Review
Developmental Biology
Lauren Bobzin, Ryan R. Roberts, Hung-Jhen Chen, J. Gage Crump, Amy E. Merrill
Summary: Tendons and ligaments, fibrous connective tissues crucial for musculoskeletal system function, exhibit heterogeneity and plasticity at the cellular level, posing questions about their developmental mechanisms and repair processes. Recent research advances have shed light on the establishment and maintenance of tendons and ligaments, contributing to a deeper understanding of these structures.
Article
Immunology
Xinjie Wu, Junyu Chen, Wei Sun, David A. Hart, Paul W. Ackermann, Aisha S. Ahmed
Summary: The suboptimal or protracted regeneration of injured connective tissues often leads to dysfunction and pain. This study focuses on biomarkers and key molecules involved in healing outcomes. The results showed that inter-alpha-trypsin inhibitor heavy chain 4 (ITIH4) plays a crucial role in connective tissue repair and could be a potential therapeutic target.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Giuliana Cerro Chiang, Tanyalak Parimon
Summary: CTD-ILD is a group of systemic autoimmune disorders that cause lung interstitial abnormalities or lung fibrosis. The pathogenesis of CTD-ILD is not well understood, but it shares common risk factors with idiopathic pulmonary fibrosis. The primary mechanism involves dysfunction of alveolar type II cells, triggering inflammatory cascades and leading to abnormal lung remodeling and fibrosis. Understanding these mechanisms is important for developing targeted therapies and identifying disease biomarkers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Joanna G. Escalon, Alan C. Legasto, Dennis Toy, James F. Gruden
Summary: In this study, central paradiaphragmatic middle lobe (ML) involvement was found in most NSIP patients, with high interobserver agreement. Fibrosis was present in nearly all cases, while other features such as subpleural sparing, homogeneity, and bronchiectasis varied among patients.
EUROPEAN RADIOLOGY
(2021)
Article
Multidisciplinary Sciences
Raquel Rouco, Olimpia Bompadre, Antonella Rauseo, Olivier Fazio, Rodrigue Peraldi, Fabrizio Thorel, Guillaume Andrey
Summary: Developmental genes are often controlled by multiple enhancers with similar specificities, making it difficult to fully understand their function when these regulatory elements are deleted. The authors show that deleting one enhancer in the Pitx1 testbed locus leads to regulatory and cellular changes, resulting in altered cell identities and gene expression levels.
NATURE COMMUNICATIONS
(2021)
Article
Agriculture, Dairy & Animal Science
Yuka Katayama, Osamu Ichii, Teppei Nakamura, Keita Yanase, Masaya Hiraishi, Takashi Namba, Yuki Otani, Teppei Ikeda, Erika Tsuji, Natsuko Tsuzuki, Ken Kobayashi, Yasuhiro Kon, Takanori Nishimura
Summary: This study demonstrated the formation of connective tissue in dairy cows following subcutaneous implantation of acrylic resin-based implants created using 3D printing technology. The results provide insights into the tissue remodeling process related to foreign body reactions.
Article
Biochemistry & Molecular Biology
Toyoshi Yanagihara, Kazuya Tsubouchi, Mahsa Gholiof, Sy Giin Chong, Kenneth E. Lipson, Quan Zhou, Ciaran Scallan, Chandak Upagupta, Jussi Tikkanen, Shaf Keshavjee, Kjetil Ask, Martin R. J. Kolb
Summary: Idiopathic pulmonary fibrosis is a fatal lung disease characterized by the accumulation of myofibroblasts. The study found that connective-tissue growth factor (CTGF) plays a key role in pulmonary fibrosis. Increased levels of CTGF exacerbate lung fibrosis and CTGF expression is upregulated in patients with idiopathic pulmonary fibrosis. Different cells contribute to the maintenance of the fibrotic phenotype during fibrogenesis.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2022)
Article
Medicine, General & Internal
Puneeta Arya, Sjirk J. Westra, Oscar J. Benavidez, Marc D. Natter, Mandakolathur R. Murali
Summary: This passage describes the case of a 17-year-old boy who was admitted to the ICU with chest pain. He had developed symptoms such as fever, nausea, diarrhea, muscle aches, and chest pain 5 days prior.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Respiratory System
Noriyuki Enomoto, Sakae Homma, Naohiko Inase, Yasuhiro Kondoh, Takeshi Saraya, Hajime Takizawa, Yoshikazu Inoue, Hiroshi Ishii, Yoshio Taguchi, Shinyu Izumi, Yasuhiko Yamano, Yoshinori Tanino, Yasuhiko Nishioka, Mikio Toyoshima, Koshi Yokomura, Shiro Imokawa, Naoki Koshimizu, Takehisa Sano, Taisuke Akamatsu, Hiroshi Mukae, Motoyasu Kato, Naoki Hamada, Hirofumi Chiba, Shinobu Akagawa, Shigeo Muro, Hironori Uruga, Hiroyuki Matsuda, Yusuke Kaida, Miho Kanai, Kazutaka Mori, Masafumi Masuda, Hironao Hozumi, Tomoyuki Fujisawa, Yutaro Nakamura, Noriyoshi Ogawa, Takafumi Suda
Summary: This nationwide multicentre study prospectively evaluated 376 patients with IIP, finding that 18.6% of them met the IPAF criteria. Patients with IPAF were more likely to develop systemic autoimmune diseases, had fewer acute exacerbations of IIP, and showed better survival outcomes. Cluster analysis identified a subgroup with more autoimmune features, predominantly female, and with a better prognosis.
Article
Rheumatology
Goncalo Boleto, Silje Reiseter, Anna-Maria Hoffmann-Vold, Adrien Mirouse, Patrice Cacoub, Marco Matucci-Cerinic, Manuel Silverio-Antonio, Joao Eurico Fonseca, Ana Catarina Duarte, Jorge Pestana Lopes, Valeria Riccieri, Alain Lescoat, Erwan Le Tallec, Ivan Castellvi Barranco, Jose Luis Tandaipan, Paolo Airo, Masataka Kuwana, Hoda Kavosi, Jerome Avouac, Yannick Allanore
Summary: This study compared predictive factors for interstitial lung disease (ILD) in patients with mixed connective tissue disease (MTCD) and found different factors associated with ILD. The study also found that MCTD-ILD patients have increased mortality and that digital ulcers (DU) are associated with progressive lung disease.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2023)
Article
Engineering, Biomedical
Julian Sartori, Heiko Stark
Summary: This study analyzed the 3D fiber tracks in macroscopic tendon samples, revealing that the insertion is not reinforced in terms of fiber numbers or sizes. The orientation of fibers in the tendon center is higher than in the margins, which could inspire material development. Fibers inserting at a protrusion of the insertion area stem from a distinct portion within the tendon, suggesting that fibrous structure analysis can link macro- to micromechanics.
ACTA BIOMATERIALIA
(2021)
Article
Nanoscience & Nanotechnology
Rong Liu, Min Zhu, Jiaojiao Chen, Junwei Gai, Jing Huang, Yingqun Zhou, Yakun Wan, Chuantao Tu
Summary: In this study, a novel nanobody (Nb) against human connective tissue growth factor (CTGF) was identified, which showed antifibrotic effects in vitro by regulating the biological functions of human stellate cells. This study is of great importance for the development of antifibrotic therapies for liver fibrosis.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Takuya Kotani, Masaki Ikemoto, Shogo Matsuda, Ryota Masutani, Tohru Takeuchi
Summary: In this study, it was found that the hybrid protein hMIKO-1 can suppress the abnormal activation of macrophages, reduce lung fibrosis in mice, and decrease the expression of related inflammation factors, indicating its potential as a therapeutic candidate for ILD treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Zeliha Guler, Jan Paul Roovers
Summary: Pelvic organ prolapse (POP) is a connective tissue disorder that occurs due to damage to the supportive structures of the pelvic floor, causing pelvic organs to descend into the vagina. The impaired function of fibroblasts results in disrupted collagen metabolism and affects tissue mechanics. Surgical repair aims to create a load-bearing functional pelvic floor by activating fibroblasts to regulate collagen metabolism without fibrotic tissue formation. Fibroblast function plays a crucial role in the pathophysiology of POP and determines the success of treatment.
Article
Pharmacology & Pharmacy
Lesley Ann Saketkoo, Reuben Escorpizo, Janos Varga, Kevin John Keen, Kim Fligelstone, Surinder S. Birring, Helene Alexanderson, Henrik Pettersson, Humza Ahmad Chaudhry, Janet L. Poole, Malin Regardt, Daphne LeSage, Catherine Sarver, Joseph Lanario, Elisabetta Renzoni, Mary Beth Scholand, Matthew R. Lammi, Otylia Kowal-Bielecka, Oliver Distler, Tracy Frech, Lee Shapiro, Cecilia Varju, Elizabeth R. Volkmann, Elana J. Bernstein, Marjolein Drent, Ogugua Ndili Obi, Karen C. Patterson, Anne-Marie Russell
Summary: This study is the first known effort to link ILD with ICF, providing important insights into the current utility of the ICF in lung diseases. The results have indicated areas for meaningful assessment of ICF descriptors for lung impairment and the mapping across multiple PROMs provides insight into possibilities of developing more streamlined and precise instrumentation.
FRONTIERS IN PHARMACOLOGY
(2022)