Article
Nutrition & Dietetics
Igor Pravst, Ziva Lavrisa, Masa Hribar, Hristo Hristov, Naska Kvarantan, Barbara Korousic Seljak, Matej Gregoric, Urska Blaznik, Nadan Gregoric, Katja Zaletel, Adrijana Oblak, Josko Osredkar, Katja Zmitek, Anita Kusar
Summary: Folate deficiency is common in Slovenia, with low folate intake observed in various age groups. Public health strategies are needed to promote the consumption of folate-rich foods and supplementation with folic acid may be necessary in specific vulnerable populations.
Article
Obstetrics & Gynecology
Heidi T. Cueto, Bjarke H. Jacobsen, Anne Sofie Dam Laursen, Anders H. Riis, Elizabeth E. Hatch, Lauren A. Wise, Ellen Trolle, Henrik Toft Sorensen, Kenneth J. Rothman, Amelia K. Wesselink, Sydney Willis, Benjamin R. Johannesen, Ellen M. Mikkelsen
Summary: Preconception dietary folate intake is positively associated with fecundability in a monotonic pattern. Two internet-based cohort studies found that compared to a dietary folate intake of >= 400 μg/day, intake of 250-399 μg/day and <250 μg/day were associated with decreased fecundability. Additionally, low dietary folate intake (<250 μg/day) combined with folic acid supplementation was also associated with reduced fecundability.
HUMAN REPRODUCTION
(2022)
Article
Nutrition & Dietetics
Ziva Lavrisa, Hristo Hristov, Masa Hribar, Katja Zmitek, Anita Kusar, Barbara Korousic Seljak, Matej Gregoric, Urska Blaznik, Nadan Gregoric, Katja Zaletel, Adrijana Oblak, Josko Osredkar, Igor Pravst
Summary: Vitamin B12 deficiency is a common issue in the Slovenian population, especially among the elderly. Lower intake is observed in females, and meat and milk are the main contributors to vitamin B12 intake across all age groups. Serum vitamin B12 levels have a significant impact on the health of the elderly.
Article
Nutrition & Dietetics
Ying Thou, Arick Wang, Lorraine F. Yeung, Yan Ping Qi, Christine M. Pfeiffer, Krista S. Crider
Summary: This study aimed to evaluate folate and vitamin B12 intake among US adults and explore the biomarker levels of folate and vitamin B12 by intake source. The results showed that folate fortification plays a critical role in helping US adults meet the recommended folate intake. At current fortification levels, US adults who do not take supplements do not exceed the maximum intake level for folate.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Public, Environmental & Occupational Health
Liping Yang, Wenjuan Wang, Baohong Mao, Jie Qiu, Huaqi Guo, Bin Yi, Xiaochun He, Xiaojuan Lin, Ling Lv, Xiaoying Xu, Qing Liu, Yongchun Cao, Yiming Chen
Summary: This study found that folic acid supplementation was associated with a reduced risk of LBW, mainly in term-LBW and multiparous-LBW. There were no significant associations between dietary folate intake and LBW, and no interaction between folic acid supplementation and dietary folate intake on LBW.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Nutrition & Dietetics
Khadijah Alnabbat, Ali M. Fardous, Aiman Shahab, Andrew A. James, Manhel R. Bahry, Ahmad R. Heydari
Summary: This study found that high consumption of folic acid from fortified foods can lead to genomic instability in peripheral lymphocytes, which is consistent with previous reports.
Article
Nutrition & Dietetics
Marisa A. Patti, Joseph M. Braun, Tye E. Arbuckle, Amanda J. MacFarlane
Summary: Maintaining optimal folate levels during early gestation helps reduce the risk of neural tube defects. While inadequate folate intake remains a concern, consuming higher than recommended doses of folic acid does not offer much additional benefit. In the context of mandatory fortification, factors such as socioeconomic status, maternal age, parity, and pre-pregnancy BMI are associated with adequate folate intake and reduced risk of neural tube defects.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Nutrition & Dietetics
Cecilia Zanin Palchetti, Josiane Steluti, Eliseu Verly-Jr, Eduardo De Carli, Rosely Sichieri, Edna Massae Yokoo, Rosangela Alves Pereira, Dirce Maria Lobo Marchioni
Summary: The study compared the evolution of dietary folate intake in the Brazilian population in two post-fortification periods, estimating the prevalence of folate inadequacy (POFI) and the contribution of food groups to folate intake. Despite mandatory folic acid flour fortification in Brazil for nearly two decades, an increase in POFI was observed in 2017-2018. This study provides important scientific information to guide public health fortification strategies.
BRITISH JOURNAL OF NUTRITION
(2022)
Article
Cell Biology
Renuka Sharma, Taqveema Ali, Jyotdeep Kaur
Summary: The study evaluated the impact of dietary folate modulations on the expression of tumor suppressor genes during hepatocellular carcinoma development, finding differential expression patterns and promoter methylation in folate deficiency and oversupplemented groups. The results suggest that TSGs play a role in HCC development, with potential contributions from promoter methylation.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Sanne D. D. van Otterdijk, Hagen Klett, Melanie Boerries, Karin B. B. Michels
Summary: This study examines the influence of folate and S-Adenosylmethionine (SAM) on placental DNA methylation. The study finds that maintaining sufficient levels of folate and SAM is particularly important for individuals carrying the MTHFR C677T polymorphism. The MTHFR genotype is associated with DNA methylation.
Article
Food Science & Technology
Omer F. Celik, Daniel J. O'Sullivan
Summary: Five different bifidobacterial cultures were tested for their de novo folate production ability based on their folate biosynthetic gene content. A new medium (YNB+) was developed as the previous folate-free media could not support their growth. The presence of certain genes or the absence of others in the genome annotations cannot accurately predict their folate dependency.
Article
Nutrition & Dietetics
Malia S. Q. Murphy, Katherine A. Muldoon, Hauna Sheyholislami, Nathalie Behan, Yvonne Lamers, Natalie Rybak, Ruth Rennicks White, Alysha L. J. Harvey, Laura M. Gaudet, Graeme N. Smith, Mark C. Walker, Shi Wu Wen, Amanda J. MacFarlane
Summary: The study found that high-dose folic acid supplementation in early pregnancy can increase maternal serum folate concentrations but does not increase red blood cell folate concentrations, suggesting tissue saturation. Higher UMFA concentrations in women receiving high-dose folic acid supplements suggest that these doses may be supraphysiological, but there is no evidence of altered 1-carbon metabolism.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2021)
Article
Nutrition & Dietetics
Caroline Buffiere, Manon Hiolle, Marie-Agnes Peyron, Ruddy Richard, Nathalie Meunier, Cindy Batisse, Didier Remond, Didier Dupont, Francoise Nau, Bruno Pereira, Isabelle Savary-Auzeloux
Summary: The structure of food matrix affects the absorption of folate and other macronutrients, with pudding and sponge cake showing the highest folate availability while custard and biscuit showing the lowest. Analysis of plasma kinetics of other nutrients helps explain the lower bioavailability of folates in custard and biscuit.
EUROPEAN JOURNAL OF NUTRITION
(2021)
Review
Pediatrics
Zekun Chen, Yan Xing, Xue Yu, Yuqi Dou, Defu Ma
Summary: Folic acid intake during pregnancy may be a risk factor for allergic diseases in infants and young children, especially impacting respiratory allergies.
FRONTIERS IN PEDIATRICS
(2021)
Review
Oncology
Nienke R. K. Zwart, Mira D. Franken, Wim J. E. Tissing, Floor J. E. Lubberman, Jill A. Mckay, Ellen Kampman, Dieuwertje E. Kok
Summary: A systematic literature review indicates that folate and folic acid have an impact on the treatment tolerance of cancer patients. In studies on antifolate treatments, a deficient folate status and lower intake were associated with a higher risk of toxicities. In studies on fluoropyrimidine treatments, a higher folate status and intake were associated with a higher risk of toxicities.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Sophia D. Amenyah, Mary Ward, Amy McMahon, Jennifer Deane, Helene McNulty, Catherine Hughes, J. J. Strain, Geraldine Horigan, John Purvis, Colum P. Walsh, Diane J. Lees-Murdock
Summary: This study found that individuals with the MTHFR 677TT v CC genotype had higher DNA methylation levels at NOS3. In TT individuals who received riboflavin supplementation, DNA methylation levels increased at IGF2 and decreased at ACE. Specific CpG sites were found to be hypomethylated in GNA12 and hypermethylated in AGTR1.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Medicine, General & Internal
Aoife Caffrey, Helene McNulty, Mark Rollins, Girijesh Prasad, Pramod Gaur, Joel B. Talcott, Caroline Witton, Tony Cassidy, Barry Marshall, James Dornan, Adrian J. Moore, Mary Ward, J. J. Strain, Anne M. Molloy, Marian McLaughlin, Diane J. Lees-Murdock, Colum P. Walsh, Kristina Pentieva
Summary: This study suggests that continued folic acid supplementation throughout pregnancy can benefit the neurocognitive development of children, with improvements in processing speed, verbal comprehension, and more efficient semantic processing of language. The use of magnetoencephalography (MEG) provides an objective tool to assess brain activity in response to nutrition interventions in pediatric research.
Article
Nutrition & Dietetics
Avril Beirne, Kevin McCarroll, James Bernard Walsh, Miriam Casey, Eamon Laird, Helene McNulty, Mary Ward, Leane Hoey, Anne M. Molloy, Martin Healy, Catherine Hughes, Sean Strain, Conal Cunningham
Summary: This study found an independent prospective association between vitamin D deficiency and increased hospitalization among older adults. Lower vitamin D concentrations were associated with higher rates of ED attendance and hospital admission, highlighting the potential importance of vitamin D supplementation beyond bone health in this population. Further investigation through randomized controlled trials is needed to evaluate current recommendations regarding vitamin D supplementation.
Article
Gerontology
C. Potts, J. Richardson, R. B. Bond, R. K. Price, M. D. Mulvenna, P. Zvolsky, M. Harvey, C. F. Hughes, F. Duffy
Summary: The study found that ACE-III is reliable in differentiating between dementia, MCI, and controls, but not reliable in discriminating between dementia subtypes. Despite significant differences in scores across different cognitive domains, there is a high degree of overlap with no clinical relevance.
EUROPEAN JOURNAL OF AGEING
(2022)
Article
Nutrition & Dietetics
Oonagh C. Lyons, Maeve A. Kerr, Helene McNulty, Fiona Ward, Janette Walton, M. Barbara E. Livingstone, Breige A. McNulty, Laura Kehoe, Pamela A. Byrne, Ita Saul, Mary A. T. Flynn
Summary: This study establishes a protocol for addressing nutrient shortfalls among 1- to 5-y-old children by analyzing dietary patterns. The majority of children in this age group do not meet the recommended intake for important nutrients such as vitamin D, vitamin E, DHA+EPA, and fiber. The intake of free sugars also exceeds the recommended limits. Only the milk-feeding scenario of human milk + cow milk can address the DHA+EPA deficiency in 1-3-year-olds. Iron and vitamin E deficiencies are most prevalent in children below the 25th growth percentile.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Nutrition & Dietetics
Guy-Marino Hinnouho, Daniela Hampel, Setareh Shahab-Ferdows, Maxwell A. Barffour, Liadhan McAnena, Charles D. Arnold, K. Ryan Wessells, Sengchanh Kounnavong, Lindsay H. Allen, Helene McNulty, Sonja Y. Hess
Summary: The study found that daily use of a multiple micronutrient powder (MNP) for 9 months only affected the folate status of young Laotian children, with no improvement in thiamine, riboflavin, or B-12 status.
EUROPEAN JOURNAL OF NUTRITION
(2022)
Article
Nutrition & Dietetics
Oonagh C. Lyons, Mary A. T. Flynn, Clare A. Corish, Eileen R. Gibney, Maeve A. Kerr, Malachi J. McKenna, Helene McNulty, Emeir M. McSorley, Anne P. Nugent, Claire O'Brien, Mary Ward, Katherine M. Younger, Ita Saul
Summary: Ensuring the nutritional well-being of older adults is critically important, and specific dietary guidelines are needed for elderly individuals living independently. In Ireland, a large percentage of older adults are overweight or obese, highlighting the importance of addressing these issues. Updating nutrient intake goals and considering specific nutritional concerns of aging, such as muscle preservation, weight management, fortified foods, and vitamin D supplementation, are crucial in developing appropriate dietary guidelines for this population.
PROCEEDINGS OF THE NUTRITION SOCIETY
(2022)
Article
Oncology
Miroslava Ondicova, Rachelle E. Irwin, Sara-Jayne Thursby, Luke Hilman, Aoife Caffrey, Tony Cassidy, Marian McLaughlin, Diane J. Lees-Murdock, Mary Ward, Michelle Murphy, Yvonne Lamers, Kristina Pentieva, Helene McNulty, Colum P. Walsh
Summary: This study reveals clear alterations in DNA methylation at specific neurodevelopmental genes in children born to mothers who were supplemented with folic acid during pregnancy. These changes play an important role in transcriptional regulation and provide supporting evidence for continued folic acid supplementation throughout later gestation.
CLINICAL EPIGENETICS
(2022)
Article
Geriatrics & Gerontology
Adam H. Dyer, Eamon Laird, Leane Hoey, Catherine F. Hughes, Helene McNulty, Mary Ward, J. J. Strain, Maurice O'Kane, Fergal Tracey, Anne M. Molloy, Conal Cunningham, Donal J. Sexton, Kevin McCarroll
Summary: This study found that reduced kidney function in older adults is associated with poorer cognitive performance, especially in domain-specific areas. The strongest associations were observed in individuals with eGFR <45 ml/min/1.73 m(2) and those aged 60-70.
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2022)
Article
Nutrition & Dietetics
Martina Rooney, Catherine F. Hughes, J. J. Strain, Michelle Clements, Helene McNulty, Mary Ward
Summary: This study provides the first evidence that brachial and central blood pressure are significantly higher in adults with the variant MTHFR 677TT genotype, and this phenomenon is more pronounced in women.
JOURNAL OF HUMAN NUTRITION AND DIETETICS
(2022)
Article
Nutrition & Dietetics
Harry Jarrett, Helene McNulty, Catherine F. Hughes, Kristina Pentieva, J. J. Strain, Adrian McCann, Liadhan McAnena, Conal Cunningham, Anne M. Molloy, Albert Flynn, Sinead M. Hopkins, Geraldine Horigan, Ciara O'Connor, Janette Walton, Breige A. McNulty, Michael J. Gibney, Yvonne Lamers, Mary Ward
Summary: The concentration of vitamin B-6 is lower in older adults, and riboflavin levels affect the status of vitamin B-6, especially in older individuals. The combination of the MTHFR 677TT genotype with riboflavin deficiency leads to a decrease in vitamin B-6 levels. Intake of vitamin B-6, supplement use, and EGRac are associated with PLP levels.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Endocrinology & Metabolism
Michelle Clements, Maria Heffernan, Mary Ward, Leane Hoey, Leanne C. Doherty, Roberta Hack Mendes, Michelle M. Clarke, Catherine F. Hughes, Ingrid Love, Shauna Murphy, Eilish McDermott, Jennifer Grehan, Adrian McCann, Liadhan B. McAnena, J. J. Strain, Lorraine Brennan, Helene McNulty
Summary: This study investigates the effect of low-dose B-vitamins on bone mineral density in adults aged >= 50 years. The results show that the intervention had no overall effect on BMD, but improving B-vitamin status appears to have specific benefits for bone health in adults with lower B12 status.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Editorial Material
Nutrition & Dietetics
Ali Niklewicz, A. David Smith, Alison Smith, Andre Holzer, Andrew Klein, Andrew McCaddon, Anne M. Molloy, Bruce H. R. Wolffenbuttel, Ebba Nexo, Helene McNulty, Helga Refsum, Jean-Louis Gueant, Marie-Joe Dib, Mary Ward, Michelle Murphy, Ralph Green, Kourosh R. Ahmadi, Luciana Hannibal, Martin J. Warren, P. Julian Owen
Summary: Vitamin B-12 deficiency is common among vegetarians and vegans, especially pregnant women or women of child-bearing age. It is associated with increased risk of neuro, vascular, immune, and inflammatory disorders. However, the current recommended nutrient intake for vitamin B-12 does not adequately consider the needs of individuals choosing a plant-based diet.
EUROPEAN JOURNAL OF NUTRITION
(2023)