Article
Biophysics
Alain Bolano Alvarez, Marcelo Pino, Steffen B. Petersen, Gerardo Daniel Fidelio
Summary: Langmuir monolayer enables the organization of amphiphilic molecules in a two-dimensional nano-scale, which has been adapted to measure lateral and transverse conductivity in confined peptide nanosheets for the first time. The study shows that amphipathic peptides form stable monolayers with semiconductor-like behavior, with differences in lateral conductivity and current-voltage due to asymmetric peptide bond backbone orientation. The results suggest the potential to design extended nano-sheets with specific electrical properties for applications in biosensing and neural interfaces.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Biochemistry & Molecular Biology
Daisuke Fujii, Kento Takase, Ami Takagi, Kei Kamino, Yoshiaki Hirano
Summary: The study focuses on the design and role of RGD-containing peptides in cellular activities, exploring their application in tissue engineering through analysis of peptide structures and mechanical properties, and demonstrating that peptide-coated cell culture substrates have a significant promoting effect on cell adhesion and spreading.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Chiho Miyamaru, Mao Koide, Nana Kato, Shogo Matsubara, Masahiro Higuchi
Summary: We fabricated CaCO3-coated vesicles as drug carriers that release drugs under weakly acidic condition. The vesicles had inner spaces for drug cargo and retained their spherical shapes. The CaCO3 shell on the vesicle surface dissolved under weakly acidic conditions, allowing for effective drug release. The study suggests the potential application of CaCO3-coated vesicles in cancer therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Physical
Yi-Ming Ju, Fang Huang, Xin Ding, Li-Bo Mao, Shu-Hong Yu
Summary: This study investigates the mechanism of Mg2+ ion-regulated mineralization of CaCO3 by tracing Mg isotope fractionation. The different mineralization pathways of CaCO3 under different Mg2+ ion concentrations are clarified, and the detailed regulatory role of Mg2+ ions at different stages of mineralization is proposed. These results provide important insights for finely controlling the phase of crystalline products.
Article
Cell Biology
Yuhui Yang, Hao Liu, Ruoxi Wang, Yi Zhao, Yunfei Zheng, Yiping Huang, Weiran Li
Summary: Repairing orthodontic external root resorption and periodontal tissue dysfunction caused by mechanical force is difficult in clinical practice. Cementoblasts play a vital role in cementum mineralization, which is important for restoring damaged cementum. The underlying mechanism of how autophagy mediates cementoblast mineralization is unclear. In this study, we found that murine cementoblasts exhibit compromised mineralization under compressive force. Autophagy is indispensable for cementoblast mineralization and activating it can reverse cementoblast mineralization and prevent cementum damage during tooth movement. We also identified periostin as a mediator of autophagy and mineralization in cementoblasts. Silencing periostin significantly inhibited cementoblast mineralization and suppressed Wnt signaling by modulating the stability of β-catenin. These findings highlight the importance of autophagy in cementoblast mineralization and provide a potential strategy for cementum remineralization and periodontal tissue regeneration under compressive force.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Chandradeep Basu, Himal Kanti Ganguly, Gautam Basu
Summary: The study shows that replacing a single residue in a beta-hairpin by Gly-Pro is well accommodated in the isolated beta-hairpin without causing much structural distortion, while Pro-Gly is not well accommodated in the same context.
CHEMICAL COMMUNICATIONS
(2021)
Article
Energy & Fuels
Dharmjeet Madhav, Bart Buffel, Frederik Desplentere, Paula Moldenaers, Veerle Vandeginste
Summary: In this study, CaCO3 particles with different morphologies were produced via single-step CO2 capture and mineralization, inspired by the natural formation of nacre. It was found that a combination of triethanolamine and ammonium hydroxide as absorption promoters resulted in 53.2% conversion of Ca2+ into stable CaCO3 particles within 5 minutes. Polymer and surfactant-mediated mineralization of CO2 produced spherical and hollow, stable calcite particles that could have various applications.
Article
Computer Science, Artificial Intelligence
Mario Alberto da Silveira Dib, Pedro Prates, Bernardete Ribeiro
Summary: With the ongoing digitization of the manufacturing industry, machine learning techniques have great potential in predicting defects and improving production process reliability. However, small and medium-sized companies lack sufficient data for applying machine learning models. This paper proposes a framework based on Federated Learning and Digital Envelopes to address data privacy concerns and effectively handle data poisoning attacks.
EXPERT SYSTEMS WITH APPLICATIONS
(2024)
Article
Chemistry, Physical
Matthew P. Confer, Brooke M. Holcombe, Abigail G. Foes, John M. Holmquist, Savannah C. Walker, Sanghamitra Deb, Ayanjeet Ghosh
Summary: The study demonstrates the heterogeneities of Aβ plaques in terms of secondary structure and phospholipid content in AD brains using infrared spectroscopic imaging. Discrete frequency infrared imaging (DFIR) is shown to be effective in characterizing amyloid deposits and identifying non-plaque β-sheet aggregates throughout brain tissues. The presence of phospholipid-rich β-sheet deposits outside of plaques suggests potential clinical significance and offers insights for future therapeutic strategies.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2021)
Article
Crystallography
Ya-Xin Li, Yuan Jiang
Summary: An emerging approach to synthesizing drug-loaded CaCO3 composites via the synergistic occlusion of alginate hydrogel matrices and the associated drug has been proposed. The technique was shown to result in the uniform dispersion of the anticancer drug doxorubicin within the hydrogel matrices, leading to CaCO3-based composites with high drug loadings and sustained and pH-responsive drug release. This occlusion strategy has the potential to be a general approach for designing smart drug delivery systems, considering the ability of many drug molecules to form molecular solutions with polymeric components.
Article
Biochemistry & Molecular Biology
Xinyu Liu, Samuel H. Gellman
Summary: The assembly of racemic beta-sheet-forming peptides is more avid due to their ability to self-associate better than single enantiomers, suggesting that rippled beta-sheet assemblies are stabilized by interactions between beta-sheet layers. Strong evidence supports the occurrence of rippled beta-sheets in some racemic peptide assemblies.
Article
Chemistry, Physical
Hai Xu, Henghao Yu, Yingjie Chen, Jing Deng, Zhaoyu Chen, Peng Zhou, Jian R. Lu, Jun Yang, Yurong Zhao
Summary: Zippers between complementary sidechains have potential in preparing peptide self-assemblies with long-range ordering. This study achieved well-defined nanostructures through nonpolar zippers by designing a series of short amphiphilic peptides. Only one peptide, Ac-I3VGK-NH2, could self-assemble into wide and uniform nanoribbons, thanks to the formation of extensive nonpolar zippers between beta-sheets. The failure of other peptide variants highlighted the importance of the interaction mode of hydrophobic sidechains in the formation of wide and flat nanoribbons.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2023)
Article
Nanoscience & Nanotechnology
Emma Olson, Justin S. Plaut, Sarah A. Barnhill, Sinan Sabuncu, Corey M. Dambacher, Sean D. Speese, Srivathsan Ranganathan, Bruce P. Branchaud, Adem Yildirim
Summary: A sensitive method for detecting protease activity using a beta-sheet-rich nanoplatelet-forming peptide precursor and thioflavin T has been developed, allowing for detection of specific proteases like legumain. This method shows promise for various protease-detection applications due to its simplicity and low cost, and does not require time-consuming conjugation reactions or purification steps.
ACS APPLIED NANO MATERIALS
(2021)
Article
Chemistry, Physical
Wojciech Wieckowski, Janina Adamus, Marcin Dyner, Maciej Motyka
Summary: Friction, wear, and lubrication are common challenges in metal-forming processes, especially when forming titanium materials. Using environmentally friendly lubricants with boric acid can effectively reduce tool wear and eliminate galling. This paper explores the tribological aspects of forming titanium sheets with these lubricants through technological tests and numerical simulations. The results demonstrate the positive impact of lubricants with boric acid on sheet titanium forming.
Article
Chemistry, Medicinal
Ying Wang, Jia Xu, Fengjuan Huang, Jiajia Yan, Xinjie Fan, Yu Zou, Chuang Wang, Feng Ding, Yunxiang Sun
Summary: In this study, we investigated the inhibitory mechanism of SEVI against Aβ42 fibrillization using molecular dynamic simulations. Our findings revealed that SEVI can bind to various Aβ aggregation species by capping the exposed β-sheet elongation edges, thereby inhibiting their aggregation processes. This study provides novel insights into the development of therapeutic strategies against Alzheimer's disease.
JOURNAL OF CHEMICAL INFORMATION AND MODELING
(2023)
Article
Chemistry, Multidisciplinary
D. Vollhardt, G. Brezesinski
Article
Chemistry, Physical
Christopher Janich, Stephanie Tassler, Annette Meister, Gerd Hause, Jens Schaefer, Udo Bakowsky, Gerald Brezesinski, Christian Woelk
Article
Nanoscience & Nanotechnology
Joana S. L. Oliveira, Gerald Brezesinski, Alexandra Hill, Arne Gericke
BEILSTEIN JOURNAL OF NANOTECHNOLOGY
(2016)
Article
Chemistry, Multidisciplinary
Ana C. N. Oliveira, Sara S. Nogueira, Odete Goncalves, M. F. Cerqueira, P. Alpuim, Julia Tovar, Carlos Rodriguez-Abreu, Gerald Brezesinski, Andreia C. Gomes, Marlene Lucio, M. E. C. D. Real Oliveira
Article
Chemistry, Multidisciplinary
Antje Reinecke, Gerald Brezesinski, Matthew J. Harrington
ADVANCED MATERIALS INTERFACES
(2017)
Article
Pharmacology & Pharmacy
Marija N. Todosijevic, Gerald Brezesinski, Sndana D. Savic, Reinhard H. H. Neubert
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2017)
Article
Chemistry, Multidisciplinary
M. Orczyk, K. Wojciechowski, G. Brezesinski
Article
Biochemistry & Molecular Biology
Doreen Hentrich, Soraya Taabache, Gerald Brezesinski, Nele Lange, Wolfgang Unger, Christian Kuebel, Annabelle Bertin, Andreas Taubert
MACROMOLECULAR BIOSCIENCE
(2017)
Article
Chemistry, Physical
D. Vollhardt, G. Brezesinski
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2017)
Proceedings Paper
Materials Science, Multidisciplinary
A. I. Buzin, G. Brezesinski, V. S. Papkov, S. N. Chvalun
16TH INTERNATIONAL CONFERENCE ON ORGANIZED MOLECULAR FILMS (ICOMF16-LB16)
(2017)
Article
Chemistry, Multidisciplinary
Frederik Neuhaus, Dennis Mueller, Radu Tanasescu, Sandor Balog, Takashi Ishikawa, Gerald Brezesinski, Andreas Zumbuehl
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2017)
Article
Multidisciplinary Sciences
J. S. L. Oliveira, S. Lange, B. Dobner, G. Brezesinski
Article
Chemistry, Physical
D. Vollhardt, G. Brezesinski
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2017)
Article
Biochemistry & Molecular Biology
J. S. L. Oliveira, S. Lange, B. Dobner, G. Brezesinski
CHEMISTRY AND PHYSICS OF LIPIDS
(2017)
Article
Nanoscience & Nanotechnology
Stefan Reinicke, Huw C. Rees, Pieter Espeel, Nane Vanparijs, Carolin Bisterfeld, Markus Dick, Ruben R. Rosencrantz, Gerald Brezesinski, Bruno G. de Geest, Filip E. Du Prez, Joerg Pietruszka, Alexander Boeker
ACS APPLIED MATERIALS & INTERFACES
(2017)