Advancing human health risk assessment: Integrating recent advisory committee recommendations

A mechanistic redefinition of adverse effects – a key step in the toxicity testing paradigm shift

(2016) Kim Boekelheide   ALTEX-Alternatives to Animal Experimentation

Quantitative approaches for assessing dose-response relationships in genetic toxicology studies

(2012) B.B. Gollapudi et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Integrated Molecular Analysis Indicates Undetectable Change in DNA Damage in Mice after Continuous Irradiation at ~ 400-fold Natural Background Radiation

(2012) Werner Olipitz et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Approaches to Human Health Risk Assessment Based on the Signal-To-Noise Crossover Dose

(2012) Weihsueh A. Chiu et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Evaluation of Biomonitoring Data from the CDC National Exposure Report in a Risk Assessment Context: Perspectives across Chemicals

(2012) Lesa L. Aylward et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Integrating pathway-based transcriptomic data into quantitative chemical risk assessment: A five chemical case study

(2012) Russell S. Thomas et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Use of NHANES Data to Link Chemical Exposures to Chronic Diseases: A Cautionary Tale

(2012) Judy S. LaKind et al.   PLoS One

Identification and Characterization of Adverse Effects in 21st Century Toxicology

(2012) Douglas A. Keller et al.   TOXICOLOGICAL SCIENCES

A Comprehensive Statistical Analysis of Predicting In Vivo Hazard Using High-Throughput In Vitro Screening

(2012) Russell S. Thomas et al.   TOXICOLOGICAL SCIENCES

Predictive Model of Rat Reproductive Toxicity from ToxCast High Throughput Screening1

(2011) Matthew T Martin et al.   BIOLOGY OF REPRODUCTION

Using mode of action information to improve regulatory decision-making: An ECETOC/ILSI RF/HESI workshop overview

(2011) Neil Carmichael et al.   CRITICAL REVIEWS IN TOXICOLOGY

Linear low-dose extrapolation for noncancer health effects is the exception, not the rule

(2011) Lorenz R. Rhomberg et al.   CRITICAL REVIEWS IN TOXICOLOGY

A Signal-to-Noise Crossover Dose as the Point of Departure for Health Risk Assessment

(2011) Salomon Sand et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Environmental Chemicals in Pregnant Women in the United States: NHANES 2003–2004

(2011) Tracey J. Woodruff et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Human biomonitoring assessment values: Approaches and data requirements

(2011) Jürgen Angerer et al.   INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH

Using Nuclear Receptor Activity to Stratify Hepatocarcinogens

(2011) Imran Shah et al.   PLoS One

Application of a source-to-outcome model for the assessment of health impacts from dietary exposures to insecticide residues

(2011) Paul S. Price et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Development of a source-to-outcome model for dietary exposures to insecticide residues: An example using chlorpyrifos

(2011) Paul M. Hinderliter et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

The human relevant potency threshold: Reducing uncertainty by human calibration of cumulative risk assessments

(2011) C.J. Borgert et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Physiologically Based Pharmacokinetic Model Use in Risk Assessment—Why Being Published Is Not Enough

(2011) Eva D. McLanahan et al.   TOXICOLOGICAL SCIENCES

Predictive Models of Prenatal Developmental Toxicity from ToxCast High-Throughput Screening Data

(2011) Nisha S. Sipes et al.   TOXICOLOGICAL SCIENCES

Role of science and judgment in setting national ambient air quality standards: how low is low enough?

(2011) Roger O. McClellan   Air Quality Atmosphere and Health

Maximum Cumulative Ratio (MCR) as a Tool for Assessing the Value of Performing a Cumulative Risk Assessment

(2011) Paul S. Price et al.   International Journal of Environmental Research and Public Health

Proposed mode of action of benzene-induced leukemia: Interpreting available data and identifying critical data gaps for risk assessment

(2010) M.E. (Bette) Meek et al.   CHEMICO-BIOLOGICAL INTERACTIONS

1,3-Butadiene: III. Assessing carcinogenic modes of action

(2010) Christopher R. Kirman et al.   CRITICAL REVIEWS IN TOXICOLOGY

Genotoxicity testing: Moving beyond qualitative “screen and bin” approach towards characterization of dose-response and thresholds

(2010) Lynn H. Pottenger et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Miniaturized flow cytometric in vitro micronucleus assay represents an efficient tool for comprehensively characterizing genotoxicity dose–response relationships

(2010) Steven M. Bryce et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

A Bayesian Network Model for Biomarker-Based Dose Response

(2010) C. Eric Hack et al.   RISK ANALYSIS

Endogenous versus Exogenous DNA Adducts: Their Role in Carcinogenesis, Epidemiology, and Risk Assessment

(2010) J. A. Swenberg et al.   TOXICOLOGICAL SCIENCES

Chemical Carcinogenesis

(2010) S. M. Cohen et al.   TOXICOLOGICAL SCIENCES

PBPK modelling of inter-individual variability in the pharmacokinetics of environmental chemicals

(2010) Frédéric Y. Bois et al.   TOXICOLOGY

Application of Key Events Analysis to Chemical Carcinogens and Noncarcinogens

(2009) Alan R. Boobis et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

The Key Events Dose-Response Framework: A Cross-Disciplinary Mode-of-Action Based Approach to Examining Dose-Response and Thresholds

(2009) Elizabeth Julien* et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Derivation of inhalation toxicity reference values for propylene oxide using mode of action analysis: Example of a threshold carcinogen

(2009) Lisa M. Sweeney et al.   CRITICAL REVIEWS IN TOXICOLOGY

Using Biomonitoring Equivalents to interpret human biomonitoring data in a public health risk context

(2009) Sean M. Hays et al.   JOURNAL OF APPLIED TOXICOLOGY

Dose–response and operational thresholds/NOAELs for in vitro mutagenic effects from DNA-reactive mutagens, MMS and MNU

(2009) Lynn H. Pottenger et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

In vivo studies in the mouse to define a threshold for the genotoxicity of EMS and ENU

(2009) Elmar Gocke et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Toxicity Testing in the 21st Century: A View from the Chemical Industry

(2009) James S. Bus et al.   TOXICOLOGICAL SCIENCES

Recent developments in frameworks to consider human relevance of hypothesized modes of action for tumours in animals

(2008) M.E. Bette Meek   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Applying bioethical principles to human biomonitoring

(2008) Myron Harrison   Environmental Health

Profiling Chemicals Based on Chronic Toxicity Results from the U.S. EPA ToxRef Database

(2008) Matthew T. Martin et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Evidence-based dose–response assessment for thyroid tumorigenesis from acrylamide

(2008) Michael Dourson et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Guidelines for the communication of Biomonitoring Equivalents: Report from the Biomonitoring Equivalents Expert Workshop

(2008) Judy S. LaKind et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Guidelines for the derivation of Biomonitoring Equivalents: Report from the Biomonitoring Equivalents Expert Workshop

(2008) Sean M. Hays et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

An Adjustment Factor for Mode-of-Action Uncertainty with Dual-Mode Carcinogens: The Case of Naphthalene-Induced Nasal Tumors in Rats

(2008) Kenneth T. Bogen   RISK ANALYSIS

Toxicity Testing in the 21st Century: Bringing the Vision to Life

(2008) Melvin E. Andersen et al.   TOXICOLOGICAL SCIENCES