Peptidoglycan biosynthesis machinery: A rich source of drug targets

Inhibitory Mechanism of Novel Inhibitors of UDP-N-Acetylglucosamine Enolpyruvyl Transferase from Haemophilus influenzae

(2013) Bong-Suk Jin   JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY

The mechanism of sugar phosphate isomerization by glucosamine 6-phosphate synthase

(2010) Alexei Teplyakov et al.   PROTEIN SCIENCE

Structures of K0.05Na0.95NbO3(50–300 K) and K0.30Na0.70NbO3(100–200 K)

(2009) N. Zhang et al.   ACTA CRYSTALLOGRAPHICA SECTION B-STRUCTURAL SCIENCE

Structure ofN-acetylglucosamine-1-phosphate uridyltransferase (GlmU) fromMycobacterium tuberculosisin a cubic space group

(2009) Sunil Kumar Verma et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

MurF Inhibitors with Antibacterial Activity: Effect on Muropeptide Levels

(2009) E. Z. Baum et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Beta-lactam antibiotics: from antibiosis to resistance and bacteriology

(2009) KOK-FAI KONG et al.   APMIS

Evidence of Kinetic Control of Ligand Binding and Staged Product Release in MurA (Enolpyruvyl UDP-GlcNAc Synthase)-Catalyzed Reactions,

(2009) Sean G. Jackson et al.   BIOCHEMISTRY

Discovery of new inhibitors of the bacterial peptidoglycan biosynthesis enzymes MurD and MurF by structure-based virtual screening

(2009) Samo Turk et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Phosphorylated hydroxyethylamines as novel inhibitors of the bacterial cell wall biosynthesis enzymes MurC to MurF

(2009) Matej Sova et al.   BIOORGANIC CHEMISTRY

5-Benzylidenethiazolidin-4-ones as Multitarget Inhibitors of Bacterial Mur Ligases

(2009) Tihomir Tomašić et al.   ChemMedChem

Structure-Based Drug Design Strategies in Medicinal Chemistry

(2009) Adriano Andricopulo et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Characterization of the active site of S. aureus monofunctional glycosyltransferase (Mtg) by site-directed mutation and structural analysis of the protein complexed with moenomycin

(2009) Holly Heaslet et al.   JOURNAL OF STRUCTURAL BIOLOGY

Crystal structure of the membrane-bound bifunctional transglycosylase PBP1b from Escherichia coli

(2009) M.-T. Sung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ATP-dependent MurE ligase in Mycobacterium tuberculosis: Biochemical and structural characterisation

(2009) Chandrakala Basavannacharya et al.   TUBERCULOSIS

Structural Analysis of the Contacts Anchoring Moenomycin to Peptidoglycan Glycosyltransferases and Implications for Antibiotic Design

(2008) Yanqiu Yuan et al.   ACS Chemical Biology

Crystal Structures of Biapenem and Tebipenem Complexed with Penicillin-Binding Proteins 2X and 1A from Streptococcus pneumoniae

(2008) M. Yamada et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

2-Aminotetralones: Novel inhibitors of MurA and MurZ

(2008) Colin J. Dunsmore et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and Biological Evaluation ofN-Acylhydrazones as Inhibitors of MurC and MurD Ligases

(2008) Roman Šink et al.   ChemMedChem

Structural details of the glycosyltransferase step of peptidoglycan assembly

(2008) Andrew L Lovering et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Novel Naphthalene-N-sulfonyl-d-glutamic Acid Derivatives as Inhibitors of MurD, a Key Peptidoglycan Biosynthesis Enzyme‡,§

(2008) Jan Humljan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Ordering of C-terminal Loop and Glutaminase Domains of Glucosamine-6-Phosphate Synthase Promotes Sugar Ring Opening and Formation of the Ammonia Channel

(2008) Stéphane Mouilleron et al.   JOURNAL OF MOLECULAR BIOLOGY

Identification of Dynamic Structural Motifs Involved in Peptidoglycan Glycosyltransfer

(2008) Andrew L. Lovering et al.   JOURNAL OF MOLECULAR BIOLOGY

PknB-Mediated Phosphorylation of a Novel Substrate, N-Acetylglucosamine-1-Phosphate Uridyltransferase, Modulates Its Acetyltransferase Activity

(2008) Amit Parikh et al.   JOURNAL OF MOLECULAR BIOLOGY

Design and Synthesis of Novel N-Benzylidenesulfonohydrazide Inhibitors of MurC and MurD as Potential Antibacterial Agents

(2008) Rok Frlan et al.   MOLECULES

Structure of a small-molecule inhibitor complexed with GlmU from Haemophilus influenzae reveals an allosteric binding site

(2008) Igor Mochalkin et al.   PROTEIN SCIENCE

Crystal structure of UDP-N-acetylglucosamine enolpyruvyl transferase fromHaemophilus influenzae in complex with UDP-N-acetylglucosamine and fosfomycin

(2008) Hye-Jin Yoon et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Trapping of an Acyl–Enzyme Intermediate in a Penicillin-binding Protein (PBP)-catalyzed Reaction

(2007) Pauline Macheboeuf et al.   JOURNAL OF MOLECULAR BIOLOGY