ulcers that can lead to permanent disfigurement if not appropriately treated. It is often observed in various autoimmune disorders but rarely associated with systemic sclerosis. Treatment with intravenous methylprednisolone and topical clobetasol can lead to complete resolution of the ulcerated lesions.
CLINICAL RHEUMATOLOGY
(2021)