Article
Chemistry, Physical
Haonan Li, Rong Chen, Xun Zhu, Dingding Ye, Yang Yang, Wei Li, Dongliang Li, Qiang Liao
Summary: A novel and facile light strategy is presented to manipulate macroscopic crystal morphology during droplet evaporative crystallization. Different crystal skeletons, such as spherical coronal shell, alms bowl-like skeleton, and cylindrical shell-like skeleton with controllable cavity, can be achieved on photosensitive hydrophobic substrates. The study also shows that the addition of certain compounds can lead to the formation of closed crystal skeletons with the solution wrapped inside.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2022)
Article
Chemistry, Physical
Cathryn G. Conner, James McAndrew, Stefano Menegatti, Orlin D. Velev
Summary: A rapid method for determining the colloidal stability of protein molecules in solution has been reported, which serves as an efficient tool for evaluating the stability of antibody formulations. The method involves the use of human polyclonal immunoglobulin G (IgG) as a model protein and dynamic light scattering (DLS) to determine particle size in solution, enabling the investigation of aggregation rates at different temperatures and antibody concentrations.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2022)
Article
Chemistry, Physical
Cathryn G. Conner, James McAndrew, Stefano Menegatti, Orlin D. Velev
Summary: This study reports a rapid method for evaluating the stability of antibody formulations using dynamic light scattering (DLS) to determine the size of particles in solution. The method involves analyzing high-resolution data, conducting temperature and stress tests, and plotting 3-D graphs to assess the stability of antibody solutions under different conditions.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2022)
Article
Chemistry, Physical
Anna Yucknovsky, Benjamin B. Rich, Sara Gutkin, Ambili Ramanthrikkovil Variyam, Doron Shabat, Boaz Pokroy, Nadav Amdursky
Summary: The dynamic control of pH-responsive systems using super photoacids for proton transfer enables self-propulsion of droplets, demonstrating the application of super photoacids in controlling dynamic processes and opening up new possibilities in the field of light-triggered dynamic systems.
JOURNAL OF PHYSICAL CHEMISTRY B
(2022)
Article
Engineering, Chemical
Adrian Roth, David Frantz, Mehdi Stiti, Edouard Berrocal
Summary: The COVID-19 pandemic has highlighted the lack of understanding regarding the airborne transmission pathway of diseases. This study presents a new method using high-speed scattered light imaging to measure the size of liquid particles (droplets) in respiratory events, providing valuable data to improve the understanding of airborne transmission pathway.
JOURNAL OF AEROSOL SCIENCE
(2023)
Article
Chemistry, Analytical
Maria Antonio, Tania Lima, Rui Vitorino, Ana L. Daniel-da-Silva
Summary: A simple method for label-free detection of CRP in saliva samples was developed using silica-coated Fe3O4 nanoparticles functionalized with amino carboxylate moieties. The nanoparticles showed higher selectivity towards CRP compared to nonfunctionalized nanoparticles, providing more accurate detection of CRP concentration.
ANALYTICA CHIMICA ACTA
(2022)
Article
Mathematics, Applied
Amit Lahiri, Md. Kamrul Hassan, Bernd Blasius, Juergen Kurths
Summary: This study investigates a class of nucleation and growth models of a stable phase, finding that the stable phase decays following a power law within a certain range of growth velocities, and the distribution of particle size of the stable phase obeys dynamic scaling. However, when the growth velocity is constant or exceeds a critical value, the decay of the stable phase is exponential and does not exhibit dynamic scaling.
Article
Engineering, Chemical
Silvia Tappi, Virginia Glicerina, Luigi Ragni, Amanda Dettori, Santina Romani, Pietro Rocculi
Summary: The study aimed to investigate the physical and structural properties of honey during static and dynamic induced crystallization. Results showed that dynamic process significantly reduced crystallization time and resulted in honey products with lower hardness and viscosity. Despite starting from different values, dynamic process led to final crystallized honeys with very similar color and structural characteristics.
JOURNAL OF FOOD ENGINEERING
(2021)
Article
Chemistry, Multidisciplinary
Patricia Besirske, Arianna Menichetti, Marco Montalti, Juan Manuel Garcia-Ruiz, Martin Winterhalder, Johannes Boneberg, Helmut Coelfen
Summary: Proof of principle is established for the successful light-induced crystallization of carbonate-hydroxyapatite, offering new opportunities for more precise reaction control and enhanced treatment of calcium phosphate containing biomaterials.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Optics
Eylul Simsek, Keyong Zhu, Glareh N. Kashanchi, Megan J. Williams, Tiphaine Galy, Michal Marszewski, Sarah H. Tolbert, Laurent Pilon
Summary: This study quantified the effect of pendant droplets on the transmittance and reflectance of semitransparent glass panes, demonstrating that droplets with a contact angle smaller than the critical angle did not significantly impact the transmittance and reflectance, while droplets with a contact angle less than 90 degrees led to a significant decrease in transmittance and increase in reflectance.
JOURNAL OF QUANTITATIVE SPECTROSCOPY & RADIATIVE TRANSFER
(2021)
Article
Computer Science, Artificial Intelligence
Marie Weiel, Markus Gotz, Andre Klein, Daniel Coquelin, Ralf Floca, Alexander Schug
Summary: Molecular simulations informed by experimental data provide detailed knowledge of complex biomolecular structure, but the challenge lies in weighting experimental information with respect to the model. A self-adapting dynamic particle swarm optimization, FLAPS, is introduced to tackle the parameter selection problem by dynamically evolving and iteratively refining the search-space topology. This method is demonstrated on small-angle X-ray scattering-guided protein simulations.
NATURE MACHINE INTELLIGENCE
(2021)
Article
Optics
Xiaobing Feng, Guiqiong Huang, Jian Qiu, Li Peng, Kaiqing Luo, Dongmei Liu, Peng Han
Summary: Dynamic light scattering, a technique for sub-micrometer particle sizing based on Brownian motion theory, is not suitable for particles undergoing both random and directional movement, especially in uncertain directions. This paper derives the intensity autocorrelation function of scattered light for particle systems with random and directional movement, and introduces additional sinc functions to account for the directional movement. Experimental results confirm the validity of the derivation, and the application of this technique can be extended to investigate complex fluid systems with particles undergoing directional movement in known or unknown directions.
OPTICS COMMUNICATIONS
(2023)
Article
Medicine, Research & Experimental
Katharina Dauer, Walter Kamm, Karl Gerhard Wagner, Stefania Pfeiffer-Marek
Summary: The study investigated the use of diffusion self-interaction parameters and osmotic second virial coefficients for high-throughput screening of peptide formulations to evaluate aggregation risk. The results showed that electrostatic interactions play a key role in controlling colloidal stability, and k(D) was proven to be a suitable indicator for high colloidal stability in peptides. Formulation assessment based on k(D) obtained through high-throughput methods offers important insights into optimizing colloidal stability during early development of peptide-based liquid formulations.
MOLECULAR PHARMACEUTICS
(2021)
Article
Pharmacology & Pharmacy
Katharina Dauer, Stefania Pfeiffer-Marek, Walter Kamm, Karl G. Wagner
Summary: This study evaluated the intra- and inter-plate variability of high-throughput light scattering instruments for protein and peptide solutions. The reliability and precision of k(D) was found to be dependent on the plate position of the sample replicates and the numerical value. Positive k(D) values showed lower variability compared to negative values, and increasing data points did not reduce variability.
Review
Cell Biology
Marta Bosch, Matthew J. Sweet, Robert G. Parton, Albert Pol
Summary: Lipid droplets play a crucial role in the ongoing conflict between eukaryotic cells and pathogens, with innate immunity rewiring lipid metabolism to defend against pathogens. Understanding immune strategies developed by eukaryotic cells may inform future anti-infective strategies in the age of antimicrobial resistance and viral pandemics.
JOURNAL OF CELL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Rehana Masood, Kifayat Ullah, Hamid Ali, Ijaz Ali, Christian Betzel, Anwar Ullah
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2018)
Article
Biotechnology & Applied Microbiology
Esther Frohnmeyer, Farina Frisch, Sven Falke, Christian Betzel, Markus Fischer
JOURNAL OF BIOTECHNOLOGY
(2018)
Article
Chemistry, Physical
Saima Rasheed, Shoaib Ahmad Malik, Sven Falke, Ali ArsIan, Ramin Fazel, Hartmut Schlueter, Christian Betzel, M. Iqbal Choudhary
JOURNAL OF MOLECULAR STRUCTURE
(2018)
Article
Chemistry, Medicinal
Malik S. Ahmad, Saima Rasheed, Sven Falke, Binish Khaliq, Markus Perbandt, Muhammad Choudhary, Wojciech T. Markiewicz, Jan Barciszewski, Christian Betzel
MEDICINAL CHEMISTRY
(2018)
Article
Multidisciplinary Sciences
Yannig Gicquel, Robin Schubert, Svetlana Kapis, Gleb Bourenkov, Thomas Schneider, Markus Perbandt, Christian Betzel, Henry N. Chapman, Michael Heymann
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2018)
Article
Biochemical Research Methods
V. V. Balaev, I. I. Prokofev, A. G. Gabdoulkhakov, C. Betzel, A. A. Lashkov
ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS
(2018)
Article
Plant Sciences
Binish Khaliq, Sven Falke, Sadaf Iqbal, Friedrich Buck, Seema Mahmood, Zahid Ali, Maqsood Ahmad, Abdul Wahid, Christian Betzel, Ahmed Akrem
PAKISTAN JOURNAL OF BOTANY
(2019)
Article
Oncology
Leonie Konczalla, Daniel R. Perez, Nadine Wenzel, Gerrit Wolters-Eisfeld, Clarissa Klemp, Johanna Lueddeke, Annika Wolski, Dirk Landschulze, Chris Meier, Anika Buchholz, Dichao Yao, Bianca T. Hofmann, Julia K. Grass, Sarah L. Spriestersbach, Katharina Grupp, Udo Sch Umacher, Christian Betzel, Svetlana Kapis, Theresa Nuguid, Pablo Steinberg, Klaus Pueschel, Guido Sauter, Maximillian Bockhorn, Fail G. Uzunoglu, Jakob R. Izbicki, Cenap Guengoer, Alexander T. El Gammal
INTERNATIONAL JOURNAL OF CANCER
(2020)
Article
Multidisciplinary Sciences
Patrizia Hanhart, Sven Falke, Marcel Garbe, Victoria Rose, Melanie Thiess, Christian Betzel, Julia Kehr
SCIENTIFIC REPORTS
(2019)
Review
Cell Biology
Celestin N. Mudogo, Sven Falke, Hevila Brognaro, Michael Duszenko, Christian Betzel
Article
Biochemistry & Molecular Biology
Aisha Munawar, Fakhar Zaman, Muhammad Waqas Ishaq, Khwaja Ali Hassan, Saima Masood, Zahid Ali, Khalid Abdul Majeed, Ahmed Akrem, Syed Abid Ali, Christian Betzel
Summary: This study compared the in vivo activity of four synthesized snake venom BPPs and found that their bioactivity varied. The sequences of peptide II and peptide IV can be used to improve the design of current ACE inhibitors used for hypertension treatment.
CURRENT MEDICINAL CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Arayik Martirosyan, Sven Falke, Deborah McCombs, Martin Cox, Christopher D. Radka, Jan Knop, Christian Betzel, Lawrence J. DeLucas
Summary: Microgravity conditions have been found to improve protein crystallization by reducing impurity incorporation and increasing crystal quality. Experiments conducted on the International Space Station provide valuable insights into macromolecular transport phenomena.
Article
Crystallography
Mengying Wang, Angelica Luana C. Barra, Hevila Brognaro, Christian Betzel
Summary: The scientific discussion about classical and nonclassical nucleation theories has been ongoing for two decades. Recent studies have focused on multiple nucleation pathways and the role of metastable intermediates in crystallization processes. By investigating a model protein and employing a pulsed electric field, the researchers discovered new insights into nucleation processes and proposed a novel experimental strategy for adjusting and facilitating crystallization.
Article
Multidisciplinary Sciences
Sven Falke, Hevila Brognaro, Arayik Martirosyan, Karsten Dierks, Christian Betzel
Article
Chemistry, Physical
Bjorn Drobot, Moritz Schmidt, Yuji Mochizuki, Takaya Abe, Koji Okuwaki, Florian Brulfert, Sven Falke, Sergey A. Samsonov, Yuto Komeiji, Christian Betzel, Thorsten Stumpf, Johannes Raff, Satoru Tsushima
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2019)
