Journal
JOURNAL OF NANOMATERIALS
Volume 2015, Issue -, Pages -Publisher
HINDAWI LTD
DOI: 10.1155/2015/417389
Keywords
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Funding
- National Natural Science Foundation of China [51273033]
- Projects of Medical and Health Technology Development Program in Shandong Province [2011HZ005]
- Promotive Research Fund for Young and Middle-aged Scientists of Shandong Province [BS2014HZ007]
- Project of Shandong Province Higher Educational Science and Technology Program [J14LC56]
- Shandong Provincial Development Project of Science and Technology [2014GGX102037]
- Shandong Province Young and Middle-Aged Scientists Research Awards Fund [BS2011CL001]
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Novel method for synthesis of superparamagnetic iron oxide nanoparticles (SPIONs) coated with polyethylenimine (PEI) and modified with poly(ethylene glycol) methyl ether (MPEG), MPEG-PEI-SPIONs, was developed. PEI-SPIONs were successfully prepared in aqueous system via photochemistry, and their surface was modified with poly(ethylene glycol) methyl ether (MPEG). The so-obtained MPEG-PEI-SPIONs had a uniform hydrodynamic particle size of 34 nm. The successful coating of MPEG-PEI on the SPIONs was ascertained from FT-IR analysis, and the PEI and MPEG fractions in MPEG-PEI-SPIONs were calculated to account for 31% and 12%, respectively. Magnetic measurement revealed that the saturated magnetization of MPEG-PEI-SPIONs reached 46 emu/g and the nanoparticles showed the characteristic of being superparamagnetic. The stability experiment revealed that the MPEG-PEI modification improved the nanoparticles stability greatly. T2 relaxation measurements showed that MPEG-PEI-SPIONs show similar R2 value to the PEI-SPIONs. The T2-weighted magnetic resonance imaging (MRI) of MPEG-PEISPIONs showed that themagnetic resonance signal was enhanced significantly with increasing nanoparticle concentration in water. These results indicated that the MPEG-PEI-SPIONs had great potential for application in MRI.
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