Virus/Allergen Interactions in Asthma

The E3 ubiquitin ligase midline 1 promotes allergen and rhinovirus-induced asthma by inhibiting protein phosphatase 2A activity

(2013) Adam Collison et al.   NATURE MEDICINE

Human Rhinovirus Species and Season of Infection Determine Illness Severity

(2012) Wai-Ming Lee et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

P2X7-Regulated Protection from Exacerbations and Loss of Control Is Independent of Asthma Maintenance Therapy

(2012) Loren C. Denlinger et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Rhinovirus-Induced IL-1β Release from Bronchial Epithelial Cells Is Independent of Functional P2X7

(2012) Lei Shi et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Innate type 2 cells and asthma

(2012) Emily Hams et al.   CURRENT OPINION IN PHARMACOLOGY

Protection from asthma in a high-risk birth cohort by attenuated P2X7 function

(2012) David M. Manthei et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Innate immune responses to rhinovirus are reduced by the high-affinity IgE receptor in allergic asthmatic children

(2012) Sandy R. Durrani et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Deficient antiviral immune responses in childhood: Distinct roles of atopy and asthma

(2012) Simonetta Baraldo et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

High titers of IgE antibody to dust mite allergen and risk for wheezing among asthmatic children infected with rhinovirus

(2012) Manuel Soto-Quiros et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Rhinovirus 16–induced IFN-α and IFN-β are deficient in bronchoalveolar lavage cells in asthmatic patients

(2012) Annemarie Sykes et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Asthma as a chronic disease of the innate and adaptive immune systems responding to viruses and allergens

(2012) Michael J. Holtzman   JOURNAL OF CLINICAL INVESTIGATION

Impaired innate interferon induction in severe therapy resistant atopic asthmatic children

(2012) M R Edwards et al.   Mucosal Immunology

Early infection with respiratory syncytial virus impairs regulatory T cell function and increases susceptibility to allergic asthma

(2012) Nandini Krishnamoorthy et al.   NATURE MEDICINE

Concomitant asthma medications in moderate-to-severe allergic asthma treated with omalizumab

(2012) Hubert Chen et al.   RESPIRATORY MEDICINE

TSLP Expression: Cellular Sources, Triggers, and Regulatory Mechanisms

(2012) Toshiro Takai   ALLERGOLOGY INTERNATIONAL

Anti-IL-33 antibody has a therapeutic effect in a murine model of allergic rhinitis

(2011) Y. H. Kim et al.   ALLERGY

Lower Airway Rhinovirus Burden and the Seasonal Risk of Asthma Exacerbation

(2011) Loren C. Denlinger et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

A Mechanistic Role for Type III IFN-λ1in Asthma Exacerbations Mediated by Human Rhinoviruses

(2011) E. Kathryn Miller et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Evidence for a Causal Relationship between Allergic Sensitization and Rhinovirus Wheezing in Early Life

(2011) Daniel J. Jackson et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Infection with Influenza Virus Induces IL-33 in Murine Lungs

(2011) Ronan Le Goffic et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

The Airway Epithelium: Soldier in the Fight against Respiratory Viruses

(2011) M. Vareille et al.   CLINICAL MICROBIOLOGY REVIEWS

Increased expression of immunoreactive thymic stromal lymphopoietin in patients with severe asthma

(2011) Aarti Shikotra et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The Danger Signal, Extracellular ATP, Is a Sensor for an Airborne Allergen and Triggers IL-33 Release and Innate Th2-Type Responses

(2011) Hideaki Kouzaki et al.   JOURNAL OF IMMUNOLOGY

Human Rhinovirus Species Associated With Hospitalizations for Acute Respiratory Illness in Young US Children

(2011) Marika K. Iwane et al.   JOURNAL OF INFECTIOUS DISEASES

Viral Stimuli Trigger Exaggerated Thymic Stromal Lymphopoietin Expression by Chronic Obstructive Pulmonary Disease Epithelium: Role of Endosomal TLR3 and Cytosolic RIG-I-Like Helicases

(2011) Jenny Calvén et al.   Journal of Innate Immunity

Human IL-25- and IL-33-responsive type 2 innate lymphoid cells are defined by expression of CRTH2 and CD161

(2011) Jenny M Mjösberg et al.   NATURE IMMUNOLOGY

Randomized Trial of Omalizumab (Anti-IgE) for Asthma in Inner-City Children

(2011) William W. Busse et al.   NEW ENGLAND JOURNAL OF MEDICINE

CD14+ cell-derived IL-29 modulates proinflammatory cytokine production in patients with allergic airway inflammation

(2010) S. He et al.   ALLERGY

Interleukin-33 in Asthma: How Big of a Role Does It Play?

(2010) Larry Borish et al.   CURRENT ALLERGY AND ASTHMA REPORTS

Association between human rhinovirus C and severity of acute asthma in children

(2010) J. Bizzintino et al.   EUROPEAN RESPIRATORY JOURNAL

Weekly monitoring of children with asthma for infections and illness during common cold seasons

(2010) Jaime P. Olenec et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The effect of respiratory syncytial virus on subsequent recurrent wheezing in atopic and nonatopic children

(2010) Eric A.F. Simões et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Thymic Stromal Lymphopoietin-Activated Plasmacytoid Dendritic Cells Induce the Generation of FOXP3+ Regulatory T Cells in Human Thymus

(2010) S. Hanabuchi et al.   JOURNAL OF IMMUNOLOGY

Counterregulation between the Fc RI Pathway and Antiviral Responses in Human Plasmacytoid Dendritic Cells

(2010) M. A. Gill et al.   JOURNAL OF IMMUNOLOGY

A Randomized Intervention of Montelukast for Post-Bronchiolitis: Effect on Eosinophil Degranulation

(2010) Chang-Keun Kim et al.   JOURNAL OF PEDIATRICS

Relationships between Levels of Serum IgE, Cell-Bound IgE, and IgE-Receptors on Peripheral Blood Cells in a Pediatric Population

(2010) Eleonora Dehlink et al.   PLoS One

Opposing roles of IL-17A and IL-25 in the regulation of TSLP production in human nasal epithelial cells

(2009) G. Xu et al.   ALLERGY

Attenuated P2X7Pore Function as a Risk Factor for Virus-induced Loss of Asthma Control

(2009) Loren C. Denlinger et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Exploring the Association between Severe Respiratory Syncytial Virus Infection and Asthma

(2009) Simon Francis Thomsen et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Human rhinoviruses induce IL-35-producing Tregviainduction of B7-H1 (CD274) and sialoadhesin (CD169) on DC

(2009) Maria Seyerl et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Fc RI-mediated thymic stromal lymphopoietin production by interleukin-4-primed human mast cells

(2009) Y. Okayama et al.   EUROPEAN RESPIRATORY JOURNAL

Similar colds in subjects with allergic asthma and nonatopic subjects after inoculation with rhinovirus-16

(2009) Jennifer P. DeMore et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

In vitro susceptibility to rhinovirus infection is greater for bronchial than for nasal airway epithelial cells in human subjects

(2009) Nilceia Lopez-Souza et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Increased Expression of IL-33 in Severe Asthma: Evidence of Expression by Airway Smooth Muscle Cells

(2009) D. Prefontaine et al.   JOURNAL OF IMMUNOLOGY

Rhinovirus-induced modulation of gene expression in bronchial epithelial cells from subjects with asthma

(2009) Y A Bochkov et al.   Mucosal Immunology

Mepolizumab and Exacerbations of Refractory Eosinophilic Asthma

(2009) Pranabashis Haldar et al.   NEW ENGLAND JOURNAL OF MEDICINE

Status of Childhood Asthma in the United States, 1980–2007

(2009) Lara J. Akinbami et al.   PEDIATRICS

P2 receptor-mediated signaling in mast cell biology

(2009) Elena Bulanova et al.   Purinergic Signalling

Wheezing Rhinovirus Illnesses in Early Life Predict Asthma Development in High-Risk Children

(2008) Daniel J. Jackson et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Evidence of a Causal Role of Winter Virus Infection during Infancy in Early Childhood Asthma

(2008) Pingsheng Wu et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Rhinovirus Disrupts the Barrier Function of Polarized Airway Epithelial Cells

(2008) Umadevi Sajjan et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Type III IFN-λ mRNA expression in sputum of adult and school-aged asthmatics

(2008) Dominique M. A. Bullens et al.   CLINICAL AND EXPERIMENTAL ALLERGY

The Role of Regulatory T Cells in Chronic and Acute Viral Infections

(2008) Yoav Keynan et al.   CLINICAL INFECTIOUS DISEASES

Extracellular purines are biomarkers of neutrophilic airway inflammation

(2008) C. R. Esther et al.   EUROPEAN RESPIRATORY JOURNAL

A novel IL-1 family cytokine, IL-33, potently activates human eosinophils

(2008) W. Brett Cherry et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A novel group of rhinoviruses is associated with asthma hospitalizations

(2008) E. Kathryn Miller et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Early identification of atopy in the prediction of persistent asthma in children

(2008) Peter D Sly et al.   LANCET

The IL-1-Like Cytokine IL-33 Is Constitutively Expressed in the Nucleus of Endothelial Cells and Epithelial Cells In Vivo: A Novel ‘Alarmin’?

(2008) Christine Moussion et al.   PLoS One

Rhinovirus-induced lower respiratory illness is increased in asthma and related to virus load and Th1/2 cytokine and IL-10 production

(2008) S. D. Message et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Basal Cells of Differentiated Bronchial Epithelium Are More Susceptible to Rhinovirus Infection

(2007) Bogdan Jakiela et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Regulatory T Cells: Mechanisms of Differentiation and Function

(2007) Steven Z. Josefowicz et al.   Annual Review of Immunology