Article
Plant Sciences
Chien-Ming Wu, Chun-Nan Lin, Hui-Chia Chen, Shin C. Chang, Ming-Fu Chang, Kai-Wei Lin
Summary: Two undescribed lanostane triterpenoids, tsugaric acids G (1) and H (2), and a known compound, N-(3';alpha,4';beta-dihydroxy-2';beta-(hydroxymethyl)-1';beta-(cyclobutyl) palmitamide (3), were isolated and characterized from the fruiting bodies of Ganoderma tsugae. Compound 3 exhibited significant anti-HCV activity.
PHYTOCHEMISTRY LETTERS
(2022)
Article
Biochemistry & Molecular Biology
Zhen-Zhu Zhao, Bao-Yu Ji, Zhen-Zhen Wang, Ying-Ying Si, Yan-Jun Sun, Hui Chen, Wei-Sheng Feng, Xiao-Ke Zheng, Ji-Kai Liu
Summary: Eight new lanostane triterpenoids and nine known ones were discovered in the fruiting bodies of Ganoderma lingzhi S.H. Wu, Y. Cao & Y.C. Dai. Their structures were determined using spectroscopic data and quantum chemical calculations. Among them, ganoderane GL-1, containing a hydrogenated tetramethylsphenanthraquinone, is the first example in the lanostane nor-triterpenoid group. In terms of biological activity, ganoderanes GL-2 and GL-3, which have a rare 1,11-epoxy moiety, showed significant inhibition against nitric oxide production induced by lipopolysaccharide in RAW264.7 macrophage cells, while ganoderanes GL-4 and GL-8 exhibited bifunctional activities of anti-proliferation and anti-inflammation.
Article
Plant Sciences
An-An Yang, Ying-Xiang Yan, Pei-Dong Shi, Chao Yu, Yu-Zhu Feng, Meng-Ke Zhang, Liang Xing, Chen-Yu Cao, Xia Yin
Summary: Two new lanostane triterpenes, ganorbifoins A and B, along with a known compound, were isolated from Ganoderma orbiforme. Ganorbifoin A showed the best glucose uptake induction in a zebrafish-based system, while compounds 2 and 3 exhibited inhibitory effects on nitric oxide production.
PHYTOCHEMISTRY LETTERS
(2022)
Article
Microbiology
Xing-Rong Peng, Qian Wang, Hai-Guo Su, Lin Zhou, Wen-Yong Xiong, Ming-Hua Qiu
Summary: This study focused on the lanostane triterpenoids from Ganoderma applanatum and isolated forty highly oxygenated compounds, including sixteen new compounds. The structures of these compounds were identified and their anti-adipogenesis activities were evaluated. Some compounds exhibited stronger effects than the positive control and a key role of the A-seco-23 -> 26 lactone skeleton in anti-adipogenesis activity was established.
Article
Biochemistry & Molecular Biology
Hai-Guo Su, Qian Wang, Lin Zhou, Xing-Rong Peng, Wen-Yong Xiong, Ming -Hua Qiu
Summary: The study identified compounds in Ganoderma applanatum extract that have antiadipogenic effects, with a new compound showing potential in inhibiting adipogenesis. This suggests a new perspective for treating obesity by utilizing these compounds.
BIOORGANIC CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Li Yang, De-Xian Kong, Na Xiao, Qing-Yun Ma, Qing-Yi Xie, Jiao-Cen Guo, Chun Ying Deng, Hai-Xia Ma, Yan Hua, Hao-Fu Dai, You-Xing Zhao
Summary: Eight new lanostane triterpenoids, along with eighteen known compounds, were isolated from Ganoderma weberianum. The structures and configurations of the new compounds were determined through spectroscopic analysis, NMR chemical shifts, and ECD calculations. Some of the isolated compounds showed significant alpha-glucosidase inhibitory activity, inhibition of hepatic glucose production, and antitumor activity against HeLa cells.
BIOORGANIC CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Ivana Sofrenic, Boban Andelkovic, Nina Todorovic, Tatjana Stanojkovic, Ljubodrag Vujisic, Miroslav Novakovic, Slobodan Milosavljevic, Vele Tesevic
Summary: Thirteen previously uncharacterized 24-methylene lanostane triterpenoids, along with seventeen known analogues, were isolated from the fruiting bodies of Fomitopsis betulina. Among them, fomitoside L and fomitoside N showed cytotoxicity against HL60 leukemia cells. Some known compounds exhibited significant cytotoxicity against HL60 leukemia cells and selectivity towards MRC-5 healthy cells.
Article
Plant Sciences
Malipan Sappan, Pranee Rachtawee, Kitlada Srichomthong, Thitiya Boonpratuang, Rattaket Choeyklin, Tao Feng, Ji-Kai Liu, Masahiko Isaka
Summary: Three new lanostane triterpenoids, named ganoellipsic acids A-C (1-3), along with seven known Ganoderma lanostanoids (4-10), were isolated from artificially cultivated fruiting bodies of Ganoderma ellipsoideum, strain BCC 16634. The structures of these compounds were determined by NMR spectroscopy and mass spectrometry. The absolute configuration of compound 1 at C-25 was found to be 25S using the phenylglycine methyl ester (PGME) method.
PHYTOCHEMISTRY LETTERS
(2022)
Article
Chemistry, Medicinal
Lin Zhou, He-Ping Chen, Xinyang Li, Ji-Kai Liu
Summary: Two triterpenes with unique 6/6/6/5/6 scaffolds, ganoaustralins A and B, were isolated from the fruiting bodies of Ganoderma australe. Their structures, absolute configurations, and biosynthetic pathways were determined, with ganoaustralin B showing weak inhibition against beta-secretase 1.
Review
Pharmacology & Pharmacy
David M. Dolivo, Charlotte R. Reed, Kristine A. Gargiulo, Adrian E. Rodrigues, Robert D. Galiano, Thomas A. Mustoe, Seok Jong Hong
Summary: Fibrosis is a common pathological repair process in organs, but there is a lack of effective therapeutic methods. Repurposing existing drugs, such as statins, can be a complementary strategy to treat tissue fibrosis. Statins have been found to have anti-fibrotic effects through various mechanisms, and a better understanding of these effects can aid in the development of novel therapeutic agents.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Li Yang, Ting-Ting Zhang, Qing-Yun Ma, Qing-Yi Xie, Jiao-Cen Guo, Jia-Ju Lu, Zhi-Fang Yu, Hao-Fu Dai, You-Xing Zhao
Summary: Twelve previously undescribed and four known lanostane triterpenoids were isolated from Ganoderma calidophilum. Compound 4 showed significant inhibitory activity against human leukaemia, gastric cancer, and cervical cancer cell lines. Compound 16 exhibited inhibitory potency against protein tyrosine phosphatase 1B and alpha-glucosidase.
Article
Chemistry, Applied
De Xian Kong, Qing Yun Ma, Li Yang, Qing Yi Xie, Chun Ying Deng, Hao Fu Dai, Yan Hua, You Xing Zhao
Summary: A new oxygenated lanostane-type triterpenoid has been isolated from the fruiting bodies of Ganoderma weberianum, along with three known compounds. Extensive analysis revealed the structure of the new compound, and one of the known compounds showed significant inhibitory activity against α-glucosidase.
NATURAL PRODUCT RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Ayaz Shahid, Mengbing Chen, Steven Yeung, Cyrus Parsa, Robert Orlando, Ying Huang
Summary: This study investigated the effects of a commercial Ganoderma lucidum product (GLSF) on tobacco smoke carcinogen-induced lung toxicity and carcinogenesis. GLSF was found to inhibit malignant transformation in human bronchial epithelial cells and reduce lung toxicity and tumor development in mice. Therefore, GLSF may be used to alleviate tobacco smoke carcinogen-induced lung toxicity and carcinogenesis.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Chemistry, Medicinal
Xing-Zi Li, Shi-You Jiang, Guo-Qiang Li, Qian-Ru Jiang, Jue-Wan Li, Chen-Chen Li, Yu-Qin Han, Bao-Liang Song, Xin-Ran Ma, Wei Qi, Wen-Wei Qiu
Summary: A series of novel HMG499 analogs were synthesized and one of the compounds, 29 (QH536), showed potent activity in promoting HMGCR degradation without inducing cholesterol accumulation in cells. Compound 29 also exhibited effects on lowering cholesterol levels and suppressing various related genes, making it a potential candidate for the treatment of CVD and NASH.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Ayaz Shahid, Matthew Huang, Mandy Liu, Md Abdullah Shamim, Cyrus Parsa, Robert Orlando, Ying Huang
Summary: This study suggests that Ganoderma lucidum, a medicinal mushroom, prevents skin cancer by attenuating UV-induced immunosuppression. In both in vitro and in vivo models, a commercial product containing spore and fruiting body extracts showed potential in inhibiting cancer cell transformation and reducing skin tumor incidence.
Article
Biotechnology & Applied Microbiology
Zhongyong Zheng, Baosong Chen, Kai Wang, Li Bao, Zhengdi Wang, Liping Xie, Changbin Guo, Hongwei Liu
JOURNAL OF ANTIBIOTICS
(2020)
Article
Plant Sciences
Baosong Chen, Junjie Han, Li Bao, Wenzhao Wang, Ke Ma, Hongwei Liu
Article
Cell Biology
Shanshan Qiao, Li Bao, Kai Wang, Shanshan Sun, Mingfang Liao, Chang Liu, Nan Zhou, Ke Ma, Yuwei Zhang, Yihua Chen, Shuang-Jiang Liu, Hongwei Liu
Article
Biotechnology & Applied Microbiology
Juan Chen, Jia-Mei Li, Yan-Jing Tang, Ke Ma, Bing Li, Xu Zeng, Xiao-Bin Liu, Yang Li, Zhu-Liang Yang, Wei-Nan Xu, Bao-Gui Xie, Hong-Wei Liu, Shun-Xing Guo
Review
Cell Biology
Jiayu Wu, Kai Wang, Xuemei Wang, Yanli Pang, Changtao Jiang
Summary: The gut microbiome and its metabolites are crucial in the onset and development of many metabolic diseases. Targeting the gut microbiome and relevant metabolic pathways may be effective therapeutic treatments for metabolic diseases in the future. Advances in improving metabolic diseases by regulating the gut microbiome will be discussed in this review.
Article
Pharmacology & Pharmacy
Ke Ma, Yuting Zhang, Cui Guo, Yanlong Yang, Junjie Han, Bo Yu, Wenbing Yin, Hongwei Liu
Summary: This study identified new enzymes involved in the biosynthesis of mushroom-derived cyathane diterpenes and successfully established S. cerevisiae strains capable of producing 22 different cyathane-type diterpenes. Some of these compounds showed significant neurotrophic effects on PC12 cells.
ACTA PHARMACEUTICA SINICA B
(2021)
Article
Cell Biology
Qing Wu, Xianyi Liang, Kai Wang, Jun Lin, Xuemei Wang, Pengcheng Wang, Yangming Zhang, Qixing Nie, Huiying Liu, Zhipeng Zhang, Junhui Liu, Yanli Pang, Changtao Jiang
Summary: Accumulating evidence suggests that gut microbiota regulates obesity through metabolite-host interactions. This study found that intestinal HIF-2 alpha controls lactate levels in the gut, impacting the microbiome abundance and adipose tissue thermogenesis. Manipulating these interactions may offer novel strategies for alleviating obesity.
Article
Biology
Shanshan Sun, Li Sun, Kai Wang, Shanshan Qiao, Xinyue Zhao, Xiaomin Hu, Wei Chen, Shuyang Zhang, Hantian Li, Huanqin Dai, Hongwei Liu
Summary: The study found that the gut commensal Candida parapsilosis is a causative fungus for the development of high fat-diet induced obesity in mice, highlighting the therapeutic strategy targeting gut fungi. In addition, the results suggest that fungi could represent possible targets for combating obesity.
COMMUNICATIONS BIOLOGY
(2021)
Article
Food Science & Technology
Shanshan Qiao, Kai Wang, Chang Liu, Nan Zhou, Li Bao, Jun Wang, Shuangjiang Liu, Hongwei Liu
Summary: Ganoderma meroterpene derivative (GMD) can increase the abundance of butyrate-producing bacteria in the gut, leading to beneficial effects on host metabolic disorders. In this study, Faeciroseburia intestinalis was identified as a key commensal bacteria associated with the therapeutic effects of GMD. Oral administration of F. intestinalis showed benefits in regulating hyperglycemia, hyperlipidemia, reducing plasma lipopolysaccharide (LPS) and inflammation, and improving hepatic injuries. F. intestinalis enhanced the production of gut butyrate, which improved intestinal barrier function and activated epithelial PPAR-? signaling pathway to regulate gut microbiome homeostasis.
FOOD SCIENCE AND HUMAN WELLNESS
(2022)
Article
Cardiac & Cardiovascular Systems
Junxia Zhang, Ruqi Liang, Kai Wang, Wenjia Zhang, Mao Zhang, Li Jin, Peng Xie, Wen Zheng, Haibao Shang, Qingmei Hu, Jiayi Li, Gengjia Chen, Fujian Wu, Feng Lan, Lipeng Wang, Shi-Qiang Wang, Yongfeng Li, Yong Zhang, Jinghao Liu, Fengxiang Lv, Xinli Hu, Rui-Ping Xiao, Xiaoguang Lei, Yan Zhang
Summary: This study identified hesperadin as a specific small-molecule inhibitor of CaMKII-delta with dual functions of cardioprotective and antitumor effects. These findings may contribute to the development of new approaches for the treatment of heart disease and cancer.
Article
Multidisciplinary Sciences
Bo Chen, Lulu Sun, Guangyi Zeng, Zhe Shen, Kai Wang, Limin Yin, Feng Xu, Pengcheng Wang, Yong Ding, Qixing Nie, Qing Wu, Zhiwei Zhang, Jialin Xia, Jun Lin, Yuhong Luo, Jie Cai, Kristopher W. Krausz, Ruimao Zheng, Yanxue Xue, Ming-Hua Zheng, Yang Li, Chaohui Yu, Frank J. Gonzalez, Changtao Jiang
Summary: Tobacco smoking is positively correlated with non-alcoholic fatty liver disease (NAFLD), but the underlying mechanism is unclear. This study found that nicotine accumulates in the intestine during tobacco smoking and activates intestinal AMPK alpha. The gut bacterium Bacteroides xylanisolvens is identified as an effective nicotine degrader. These findings highlight the role of intestinal nicotine accumulation in NAFLD progression and the presence of an endogenous bacterium in the human intestine that can metabolize nicotine.
Article
Microbiology
Yanpeng Ma, Yi Zhang, Ruize Qu, Xin Zhou, Lulu Sun, Kai Wang, Changtao Jiang, Zhipeng Zhang, Wei Fu
Summary: Colorectal cancer is closely related to microbiota and bile acids. This study found that mucosal microbiota in cancerous tissues showed alterations, with increased levels of certain genera and higher production of deoxycholic acid (DCA). The downregulation of FXR was observed in cancer cell lines, which played an important role in CRC development. These findings have implications for potential therapeutic targets for CRC prevention.
Article
Multidisciplinary Sciences
Kai Wang, Zhiwei Zhang, Jing Hang, Jia Liu, Fusheng Guo, Yong Ding, Meng Li, Qixing Nie, Jun Lin, Yingying Zhuo, Lulu Sun, Xi Luo, Qihang Zhong, Chuan Ye, Chuyu Yun, Yi Zhang, Jue Wang, Rui Bao, Yanli Pang, Guang Wang, Frank J. Gonzalez, Xiaoguang Lei, Jie Qiao, Changtao Jiang
Summary: A mechanistic understanding of how microbial proteins affect the host could provide valuable insights into the interaction between gut microbiota and the host. Researchers have developed an enzyme activity-screening platform to examine how gut microbiota-derived enzymes impact host physiology. They have identified specific bacterial taxa that express dipeptidyl peptidase 4 (DPP4) and found that microbial DPP4 can decrease active glucagon-like peptide-1 (GLP-1) levels and disrupt glucose metabolism in mice with a leaky gut. They have also discovered a selective microbial DPP4 inhibitor called daurisoline-d4 (Dau-d4) that improves glucose tolerance in diabetic mice.
Correction
Endocrinology & Metabolism
Shanshan Qiao, Chang Liu, Li Sun, Tao Wang, Huanqin Dai, Kai Wang, Li Bao, Hantian Li, Wenzhao Wang, Shuang-Jiang Liu, Hongwei Liu
Article
Endocrinology & Metabolism
Shanshan Qiao, Chang Liu, Li Sun, Tao Wang, Huanqin Dai, Kai Wang, Li Bao, Hantian Li, Wenzhao Wang, Shuang-Jiang Liu, Hongwei Liu
Summary: This study reveals that a Ganoderma meroterpene derivative can prevent atherosclerosis by increasing the abundance of Parabacteroides merdae in the gut, leading to enhanced branched-chain amino acid catabolism and cardiometabolic benefits.