A Type-II Positive Allosteric Modulator of α7 nAChRs Reduces Brain Injury and Improves Neurological Function after Focal Cerebral Ischemia in Rats

In vivopharmacological interactions between a type II positive allosteric modulator of α7 nicotinic ACh receptors and nicotinic agonists in a murine tonic pain model

(2012) K Freitas et al.   BRITISH JOURNAL OF PHARMACOLOGY

Positive allosteric modulator of alpha 7 nicotinic-acetylcholine receptors, PNU-120596 augments the effects of donepezil on learning and memory in aged rodents and non-human primates

(2012) Patrick M. Callahan et al.   NEUROPHARMACOLOGY

Somatic Integration of Single Ion Channel Responses of α7 Nicotinic Acetylcholine Receptors Enhanced by PNU-120596

(2012) Victor V. Uteshev   PLoS One

PNU-120596, a positive allosteric modulator of α7 nicotinic acetylcholine receptors, reverses a sub-chronic phencyclidine-induced cognitive deficit in the attentional set-shifting task in female rats

(2011) Samantha L McLean et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Pathophysiology, treatment, and animal and cellular models of human ischemic stroke

(2011) Trent M Woodruff et al.   Molecular Neurodegeneration

Neurotoxicity Induced by Okadaic Acid in the Human Neuroblastoma SH-SY5Y Line Can Be Differentially Prevented by α7 and β2* Nicotinic Stimulation

(2011) Laura del Barrio et al.   TOXICOLOGICAL SCIENCES

Voltage- and Temperature-Dependent Allosteric Modulation of α7 Nicotinic Receptors by PNU120596

(2011) Fabrio Sitzia et al.   Frontiers in Pharmacology

Activation of α7 nicotinic receptors improves phencyclidine-induced deficits in cognitive tasks in rats: Implications for therapy of cognitive dysfunction in schizophrenia

(2010) Samantha L. McLean et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

In Vivo Pharmacological Characterization of a Novel Selective  7 Neuronal Nicotinic Acetylcholine Receptor Agonist ABT-107: Preclinical Considerations in Alzheimer's Disease

(2010) R. S. Bitner et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Activation of Functional α7-Containing nAChRs in Hippocampal CA1 Pyramidal Neurons by Physiological Levels of Choline in the Presence of PNU-120596

(2010) Bopanna I. Kalappa et al.   PLoS One

Trace Eyeblink Conditioning is Impaired in α7 but not in β2 Nicotinic Acetylcholine Receptor Knockout Mice

(2010) Kevin L. Brown et al.   Frontiers in Behavioral Neuroscience

Evaluation of Ca2+ permeability of nicotinic acetylcholine receptors in hypothalamic histaminergic neurons

(2009) V. V. Uteshev   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Multiple roles for nicotine in Parkinson's disease

(2009) Maryka Quik et al.   BIOCHEMICAL PHARMACOLOGY

Nicotinic Receptor-Mediated Neuroprotection in Neurodegenerative Disease Models

(2009) Shun Shimohama   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Metabolic and transmitter changes in core and penumbra after middle cerebral artery occlusion in mice

(2009) Cornelia Kiewert et al.   BRAIN RESEARCH

Cognitive Improvement by Activation of α7 Nicotinic Acetylcholine Receptors: From Animal Models to Human Pathophysiology

(2009) Morten Thomsen et al.   CURRENT PHARMACEUTICAL DESIGN

Research Review: Cholinergic mechanisms, early brain development, and risk for schizophrenia

(2009) Randal G. Ross et al.   JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY

Mechanisms of Neuroprotective Effects of Nicotine and Acetylcholinesterase Inhibitors: Role of α4 and α7 Receptors in Neuroprotection

(2009) Akinori Akaike et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Physiological Concentrations of Choline Activate Native  7-Containing Nicotinic Acetylcholine Receptors in the Presence of PNU-120596 [1-(5-Chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)-urea]

(2009) A. G. Gusev et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Alpha 7 nicotinic acetylcholine receptor modulates lymphocyte activation

(2009) María José De Rosa et al.   LIFE SCIENCES

A cog in cognition: How the α7 nicotinic acetylcholine receptor is geared towards improving cognitive deficits

(2009) Steven C. Leiser et al.   PHARMACOLOGY & THERAPEUTICS

Nicotinic receptor stimulation protects nigral dopaminergic neurons in rotenone-induced Parkinson's disease models

(2008) Hiroki Takeuchi et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Dietary Choline Supplementation Improves Behavioral, Histological, and Neurochemical Outcomes in a Rat Model of Traumatic Brain Injury

(2008) Maria V. Guseva et al.   JOURNAL OF NEUROTRAUMA

A new penumbra: transitioning from injury into repair after stroke

(2008) Eng H Lo   NATURE MEDICINE

Lipid Alterations in Transient Forebrain Ischemia

(2003) A. Muralikrishna Rao et al.   JOURNAL OF NEUROCHEMISTRY