Review
Biotechnology & Applied Microbiology
Janne Verreycken, Paulien Baeten, Bieke Broux
Summary: Multiple sclerosis (MS) is an autoimmune disorder characterized by demyelination and neurodegeneration in the central nervous system. Regulatory T cells (Tregs), which have the ability to suppress immune reactions and regenerate, may have therapeutic potential for MS. However, Tregs in people with MS are functionally impaired. To exert their anti-inflammatory and regenerative effects in the brain, Tregs must first migrate across the blood-brain barrier (BBB).
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2023)
Article
Clinical Neurology
Casper L. de Mol, Kirsten I. M. Looman, Marvin M. van Luijn, Karim L. Kreft, Philip R. Jansen, Menno C. van Zelm, Joost J. F. M. Smolders, Tonya J. H. White, Henriette A. Moll, Rinze F. Neuteboom
Summary: This study found that genetic risk variants for multiple sclerosis affect T cell composition in children from the general population, with specific risk variants negatively correlating with CD8(+) T cell frequencies and positively associating with CD4(+)/CD8(+) T cell ratios.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Valentina Rubino, Anna Teresa Palatucci, Giuliana La Rosa, Angela Giovazzino, Francesco Aruta, Simona Damiano, Flavia Carriero, Mariarosaria Santillo, Rosa Iodice, Paolo Mondola, Giuseppina Ruggiero, Giuseppe Terrazzano
Summary: Reactive oxygen species (ROS) play a role in T-cell activation, with SOD-1 production and secretion influenced by antigen-dependent activation. In patients with MS, SOD-1 levels are associated with T cell function and regulatory T cell populations, impacting cytokine secretion.
Article
Medicine, Research & Experimental
Hong Ki Min, Sehee Kim, Ji-Yeon Lee, Kyoung-Woon Kim, Sang-Heon Lee, Hae-Rim Kim
Summary: Patients with rheumatoid arthritis (RA) have higher levels of interleukin-18 (IL-18) and lower levels of IL-18 binding protein (IL-18BP) in their serum and synovial fluid compared to those with osteoarthritis (OA) or healthy controls. In vitro studies show that IL-18BP can correct the Th17/Treg imbalance in CD4(+) T cells of RA patients and reduce IL-17-induced osteoclastogenesis, suggesting therapeutic potential for RA treatment.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Review
Immunology
Jaehwan Kim, Ariana Moreno, James G. G. Krueger
Summary: Psoriasis vulgaris is a common inflammatory disease affecting 7.5 million adults in the US, with immunopathogenesis paradigms rapidly evolving due to advancements in technology. Single-cell RNA sequencing technology is now being applied to clinical trials of biologics to test the expansion of regulatory immune cell subsets involved in skin homeostasis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Clinical Neurology
Matthew T. Patrick, Rajan P. Nair, Kevin He, Philip E. Stuart, Allison C. Billi, Xiang Zhou, Johann E. Gudjonsson, Jorge R. Oksenberg, James T. Elder, Lam C. Tsoi
Summary: By using epidemiology and genetics, we have comprehensively studied the relationship between psoriasis and multiple sclerosis (MS). We found that psoriatic patients have a significantly higher risk of developing MS. Through genetic analysis, we identified shared genetic loci and pathways related to immune functions. Furthermore, we found that psoriasis has a causal effect on MS, independent of other risk factors.
ANNALS OF NEUROLOGY
(2023)
Article
Immunology
Jennifer Massey, Katherine Jackson, Mandeep Singh, Brendan Hughes, Barbara Withers, Carole Ford, Melissa Khoo, Kevin Hendrawan, John Zaunders, Benedicte Charmeteau-De Muylder, Remi Cheynier, Fabio Luciani, David Ma, John Moore, Ian Sutton
Summary: This study investigates T cell reconstitution in highly active MS patients for 36 months after AHSCT. The results show that AHSCT induces significant changes in the dominant T cell clones of CD4+ and CD8+ memory T cells. After lymphopenia-induced homeostatic proliferation, clonal attrition occurs. Recovery of thymically-derived CD4 naive T cell repertoire begins at 12 months and continues, but the diversity of the naive populations does not increase compared to baseline, indicating that the principal mechanism for durable remission from MS after AHSCT relates to depletion of putative auto-reactive clones.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Mona Tarighi, Mehdi Shahbazi, Payam Saadat, Abdolreza Daraei, Ali Alizadeh Khatir, Kimiya Rahimifard, Mousa Mohammadnia-Afrouzi
Summary: This study examined the frequency and gene expression levels of regulatory T cells (Tregs) in secondary progressive multiple sclerosis (SPMS) patients. The results showed that the percentage of Tregs with CD4 and CD25 markers did not differ significantly compared to healthy controls, but the lymphocytes with CD4/CD25/FOXP3/Helios markers were significantly reduced in SPMS patients. The expression of the Helios gene was also decreased in these patients. These findings suggest that a deficiency in Tregs may be involved in the immunological mechanisms of SPMS.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Marlos Aureliano Dias de Sousa, Chamberttan Souza Desiderio, Jonatas da Silva Catarino, Rafael Obata Trevisan, Djalma Alexandre Alves da Silva, Vinicius Ferreira Resende Rocha, Weslley Guimaraes Bovi, Rodolfo Pessato Timoteo, Renata Cristina Franzon Bonatti, Alex Eduardo da Silva, Alfredo Leboreiro Fernandez, Helioswilton Sales-Campos, Virmondes Rodrigues Junior, Marcos Vinicius da Silva, Carlo Jose Freire de Oliveira
Summary: The immune response in multiple sclerosis involves CD4(+) T cells that produce cytokines and chemokines. Changes in certain cytokines and chemokines, along with the presence of double positive lymphocytes, can help better understand the clinical forms and progression of the disease.
Article
Biochemistry & Molecular Biology
Alberto Lozano-Ros, Maria L. Martinez-Gines, Jose M. Garcia-Dominguez, Sara Salvador-Martin, Haydee Goicochea-Briceno, Juan P. Cuello, Ariana Meldana-Rivera, Yolanda Higueras-Hernandez, Maria Sanjurjo-Saez, Luis A. Alvarez-Sala-Walther, Luis A. Lopez-Fernandez
Summary: Vitamin D plays a significant role in regulating multiple sclerosis. This study analyzed the regulatory effect of vitamin D on the TGF-beta signaling pathway in patients with relapsing-remitting multiple sclerosis. The results showed that the regulation of TGF-beta pathway genes by vitamin D is indirect.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Nicole Kashani, Eve E. Kelland, Borna Vajdi, Lauren M. Anderson, Wendy Gilmore, Brett T. Lund
Summary: This study revealed that patients treated with alemtuzumab for multiple sclerosis showed an increase in the number and function of regulatory B cells after treatment, which were positively correlated with regulatory T cells. Additionally, an anti-inflammatory bias in monocytes was observed after the second annual course of treatment. These findings highlight the importance of further studies on all regulatory cell types following alemtuzumab treatment to understand the mechanisms of drug action and identify key predictors of durable clinical efficacy.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Samira Ghorbani, Emily Jelinek, Rajiv Jain, Benjamin Buehner, Cenxiao Li, Brian M. Lozinski, Susobhan Sarkar, Deepak K. Kaushik, Yifei Dong, Thomas N. Wight, Soheila Karimi-Abdolrezaee, Geert J. Schenk, Eva M. Strijbis, Jeroen Geurts, Ping Zhang, Chang-Chun Ling, V. Wee Yong
Summary: Ghorbani and colleagues have found that versican-V1 acts as an inhibitor of oligodendrocyte regeneration by directly inhibiting oligodendrocytes and promoting the production of Th17 cells. In experimental models of multiple sclerosis, versican-V1 is selectively upregulated among other chondroitin sulfate proteoglycans (CSPGs). The study suggests that reducing CSPG levels could be a potential therapeutic approach for promoting repair and modulating the immune response in multiple sclerosis.
NATURE COMMUNICATIONS
(2022)
Review
Immunology
Junxia Huang, Xinzhi Xu, Ji Yang
Summary: Th17 cells play a crucial role in the immune response against bacterial and fungal infections, but excessive IL-17 production can lead to immunopathology and inflammatory autoimmune diseases. Understanding the regulation of Th17 cells by miRNAs has enhanced our knowledge of their function in immune response and disease, including recent advances in miRNA-mediated dysregulation of Th17 cell fate in autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Nutrition & Dietetics
Julie Langlois, Damien Denimal
Summary: This systematic review examined the effects of vitamin D supplementation on clinical and imaging outcomes in patients with multiple sclerosis (MS). The results showed no significant impact of vitamin D supplementation on relapse events, disability progression, and magnetic resonance imaging (MRI) lesions. However, recent studies found a significant reduction in new MRI lesions in the central nervous system of MS patients during supplementation with vitamin D3.
Article
Clinical Neurology
Quentin Howlett-Prieto, Xuan Feng, John F. Kramer, Kevin J. Kramer, Timothy W. Houston, Anthony T. Reder
Summary: Long-term treatment with ocrelizumab significantly increases the levels of CD8(+) CD28(-) regulatory T cells and corrects the deficiencies seen in MS patients before treatment, while causing slight decreases in CD4(+) FOXP3+ regulatory T cells. The homeostatic enrichment of CD8 T regulatory cells provides a mechanism, in addition to B cell depletion, for the therapeutic benefits of anti-CD20 treatment in MS.
MULTIPLE SCLEROSIS JOURNAL
(2021)
Article
Oncology
Somayeh Asbaghi, Ahmad Saedisomeolia, Mostafa Hosseini, Niyaz Mohammadzadeh Honarvar, Adnan Khosravi, Eznollah Azargashb
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
(2015)
Article
Biochemistry & Molecular Biology
Niyaz Mohammadzadeh Honarvar, Mohammad Hossein Harirchian, Mina Abdolahi, Elahe Abedi, Sama Bitarafan, Fariba Koohdani, Feridoun Siassi, Mohammad Ali Sahraian, Reza Chahardoli, Mahnaz Zareei, Eisa Salehi, Maziyar Geranmehr, Ali Akbar Saboor-Yaraghi
JOURNAL OF MOLECULAR NEUROSCIENCE
(2016)
Article
Biochemistry & Molecular Biology
Ahmad Reza Dorosty-Motlagh, Niyaz Mohammadzadeh Honarvar, Mohsen Sedighiyan, Mina Abdolahi
JOURNAL OF MOLECULAR NEUROSCIENCE
(2016)
Review
Biochemistry & Molecular Biology
Niyaz Mohammadzadeh Honarvar, Ahmad Saedisomeolia, Mina Abdolahi, Amir Shayeganrad, Gholamreza Taheri Sangsari, Babak Hassanzadeh Rad, Gerald Muench
JOURNAL OF MOLECULAR NEUROSCIENCE
(2017)
Article
Nutrition & Dietetics
H. Mohammadi, M. Djalali, M. Daneshpazhooh, N. M. Honarvar, C. Chams-Davatchi, F. Sepandar, Z. Fakhri, E. Yaghubi, M. Zarei, M. H. Javanbakht
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2018)
Review
Clinical Neurology
Mohammad Hossein Harirchian, Farzad Fatehi, Payam Sarraf, Niyaz Mohammadzadeh Honarvar, Sama Bitarafan
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2018)
Article
Biochemistry & Molecular Biology
Sama Bitarafan, Mohammad Hossein Harirchian, Mohammad Ali Sahraian, Mohammad Keramatipour, Nahid Beladi Moghadam, Mansoureh Togha, Shahriar Nafissi, Fereydoun Siassi, Mohammad Reza Eshraghian, Niyaz Mohammadzadeh Honarvar, Hasti Ansar, Saeed Talebi, Ali Akbar Saboor-Yarghi
JOURNAL OF MOLECULAR NEUROSCIENCE
(2013)
Article
Biochemistry & Molecular Biology
Niyaz Mohammadzadeh Honarvar, Mohammad Hossein Harirchian, Fariba Koohdani, Feridoun Siassi, Mina Abdolahi, Sama Bitarafan, Eisa Salehi, Mohammad Ali Sahraian, Mohammad Reza Eshraghian, Ali Akbar Saboor-Yarghi
JOURNAL OF MOLECULAR NEUROSCIENCE
(2013)
Article
Endocrinology & Metabolism
Motahareh Makhdoomi Arzati, Niyaz Mohammadzadeh Honarvar, Ahmad Saedisomeolia, Siyamand Anvari, Mohammad Effatpanah, Raoofe Makhdoomi Arzati, Mir Saeed Yekaninejad, Rezvan Hashemi, Mahmoud Djalali
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM
(2017)
Article
Endocrinology & Metabolism
Samaneh Ansari, Mahmoud Djalali, Niyaz Mohammadzadeh Honarvar, Maryam Mazaherioun, Mahnaz Zarei, Fahimeh Agh, Zahra Gholampour, Mohammad Hassan Javanbakht
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM
(2017)