Article
Urology & Nephrology
Alexandre O. Gerard, Susana Barbosa, Nadege Parassol, Marine Andreani, Diane Merino, Marion Cremoni, Audrey Laurain, Sylvine Pinel, Delphine Bourneau-Martin, Fanny Rocher, Vincent L. M. Esnault, Delphine Borchiellini, Antoine Sicard, Milou-Daniel Drici
Summary: Immune checkpoint inhibitors (ICIs) can lead to immune-related adverse events (IRAEs), including acute tubulointerstitial nephritis. This study compared patients with renal IRAEs (ICI-AKI) to those with other IRAEs and found that ICI-AKI patients were older, had a higher prevalence of chronic kidney disease, and were more likely to be treated with fluindione, NSAIDs, or PPIs.
CLINICAL KIDNEY JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Xinying Yang, Xiaoyu Du, Ke Ma, Guoqi Li, Zhuohui Liu, Wei Rong, Huangtai Miao, Fuli Zhu, Qinghua Cui, Shaowei Wu, Yulin Li, Jie Du
Summary: This study found that circulating miR-26a-5p, miR-21-5p, and miR-191-5p levels were lower in patients who experienced major adverse cardiovascular events after acute myocardial infarction compared to those who did not. Multivariate conditional logistic regression analysis showed that these miRNAs were significantly inversely associated with incident primary composite outcomes. Combining these miRNAs with B-type natriuretic peptide improved risk scores recommended in the current guidelines.
CANADIAN JOURNAL OF CARDIOLOGY
(2021)
Review
Nanoscience & Nanotechnology
Shuai Bian, Hongfei Cai, Youbin Cui, Wanguo Liu, Chunsheng Xiao
Summary: ALI and ARDS can cause life-threatening respiratory failure with a high mortality rate. Despite some clinical interventions, there is still no completely effective treatment for ALI. Recent advances in nanotechnology may provide new possibilities for the pharmacotherapy of ALI.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Horng-Ruey Chua, Sanmay Low, Tanusya Murali Murali, Emmett Tsz-Yeung Wong, Hai-Dong He, Boon-Wee Teo, Yee-Liang Thian, K. Akalya, Anantharaman Vathsala
Summary: The use of contrast-enhanced CT contrast in patients with AKI is associated with worse renal outcomes, including higher rates of MAKE and delayed renal recovery.
EUROPEAN RADIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Jinpeng Zheng, Caihong Lu, Meiyan Yang, Jiejie Sun, Jinbang Zhang, Yuanyuan Meng, Yuli Wang, Zhiping Li, Yang Yang, Wei Gong, Chunsheng Gao
Summary: This study demonstrates the outstanding advantages of erythrocyte-anchored CPA-CNPs in improving the pharmacokinetics and bioavailability of CPA, which offers great promise for a lung-targeted drug delivery system for the effective treatment of ALI.
Article
Nanoscience & Nanotechnology
Myoungjee Choi, Le Thi Thuy, Youngki Lee, Chunxian Piao, Joon Sig Choi, Minhyung Lee
Summary: The dendrimer micelles with glycyrrhizic acid (GA) successfully integrated the anti-inflammatory drug GA and improved gene delivery efficiency. By enhancing cellular uptake, increasing gene delivery efficiency to the lungs, and interacting with the GA receptor, the micelles showed enhanced transfection efficiency.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Yang Wang, Qing Li, Mengsheng Deng, Kuijun Chen, Jianmin Wang
Summary: Metal-organic frameworks (MOFs) have shown great potential in various fields, including nanotechnology and biomedical applications. In this study, zeolite imidazole skeleton-8 (ZIF-8) was used as a drug carrier for the treatment of lung injury. The results demonstrated that ZIF-8 encapsulating plumbagin (PLB) effectively reduced collagen fibers deposition and decreased the secretion of inflammatory factors in a severe lung injury animal model. This research presents a promising strategy for the application of MOF materials in the biomedical field.
CHINESE CHEMICAL LETTERS
(2022)
Article
Pharmacology & Pharmacy
Dan-Li Hao, Ya-Jie Wang, Jia-Ying Yang, Ran Xie, Ling-Yu Jia, Jin-Tang Cheng, Hai Ma, Ji-Xiang Tian, Shan-Shan Guo, Ting Liu, Feng Sui, Yu Zhao, Yan-Jun Chen, Qing-He Zhao
Summary: Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are common clinical syndromes that can lead to severe respiratory failure and high mortality. Nanotechnology-mediated anti-inflammatory therapy is a promising approach for ALI treatment. This study demonstrated that the artesunate prodrugs can effectively attenuate LPS-induced ALI, suggesting a novel strategy for treating inflammation-induced lung injury.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Chuanyu Zhuang, Minji Kang, Minhyung Lee
Summary: Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a life-threatening inflammatory lung disease, mainly caused by sepsis, infections, trauma, toxic reagents, and COVID-19. Current treatment options for ALI/ARDS are limited, but gene therapy using therapeutic nucleic acids has shown potential. Two classes of therapeutic nucleic acids, knock-in genes and oligonucleotides, have been developed for the treatment of ALI/ARDS. Delivery systems for efficient delivery of therapeutic nucleic acids into the lungs have also been explored. This review discusses ALI/ARDS gene therapy mainly in terms of delivery systems and provides insights for the development of new treatment strategies.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Cardiac & Cardiovascular Systems
Mayooran Shanmuganathan, Ambra Masi, Matthew K. Burrage, Rafail A. Kotronias, Alessandra Borlotti, Roberto Scarsini, Abhirup Banerjee, Dimitrios Terentes-Printzios, Qiang Zhang, Evan Hann, Elizabeth Tunnicliffe, Andrew Lucking, Jeremy Langrish, Rajesh Kharbanda, Giovanni Luigi De Maria, Adrian P. Banning, Robin P. Choudhury, Keith M. Channon, Stefan K. Piechnik, Vanessa M. Ferreira
Summary: The acute responses in both infarcted and noninfarcted myocardium post-STEMI are independent incremental predictors of long-term major adverse cardiac events (MACE). These findings may have implications for treatment and risk stratification in STEMI.
JACC-CARDIOVASCULAR IMAGING
(2023)
Article
Critical Care Medicine
Michael L. Behal, Jonny L. Nguyen, Xilong Li, David J. Feola, Javier A. Neyra, Alexander H. Flannery
Summary: Early exposure to azithromycin in SA-AKI is independently associated with a reduction in major adverse kidney events (MAKE) at hospital discharge.
Letter
Medicine, General & Internal
Malini DeSilva, Jacob Haapala, Gabriela Vazquez-Benitez, Kimberly K. Vesco, Matthew F. Daley, Darios Getahun, Ousseny Zerbo, Allison Naleway, Jennifer C. Nelson, Joshua T. B. Williams, Simon J. Hambidge, Thomas G. Boyce, Candace C. Fuller, Heather S. Lipkind, Eric Weintraub, Michael M. McNeil, Elyse O. Kharbanda
Summary: This retrospective cohort study suggests that pregnant women who have been vaccinated against Covid-19 do not have a higher risk of clinically serious adverse events compared to those who are unvaccinated.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Di Liang, Wanmei Wang, Guangrui Chen, Jian Li, Guifang Dou, Hui Gan, Peng Han, Lina Du, Ruolan Gu
Summary: SARS-CoV-2 induces a severe cytokine storm that can cause acute lung injury/acute respiratory distress syndrome (ARDS). In this study, we developed dry powder inhalers (DPI) for the treatment of acute lung injury (ALI) in rats. CEP dry powder inhalers showed promising results in reducing pulmonary edema and inflammation.
Article
Cardiac & Cardiovascular Systems
Patrick M. Wanner, Dirk U. Wulff, Mirjana Djurdjevic, Wolfgang Korte, Thomas W. Schnider, Miodrag Filipovic
Summary: This study found that targeting higher intraoperative mean arterial blood pressures (75 mm Hg) in cardiovascular risk patients undergoing major noncardiac surgery did not significantly reduce the incidence of postoperative major adverse cardiovascular events. Despite a shorter duration of hypotensive time during surgery, there were no significant differences in outcomes such as acute myocardial injury and 30-day MACE/AKI between the higher and lower blood pressure target groups.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Kun Wang, Guangyu Rong, Yixuan Gao, Muyun Wang, Jiaxing Sun, He Sun, Ximing Liao, Yuanyuan Wang, Qiang Li, Wei Gao, Yiyun Cheng
Summary: This study developed a novel nanoparticle, CFF13F, which can be efficiently internalized by macrophages and suppress the excessive inflammation and reactive oxygen species production triggered by LPS. The therapeutic efficacy of CFF13F was demonstrated in an ALI murine model, and the local intratracheal injection was found to be the optimal administration route.
Review
Psychiatry
Rakesh Kumar, Juan Garzon, Deniz Yuruk, Leslie C. Hassett, Maria Saliba, Can Ozger, Cinar Oztosun, Kelly Ahern, Arjun P. Athreya, Balwinder Singh, Paul E. Croarkin, Jennifer L. Vande Voort
Summary: This article evaluated the efficacy and safety of lamotrigine in the treatment of pediatric mood disorders. The study found that lamotrigine was effective in treating bipolar disorder and was well tolerated. However, there is still insufficient data regarding the therapeutic range for lamotrigine.
ACTA PSYCHIATRICA SCANDINAVICA
(2023)
Article
Critical Care Medicine
Heyi Li, Shailesh Bihari, Timothy Weister, Allison LeMahieu, Rahul Kashyap, Sarah Chalmers, Amos Lal, Andrew Bersten, Ognjen Gajic
Summary: In the ICU, admission serum sodium and osmolarity are not associated with the occurrence and outcomes of ARDS.
JOURNAL OF CRITICAL CARE
(2023)
Article
Oncology
Niveditha Balakumar, Samanta Catueno, Meghana Nadiger, Prithvi Raj Sendi Keshavamurthy, Balagangadhar R. Totapally, Farha Sherani, Nkechi Mba, Katja M. Gist, Sandeep Tripathi, Ognjen Gajic, Neha Deo, Vishakha Kumar, Allan Walkey, Rahul Kashyap, Utpal S. Bhalala
Summary: This study used a large, multicenter database to assess the impact of COVID-19 on hospitalized pediatric oncology patients. The results showed that ICU admission rate, interventions, and outcomes of COVID-19 were similar between oncology patients and control patients. However, the incidence of MIS-C was lower in oncology patients.
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
(2023)
Article
Medicine, General & Internal
Aysun Tekin, Shahraz Qamar, Mayank Sharma, Romil Singh, Michael Malinchoc, Vikas Bansal, Neha Deo, Marija Bogojevic, Diana J. Valencia-Morales, Simon Zec, Nika Zorko-Garbajs, Nikhil Sharma, Amos Lal, Devang K. Sanghavi, Rodrigo Cartin-Ceba, Syed A. Khan, Abigail T. La Nou, Anusha Cherian, Igor B. Zabolotskikh, Vishakha K. Kumar, Rahul Kashyap, Allan J. Walkey, Juan P. Domecq, Hemang Yadav, Ognjen Gajic, Yewande E. Odeyemi
Summary: Objective: To develop and validate a lung injury prediction score (c-LIPS) tailored for predicting Acute Respiratory Distress Syndrome (ARDS) in COVID-19 patients. Methods: A registry-based cohort study was conducted using the Viral Infection and Respiratory Illness Universal Study. The c-LIPS score was developed using COVID-19-specific laboratory risk factors and validated in a large cohort of patients from multiple countries. Results: The c-LIPS score showed good discriminatory performance in predicting ARDS development and the need for invasive mechanical ventilation. Conclusion: The c-LIPS score can successfully predict ARDS in COVID-19 patients and may be a useful tool for clinicians.
MAYO CLINIC PROCEEDINGS
(2023)
Article
Neurosciences
Boney Joseph, Nicolas A. A. Nunez, Vanessa Pazdernik, Rakesh Kumar, Mehak Pahwa, Mete Ercis, Aysegul Ozerdem, Alfredo B. B. Cuellar-Barboza, Francisco Romo-Nava, Susan L. L. McElroy, Brandon J. J. Coombes, Joanna M. M. Biernacka, Marius N. N. Stan, Mark A. A. Frye, Balwinder Singh
Summary: This study examined the incidence of thyroid disorders in bipolar disorder patients on long-term lithium therapy (LTLT) and analyzed their response to lithium. The results showed that 32% of patients developed a thyroid disorder, with 79% developing hypothyroidism which improved with thyroid hormone replacement. There were no significant differences in lithium response between patients with or without thyroid disorders in bipolar disorder.
Article
Public, Environmental & Occupational Health
Nancy Nagib, Ruisu Chen, Juan Pablo Noriega, Randell Turner, Rahul Kashyap
Summary: This study introduces a culturally sensitive educational intervention to promote the acceptance and sustained use of a safer cooking stove. Two villages in Guatemala were provided with wood-burning stoves, and usage rates were measured over a seven-month period. The findings show that both the village with the educational intervention and the control village displayed acceptance and sustained usage rates of the stoves, indicating the effectiveness of culturally sensitive educational interventions and community-based programs in promoting acceptance.
Article
Cardiac & Cardiovascular Systems
Clea du Toit, Tran Quoc Bao Tran, Neha Deo, Sachin Aryal, Stefanie Lip, Robert Sykes, Ishan Manandhar, Aristeidis Sionakidis, Leah Stevenson, Harsha Pattnaik, Safaa Alsanosi, Maria Kassi, Ngoc Le, Maggie Rostron, Sarah Nichol, Alisha Aman, Faisal Nawaz, Dhruven Mehta, Ramakumar Tummala, Linsay McCallum, Sandeep Reddy, Shyam Visweswaran, Rahul Kashyap, Bina Joe, Sandosh Padmanabhan
Summary: This study conducted a survey on the use of machine learning in hypertension research, evaluated the reporting quality, and identified barriers to transforming hypertension care using machine learning. The most common research topics were blood pressure prediction, hypertension, and cardiovascular outcomes. The reporting quality of the articles varied and improvements are needed.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Chemistry, Medicinal
Boney Joseph, Nicolas A. Nunez, Simon Kung, Jennifer L. Vande Voort, Vanessa K. Pazdernik, Kathryn M. Schak, Stacey M. Boehm, Brooke Carpenter, Emily K. Johnson, Grigoriy Malyshev, Nathan Smits, Daniel O. Adewunmi, Sarah K. Brown, Balwinder Singh
Summary: This study investigates the response to serial ketamine/esketamine treatment among patients with treatment-resistant depression (TRD) with or without lamotrigine therapy. The results showed no significant differences in response or remission rates among patients on or not on lamotrigine during the ketamine/esketamine treatments.
Article
Psychology, Clinical
Balwinder Singh, Simon Kung, Vanessa Pazdernik, Kathryn M. Schak, Jennifer Geske, Phillip J. Schulte, Mark A. Frye, Jennifer Vande Voort
Summary: This study compared the efficacy and time to achieve remission/response between intravenous ketamine and intranasal esketamine for treatment-resistant depression. The results showed similar rates of response and remission between the two treatment methods, but intravenous ketamine required significantly fewer treatments to achieve remission than intranasal esketamine.
JOURNAL OF CLINICAL PSYCHIATRY
(2023)
Meeting Abstract
Critical Care Medicine
Vikas Bansal, Kinza Iqbal, Akshat Banga, Sawai Rathore, Abhishek Bhurwal, Rahul Kashyap, Amos Lal, Emir Festic, Juan Pablo Domecq Garces
CRITICAL CARE MEDICINE
(2023)
Meeting Abstract
Critical Care Medicine
Smith Heavner, Kerry Howard, Mike Pauley, Pam Dasher, Laksika Sivaraj, Jagdeep Podichetty, Vishakha Kumar, Marco Schito, Rahul Kashyap
CRITICAL CARE MEDICINE
(2023)
Meeting Abstract
Critical Care Medicine
Gowthami Sai Kogilathota Jagirdhar, Rakhtan Qasba, Anna Flumignan, Akshat Banga, Kaanthi Rama, Harsha Patnaik, Shiva Teja Reddy, Vikas Bansal, Rahul Kashyap, Yatinder Bains, Theodore DaCosta
CRITICAL CARE MEDICINE
(2023)
Meeting Abstract
Critical Care Medicine
Gowthami Sai Kogilathota Jagirdhar, Rakhtan Qasba, Harsha Patnaik, Anna Flumignan, Akshat Banga, Kaanthi Rama, Shiva Teja Reddy, Vikas Bansal, Rahul Kashyap, Yatinder Bains, Theodore DaCosta
CRITICAL CARE MEDICINE
(2023)
Meeting Abstract
Critical Care Medicine
Ayushi Mendiratta, Akshat Banga, Balakrishnan Kamaraj, Piyush Garg, Rahul Kashyap, Vinay Sagar
CRITICAL CARE MEDICINE
(2023)
Article
Medicine, Research & Experimental
Amy J. Montgomery, John Litell, Johnny Dang, Laure Flurin, Ognjen Gajic, Amos Lal
Summary: Digital twin technology creates a virtual patient model for testing interventions in healthcare without harming actual patients. This study achieved consensus among a panel of experts on respiratory pathophysiology in the intensive care unit. The expert rule statements produced align with expert knowledge and can be used for developing a digital twin-patient model for acute respiratory failure.
BIOMOLECULES AND BIOMEDICINE
(2023)