Article
Biochemistry & Molecular Biology
Balazs Sonkodi, Laszlo Marsovszky, Anita Csorba, Attila Balog, Bence Kopper, Zoltan Zsolt Nagy, Miklos D. Resch
Summary: The objective of this study was to analyze the neural regeneration activity in the cornea of systemic lupus erythematosus patients with dry eye disease. The study found that corneal nerve fiber density and peripheral Langerhans cell morphology were lower in lupus patients compared to the control group. The results also showed a negative correlation between corneal nerve measurements and disease duration, as well as between corneal nerve density and Langerhans cell density.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Rheumatology
Hilde Julie T. Lien, Tina T. Pedersen, Bente Jakobsen, Arnar Flatberg, Konika Chawla, Pal Saetrom, Mona H. Fenstad
Summary: The study compared cellular composition and peripheral blood gene expression in Rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and healthy pregnancies. The results showed distinct RA, SLE, and pregnancy signatures that were not attributed to medication or disease activity. The study supports the need for close postpartum follow-up of patients with SLE and highlights the importance of cell-type adjustment in gene expression analysis.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Medicine, Research & Experimental
Vera Kim, Kyungwoo Lee, Hong Tian, Su Hwa Jang, Betty Diamond, Sun Jung Kim
Summary: This study found that there is an increase in the number of follicular helper T cells (Tfh cells) in lupus-prone mice, and these cells play a role in promoting the differentiation of antibody-secreting cells (ASCs). The increased ASC differentiation is mainly due to the elevated expression of molecules in the IL-23/IL-17 pathway in Tfh cells. IL-17A and IL-21 are the key cytokines secreted by Tfh cells, and neutralizing them can reduce ASC differentiation. Additionally, the lack of BLIMP-1 expression in dendritic cells (DCs) leads to an increased number of Tfh cells and functionally distinct Tfh cells, contributing to the increased ASC differentiation.
Article
Immunology
Junxia Huang, Xinzhi Xu, Xiuyuan Wang, Jie Yang, Meijuan Xue, Yiming Yang, Ruomei Zhang, Xue Yang, Ji Yang
Summary: Inhibition of T helper 17 cells through upregulation of miR-590-3p reduces inflammation in autoimmune diseases like SLE. Our study shows that miR-590-3p promotes apoptosis in Th17 cells by inhibiting autophagy, offering a promising therapeutic strategy for SLE.
Article
Immunology
Akram Hoseinzadeh, Zahra Rezaieyazdi, Mahmoud Mahmoudi, Jalil Tavakol Afshari, Fahimeh Lavi Arab, Seyed-Alireza Esmaeili, Arezoo Faridzadeh, Amin Rezaeian, Sara Hoseini, Mehdi Barati, Ali Mahmoudi, Nafiseh Sadat Tabasi
Summary: This study investigated the potential of MSCs in the treatment of refractory SLE. The results showed that MSCs can reduce inflammation, modulate immune function, and repair damaged tissues. Animal experiments demonstrated that MSCs transplantation can decrease proteinuria and anti-dsDNA antibody levels, reduce serum creatinine levels, and attenuate lupus renal pathology.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Immunology
Mingxuan Chi, Kuai Ma, Yunlong Li, Min Quan, Zhongyu Han, Zhaolun Ding, Xin Liang, Qinxiu Zhang, Linjiang Song, Chi Liu
Summary: Systemic lupus erythematosus (SLE) is a typical autoimmune disease characterized by multiple immunoregulatory abnormalities that lead to damage to various tissues and organs. Researchers have identified aberrant expression of miRNAs in SLE patients, which may be associated with abnormal immune responses and disease progression in SLE.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Marcio Luis Acencio, Marek Ostaszewski, Alexander Mazein, Philip Rosenstiel, Konrad Aden, Neha Mishra, Vibeke Andersen, Prodromos Sidiropoulos, Aggelos Banos, Anastasia Filia, Souad Rahmouni, Axel Finckh, Wei Gu, Reinhard Schneider, Venkata Satagopam
Summary: Chronic inflammatory diseases involve complex molecular mechanisms and pose challenges for effective treatments. Using a systemic network model can help understand the interaction of key pathways. The SYSCID map is an interactive causal interaction network that aids in understanding the molecular mechanisms of inflammatory bowel disease, rheumatoid arthritis, and systemic lupus erythematosus, as well as the complexity of omics data.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Patricia Richter, Luana Andreea Macovei, Ioana Ruxandra Mihai, Anca Cardoneanu, Maria Alexandra Burlui, Elena Rezus
Summary: Systemic lupus erythematosus (SLE) is a complex autoimmune disorder in which cytokines, such as TNF-alpha and IL-17, play crucial roles. The modulation of these cytokines may impact disease progression and serve as potential biomarkers. Elevated levels of TNF-alpha and IL-17 are associated with high disease activity in SLE patients, although their inhibition as a treatment option is still under discussion. Further studies are needed to explore the therapeutic potential of targeting these cytokines in SLE.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Naeun Yoon, Ah-Kyung Jang, Yerim Seo, Byung Hwa Jung
Summary: This paper outlines recent advances in metabolomics research of autoimmune diseases such as rheumatoid arthritis, multiple sclerosis, and systemic lupus erythematosus, describing newly discovered biomarkers and metabolic mechanism studies for these diseases. It also presents studies elucidating the metabolic mechanisms underlying these diseases and summarizes biomarker studies aimed at predicting personalized medicine and drug response.
Review
Medicine, General & Internal
Grant Sprow, Joshua Dan, Joseph F. Merola, Victoria P. Werth
Summary: Cutaneous lupus erythematosus (CLE) is an autoimmune disease that can greatly impact patient's quality of life. New therapies are needed to effectively treat CLE. Anifrolumab and belimumab have shown efficacy in treating CLE, while other therapies targeting specific cells and pathways are currently being developed.
FRONTIERS IN MEDICINE
(2022)
Review
Cell Biology
Tomasz Kmiolek, Agnieszka Paradowska-Gorycka
Summary: In recent years, there has been increasing attention on the epigenetic dysregulation in autoimmune rheumatic diseases. MicroRNAs (miRNA) have been identified as key regulators of immune cell development and function, and could potentially serve as biomarkers for RA diagnosis, prognosis, and treatment.
Article
Rheumatology
Anella Saviano, Adel Abo Manosour, Federica Raucci, Francesco Merlino, Noemi Marigliano, Anna Schettino, Mussarat Wahid, Jenefa Begum, Andrew Filer, Julia E. Manning, Gian Marco Casillo, Marialuisa Piccolo, Maria Grazia Ferraro, Simona Marzano, Pasquale Russomanno, Rosa Bellavita, Carlo Irace, Jussara Amato, Mohammed Alfaifi, Peter Rimmer, Tariq Iqbal, Stefano Pieretti, Valentina Vellecco, Francesco Caso, Luisa Costa, Roberto Giacomelli, Raffaele Scarpa, Giuseppe Cirino, Mariarosaria Bucci, Helen M. McGettrick, Paolo Grieco, Asif Jilani Iqbal, Francesco Maione
Summary: This study identified a novel IL-17A/F-derived peptide and generated a new anti-IL-17 antibody that can effectively reverse the pro-inflammatory actions of IL-17A/F. The antibody showed less off-target effects compared to the current gold-standard biologic. Preclinical and clinical evidence demonstrated the high efficacy and therapeutic potency of the antibody in patients with IMIDs.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Immunology
Manuel Rojas, Carolina Ramirez-Santana, Yeny Acosta-Ampudia, Diana M. Monsalve, Monica Rodriguez-Jimenez, Elizabeth Zapata, Angie Naranjo-Pulido, Ana Suarez-Avellaneda, Lady J. Rios-Serna, Carolina Prieto, William Zambrano-Romero, Maria Alejandra Valero, Yhojan Rodriguez, Ruben D. Mantilla, Chengsong Zhu, Quan-Zhen Li, Carlos Enrique Toro-Gutierrez, Gabriel J. Tobon, Juan-Manuel Anaya
Summary: This study explored a new taxonomy of ADs based on PolyA, finding that latent PolyA is more common than overt PolyA. The combination of autoantibodies allows high accuracy in the classification of ADs, and three distinct clusters based on PolyA were observed with unique clinical and immunological phenotypes.
JOURNAL OF AUTOIMMUNITY
(2022)
Article
Immunology
Yanming Cui, Jianbo Wei, Xiang Peng
Summary: Vaccination in patients with autoimmune diseases is controversial due to the possibility of thrombotic thrombocytopenic purpura. This case report describes a patient with systemic lupus erythematosus who developed thrombotic thrombocytopenic purpura after rabies vaccination. Prompt identification and treatment saved the patient from danger. This highlights the potential unexpected adverse effects of attenuated vaccines in patients on long-term immunosuppressive drugs and with autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Kun Xiang, Peng Wang, Zhiwei Xu, Yu-Qian Hu, Yi-Sheng He, Yue Chen, Ya-Ting Feng, Kang-Jia Yin, Ji-Xiang Huang, Jie Wang, Zheng-Dong Wu, Xiao-Ke Yang, De-Guang Wang, Dong-Qing Ye, Hai-Feng Pan
Summary: This study used Mendelian randomization to examine the causal links between gut microbiome components and SLE risk. The results suggest that certain gut microbiome components may have causal effects on the risk of SLE, with some components increasing the risk and others reducing it.
FRONTIERS IN IMMUNOLOGY
(2021)
