Botulinum neurotoxin: Where are we with detection technologies?

Towards an international standard for detection and typing botulinum neurotoxin-producing Clostridia types A, B, E and F in food, feed and environmental samples: A European ring trial study to evaluate a real-time PCR assay

(2011) Lucia Fenicia et al.   INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY

Phrenic nerve-hemidiaphragm as a highly sensitive replacement assay for determination of functional botulinum toxin antibodies

(2011) C. Rasetti-Escargueil et al.   TOXICON

Towards New Uses of Botulinum Toxin as a Novel Therapeutic Tool

(2011) Andy Pickett et al.   Toxins

Symptomatic Relief of Botulinum Neurotoxin/A Intoxication with Aminopyridines: A New Twist on an Old Molecule

(2010) Alexander V. Mayorov et al.   ACS Chemical Biology

Llama-derived single-domain antibodies for the detection of botulinum A neurotoxin

(2010) Marla D. Swain et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

A label-free biosensor assay for botulinum neurotoxin B in food and human serum

(2010) Géraldine Ferracci et al.   ANALYTICAL BIOCHEMISTRY

Pentaplexed Quantitative Real-Time PCR Assay for the Simultaneous Detection and Quantification of Botulinum Neurotoxin-Producing Clostridia in Food and Clinical Samples

(2010) S. Kirchner et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Rapid Affinity Immunochromatography Column-Based Tests for Sensitive Detection of Clostridium botulinum Neurotoxins and Escherichia coli O157

(2010) J. Brunt et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Universal and specific quantitative detection of botulinum neurotoxin genes

(2010) Brenna J Hill et al.   BMC MICROBIOLOGY

A self-pumping lab-on-a-chip for rapid detection of botulinum toxin

(2010) Peter B. Lillehoj et al.   LAB ON A CHIP

Detection and differentiation of Clostridium botulinum type A strains using a focused DNA microarray

(2010) Brian H. Raphael et al.   MOLECULAR AND CELLULAR PROBES

Detection of Botulinum Neurotoxin Serotype B at Sub Mouse LD50 Levels by a Sandwich Immunoassay and Its Application to Toxin Detection in Milk

(2010) Miles C. Scotcher et al.   PLoS One

Extraction of BoNT/A, /B, /E, and /F with a Single, High Affinity Monoclonal Antibody for Detection of Botulinum Neurotoxin by Endopep-MS

(2010) Suzanne R. Kalb et al.   PLoS One

Gaining ground: assays for therapeutics against botulinum neurotoxin

(2010) Ramin Mollaaghababa Hakami et al.   TRENDS IN MICROBIOLOGY

Comparison of the primary rat spinal cord cell (RSC) assay and the mouse bioassay for botulinum neurotoxin type A potency determination

(2010) Sabine Pellett et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Sensing the Deadliest Toxin: Technologies for Botulinum Neurotoxin Detection

(2010) Petr Čapek et al.   Toxins

Renewable surface fluorescence sandwich immunoassay biosensor for rapid sensitive botulinum toxin detection in an automated fluidic format

(2009) Jay W. Grate et al.   ANALYST

Simultaneous quantification of five bacterial and plant toxins from complex matrices using a multiplexed fluorescent magnetic suspension assay

(2009) Diana Pauly et al.   ANALYST

Aptamer-based electrochemical biosensor for Botulinum neurotoxin

(2009) Fang Wei et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Self-Assembled Peptide Monolayers as a Toxin Sensing Mechanism within Arrayed Microchannels

(2009) Megan L. Frisk et al.   ANALYTICAL CHEMISTRY

Rapid Multiplexed Flow Cytometric Assay for Botulinum Neurotoxin Detection Using an Automated Fluidic Microbead-Trapping Flow Cell for Enhanced Sensitivity

(2009) Richard M. Ozanich et al.   ANALYTICAL CHEMISTRY

Multiplex PCR for Detection of Botulinum Neurotoxin-Producing Clostridia in Clinical, Food, and Environmental Samples

(2009) D. De Medici et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Comparative Genomic Hybridization Analysis of Two Predominant Nordic Group I (Proteolytic) Clostridium botulinum Type B Clusters

(2009) M. Lindstrom et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Quantum dot immunoassays in renewable surface column and 96-well plate formats for the fluorescence detection of botulinum neurotoxin using high-affinity antibodies

(2009) Marvin G. Warner et al.   BIOSENSORS & BIOELECTRONICS

Development of real-time PCR tests for detecting botulinum neurotoxins A, B, E, F producingClostridium botulinum,Clostridium baratiiandClostridium butyricum

(2009) P. Fach et al.   JOURNAL OF APPLIED MICROBIOLOGY

Amplification of immunoassays using phage-displayed single domain antibodies

(2009) Ellen R. Goldman et al.   JOURNAL OF IMMUNOLOGICAL METHODS

A quadruplex real-time PCR assay for rapid detection and differentiation of the Clostridium botulinum toxin genes A, B, E and F

(2009) B. A. Satterfield et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Extraction and Inhibition of Enzymatic Activity of Botulinum Neurotoxins/A1, /A2, and /A3 by a Panel of Monoclonal Anti-BoNT/A Antibodies

(2009) Suzanne R. Kalb et al.   PLoS One

Tandem fluorescent proteins as enhanced FRET-based substrates for botulinum neurotoxin activity

(2009) Melissa Pires-Alves et al.   TOXICON

Measurement of botulinum types A, B and E neurotoxicity using the phrenic nerve–hemidiaphragm: Improved precision with in-bred mice

(2009) C. Rasetti-Escargueil et al.   TOXICON

Thermostable Llama Single Domain Antibodies for Detection of Botulinum A Neurotoxin Complex

(2008) Ellen R. Goldman et al.   ANALYTICAL CHEMISTRY

Monoclonal Antibody-Based Lateral Flow Assay for Detection of Botulinum Neurotoxin Type A

(2008) Der-Jiang Chiao et al.   HYBRIDOMA

Cortical Networks Grown on Microelectrode Arrays As a Biosensor for Botulinum Toxin

(2008) A. Scarlatos et al.   JOURNAL OF FOOD SCIENCE

Development and partial characterization of high-affinity monoclonal antibodies for botulinum toxin type A and their use in analysis of milk by sandwich ELISA

(2008) Larry H. Stanker et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Botulinum toxin drugs: future developments

(2008) D. Dressler   JOURNAL OF NEURAL TRANSMISSION

Attomolar Detection of Botulinum Toxin Type A in Complex Biological Matrices

(2008) Karine Bagramyan et al.   PLoS One

A protein chip membrane-capture assay for botulinum neurotoxin activity

(2008) Séverine Marconi et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Crystal Structure of Botulinum Neurotoxin Type A in Complex with the Cell Surface Co-Receptor GT1b—Insight into the Toxin–Neuron Interaction

(2008) Pål Stenmark et al.   PLoS Pathogens

A sensitive sandwich enzyme immunoassay for free or complexed Clostridium botulinum neurotoxin type A

(2007) Hervé Volland et al.   JOURNAL OF IMMUNOLOGICAL METHODS