Article
Nutrition & Dietetics
Ling-Jun Li, Ruochen Du, Marion Ouidir, Ruijin Lu, Zhen Chen, Natalie L. Weir, Michael Y. Tsai, Paul S. Albert, Cuilin Zhang
Summary: Saturated fatty acids (SFAs) during pregnancy have an impact on metabolic programming and fetal growth. In this study, plasma phospholipid SFAs were measured in early pregnancy and fetal growth was monitored. It was found that even-chain and very long even-chain SFAs were negatively associated, while odd-chain SFAs were positively associated with fetal weight and size. Pentadecanoic acid (15:0) in the highest tertile showed a greater fetal weight and size compared to the lowest tertile. These findings suggest the potential use of an alternative high-fat diet rich in odd-chain SFAs for optimal fetal growth.
Article
Cell Biology
Remi Karadayi, Charlotte Pallot, Stephanie Cabaret, Julie Mazzocco, Pierre-Henry Gabrielle, Denis S. Semama, Corinne Chantegret, Ninon Ternoy, Delphine Martin, Aurelie Donier, Stephane Gregoire, Catherine P. Creuzot-Garcher, Alain M. Bron, Lionel Bretillon, Olivier Berdeaux, Niyazi Acar
Summary: The study suggests that the accumulation of n-6 PUFAs and the decrease of n-3 PUFAs in the blood of preterm infants may be partly due to plasmalogens, which are associated with the development of retinopathy of prematurity.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Microbiology
Malavika Prithviraj, Takehiro Kado, Jacob A. Mayfield, David C. Young, Annie D. Huang, Daisuke Motooka, Shota Nakamura, M. Sloan Siegrist, D. Branch Moody, Yasu S. Morita
Summary: Tuberculostearic acid, an abundant and genus-specific fatty acid, has been extensively studied as a diagnostic marker for tuberculosis. The discovery of the Cfa gene and its role in the synthesis of tuberculostearic acid provides valuable insights into the mechanisms of mycobacterial membrane compartmentalization. These findings contribute to a better understanding of the survival mechanisms of tuberculosis bacteria.
Review
Oncology
Leqiang Zhang, Ning Chang, Jia Liu, Zhuojun Liu, Yajin Wu, Linlin Sui, Wei Chen
Summary: Lipid metabolism plays a significant role in hematological malignancies, and dysregulated lipid metabolism can affect tumor growth, migration, and drug resistance. Targeting lipid metabolism pathways can be an effective therapeutic approach in the treatment of these malignancies.
FRONTIERS IN ONCOLOGY
(2022)
Article
Nutrition & Dietetics
Qixin Wu, Dandan Shi, Ting Dong, Zhuolin Zhang, Qingjian Ou, Yujing Fang, Caixia Zhang
Summary: This study investigated the association between circulating saturated fatty acids (SFAs) including very long-chain SFAs (VLCSFAs) and the risk of colorectal cancer (CRC). The results showed that higher levels of total SFAs were associated with an increased risk of CRC, while higher levels of VLCSFAs were associated with a decreased risk of CRC. Specifically, certain types of SFAs like lauric acid, myristic acid, palmitic acid, heptadecanoic acid, and arachidic acid were positively associated with CRC risk.
Article
Clinical Neurology
Ting Liu, Lu Wang, Jimin Guo, Tingyu Zhao, Hui Tang, Fang Dong, Chuanyue Wang, Jindong Chen, Mimi Tang
Summary: The levels of erythrocyte membrane fatty acids were found to be elevated in patients with severe depression and anxiety. These findings suggest that erythrocyte membrane fatty acid levels could serve as biological indicators for the severity of depressive symptoms and anxiety.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2023)
Review
Food Science & Technology
Ibrahim A. Bakry, Lan Yang, Mohamed A. Farag, Sameh A. Korma, Ibrahim Khalifa, Ilaria Cacciotti, Noha Ziedan, Jun Jin, Qingzhe Jin, Wei Wei, Xingguo Wang
Summary: Camel milk is gaining attention for its health-promoting properties and unique nutritional composition, making it a suitable alternative for individuals allergic to cow's milk. Future studies are expected to focus on a better understanding of camel milk fat, potentially leading to the development of new products with significant health benefits.
Article
Nutrition & Dietetics
Matina Kouvari, Evangelia Damigou, Matilda Florentin, Rena Kosti, Christina Chrysohoou, Christos S. Pitsavos, Demosthenes B. Panagiotakos
Summary: This study aimed to explore the association between egg intake and 10-year risk of cardiovascular disease (CVD) and other cardiometabolic risk factors. The findings showed that moderate egg consumption was associated with a lower risk of CVD, but this association became non-significant when adjusted for total saturated fatty acid intake.
Article
Nutrition & Dietetics
Kristina Pigsborg, Goezde Guerdeniz, Oscar Daniel Rangel-Huerta, Kirsten B. Holven, Lars Ove Dragsted, Stine M. Ulven
Summary: This study aimed to investigate the changes in serum metabolome after replacing SFA with PUFA and explore the association between dietary metabolites and cardiometabolic risk markers.
EUROPEAN JOURNAL OF NUTRITION
(2022)
Article
Oncology
Xiaoying Wang, Bingqian Sun, Lengyun Wei, Xiao Jian, Kai Shan, Qingwen He, Fengjiao Huang, Xiaosong Ge, Xiang Gao, Ninghan Feng, Yong Q. Chen
Summary: This study found that prostate cancer patients have significantly higher levels of lipoproteins, apolipoproteins, triglycerides, and free fatty acids in their blood. Furthermore, the expression of certain genes related to fatty acid metabolism and cholesterol synthesis is also higher in prostate cancer tissues and positively correlated with the severity of cancer. Mouse models showed that overexpression of fatty acid synthase and knockout of cholesterol efflux pump resulted in the progression of prostate cancer, accompanied by an increase in cancer stem cells and activation of specific signaling pathways. These findings suggest that the combination of fatty acid and cholesterol may contribute to the rising incidence of prostate cancer, and reducing fat and cholesterol intake could slow down disease progression.
Article
Food Science & Technology
Mingyu Yin, Ryosuke Matsuoka, Yinci Xi, Xichang Wang
Summary: The study found that phospholipids derived from egg yolk and soya bean exhibited significant antioxidant and lipid-lowering abilities in a high-fat-and-sucrose diet model, reducing liver burden and improving blood lipid and inflammation markers, with egg yolk phospholipids showing more effective therapeutic benefits.
Article
Nutrition & Dietetics
Zhi Huang, Xing Liu, Ziming Li, Luwei Cui, Candi Liu, Weifeng Wang, Yuming Hu, Bo Chen
Summary: This study found direct correlations between mineral elements (Cu, Zn, and Mg) in whole blood and fatty acid levels in erythrocytes of Chinese children. The interactions between Mg, Cu, and Zn with fatty acids may affect fatty acid metabolism.
Article
Agriculture, Multidisciplinary
Yi Wang, Jinqiu Wang, Hanmei Li, Yu Xiao, Putri Widyanti Harlina, Fang Geng
Summary: The accumulation of lipids in egg yolk during its formation was studied by researchers in both food science and animal science. Results showed significant differences in fatty acid profiles and lipidomes at different stages of egg yolk formation. Transport and accumulation of lipids in egg yolk are dynamically adjusted, with different lipid molecular species having different timing and transport mechanisms.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)
Article
Geriatrics & Gerontology
Permal Deo, Varinderpal S. Dhillon, Philip Thomas, Michael Fenech
Summary: The study found a negative association between saturated fatty acids and a blood biomarker of AGE, while unsaturated fatty acids showed a positive association with it. However, these associations weakened after adjusting for age, BMI, and gender.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Article
Neurosciences
Yan Liu, Han Xu, Naima Dahir, Ashley Calder, Fangjun Lin, Timothy A. Gilbertson
Summary: Recent studies have identified a new receptor, GPR84, in the gustatory system that responds to medium-chain saturated fatty acids (MCFAs) in male mice. Activation of GPR84 by MCFAs leads to depolarization and an increase in intracellular free calcium in taste cells. Knockout mouse models lacking GPR84 show specific deficits in neural and behavioral responses to oral MCFAs compared to wild-type mice.
JOURNAL OF NEUROSCIENCE
(2021)