Review
Computer Science, Information Systems
Norshakirah Aziz, Md Jan Nordin, Said Jadid Abdulkadir, Muhammad Muhaimin M. Salih
Summary: Excessive computer gaming addiction, especially in MMOG, among Malaysian adolescents may lead to various physical health impacts such as obesity, back pain, and neck pain.
Review
Psychiatry
Canahmet Boz, Mehmet Dinc
Summary: The aim of this study is to examine the methodological orientations in game addiction studies in Turkey between 2019 and 2022 in a holistic way and to present suggestions for new literature studies. The study found that out of 257 studies, 69 complied with the predetermined criteria. These studies explored the relationship between academic achievement, familial and social relationship problems, gaming behavior and game addiction in children and adolescents. It was discovered that gaming addiction was higher in male students, especially between the ages of 14-15. The findings suggest that further empirical studies should be conducted to address game addiction with different approaches using new literature.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Cell Biology
Alicia Rivera, Diana Suarez-Boomgaard, Cristina Miguelez, Alejandra Valderrama-Carvajal, Jerome Baufreton, Kirill Shumilov, Anne Taupignon, Belen Gago, M. Angeles Real
Summary: Long-term exposure to morphine induces structural and synaptic plasticity in reward-related regions of the brain, playing a critical role in addiction. However, the morphine-induced neuroadaptations in the dorsal striatum, which is crucial for drug-related habit learning, have not been well studied. This study finds that prolonged treatment with morphine leads to retraction of dendritic arbor and loss of dendritic spines in the dorsal striatal projection neurons. Additionally, the dopamine D-4 receptor (D4R) is found to modulate striatal morphine-induced plasticity, as the combined treatment of morphine with a D4R agonist restores dendritic arbor and spine density while altering the electrical properties of the neurons.
Review
Cell Biology
Roy A. Wise, Chloe J. Jordan
Summary: Addictive drugs can lead to addiction, with dopamine playing a crucial role in learning and emotional arousal. Changes in dopamine levels affect the animal's response to predictive stimuli, and the mechanisms of action of different addictive drugs warrant further investigation.
JOURNAL OF BIOMEDICAL SCIENCE
(2021)
Article
Behavioral Sciences
I-Mei Liao, Jin-Chung Chen
Summary: The study suggests that the mesolimbic D4 receptor does not play a crucial role in regulating behavioral sensitization induced by hyperdopaminergia, extending to the therapeutic effects of clozapine. Alternative molecular targets should be prioritized for future therapeutics targeting hyperdopaminergia-dependent neuropsychiatric disorders.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Chemistry, Medicinal
Louisa A. Christie, Nicola L. Brice, Anna Rowland, Louise Dickson, Rishi Anand, Martin Teall, Kevin J. Doyle, Lakshminarayana Narayana, Christine Mitchell, Jenna R. M. Harvey, Victoria Mulligan, Lee A. Dawson, Stephanie J. Cragg, Mark Carlton, Roland W. Burli
Summary: The study aimed to develop potent and selective alpha 6-containing nAChR antagonists to explore modulation of dopamine release and regulation of motor function. CVN417, a novel compound, was identified as an antagonist of alpha 6-containing nAChR and was found to reduce firing frequency of noradrenergic neurons. CVN417 modulated phasic dopaminergic neurotransmission in an impulse-dependent manner and attenuated the resting tremor phenotype in a rodent model. These results suggest that selective antagonism of alpha 6-containing nAChR could be a therapeutic approach for movement dysfunctions such as Parkinson's disease.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
William N. Sanchez, Jose A. Pochapski, Leticia F. Jessen, Marek Ellenberger, Rainer K. Schwarting, Donita L. Robinson, Roberto Andreatini, Claudio Da Cunha
Summary: The study found that diazepam can mitigate the neurochemical and psychostimulant effects of cocaine, such as reducing dopamine signals, inhibiting the increase in 50-kHz calls, and decreasing cocaine-induced locomotion.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Min Liu, Shouhong Mu, Weikai Han, Xu Tan, E. Liu, Zhaofang Hang, Shaowei Zhu, Qingwei Yue, Jinhao Sun
Summary: The study demonstrated that methamphetamine (MA) increases c-Fos expression and synaptic plasticity in the orbitofrontal cortex (OFC) and dorsal striatum (DS). MA activates projection neurons from the OFC to the DS and affects conditioned place preference (CPP) scores. The study also showed that DA release in the OFC is increased in the MA group, and D1R neurons in the OFC-DS pathway play a role in MA addiction.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Cell Biology
Min-Che Tung, Yung-Wei Lin, Wei-Jiunn Lee, Yu-Ching Wen, Yu-Cheng Liu, Ji-Qing Chen, Michael Hsiao, Yi-Chieh Yang, Ming-Hsien Chien
Summary: Renal cell carcinoma (RCC) is a difficult-to-treat cancer, but recent research has found that penfluridol, a dopamine receptor D2 antagonist, can inhibit the growth of RCC cells and reduce their stemness through inducing autophagy-mediated apoptosis. This study suggests that penfluridol may be a potential therapeutic agent for treating RCC.
CELL DEATH & DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Li Zhu, Feifei Wu, Zhilan Yan, Lijun He, Shufei Wang, Haohao Hu, Eyleen L. K. Goh, Yingjie Zhu, Fanglin Guan, Teng Chen
Summary: The decreased expression of a novel microRNA, novel-m009C, is found to be implicated in the hyperlocomotion induced by METH. The study identifies dopamine receptors D1 and D2 as regulators of novel-m009C expression in the nucleus accumbens, and increasing the levels of novel-m009C attenuates the rewarding effects of METH. These findings provide insights into the molecular mechanism underlying METH addiction and suggest a potential treatment strategy targeting small non-coding RNAs.
MOLECULAR PSYCHIATRY
(2022)
Article
Biochemistry & Molecular Biology
Siroshini K. Thiagarajan, Siew Ying Mok, Satoshi Ogawa, Ishwar S. Parhar, Pek Yee Tang
Summary: This study used zebrafish as a biological model to assess the molecular and behavioral changes associated with schizophrenia, opioid addiction, and withdrawal. The findings suggest that there may be common mechanisms underlying schizophrenia-like symptoms and opioid dependence.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Medicinal
Jin Cai, Mingqi Huang, Yuhong Wang, Xixi Chen, Min Ji
Summary: Three series of novel bitopic benzopyranomorpholine analogues were designed, synthesized, and evaluated for their selective ligand activity for the dopamine D3 receptor. Most compounds showed strong binding affinities and selectivity for the D3 receptor. One compound, 20h, demonstrated nanomolar affinity for the D3 receptor and exhibited anti-drug addiction efficacy in animal models.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2021)
Review
Chemistry, Multidisciplinary
Longfei Jia, Shu-Bing Qian
Summary: Synthetic mRNA has emerged as a programmable therapeutic reagent, offering advantages in flexible design, low-cost preparation, and potential for various therapeutic applications. Recent advancements in mRNA technology have led to successful development of mRNA vaccines against SARS-CoV-2, highlighting the importance of understanding mRNA metabolism and translational control. However, challenges remain in the rational design of synthetic mRNAs for optimal stability and translation efficiency.
ACCOUNTS OF CHEMICAL RESEARCH
(2021)
Article
Neurosciences
Jacqueline A. Quigley, Molly K. Logsdon, Christopher A. Turner, Ivette L. Gonzalez, N. B. Leonardo, Jill B. Becker
Summary: This article reviews the evidence for sex differences in vulnerability to addiction, focusing on the neural mechanisms underlying these differences. The interactions between estradiol and the dopamine system in the brain result in differences in motivated behaviors and drug-seeking between males and females. Estradiol increases females' motivation for psychostimulants and enhances the value of drug-related cues, ultimately increasing their susceptibility to relapse.
Article
Biochemistry & Molecular Biology
Krzysztof Chmielowiec, Jolanta Chmielowiec, Jolanta Masiak, Aleksandra Stronska-Pluta, Milena Lachowicz, Agnieszka Boron, Dariusz Larysz, Magdalena Dzitkowska-Zabielska, Pawel Cieszczyk, Anna Grzywacz
Summary: DNA methylation is an important epigenetic mechanism that is involved in regulating dopamine release. The study found that nicotine-dependent individuals and athletes had higher levels of DNA methylation compared to the control group.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Mahsa Naeeni Davarani, Ali Arian Darestani, Peyman Hassani-Abharian, Salar Vaseghi, Mohammad-Reza Zarrindast, Mohammad Nasehi
Summary: This study investigated the effect of RehaCom on cognitive functions in patients with multiple sclerosis (MS). The results showed that RehaCom treatment improved attention, response control, processing speed, working memory, visuospatial skills, and executive functions in MS patients.
APPLIED NEUROPSYCHOLOGY-ADULT
(2022)
Review
Neurosciences
Mitra-Sadat Sadat-Shirazi, Mahsa Sadeghi-Adl, Ardeshir Akbarabadi, Ghorbangol Ashabi, Azarakhsh Mokri, Mohammad-Reza Zarrindast
Summary: Drug addiction is a chronic relapsing disorder that poses a global problem, influenced by genetics and environmental factors. Recent research has emphasized the role of epigenetics in the intergenerational and transgenerational inheritance of drug addiction. Studies have shown that parental exposure to drugs of abuse (opioids, cocaine, nicotine, alcohol, and cannabis) before conception alters offspring phenotype and impacts neurochemical and neurostructural changes in the brain. This paper reviews the effects of parental drug exposure before gestation in animal models.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
(2023)
Review
Neurosciences
Masoumeh Kourosh-Arami, Alireza Komaki, Mohammad-Reza Zarrindast
Summary: This article summarizes the importance of dopamine in learning and memory, particularly its role in spatial learning and memory. Through the study of dopamine system signaling, it explores the relationship between dopamine and various types of memory, such as reward signaling, working memory, long-term plasticity, and memory consolidation. It also analyzes memory impairment in dopamine-related neurological disorders.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
(2023)
Article
Biochemistry & Molecular Biology
Vahide Alipour, Ramin Shabani, Farhad Rahmani-Nia, Salar Vaseghi, Mohammad Nasehi, Mohammad-Reza Zarrindast
Summary: Both Thimerosal and exercise impair social memory, but glutamatergic subunits do not play a separate and influential role in modulating memory processes.
JOURNAL OF MOLECULAR NEUROSCIENCE
(2022)
Review
Pharmacology & Pharmacy
Gita Kholghi, Shirin Arjmandi-Rad, Mohammad-Reza Zarrindast, Salar Vaseghi
Summary: St. John's wort is a herbaceous plant with therapeutic effects on psychiatric and mood disorders. Its active components, hyperforin and hypericin, play a major role in these effects. Changes in neurotransmitter levels in depression are complex and St. John's wort has inconsistent effects on neurotransmitter levels. Glutamate and acetylcholine may be important neurotransmitters to study in future works, and the dualistic modulation on cholinergic signaling induced by St. John's wort is an interesting topic for future studies.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Mohammad-Hossein Mohammadi-Mahdiabadi-Hasani, Mohaddeseh Ebrahimi-Ghiri, Fatemeh Khakpai, Mohammad-Reza Zarrindast
Summary: Depression and anxiety often coexist, making treatment more complex and less effective with common drugs. Combination therapy could be more effective with lower doses to reduce side effects while maintaining optimal effects.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2022)
Article
Chemistry, Medicinal
Saereh Hosseindoost, Ardeshir Akbarabadi, Mitra-Sadat Sadat-Shirazi, Seyed M. Mousavi, Solmaz Khalifeh, Azarakhsh Mokri, Mahmoudreza Hadjighassem, Mohammad-Reza Zarrindast
Summary: This study found that chronic exposure to tramadol reduces cell viability and induces apoptotic changes in hippocampal neurons, and these effects are partially mediated through opioid receptors.
DRUG DEVELOPMENT RESEARCH
(2022)
Article
Behavioral Sciences
Naghmeh Saadati, Maryam Bananej, Fatemeh Khakpai, Mohammad-Reza Zarrindast, Hengameh Alibeik
Summary: This study evaluated the effect of orexin agents and citalopram on anxiety behavior in REM sleep-deprived mice. The results showed that SB-334867 had no effect on anxiety reaction, while citalopram had an anxiolytic effect. Interestingly, the co-treatment of citalopram and SB-334867 enhanced the anxiolytic effect.
BEHAVIOURAL PHARMACOLOGY
(2022)
Article
Neurosciences
Fatemeh Khakpai, Yasaman Issazadeh, Niloofar Rezaei, Mohammad-Reza Zarrindast
Summary: The involvement of the opioidergic system in the anxiolytic and antinociceptive responses induced by cholestasis was investigated. The results suggest that cholestasis and addiction can impact anxiety and pain behaviors, with mu-opioid receptors playing a key role in the anxiolytic and analgesic effects induced by cholestasis. Additionally, coadministration of morphine and tramadol can enhance these effects in both cholestatic and addicted mice.
Article
Behavioral Sciences
Naghmeh Saadati, Maryam Bananej, Fatemeh Khakpai, Mohammad -Reza Zarrindast, Hengameh Alibeik
Summary: This study evaluated the effects of co-treatment of orexin agents and citalopram on depression-like behavior and BDNF expression in the prefrontal cortex (PFC) of sleep-deprived male mice. It was found that sleep deprivation increased depression-like behavior while decreasing BDNF expression. Citalopram showed an antidepressant effect, which was potentiated by an orexin antagonist and reversed by orexin-1. The study suggests that the orexin system interacts with citalopram to modulate depression-like behavior in sleep-deprived mice.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2022)
Article
Genetics & Heredity
Parisa Rahimpour, Mohammad Nasehi, Mohammad -Reza Zarrindast, Solmaz Khalifeh
Summary: This study aimed to assess the effects of sleep deprivation (SD) and luteolin on spatial learning and memory. The results showed that luteolin dose-dependently restored SD-induced spatial memory impairment, possibly through modulating the levels of heat shock protein 70 and heat shock protein 90.
Review
Endocrinology & Metabolism
Salar Vaseghi, Ali Mostafavijabbari, Mohammad-Sadegh Alizadeh, Reza Ghaffarzadegan, Gita Kholghi, Mohammad-Reza Zarrindast
Summary: This review article discusses the intricate roles of sleep deprivation (SD) in modulating depression. The inconsistent effects of SD on depression have been studied for decades, with a focus on SD duration. However, the inconsistent role of SD seems to be more complicated, and other factors such as brain-derived neurotrophic factor (BDNF), vascular endothelial growth factor (VEGF), serotonin, cortisol, and tumor necrosis factor-alpha (TNF-alpha) are involved. It was concluded that SD has inconsistent effects on BDNF, VEGF, serotonin, and cortisol levels. The diurnal rhythm of BDNF is significant in the modulatory role of SD in depression. VEGF is important in blood-brain barrier permeability which affects depression. Furthermore, there is a negative correlation between cortisol and BDNF, modulating depression. TNF-alpha regulates sleep/wake cycle and increases blood-brain barrier permeability, resulting in depressive behavior. Future studies should focus on these mechanisms/factors to better understand the complex roles of SD in modulating depression.
METABOLIC BRAIN DISEASE
(2023)
Article
Endocrinology & Metabolism
Fatemeh Khakpai, Niloofar Rezaei, Yasaman Issazadeh, Mohammad-Reza Zarrindast
Summary: Cholestasis and drug dependence impair social motivation and induce depression-like behavior in mice. Administration of morphine and tramadol alone or in combination can protect against these abnormal behaviors, while naloxone administration exacerbates them. Mu-opioid receptors play a key role in the modulation of social motivation and depression behaviors in mice.
JOURNAL OF DIABETES AND METABOLIC DISORDERS
(2022)
Article
Biochemistry & Molecular Biology
Gita Kholghi, Vahide Alipour, Maede Rezaie, Mohammad-Reza Zarrindast, Salar Vaseghi
Summary: Sleep deprivation has negative effects on cognitive functions, but some studies suggest it may improve cognitive functions. This study investigated the effects of 4-hour and 24-hour sleep deprivation, as well as mild short-term and moderate long-term treadmill exercise, on spatial memory performance and oxidative and antioxidant markers in rats. The results showed that 24-hour sleep deprivation and long-term moderate treadmill exercise had negative effects on memory and oxidative status. However, both treadmill exercise protocols reversed the negative effects of sleep deprivation on memory and oxidative stress.
NEUROCHEMICAL RESEARCH
(2023)
