Review
Cell Biology
Ravi K. Adapala, Venkatesh Katari, Lakshminarayan Reddy Teegala, Sathwika Thodeti, Sailaja Paruchuri, Charles K. Thodeti
Summary: The review discusses the mechanism of fibrosis and proposes TRPV4 as a potential therapeutic target for the condition, highlighting the need for specific drugs in the treatment of fibrosis.
Review
Medicine, Research & Experimental
Shigeki Saito, Brian Deskin, Mohammad Rehan, Santosh Yadav, Yasuka Matsunaga, Joseph A. Lasky, Victor J. Thannickal
Summary: Lung fibrosis can occur in various settings, and the most common form is idiopathic pulmonary fibrosis, which is strongly associated with aging. Recent studies suggest that targeting certain components of aging biology may be effective in mitigating age-related fibrosis. This review explores molecular targets that may be relatively more selective in mediating tissue fibrosis, as well as epigenetic mechanisms and metabolic pathways that regulate aging and fibrosis.
Article
Cell Biology
Xia Guo, Oluwaseun Adeyanju, Christudas Sunil, Venkatakirankumar Mandlem, Ayobami Olajuyin, Steven Huang, Shi-You Chen, Steven Idell, Torry A. Tucker, Guoqing Qian
Summary: DOCK2 plays a crucial role in pulmonary fibrosis by modulating FMT, with its upregulation dependent on TGF-beta induction and Smad3, ERK pathways, and contributing to the changes in lung fibroblast phenotypes.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Cell Biology
Maike Kuemper, Jan Zamek, Joy Steinkamp, Elke Pach, Cornelia Mauch, Paola Zigrino
Summary: Simultaneous deletion of MMP3 and MMP14 delays wound closure during skin repair and modulates myofibroblast formation and resolution in wounds.
EUROPEAN JOURNAL OF CELL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Isabella Lurje, Nadine T. Gaisa, Ralf Weiskirchen, Frank Tacke
Summary: Fibrosis, a pathological scar tissue formation, can occur in various organs due to different etiologies and contributes to global morbidity and mortality. Common mechanisms involve sustained injury to parenchymal cells triggering a deregulated wound healing response. The transformation of fibroblasts into myofibroblasts with excessive extracellular matrix production is a hallmark of the disease, along with complex cellular interactions involving immune cells, endothelial cells, and parenchymal cells. Mediators such as growth factors, cytokines, and danger-associated molecular patterns play important roles in fibrosis across organs.
MOLECULAR ASPECTS OF MEDICINE
(2023)
Article
Medicine, Research & Experimental
Shih-Yi Lee, Yueh-Hsiung Kuo, Chen-Xuan Du, Cheng-Wei Huang, Hui-Chun Ku
Summary: Differentiation of cardiac fibroblasts into myofibroblasts is a critical event in the progression of cardiac fibrosis. The study investigated the effect of caffeic acid ethanolamide (CAEA) on cardiac remodeling induced by Angiotensin (Ang) II. CAEA inhibited fibroblast differentiation, protected against cardiac fibrosis and dysfunction, and regulated the TGF-beta/SMAD/NOX4 signaling pathway. The study supports CAEA administration as a viable method to prevent Ang II-induced cardiac remodeling.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Pharmacology & Pharmacy
Jian Sun, Tongzhu Jin, Zhihui Niu, Jiayu Guo, Yingying Guo, Ruoxuan Yang, Qianqian Wang, Huiying Gao, Yuhan Zhang, Tianyu Li, Wenxin He, Zhixin Li, Wenchao Ma, Wei Su, Liangliang Li, Xingxing Fan, Hongli Shan, Haihai Liang
Summary: This study found that lncRNA DACH1 is downregulated in patients with pulmonary fibrosis and in a mouse model of the disease. LncDACH1 inhibits lung fibrosis by interacting with SRSF1 to suppress CTNNB1 accumulation.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Medicine, Research & Experimental
Yong Mou, Juan Liu, Ting Pan, Qi Wang, Kang Miao, Yongjian Xu, Weining Xiong, Jun Yu
Summary: DA receptor agonists showed potential antifibrotic effects in IPF patients and mouse models by attenuating fibroblast differentiation and proliferation, protecting mice from pulmonary fibrosis induced by BLM.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Pharmacology & Pharmacy
David Dolivo, Pamela Weathers, Tanja Dominko
Summary: Fibrosis is a pathological reparative process in most organs, and artemisinin compounds demonstrate anti-fibrotic effects which can be used for treating fibrotic diseases.
ACTA PHARMACEUTICA SINICA B
(2021)
Review
Pathology
Margaret A. T. Freeberg, Apostolos Perelas, Jane K. Rebman, Richard P. Phipps, Thomas H. Thatcher, Patricia J. Sime
Summary: Idiopathic pulmonary fibrosis is a progressive disease characterized by accumulation of extracellular matrix in lung tissue, leading to altered mechanical properties. Recent studies suggest that these changes create a feed-forward loop, contributing to fibroblast differentiation and activation. Mechanotransduction pathways, including mechanosensors like integrins and downstream transcription factors, play a role in fibrosis progression.
AMERICAN JOURNAL OF PATHOLOGY
(2021)
Review
Cell Biology
Laxmansa C. Katwa, Chelsea Mendoza, Madison Clements
Summary: Cardiovascular disease is the leading cause of death worldwide, and patients with cardiovascular diseases are more susceptible to severe complications of COVID-19. The role of cardiac myofibroblasts in both COVID-19-induced cardiac injury and healing process is crucial.
Article
Pharmacology & Pharmacy
Eigo Ikushima, Shin Ishikane, Takehiro Kishigami, Hiroaki Matsunaga, Kazunobu Igawa, Katsuhiko Tomooka, Yosuke Nishimura, Fumi Takahashi-Yanaga
Summary: 2,5-dimethylcelecoxib (DM-C) attenuates fibroblast-to-myofibroblast transformation (FMT) and decreases cardiac fibrosis by inhibiting the TGF-beta signaling pathway through activation of GSK-3.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Min Kyung Kim, Jong-Uk Lee, Sun Ju Lee, Hun Soo Chang, Jong-Sook Park, Choon-Sik Park
Summary: Genetic and epigenetic factors have been identified in the development and prognosis of idiopathic pulmonary fibrosis (IPF). In this study, the role of erythrocyte membrane protein band 4.1-like 3 (EPB41L3) was investigated in IPF. It was found that EPB41L3 expression was significantly increased in lung fibroblasts from IPF patients compared to controls. The upregulation of EPB41L3 was also observed during epithelial-mesenchymal transition (EMT) and fibroblast-to-myofibroblast transition (FMT).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell & Tissue Engineering
Jiranuwat Sapudom, Shaza Karaman, Walaa K. E. Mohamed, Anna Garcia-Sabate, Brian C. Quartey, Jeremy C. M. Teo
Summary: Distinct anti-inflammatory macrophage (M2) subtypes M2a and M2c play exact roles in tissue repair, with MIL-4/IL-13 promoting matrix synthesis through myofibroblast differentiation and MIL-10 resolving the repair process by dedifferentiation of myofibroblasts. This biomimetic model has potential for applications in tissue healing, anti-fibrotic drug testing, and other biomedical studies.
NPJ REGENERATIVE MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Su Woong Jung, Su-Mi Kim, Arum Kim, Seon Hwa Park, Ju-Young Moon, Sang-Ho Lee
Summary: The midbody plays a crucial role in the transition of fibroblasts into myofibroblasts by mediating TGF-beta/Smad signaling. The pathway related to microtubules is implicated in kidney fibrosis, and blocking microtubule dynamics can improve kidney fibrosis.
Review
Pathology
Richard S. Nho, Megan N. Ballinger, Mauricio M. Rojas, Samir N. Ghadiali, Jeffrey C. Horowitz
Summary: Lung fibrosis is characterized by the accumulation of ECM proteins by apoptosis-resistant fibroblasts. Lung epithelial injury leads to fibroblast recruitment and activation, which are necessary for tissue repair. However, under pathological conditions, a vicious cycle of profibrotic factors and cell-matrix signaling promotes the development of lung fibrosis characterized by increased ECM proteins and changes in matrix properties. Understanding the role of ECM in fibrosis can lead to new therapeutic targets and improved outcomes.
AMERICAN JOURNAL OF PATHOLOGY
(2022)
Article
Medicine, Research & Experimental
Sonal R. Pannu, Tyler Haddad, Matthew Exline, John W. Christman, Jeffrey C. Horowitz, Jonathan Peters, Guy Brock, Philip Diaz, Elliott D. Crouser
Summary: This study aims to improve targeted oxygenation in mechanically ventilated patients by reducing excessive FiO(2) exposure. The use of algorithm-based FiO(2) titration and electronic alert system aims to curb hyperoxemia and prevent hypoxemia by shortening the time spent with high FiO(2) levels.
CONTEMPORARY CLINICAL TRIALS
(2022)
Article
Critical Care Medicine
Dania A. Shakaroun, Michael H. Lazar, Jeffrey C. Horowitz, Jeffrey H. Jennings
Summary: Elevated ferritin levels are associated with poor outcomes in Covid-19 patients. Initial ferritin levels are highly predictive of ICU admission, the need for mechanical ventilation, and in-hospital mortality. However, longitudinal measures of ferritin throughout the hospital stay do not provide additional predictive value.
JOURNAL OF INTENSIVE CARE MEDICINE
(2022)
Editorial Material
Critical Care Medicine
Sydney B. Montesi, Jeffrey C. Horowitz
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Editorial Material
Respiratory System
Laszlo Farkas, Jeffrey C. Horowitz, Ana L. Mora
EUROPEAN RESPIRATORY JOURNAL
(2022)
Article
Immunology
Anasuya Sarkar, Srabani Das, Hannah Bone, Ivana DeVengencie, Jayendra Prasad, Daniela Farkas, James D. Londino, Richard S. Nho, Mauricio Rojas, Jeffrey C. Horowitz
Summary: Fibrosis is characterized by persistent accumulation of myofibroblasts and excessive extracellular matrix deposition. This study shows that active GsdmD delivered by monocyte-derived extracellular vesicles induces caspase-independent death in fibroblasts and myofibroblasts.
JOURNAL OF IMMUNOLOGY
(2023)
Review
Cell Biology
Yohannes A. Mebratu, Sourabh Soni, Lorena Rosas, Mauricio Rojas, Jeffrey C. Horowitz, Richard Nho
Summary: IPF is a fatal lung disease primarily found in the elderly population, and aging is the major risk factor. Age-related changes in ECM and accumulation of senescent cells with SASP factors contribute to lung fibrosis. The understanding of how aging affects ECM dynamics, turnover, and the development of lung fibrosis is crucial in the context of increasing life expectancy worldwide.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Article
Physiology
Richard S. Nho, Cami Rice, Jayendra Prasad, Hannah Bone, Laszlo Farkas, Mauricio Rojas, Jeffrey C. Horowitz
Summary: Hypoxia promotes increased lactate generation in fibrotic fibroblasts, potentially contributing to lung fibrosis.
PHYSIOLOGICAL REPORTS
(2023)
Review
Medicine, Research & Experimental
Matthew E. Long, Rama K. Mallampalli, Jeffrey C. Horowitz
Summary: Pneumonia and acute lung injury present challenges for healthcare professionals, and understanding their pathogenesis can help improve clinical interventions.
Meeting Abstract
Critical Care Medicine
A. Sarkar, S. Das, I. DeVengencie, H. Bone, J. Prasad, J. C. Horowitz
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Meeting Abstract
Critical Care Medicine
D. Shakaroun, J. C. Horowitz, M. H. Lazar, J. Jennings
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Meeting Abstract
Critical Care Medicine
R. Nho, K. Glenn, H. Bone, J. Prasad, J. C. Horowitz
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Hrishikesh S. Kulkarni, Janet S. Lee, Julie A. Bastarache, Wolfgang M. Kuebler, Gregory P. Downey, Guillermo M. Albaiceta, William A. Altemeier, Antonio Artigas, Jason H. T. Bates, Carolyn S. Calfee, Charles S. Dela Cruz, Robert P. Dickson, Joshua A. Englert, Jeffrey Everitt, Michael B. Fessler, Andrew E. Gelman, Kymberly M. Gowdy, Steve D. Groshong, Susanne Herold, Robert J. Homer, Jeffrey C. Horowitz, Connie C. W. Hsia, Kiyoyasu Kurahashi, Victor E. Laubach, Mark R. Looney, Rudolf Lucas, Nilam S. Mangalmurti, Anne M. Manicone, Thomas R. Martin, Sadis Matalon, Michael A. Matthay, Daniel F. McAuley, Sharon A. McGrath-Morrow, Joseph P. Mizgerd, Stephanie A. Montgomery, Bethany B. Moore, Alexandra Noel, Carrie E. Perlman, John P. Reilly, Eric P. Schmidt, Shawn J. Skerrett, Tomeka L. Suber, Charlotte Summers, Benjamin T. Suratt, Masao Takata, Rubin Tuder, Stefan Uhlig, Martin Witzenrath, Rachel L. Zemans, Gutavo Matute-Bello
Summary: Advancements in methods and technology have led to the need for an updated definition of experimental acute lung injury (ALI). Through surveys and workshops, researchers propose that ALI presents as a multidimensional entity characterized by four domains: tissue injury, alteration of the alveolar-capillary barrier, inflammatory response, and physiologic dysfunction. They suggest measurements for each domain and divide experimental ALI into a continuum of models.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2022)
Meeting Abstract
Critical Care Medicine
J. C. Horowitz, I. DeVengencie, J. Prasad
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Respiratory System
Christopher Bob Lewis, Matthew Kevin Hensley, Julie Elizabeth Barrett, Steven Burke Van Norman, Alexander Stuart Taylor, Jeffrey Craig Horowitz
RESPIROLOGY CASE REPORTS
(2019)