Journal
EPILEPSIA
Volume 51, Issue 12, Pages 2496-2499Publisher
WILEY-BLACKWELL PUBLISHING, INC
DOI: 10.1111/j.1528-1167.2010.02774.x
Keywords
Modified Atkins; Myoclonic astatic; Doose; Ketogenic; Epilepsy; Intractable
Categories
Funding
- Johns Hopkins Hospital
- Johns Hopkins University School of Medicine General Clinical Research [M01-RR00052]
- National Center for Research Resources/NIH
- Dr. Robert C. Atkins Foundation
- Nutricia, Inc.
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P>It has been reported that children can maintain seizure control when the ketogenic diet (KD) is transitioned to the less-restrictive modified Atkins diet (MAD). What is unknown, however, is the likelihood of additional seizure control from a switch from the MAD to the KD. Retrospective information was obtained from 27 patients who made this dietary change from four different institutions. Ten (37%) patients had >= 10% additional seizure reduction with the KD over the MAD, of which five became seizure-free. The five children who did not improve on the MAD failed to improve when transitioned to the KD. A higher incidence of improvement with the KD occurred for those with myoclonic-astatic epilepsy (70% vs. 12% for all other etiologies, p = 0.004), including all who became seizure-free. These results suggest that the KD probably represents a higher dose of dietary therapy than the MAD, which may particularly benefit those with myoclonic-astatic epilepsy.
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