Survival advantage combining a BRAF inhibitor and radiation in BRAF V600E-mutant glioma

Radiosensitization by BRAF inhibitor therapy--mechanism and frequency of toxicity in melanoma patients

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Xenograft assessment of predictive biomarkers for standard head and neck cancer therapies

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Constitutive Activation of Raf-1 Induces Glioma Formation in Mice

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Increased skin and mucosal toxicity in the combination of vemurafenib with radiation therapy

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Analysis of the BRAFV600E Mutation in Central Nervous System Tumors

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Genotype-dependent cooperation of ionizing radiation with BRAF inhibition in BRAF V600E-mutated carcinomas

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Vemurafenib and radiation therapy in melanoma brain metastases

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Vemurafenib and Radiosensitization

(2013) Lise Boussemart et al.   JAMA Dermatology

Dabrafenib in BRAF-mutated metastatic melanoma: a multicentre, open-label, phase 3 randomised controlled trial

(2012) Axel Hauschild et al.   LANCET

Dabrafenib in patients with Val600Glu or Val600Lys BRAF-mutant melanoma metastatic to the brain (BREAK-MB): a multicentre, open-label, phase 2 trial

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Analysis of BRAF V600E mutation in 1,320 nervous system tumors reveals high mutation frequencies in pleomorphic xanthoastrocytoma, ganglioglioma and extra-cerebellar pilocytic astrocytoma

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Targeted Therapy for BRAFV600E Malignant Astrocytoma

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Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation

(2011) Paul B. Chapman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Melanoma cells show a heterogeneous range of sensitivity to ionizing radiation and are radiosensitized by inhibition of B-RAF with PLX-4032

(2011) Maria J. Sambade et al.   RADIOTHERAPY AND ONCOLOGY

A reproducible brain tumour model established from human glioblastoma biopsies

(2010) Jian Wang et al.   BMC CANCER

Pharmacologic Inhibition of Cyclin-Dependent Kinases 4 and 6 Arrests the Growth of Glioblastoma Multiforme Intracranial Xenografts

(2010) K. Michaud et al.   CANCER RESEARCH

Oncogenic BRAF Mutation with CDKN2A Inactivation Is Characteristic of a Subset of Pediatric Malignant Astrocytomas

(2010) J. D. Schiffman et al.   CANCER RESEARCH

RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF

(2010) Poulikos I. Poulikakos et al.   NATURE

Protocols to detect senescence-associated beta-galactosidase (SA-βgal) activity, a biomarker of senescent cells in culture and in vivo

(2009) Florence Debacq-Chainiaux et al.   Nature Protocols