Article
Pediatrics
Mariana M. Lanata, Alejandro Diaz, Shaina M. Hecht, Aspasia Katragkou, Nathaniel Gallup, Don A. Buckingham, Jessica L. Tansmore, Cheryl Sargel, Joshua R. Watson, Todd Karsies
Summary: The study aimed to reduce unnecessary vancomycin use for CAIs in PICU by developing empirical vancomycin indications based on MRSA risk factors. Through education, posting of indications, and revising the antibiotic order set, the empirical vancomycin use decreased significantly without any negative impact on patients' outcomes or balancing measures. Retrospective validation of the recommendations with local data proved to be crucial in gaining buy-in from PICU clinicians.
Review
Critical Care Medicine
Zaccaria Ricci, Stefano Romagnoli, Thiago Reis, Rinaldo Bellomo, Claudio Ronco
Summary: This narrative review provides an overview of the current knowledge regarding technical concepts, safety, and clinical results of hemoperfusion. It also focuses on the most recent literature on adsorption applied in critically ill patients, including randomized controlled trials, and future areas of investigation.
INTENSIVE CARE MEDICINE
(2022)
Article
Medical Laboratory Technology
Yuichiro Shimoyama, Noriko Kadono, Osamu Umegaki, Toshiaki Minami
Summary: The combination of NGAL and ΔNGAL with inflammation-based prognostic scores provides better prediction of mortality in septic patients, particularly on day 2 after ICU admission and beyond.
CLINICA CHIMICA ACTA
(2021)
Article
Medicine, General & Internal
Khaled Al Oweidat, Rasmieh Al-Amer, Mohammad Y. Saleh, Asma S. Albtoosh, Ahmad A. Toubasi, Mona Khaled Ribie, Manar M. Hasuneh, Daniah L. Alfaqheri, Abdullah H. Alshurafa, Mohammad Ribie, Amira Mohammed Ali, Nathir Obeidat
Summary: This study aimed to identify the factors associated with COVID-19 mortality, ICU admission, intubation, and length of hospital stay among Jordanian patients. The findings showed that chronic kidney disease, troponin, lactate dehydrogenase, and O-2 saturation <90% were significantly associated with the mortality rate. Heart failure and the use of remdesivir were variables significantly associated with ICU admission. However, O-2 saturation <90% and gastrointestinal symptoms were the only variables associated with invasive intubation.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Microbiology
Blanca Bravo-Queipo-de-Llano, Laura Sanchez Garcia, Inmaculada Casas, Francisco Pozo, Leticia La Banda, Sonia Alcolea, Jorge Atucha, Rocio Sanchez-Leon, Adelina Pellicer, Cristina Calvo
Summary: This study reports on viral respiratory infections (VRIs) in very low birthweight infants during NICU admission and compares data collected before and after the COVID-19 pandemic. The results showed a significant decrease in the incidence of VRI during the pandemic, possibly due to increased infection prevention measures globally.
Article
Pharmacology & Pharmacy
Lorenzo G. R. Romano, Nicole G. M. Hunfeld, Marieke J. H. A. Kruip, Henrik Endeman, Tim Preijers
Summary: In this study, a population pharmacokinetic analysis showed that the optimal dosing regimen of nadroparin for COVID-19 ICU patients is 5700 IU BID, which can achieve the target anti-Xa levels. The clearance of nadroparin is related to inflammation parameters, corticosteroids, vasopressors, and renal clearance in critically ill patients.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Medicine, General & Internal
Katrijn Daenen, Kirby Tong-Minh, Oliver Liesenfeld, Jilske A. Huijben, Sara C. M. Stoof, Virgil A. S. H. Dalm, Diederik Gommers, Eric C. M. van Gorp, Henrik Endeman
Summary: The accuracy of the IMX-SEV-3b classifier in predicting ICU mortality of COVID-19 patients was investigated in this study. The study also assessed the predictive performance of other biomarkers and the SOFA score. The IMX-SEV-3b had a lower accuracy in predicting ICU mortality compared to the SOFA score.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Juan Carlos Ayala, Adriana Grismaldo, Andres Felipe Aristizabal-Pachon, Elizaveta Mikhaylenko, Vladimir N. Nikolenko, Liudmila M. Mikhaleva, Siva G. Somasundaram, Cecil E. Kirkland, Gjumrakch Aliev, Ludis Morales
Summary: The study revealed a significant increase in reactive oxygen species and mitochondrial oxygen consumption in critically ill patients immediately after exposure to pathogen-associated molecular patterns/damage-associated molecular patterns. However, there were no significant changes in mitochondrial membrane potential. A strong correlation between C-reactive protein and central venous saturation was observed, indicating that clinical markers of inflammation can indirectly evaluate mitochondrial function.
CURRENT PHARMACEUTICAL DESIGN
(2021)
Article
Infectious Diseases
Gamze Gursoy, Omrum Uzun, Gokhan Metan, Mehmet Yildirim, Melda Bahap, Salih Kutay Demirkan, Arzu Topeli, Seda Banu Akinci, Mehmet Akif Topcuoglu, Mustafa Berker, Gulsen Hazirolan, Murat Akova, Serhat Unal
Summary: Antibiotic resistance is a major public health concern, with a slower rate of introducing new molecules. This study evaluated the quality of care before and after active intervention and feedback in an ICU setting, and significant improvements were observed.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Review
Gastroenterology & Hepatology
Anna DeVeaux, Jian Ryou, Gautam Dantas, Barbara B. Warner, Phillip I. Tarr
Summary: Microbiome-targeting therapies, such as probiotics and prebiotics, have shown mixed results in preventing diseases in preterm infants. While they are generally considered safe, there is uncertainty regarding their effectiveness in neonatal intensive care units. Recent comprehensive meta-analyses highlight limitations in the trials supporting the routine use of probiotics, making it challenging to confidently recommend their universal administration to preterm infants.
Article
Critical Care Medicine
Prateek Sehgal, Marion Elligsen, Jennifer Lo, Philip W. Lam, Jerome A. Leis, Rob Fowler, Ruxandra Pinto, Nick Daneman
Summary: The study evaluated the long-term uptake of an antimicrobial stewardship program in a diverse ICU population and identified factors associated with stewardship suggestions and acceptance rates. The findings showed sustained suggestion and acceptance rates over a decade and highlighted the importance of persistent presence of audit-and-feedback, especially for potentially nephrotoxic agents and specialized care units.
CRITICAL CARE MEDICINE
(2021)
Article
Infectious Diseases
Cecilia Herbozo, Irene Julca, Fiorella Flores, Roger Hernandez, Jaime Zegarra
Summary: This study aimed to determine the incidence of late onset sepsis and the most frequent causative microorganisms in the neonatal unit at Hospital Cayetano Heredia in Lima, Peru. The results showed that late onset sepsis was more prevalent in low birth weight infants, with gram-negative bacteria being the main causative microorganism in very low birth weight infants.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Cell Biology
Drew J. Schwartz, Nitan Shalon, Kate Wardenburg, Anna DeVeaux, Meghan A. Wallace, Carla Hall-Moore, I. Malick Ndao, Janice E. Sullivan, Paula Radmacher, Marilyn Escobedo, Carey-Ann D. Burnham, Barbara B. Warner, Phillip I. Tarr, Gautam Dantas
Summary: BSI in preterm infants is commonly transmitted through the gut microbiome and is associated with antibiotic exposure. Ampicillin, gentamicin, or vancomycin can increase the abundance of Enterobacteriaceae and Enterococcaceae in the gut of preterm infants. This study suggests that the microbial composition of the gut can be utilized to predict the risk of BSI in hospitalized preterm infants.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Jan Heil, Martin Schlapfer
Summary: The article introduces a simple, reliable, and reproducible animal model for sepsis treatment research. The model operates based on strict protocols to simulate the process of infection treatment in clinical intensive care units.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2021)
Article
Surgery
Jordan Rosales, Megan Ireland, Kathia Gonzalez-Gallo, Jon Wisler, Anahita Jalilvand
Summary: This study investigated the association between sepsis sources and cumulative 90-day mortality in surgical patients admitted to the surgical intensive care unit. The results showed that urologic infections were an independent negative predictor of 90-day mortality compared to other sources of sepsis.
JOURNAL OF SURGICAL RESEARCH
(2023)
Review
Critical Care Medicine
Lara C. A. Pladet, Jaimie M. M. Barten, Lisette M. Vernooij, Carlos V. Elzo Kraemer, Jeroen J. H. Bunge, Erik Scholten, Leon J. Montenij, Marijn Kuijpers, Dirk W. Donker, Olaf L. Cremer, Christiaan L. Meuwese
Summary: The purpose of this study was to provide an overview and evaluate the performance of mortality prediction models for patients requiring extracorporeal membrane oxygenation (ECMO) support. A large number of models have been developed, but only a minority has been externally validated. The models showed only moderate predictive performance and poor methodological quality overall.
INTENSIVE CARE MEDICINE
(2023)
Article
Medicine, General & Internal
Daan F. L. Filippini, Laura A. Hagens, Nanon F. L. Heijnen, Claudio Zimatore, Leila N. Atmowihardjo, Ronny M. Schnabel, Marcus J. Schultz, Dennis C. J. J. Bergmans, Lieuwe D. J. Bos, Marry R. Smit
Summary: The RALE score is not universally prognostic in mechanically ventilated ICU patients, but early changes in RALE score are associated with mortality in ARDS patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Critical Care Medicine
Aranka Akkermans, Sanne Prins, Amber S. Spijkers, Jean Wagemans, Nanon H. M. Labrie, Dick L. Willems, Marcus J. Schultz, Thomas G. V. Cherpanath, Job B. M. van Woensel, Marc van Heerde, Anton H. van Kaam, Moniek van de Loo, Anne Stiggelbout, Ellen M. A. Smets, Mirjam A. de Vos
Summary: This study examines the argumentative practices of doctors and families in making decisions about life-sustaining treatment in ICUs. The research identifies the arguments used by both parties and explores how they structure their arguments during conversations. The study reveals that there is limited and brief exchange of arguments, although the types of arguments presented by doctors and families largely overlap.
INTENSIVE CARE MEDICINE
(2023)
Editorial Material
Critical Care Medicine
Malou Janssen, Henrik Endeman, Lieuwe D. J. Bos
INTENSIVE CARE MEDICINE
(2023)
Article
Public, Environmental & Occupational Health
Christiana Kartsonaki, J. Kenneth Baillie, Noelia Garcia Barrio, Joaquin Baruch, Abigail Beane, Lucille Blumberg, Fernando Bozza, Tessa Broadley, Aidan Burrell, Gail Carson, Barbara Wanjiru Citarella, Andrew Dagens, Emmanuelle A. Dankwa, Christl A. Donnelly, Jake Dunning, Loubna Elotmani, Martina Escher, Nataly Farshait, Jean-Christophe Goffard, Bronner P. Goncalves, Matthew Hall, Madiha Hashmi, Benedict Sim Lim Heng, Antonia Ho, Waasila Jassat, Miguel Pedrera Jimenez, Cedric Laouenan, Samantha Lissauer, Ignacio Martin-Loeches, France Mentre, Laura Merson, Ben Morton, Daniel Munblit, Nikita A. Nekliudov, Alistair D. Nichol, Budha Charan Singh Oinam, David Ong, Prasan Kumar Panda, Michele Petrovic, Mark G. Pritchard, Nagarajan Ramakrishnan, Grazielle Viana Ramos, Claire Roger, Oana Sandulescu, Malcolm G. Semple, Pratima Sharma, Louise Sigfrid, Emily C. Somers, Anca Streinu-Cercel, Fabio Taccone, Pavan Kumar Vecham, Bharath Kumar Tirupakuzhi Vijayaraghavan, Jia Wei, Evert-Jan Wils, Xin Ci Wong, Peter Horby, Amanda Rojek, Piero L. Olliaro, Ali Abbas
Summary: This study analyzed demographic features, treatments, and clinical outcomes of hospitalized COVID-19 patients in 52 countries from January 2020 to January 2022. Age and male sex were associated with a higher risk of death. Symptoms, co-morbidities, and treatments were associated with clinical outcomes. This comprehensive international study provides valuable information for prioritizing treatment for COVID-19 patients at higher risk of death.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Critical Care Medicine
Willemke Stilma, Thijs A. Lilien, Lieuwe D. J. Bos, Aryen Saatpoor, Omar Elsayed, Frederique Paulus, Marcus J. Schultz, Reinout A. Bem, Rosalie S. N. Linssen
Summary: Critically ill patients on invasive mechanical ventilation are at higher risk for airway mucus accumulation, leading to complications. However, the efficacy of interventions such as humidification, endotracheal suctioning, and pharmacologic interventions is poorly supported by evidence, and there is variability in the choice and timing of interventions based on mucus classification score.
Article
Medicine, General & Internal
L. Robin Goossen, Marielle Verboom, Marielle Blacha, Illaa Smesseim, Ludo F. M. Beenen, David M. P. van Meenen, Frederique Paulus, J. Marcus Schultz
Summary: In this single-center cohort study in the Netherlands, the incidence of air leaks, including subcutaneous emphysema, pneumothorax, and pneumomediastinum, was found to be 8.4% in patients with COVID-19, which was comparable to previous reports in patients with acute hypoxemic respiratory failure.
Editorial Material
Respiratory System
M. J. Schultza, P. J. van Oostena, L. Hol
Article
Biochemistry & Molecular Biology
Luis Enrique Olmedilla Arnal, Oscar Diaz Cambronero, Guido Mazzinari, Jose Maria Perez Pena, Jaime Zorrilla Ortuzar, Marcos Rodriguez Martin, Maria Vila J. Montanes, Marcus Schultz, Lucas Rovira, Maria Pilar Argente Navarro
Summary: High intra-abdominal pressure during laparoscopic surgery is associated with reduced splanchnic blood flow. This study found that an individualized low-pneumoperitoneum-pressure strategy may prevent a reduction in liver perfusion.
Article
Physiology
Thijs A. Lilien, David M. P. Van Meenen, Marcus J. Schultz, Lieuwe D. J. Bos, Reinout A. Bem
Summary: The interest in oxygen toxicity has led to numerous studies, but there is still no consensus on the clinical impact of hyperoxia and hyperoxemia. This article explores the importance of hyperoxia-induced lung injury in current critical care practice, suggesting that it may be less important than other ventilator-related factors in patients with acute respiratory distress syndrome.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2023)
Editorial Material
Critical Care Medicine
Pedro D. Wendel-Garcia, Lieuwe D. J. Bos
Article
Critical Care Medicine
Ignacio Martin-Loeches, Luis Felipe Reyes, Saad Nseir, Otavio Ranzani, Pedro Povoa, Emili Diaz, Marcus J. Schultz, Alejandro H. Rodriguez, Cristian C. Serrano-Mayorga, Gennaro De Pascale, Paolo Navalesi, Mauro Panigada, Luis Miguel Coelho, Szymon Skoczynski, Mariano Esperatti, Andrea Cortegiani, Stefano Aliberti, Anselmo Caricato, Helmut J. F. Salzer, Adrian Ceccato, Rok Civljak, Paolo Maurizio Soave, Charles-Edouard Luyt, Pervin Korkmaz Ekren, Fernando Rios, Joan Ramon Masclans, Judith Marin, Silvia Iglesias-Moles, Stefano Nava, Davide Chiumello, Lieuwe D. Bos, Antoni Artigas, Filipe Froes, David Grimaldi, Fabio Silvio Taccone, Massimo Antonelli, Antoni Torres
Summary: This study aimed to report the clinical characteristics, microbiology, and clinical outcomes of ICU-admitted patients with nosocomial lower respiratory tract infections (LRTI). The study found that patients with ventilator-associated hospital-acquired pneumonia (VHAP) had the highest mortality rates, and multidrug-resistant pathogens were frequently the cause of the nosocomial LRTI in this multinational cohort study.
INTENSIVE CARE MEDICINE
(2023)
Article
Critical Care Medicine
Rombout B. E. van Amstel, Jason N. Kennedy, Brendon P. Scicluna, Lieuwe D. J. Bos, Hessel Peters-Sengers, Joe M. Butler, Eddie Cano-Gamez, Julian C. Knight, Alexander P. J. Vlaar, Olaf L. Cremer, Derek C. Angus, Tom van der Poll, Christopher W. Seymour, Lonneke A. van Vught
Summary: Among critically ill patients with sepsis, subtype strategies using clinical, biomarker, and transcriptomic data do not identify comparable patient populations and are likely to reflect disparate clinical characteristics and underlying biology.
INTENSIVE CARE MEDICINE
(2023)
Article
Medicine, General & Internal
Liselotte J. Hol, Marcus Schultz, Ignacio Martin-Loeches, David M. P. van Meenen, Ary Serpa Neto, Frederique Paulus
Summary: The aim of this analysis was to compare ventilation management and outcomes in invasively ventilated patients with acute hypoxemic respiratory failure due to COVID-19 between the first and second wave in the Netherlands. The study found that patients in the second wave were sicker, had more comorbidities, and had worse oxygenation parameters. Changes in ventilation management were observed, such as lower positive end-expiratory pressure and higher fraction inspired oxygen. Duration of ventilation was shorter, but mortality rates were similar.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Athiwat Tripipitsiriwat, Orawan Suppapueng, David M. P. van Meenen, Frederique Paulus, Markus W. Hollmann, Chaisith Sivakorn, Marcus J. Schultz, PRoVENT COVID Investigators
Summary: This study found that patients with chronic obstructive pulmonary disease (COPD) have a higher mortality rate in COVID-19 and higher 28-day mortality compared to non-COPD patients. The ventilation management and the use of prone positioning differed slightly between COPD and non-COPD patients.
JOURNAL OF CLINICAL MEDICINE
(2023)