Review
Materials Science, Multidisciplinary
Alex Lonergan, Colm O'Dwyer
Summary: The ability to selectively redirect specific wavelengths of light has attracted a lot attention for photonic crystal materials. A wealth of research exists on the fabrication and application of these materials. The optical responses, namely the photonic bandgap or stopband, are of particular interest. The tunable optical response in photonic crystals plays a significant role in their applications.
ADVANCED MATERIALS TECHNOLOGIES
(2023)
Article
Chemistry, Multidisciplinary
Hongmei Yu, Baoxi Zhang, Wenhui Xing, Meiju Liu, Dezhi Yang, Guorong He, Fengfeng Wang, Li Zhang, Ningbo Gong, Yang Lu, Guanhua Du
Summary: This paper reports the cocrystallization of Temozolomide with p-hydroxybenzoic acid, resulting in five different forms characterized and evaluated through single-crystal X-ray diffraction, powder X-ray diffraction, Fourier transform infrared spectroscopy, thermal analysis, and stability tests. The study found that the incorporation of solvent/water molecules, supramolecular synthon distinctions, and conformation flexibility of TMZ contribute to the crystal form differences, with the feeding ratio of starting components and the solvent used playing a crucial role in determining the resulting form.
CRYSTAL GROWTH & DESIGN
(2022)
Article
Materials Science, Multidisciplinary
Hao-Sen Kang, Ming-Yang Long, Tao Zhou, Jin-Chuang Liu, Yi-Tong Duan, Liang Ma, Xiang-Bai Chen, Si-Jing Ding, Li Zhou
Summary: This study successfully prepared PbS-Au hybrids with high-index facets and strong light absorption, showing significantly improved SERS signals for Rhodamine B detection. By adjusting the size and amount of Au nanoparticles, the SERS detection limit was lowered to 10(-12) M with an analytical enhancement factor of 5.1 x 10(8). The recycling and self-cleaning properties under visible light irradiation were demonstrated, attributed to the broad plasmon absorption and fast charge transfer between Au and PbS, offering a potential way for efficient SERS substrates development.
JOURNAL OF MATERIALS CHEMISTRY C
(2022)
Article
Chemistry, Multidisciplinary
Fuli Zhou, Laurent Collard, Koen Robeyns, Tom Leyssens, Oleksii Shemchuk
Summary: In this study, a significant development in chiral resolution is presented. By varying the stoichiometry, both R- and S-enantiomers of mandelic acid were successfully separated from a racemic mixture using l-proline as a resolving agent. This specific feature is achieved through the existence of stoichiometrically diverse cocrystal systems between R- and S-mandelic acid and l-proline.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Yanhui Wu, Xiujia Hao, Jianting Li, Aiying Guan, Zhengzheng Zhou, Fang Guo
Summary: This article discusses the improvement of the solubility of poorly soluble drugs through pharmaceutical cocrystal strategy, focusing on two DAP salts which show higher solubility in water and buffered solution. The increased solubility of the DAP salts is attributed to their structures and the prevention of N-H center dot center dot center dot O=S interactions between DAP molecules.
Review
Genetics & Heredity
Samuel Laberge, Daniel Akoum, Piotr Wlodarczyk, Jean-Daniel Masse, Dominique Fournier, Abdelhabib Semlali
Summary: Periodontitis is a chronic inflammatory disease that affects the supporting structures of teeth. Genetic variants contribute to the onset and severity of the disease, making some people more susceptible to developing it. Epigenetic modifications, including changes in CpG island promoters, histone protein structure, and post-translational regulation by microRNAs, play a potential role in the development of periodontitis and have a significant impact on gene-environment interactions and treatment response.
Article
Chemistry, Multidisciplinary
Chengqiang Ding, Ziye Ren, Jian Wang, Longfei Zhang, Yuhan Yan, Danming Wu, Zhao Wang, Zhengbiao Zhang
Summary: Mechanoredox chemistry using highly polarized piezoelectric materials as catalysts has emerged as an alternative approach for redox reactions. This study focused on the relationship between the structure of ZnO and its catalytic performance for polymerization. Various ZnO crystals with different polar facets ratios were prepared, and ZnO prepared from Zn(NO3)(2) exhibited the highest catalytic activity for mechano-RAFT. The findings highlight the significance of polar facets in ZnO for its catalytic activity.
CHINESE JOURNAL OF CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Dario Braga, Lucia Casali, Fabrizia Grepioni
Summary: This review provides an overview of the scientific, commercial, and ethical importance of investigating the crystalline forms of active pharmaceutical ingredients (API) and their implications on drug development and intellectual property protection. It discusses the significance of multiple crystal forms and their impact on physico-chemical properties of the API. The review also highlights the importance of understanding hydrates and co-crystals and provides examples of screening protocols and theoretical approaches to tackle multiple crystal forms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Applied
Selvyn Simoes, Enea Lelaj, Derick Rousseau
Summary: Sugar accelerates cocoa butter solidification while limiting the effects of emulsifiers. PGPR and CITREM promoted the formation of form V crystals, while lecithin and AP had minimal impact.
Article
Nanoscience & Nanotechnology
Khalid Naim, Subash Chandra Sahoo, Prakash P. Neelakandan
Summary: This research demonstrates that molecular engineering can transform organic crystals into functional materials with thermosalience and thermal-luminescence switching, making them ideal for optoelectronic applications.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Nanoscience & Nanotechnology
Khalid Naim, Subash Chandra Sahoo, Prakash P. Neelakandan
Summary: In this study, molecular engineering was used to transform simple naphthalidenimine-boron complexes into functional materials with thermosalience and thermal-luminescence switching properties. Crystallographic and spectroscopic investigations revealed the role of subtle molecular parameters in facilitating charge-transfer interactions.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Materials Science, Multidisciplinary
Massimiliano Cavallini, Ilse Manet, Marco Brucale, Laura Favaretto, Manuela Melucci, Lucia Maini, Fabiola Liscio, Michele della Ciana, Denis Gentili
Summary: Rubbing was used on thiophene-based organic semiconductor thin films to induce reversible mechanical amorphisation, which is associated with fluorescence switching regulated by the film's polymorphic nature. Thermal annealing of the films produced an opposite effect, inducing film crystallization starting at a low temperature and generating a stable polymorph at high temperatures in the bulk. The mechanism of mechanical transformation was explained considering the material's mechanical properties and demonstrated through X-ray diffraction, atomic force microscopy, and photoluminescence at confocal microscopy.
JOURNAL OF MATERIALS CHEMISTRY C
(2021)
Article
Chemistry, Multidisciplinary
Wongi Park, Minyong Yang, Hyewon Park, Joanna M. Wolska, Hyungju Ahn, Tae Joo Shin, Damian Pociecha, Ewa Gorecka, Dong Ki Yoon
Summary: The polymorphism in the helical nanofilament (HNF, B-4) liquid-crystalline phase depends on the fabrication methods, such as UV-driven formation and template-assisted self-assembly in the nanoconfined geometry. Different helical structures were obtained, including twisted-ribbon and cylindrical-ribbon polymorphs, showing the capability for fine control of the helical structures for potential chiro-optical applications. SEM and grazing-incidence X-ray diffraction with synchrotron radiation were used to directly observe the detailed structures.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Saki Yamada, Ayumi Hirano, Yoko Tanaka, Ryohei Akiyoshi, Hirofumi Yoshikawa, Daisuke Tanaka
Summary: By controlling nucleation using microfluidic synthesis and metal mixing, MIL-68 containing trivalent metal ions was rapidly synthesized without HF addition, resulting in a product with high crystallinity.
CRYSTAL GROWTH & DESIGN
(2022)
Article
Chemistry, Multidisciplinary
Zhonghua Li, Lingyu Wang, Ying Wang, Songgu Wu, Junbo Gong
Summary: The study successfully obtained four solid forms of dimethylaminomicheliolide fumarate, with molecular conformation and packing arrangements showing similarity between Forms C and E, while Forms B and D may also have similarities. Comprehensive exploration through various testing methods provided essential knowledge for product development and quality control of the potential drug.
CRYSTAL GROWTH & DESIGN
(2021)
Article
Chemistry, Multidisciplinary
Kuthuru Suresh, Andre P. Kalenak, Ania Sotuyo, Adam J. Matzger
Summary: This study introduces a mechanism-based approach to tailor the morphology of metal-organic frameworks (MOFs), demonstrating the ability to computationally screen appropriate additives, utilize geometric relationships between additives and metal clusters, and potentially suppress interpenetration for certain phases.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Karabi Nath, Alauddin Ahmed, Donald J. Siegel, Adam J. Matzger
Summary: This study demonstrates the remarkable methane uptake of three metal-organic frameworks through experimental and computational screening. These MOFs outperform the benchmark sorbent and show potential in efficient natural gas storage. The findings highlight the utility of computational screening in identifying overlooked sorbents.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Physical
John W. Robinson, Khurshid R. Ghani, William W. Roberts, Adam J. Matzger
Summary: Accurate measurements of physical properties related to heating and mechanical failure are needed for the quantitative understanding of laser ablation of kidney stones by near-infrared (NIR) lasers. Single crystals of the minerals that form kidney stones were grown and used to measure their NIR absorption coefficients. The reported absorption coefficients can be used to quantitatively compare laboratory investigations of ablation and surgical experience to physical properties for the first time.
JOURNAL OF PHYSICAL CHEMISTRY C
(2023)
Article
Medicine, Research & Experimental
Kristen N. Kelsall, Leila M. Foroughi, Derek S. Frank, Luke Schenck, Anthony LaBuda, Adam J. Matzger
Summary: The polymers used in amorphous solid dispersions have an influence on the drug loading, solubility, dissolution rate, and physical stability of crystalline drugs with low solubility. In this study, the hydrophobicity of crosslinked polyethylenimine (PEI) was investigated for the delivery of the BCS class II drug flufenamic acid. Synthetic variables for crosslinking PEI were manipulated, and benzoyl chloride was employed to increase the hydrophobicity of the crosslinked materials. The findings showed enhanced drug delivery and physical stability in acidic media, motivating the use of polymers with high functional group concentrations for ASD formation.
MOLECULAR PHARMACEUTICS
(2023)
Article
Chemistry, Multidisciplinary
Andrew J. Bennett, Adam J. Matzger
Summary: In contrast to neutral cocrystals, designing ionic cocrystals, especially those with an ion pair, is challenging. Previous studies that correlate specific molecular properties to cocrystal formation generally exclude ionic cocrystals, leaving few clear avenues to success for prospective ionic cocrystal engineers. In this study, ammonium nitrate was targeted for cocrystallization with a potential coformer group selected based on likely interactions with the nitrate ion. Six novel ionic cocrystals were discovered, and a high packing coefficient was found to be a consistent feature among successful coformers.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Taylor A. Bramlett, Leila M. Foroughi, Adam J. Matzger
Summary: A discovery strategy for new pyridine peroxosolvates is evaluated by using the Cambridge Structural Database. Hydrogen bonding motif featuring hydrogen bond acceptance was used to identify eight commercially available hydrates, leading to the discovery of peroxosolvates for six compounds. The competition between cocrystallization and oxidative reactivity was found to be a critical factor for success.
CRYSTAL GROWTH & DESIGN
(2023)
Article
Chemistry, Multidisciplinary
Hochul Woo, Angela M. Devlin, Adam J. Matzger
Summary: Solvent exchange within metal-organic frameworks (MOFs) is crucial for activating coordinatively unsaturated sites (CUS) and achieving optimal surface area, enabling versatile applications of MOFs. This study quantifies the exchange behavior of a copper paddlewheel-based CUS-MOF (HKUST-1) in the presence of different solvents and reveals that solvent exchange in CUS-MOFs is not diffusion-limited, but rather determined by the solvent exchange kinetics at the metal center. The insights from this study can inform best practices for solvent exchange in various copper-paddlewheel-based MOFs.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Meeting Abstract
Urology & Nephrology
Ron Marom, William W. Roberts, Timothy L. Hall, John Robinson, Adam J. Matzger, Khurshid R. Ghani
JOURNAL OF UROLOGY
(2023)
Meeting Abstract
Urology & Nephrology
Ron Marom, John Robinson, Adam J. Matzger, Adam Maxwell, Khurshid R. Ghani, Timothy L. Hall, William W. Roberts
JOURNAL OF UROLOGY
(2023)
Meeting Abstract
Urology & Nephrology
Ron Marom, William W. Roberts, Timothy L. Hall, John Robinson, Adam J. Matzger, Khurshid R. Ghani
JOURNAL OF UROLOGY
(2023)
Article
Chemistry, Multidisciplinary
Michael K. Bellas, Adam J. Matzger
Summary: Cocrystallization is a synthetic method that improves functional materials while preserving the inherent properties of molecules/ions involved. However, there is currently no general approach for salt cocrystallization. This study presents a specific approach for ammonium salts and applies it to achieve a melt-castable energetic material with the energetic oxidizing salt ammonium dinitramide.
Article
Materials Science, Multidisciplinary
Lixin Zang, Wenhao Shao, Onas Bolton, Ramin Ansari, Seong Jun Yoon, Jung-Moo Heo, John Kieffer, Adam J. Matzger, Jinsang Kim
Summary: This study investigates the dual phosphorescence emission characteristics and the effect of the environment on pure organic phosphors. The results show that the emission of pure organic phosphors gradually red-shifts with increasing solvent polarity, which is related to the T-1 to T-2 energy level conversion. Additionally, the decay curves and decay rates of pure organic phosphors vary depending on the matrix they are in.
JOURNAL OF MATERIALS CHEMISTRY C
(2022)
Article
Chemistry, Physical
Ren A. Wiscons, Rahul Nikhar, Krzysztof Szalewicz, Adam J. Matzger
Summary: This study compares hydrates and hydrogen peroxide solvates in terms of their structure, interaction, and impact on the performance of drugs and explosives. By analyzing crystal structures and potential energy surfaces, the research provides a foundation for designing and selecting candidate molecules for hydrogen peroxide solvates.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2022)
Article
Chemistry, Multidisciplinary
Michael K. Bellas, Adam J. Matzger
Summary: This article presents an efficient method for the discovery of peroxosolvates, which has been applied to discover the first ternary cocrystal comprising only energetic components.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Sorout Shalini, Adam J. Matzger
Summary: Two novel MOFs, UiO-68-EO and UiO-68-2EO, were obtained by varying the degree of ethylene oxide (EO) functionalization in the zirconium MOF UiO-68. Loading LiTFSI in their pores enables these MOFs to exhibit solvent-free ionic conductivity. The introduction of EO chains provides a pathway for lithium ion migration between the coordinated sites, resulting in high ionic conductivity at 90 degrees C for UiO-68-EO/LiTFSI and UiO-68-2EO/LiTFSI.
CHEMICAL COMMUNICATIONS
(2022)
