Article
Pediatrics
Mariana M. Lanata, Alejandro Diaz, Shaina M. Hecht, Aspasia Katragkou, Nathaniel Gallup, Don A. Buckingham, Jessica L. Tansmore, Cheryl Sargel, Joshua R. Watson, Todd Karsies
Summary: The study aimed to reduce unnecessary vancomycin use for CAIs in PICU by developing empirical vancomycin indications based on MRSA risk factors. Through education, posting of indications, and revising the antibiotic order set, the empirical vancomycin use decreased significantly without any negative impact on patients' outcomes or balancing measures. Retrospective validation of the recommendations with local data proved to be crucial in gaining buy-in from PICU clinicians.
Article
Medical Laboratory Technology
Yuichiro Shimoyama, Noriko Kadono, Osamu Umegaki, Toshiaki Minami
Summary: The combination of NGAL and ΔNGAL with inflammation-based prognostic scores provides better prediction of mortality in septic patients, particularly on day 2 after ICU admission and beyond.
CLINICA CHIMICA ACTA
(2021)
Review
Critical Care Medicine
Zaccaria Ricci, Stefano Romagnoli, Thiago Reis, Rinaldo Bellomo, Claudio Ronco
Summary: This narrative review provides an overview of the current knowledge regarding technical concepts, safety, and clinical results of hemoperfusion. It also focuses on the most recent literature on adsorption applied in critically ill patients, including randomized controlled trials, and future areas of investigation.
INTENSIVE CARE MEDICINE
(2022)
Article
Medicine, General & Internal
Khaled Al Oweidat, Rasmieh Al-Amer, Mohammad Y. Saleh, Asma S. Albtoosh, Ahmad A. Toubasi, Mona Khaled Ribie, Manar M. Hasuneh, Daniah L. Alfaqheri, Abdullah H. Alshurafa, Mohammad Ribie, Amira Mohammed Ali, Nathir Obeidat
Summary: This study aimed to identify the factors associated with COVID-19 mortality, ICU admission, intubation, and length of hospital stay among Jordanian patients. The findings showed that chronic kidney disease, troponin, lactate dehydrogenase, and O-2 saturation <90% were significantly associated with the mortality rate. Heart failure and the use of remdesivir were variables significantly associated with ICU admission. However, O-2 saturation <90% and gastrointestinal symptoms were the only variables associated with invasive intubation.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Katrijn Daenen, Kirby Tong-Minh, Oliver Liesenfeld, Jilske A. Huijben, Sara C. M. Stoof, Virgil A. S. H. Dalm, Diederik Gommers, Eric C. M. van Gorp, Henrik Endeman
Summary: The accuracy of the IMX-SEV-3b classifier in predicting ICU mortality of COVID-19 patients was investigated in this study. The study also assessed the predictive performance of other biomarkers and the SOFA score. The IMX-SEV-3b had a lower accuracy in predicting ICU mortality compared to the SOFA score.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Gastroenterology & Hepatology
Anna DeVeaux, Jian Ryou, Gautam Dantas, Barbara B. Warner, Phillip I. Tarr
Summary: Microbiome-targeting therapies, such as probiotics and prebiotics, have shown mixed results in preventing diseases in preterm infants. While they are generally considered safe, there is uncertainty regarding their effectiveness in neonatal intensive care units. Recent comprehensive meta-analyses highlight limitations in the trials supporting the routine use of probiotics, making it challenging to confidently recommend their universal administration to preterm infants.
Article
Cell Biology
Drew J. Schwartz, Nitan Shalon, Kate Wardenburg, Anna DeVeaux, Meghan A. Wallace, Carla Hall-Moore, I. Malick Ndao, Janice E. Sullivan, Paula Radmacher, Marilyn Escobedo, Carey-Ann D. Burnham, Barbara B. Warner, Phillip I. Tarr, Gautam Dantas
Summary: BSI in preterm infants is commonly transmitted through the gut microbiome and is associated with antibiotic exposure. Ampicillin, gentamicin, or vancomycin can increase the abundance of Enterobacteriaceae and Enterococcaceae in the gut of preterm infants. This study suggests that the microbial composition of the gut can be utilized to predict the risk of BSI in hospitalized preterm infants.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Infectious Diseases
Gamze Gursoy, Omrum Uzun, Gokhan Metan, Mehmet Yildirim, Melda Bahap, Salih Kutay Demirkan, Arzu Topeli, Seda Banu Akinci, Mehmet Akif Topcuoglu, Mustafa Berker, Gulsen Hazirolan, Murat Akova, Serhat Unal
Summary: Antibiotic resistance is a major public health concern, with a slower rate of introducing new molecules. This study evaluated the quality of care before and after active intervention and feedback in an ICU setting, and significant improvements were observed.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Microbiology
Blanca Bravo-Queipo-de-Llano, Laura Sanchez Garcia, Inmaculada Casas, Francisco Pozo, Leticia La Banda, Sonia Alcolea, Jorge Atucha, Rocio Sanchez-Leon, Adelina Pellicer, Cristina Calvo
Summary: This study reports on viral respiratory infections (VRIs) in very low birthweight infants during NICU admission and compares data collected before and after the COVID-19 pandemic. The results showed a significant decrease in the incidence of VRI during the pandemic, possibly due to increased infection prevention measures globally.
Article
Immunology
Kathleen Chiotos, Jennifer Blumenthal, Juri Boguniewicz, Debra L. Palazzi, Erika L. Stalets, Jessica H. Rubens, Pranita D. Tamma, Stephanie S. Cabler, Jason Newland, Hillary Crandall, Emily Berkman, Robert P. Kavanagh, Hannah R. Stinson, Jeffrey S. Gerber
Summary: In a multicenter study of pediatric intensive care unit patients, it was found that the majority of patients receive antibiotics. However, based on the results of this study, it is estimated that one-third of antibiotic orders are inappropriate.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Medical Informatics
Rahuldeb Sarkar, Christopher Martin, Heather Mattie, Judy Wawira Gichoya, David J. Stone, Leo Anthony Celi
Summary: Despite differences in discrimination among different ethnicities, severity scoring systems did not show systematic bias in predicting mortality. However, there were significant patterns of difference in calibration for Hispanic and Black individuals, with the scores consistently overpredicting mortality for these groups.
LANCET DIGITAL HEALTH
(2021)
Article
Critical Care Medicine
Prateek Sehgal, Marion Elligsen, Jennifer Lo, Philip W. Lam, Jerome A. Leis, Rob Fowler, Ruxandra Pinto, Nick Daneman
Summary: The study evaluated the long-term uptake of an antimicrobial stewardship program in a diverse ICU population and identified factors associated with stewardship suggestions and acceptance rates. The findings showed sustained suggestion and acceptance rates over a decade and highlighted the importance of persistent presence of audit-and-feedback, especially for potentially nephrotoxic agents and specialized care units.
CRITICAL CARE MEDICINE
(2021)
Article
Infectious Diseases
Cecilia Herbozo, Irene Julca, Fiorella Flores, Roger Hernandez, Jaime Zegarra
Summary: This study aimed to determine the incidence of late onset sepsis and the most frequent causative microorganisms in the neonatal unit at Hospital Cayetano Heredia in Lima, Peru. The results showed that late onset sepsis was more prevalent in low birth weight infants, with gram-negative bacteria being the main causative microorganism in very low birth weight infants.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Public, Environmental & Occupational Health
Trinh Manh Hung, Nguyen Van Hao, Lam Minh Yen, Angela McBride, Vu Quoc Dat, H. Rogier van Doorn, Huynh Thi Loan, Nguyen Thanh Phong, Martin J. Llewelyn, Behzad Nadjm, Sophie Yacoub, C. Louise Thwaites, Sayem Ahmed, Nguyen Van Vinh Chau, Hugo C. Turner
Summary: This study investigates the direct medical costs of patients with key infectious diseases (tetanus, sepsis, and dengue) admitted to the ICU in a hospital in Ho Chi Minh City, Vietnam. It explores the variation in costs and cost drivers between different diseases.
FRONTIERS IN PUBLIC HEALTH
(2022)
Review
Biochemistry & Molecular Biology
Marco Fiorentino, Francesca Bagagli, Annamaria Deleonardis, Alessandra Stasi, Rossana Franzin, Francesca Conserva, Barbara Infante, Giovanni Stallone, Paola Pontrelli, Loreto Gesualdo
Summary: Kidney transplantation is the preferred treatment for end-stage renal disease (ESRD). Kidney transplant recipients (KTRs) are at a higher risk of ICU admission, mainly in the late post-transplant period. Urosepsis and bloodstream infections are the main reasons for ICU admissions, and side effects of immunosuppressive treatment should also be accounted for. AKI incidence is common in KTRs during ICU stay, and in-hospital mortality can be high. The present review aims to explore the impact of AKI on outcomes in KTRs and provide insights into its diagnosis, management, and immunosuppression modulation.
Review
Infectious Diseases
Paraskevi C. Fragkou, Charalampos D. Moschopoulos, Dimitra Dimopoulou, David S. Y. Ong, Konstantina Dimopoulou, Philipp P. Nelson, Valentijn A. Schweitzer, Hannah Janocha, Emmanouil Karofylakis, Konstantinos A. Papathanasiou, Sotirios Tsiordras, Giulia De Angelis, Clemens Thoelken, Maurizio Sanguinetti, Ho-Ryun Chung, Chrysanthi Skevaki
Summary: This study evaluated the performance of molecular and antigen-based point-of-care tests (POCTs) for SARS-CoV-2 infection compared to laboratory-based RT-PCR in real-life settings. The results showed that molecular POCTs had higher sensitivity and specificity compared to antigen-based POCTs. Further studies are needed to assess the performance of these tests in different patient subgroups and respiratory samples.
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Review
Critical Care Medicine
Lara C. A. Pladet, Jaimie M. M. Barten, Lisette M. Vernooij, Carlos V. Elzo Kraemer, Jeroen J. H. Bunge, Erik Scholten, Leon J. Montenij, Marijn Kuijpers, Dirk W. Donker, Olaf L. Cremer, Christiaan L. Meuwese
Summary: The purpose of this study was to provide an overview and evaluate the performance of mortality prediction models for patients requiring extracorporeal membrane oxygenation (ECMO) support. A large number of models have been developed, but only a minority has been externally validated. The models showed only moderate predictive performance and poor methodological quality overall.
INTENSIVE CARE MEDICINE
(2023)
Article
Medicine, General & Internal
Daan F. L. Filippini, Laura A. Hagens, Nanon F. L. Heijnen, Claudio Zimatore, Leila N. Atmowihardjo, Ronny M. Schnabel, Marcus J. Schultz, Dennis C. J. J. Bergmans, Lieuwe D. J. Bos, Marry R. Smit
Summary: The RALE score is not universally prognostic in mechanically ventilated ICU patients, but early changes in RALE score are associated with mortality in ARDS patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Editorial Material
Anesthesiology
Marcelo Gama de Abreu, Marcus J. Schultz, Ary Serpa Neto
Summary: Spin and fragility are common in randomised controlled trials published in anaesthesia journals. Staying with the facts and addressing only the primary endpoint in the conclusion of clinical research reports might help reduce spin. Routinely reporting the fragility index, in turn, could deliver information about robustness, enhancing the transparency of positive dichotomous results. It is in the best interest of clinical research that authors, reviewers, and journals come together to reduce spin and address the fragility of randomised controlled trials.
BRITISH JOURNAL OF ANAESTHESIA
(2023)
Article
Critical Care Medicine
Aranka Akkermans, Sanne Prins, Amber S. Spijkers, Jean Wagemans, Nanon H. M. Labrie, Dick L. Willems, Marcus J. Schultz, Thomas G. V. Cherpanath, Job B. M. van Woensel, Marc van Heerde, Anton H. van Kaam, Moniek van de Loo, Anne Stiggelbout, Ellen M. A. Smets, Mirjam A. de Vos
Summary: This study examines the argumentative practices of doctors and families in making decisions about life-sustaining treatment in ICUs. The research identifies the arguments used by both parties and explores how they structure their arguments during conversations. The study reveals that there is limited and brief exchange of arguments, although the types of arguments presented by doctors and families largely overlap.
INTENSIVE CARE MEDICINE
(2023)
Article
Virology
David S. Y. Ong, Peter de Man, Tim Verhagen, Gerda Doejaaren, Marloes A. Dallinga, Esmee Alibux, Matthijs L. Janssen, Evert-Jan Wils
Summary: Airborne transmission is an important route for the spread of SARS-CoV-2. A study comparing virus detection in air samples from patients infected with different variants found a higher positivity rate in samples from Omicron variant patients compared to Delta variant patients.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Medicine, General & Internal
L. Robin Goossen, Marielle Verboom, Marielle Blacha, Illaa Smesseim, Ludo F. M. Beenen, David M. P. van Meenen, Frederique Paulus, J. Marcus Schultz
Summary: In this single-center cohort study in the Netherlands, the incidence of air leaks, including subcutaneous emphysema, pneumothorax, and pneumomediastinum, was found to be 8.4% in patients with COVID-19, which was comparable to previous reports in patients with acute hypoxemic respiratory failure.
Editorial Material
Respiratory System
M. J. Schultza, P. J. van Oostena, L. Hol
Article
Biochemistry & Molecular Biology
Luis Enrique Olmedilla Arnal, Oscar Diaz Cambronero, Guido Mazzinari, Jose Maria Perez Pena, Jaime Zorrilla Ortuzar, Marcos Rodriguez Martin, Maria Vila J. Montanes, Marcus Schultz, Lucas Rovira, Maria Pilar Argente Navarro
Summary: High intra-abdominal pressure during laparoscopic surgery is associated with reduced splanchnic blood flow. This study found that an individualized low-pneumoperitoneum-pressure strategy may prevent a reduction in liver perfusion.
Article
Health Care Sciences & Services
Katrijn Daenen, Jilske A. Huijben, Anders Boyd, Lieuwe D. J. Bos, Sara C. M. Stoof, Hugo van Willigen, Diederik A. M. P. J. Gommers, Hazra S. Moeniralam, Corstiaan A. den Uil, Nicole P. Juffermans, Merijn Kant, Abraham J. Valkenburg, Janesh Pillay, David M. P. van Meenen, Frederique Paulus, Marcus J. Schultz, Virgil A. S. H. Dalm, Eric C. M. van Gorp, Janke Schinkel, Henrik Endeman
Summary: This study aims to determine the optimal dosing and timing of corticosteroid therapy for hospitalized patients with COVID-19 and provide a personalized treatment approach to reduce morbidity and mortality. It will investigate the effect of high-dose corticosteroids throughout the entire clinical course and explore biomarker profiles for targeted therapy.
JMIR RESEARCH PROTOCOLS
(2023)
Article
Physiology
Thijs A. Lilien, David M. P. Van Meenen, Marcus J. Schultz, Lieuwe D. J. Bos, Reinout A. Bem
Summary: The interest in oxygen toxicity has led to numerous studies, but there is still no consensus on the clinical impact of hyperoxia and hyperoxemia. This article explores the importance of hyperoxia-induced lung injury in current critical care practice, suggesting that it may be less important than other ventilator-related factors in patients with acute respiratory distress syndrome.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2023)
Editorial Material
Critical Care Medicine
Pedro D. Wendel-Garcia, Lieuwe D. J. Bos
Article
Virology
Willem A. Mak, Wendy Visser, Marijke van der Vliet, Hilde Y. Markus, Johannes G. M. Koeleman, David S. Y. Ong
Summary: COVID-19 bivalent ancestral/Omicron mRNA booster vaccinations enhance immunity and induce neutralizing antibody and T-cell responses against Omicron infections. Previous infection and bivalent booster vaccination increase immune responses. Hybrid immunity is associated with improved T-cell immunity preservation.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Medicine, General & Internal
Liselotte J. Hol, Marcus Schultz, Ignacio Martin-Loeches, David M. P. van Meenen, Ary Serpa Neto, Frederique Paulus
Summary: The aim of this analysis was to compare ventilation management and outcomes in invasively ventilated patients with acute hypoxemic respiratory failure due to COVID-19 between the first and second wave in the Netherlands. The study found that patients in the second wave were sicker, had more comorbidities, and had worse oxygenation parameters. Changes in ventilation management were observed, such as lower positive end-expiratory pressure and higher fraction inspired oxygen. Duration of ventilation was shorter, but mortality rates were similar.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Athiwat Tripipitsiriwat, Orawan Suppapueng, David M. P. van Meenen, Frederique Paulus, Markus W. Hollmann, Chaisith Sivakorn, Marcus J. Schultz, PRoVENT COVID Investigators
Summary: This study found that patients with chronic obstructive pulmonary disease (COPD) have a higher mortality rate in COVID-19 and higher 28-day mortality compared to non-COPD patients. The ventilation management and the use of prone positioning differed slightly between COPD and non-COPD patients.
JOURNAL OF CLINICAL MEDICINE
(2023)