Indian Hedgehog, a critical modulator in osteoarthritis, could be a potential therapeutic target for attenuating cartilage degeneration disease

Disrupting the Indian hedgehog signaling pathway in vivo attenuates surgically induced osteoarthritis progression in Col2a1-CreERT2; Ihhfl/fl mice

(2014) Jingming Zhou et al.   ARTHRITIS RESEARCH & THERAPY

Activation of hedgehog signaling during fracture repair enhances osteoblastic-dependent matrix formation

(2013) Gurpreet S Baht et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Ihh and Runx2/Runx3 Signaling Interact to Coordinate Early Chondrogenesis: A Mouse Model

(2013) Eun-Jung Kim et al.   PLoS One

Non-invasive imaging of cartilage in early osteoarthritis

(2013) A. J. R. Palmer et al.   Bone & Joint Journal

A delivery system targeting bone formation surfaces to facilitate RNAi-based anabolic therapy

(2012) Ge Zhang et al.   NATURE MEDICINE

Activation of Indian hedgehog promotes chondrocyte hypertrophy and upregulation of MMP-13 in human osteoarthritic cartilage

(2012) F. Wei et al.   OSTEOARTHRITIS AND CARTILAGE

Gene Expression Analyses of Subchondral Bone in Early Experimental Osteoarthritis by Microarray

(2012) RongKai Zhang et al.   PLoS One

Health care quality indicators on the management of rheumatoid arthritis and osteoarthritis: a literature review

(2012) B. Strombeck et al.   RHEUMATOLOGY

Indian hedgehog positively regulates calvarial ossification and modulates bone morphogenetic protein signaling

(2011) Kelly Lenton et al.   GENESIS

The skeleton: a multi-functional complex organ. The growth plate chondrocyte and endochondral ossification

(2011) E J Mackie et al.   JOURNAL OF ENDOCRINOLOGY

Chondrocyte hypertrophy and osteoarthritis: role in initiation and progression of cartilage degeneration?

(2011) P.M. van der Kraan et al.   OSTEOARTHRITIS AND CARTILAGE

Gli2 activator function in preosteoblasts is sufficient to mediate ihh-dependent osteoblast differentiation, whereas the repressor function of Gli2 is dispensable for endochondral ossification

(2010) Dörthe Andrea Kesper et al.   DEVELOPMENTAL DYNAMICS

Rational design of cationic lipids for siRNA delivery

(2010) Sean C Semple et al.   NATURE BIOTECHNOLOGY

Partial rescue of postnatal growth plate abnormalities in Ihh mutants by expression of a constitutively active PTH/PTHrP receptor

(2009) Yukiko Maeda et al.   BONE

Hedgehog-Gli Signaling Pathway Inhibitors as Anticancer Agents

(2009) Neeraj Mahindroo et al.   JOURNAL OF MEDICINAL CHEMISTRY

Modulating hedgehog signaling can attenuate the severity of osteoarthritis

(2009) Alvin C Lin et al.   NATURE MEDICINE

Transcriptional networks controlling chondrocyte proliferation and differentiation during endochondral ossification

(2009) Manuela Wuelling et al.   PEDIATRIC NEPHROLOGY

Targeted inhibition of hedgehog signaling by cyclopamine prodrugs for advanced prostate cancer

(2008) Srinivas K. Kumar et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Transient Inhibition of the Hedgehog Pathway in Young Mice Causes Permanent Defects in Bone Structure

(2008) Hiromichi Kimura et al.   CANCER CELL

Indian hedgehog signals independently of PTHrP to promote chondrocyte hypertrophy

(2008) K. K. Mak et al.   DEVELOPMENT

Etiopathogenesis of Osteoarthritis

(2008) Kenneth D. Brandt et al.   MEDICAL CLINICS OF NORTH AMERICA

Dose- and Route-Dependent Teratogenicity, Toxicity, and Pharmacokinetic Profiles of the Hedgehog Signaling Antagonist Cyclopamine in the Mouse

(2008) Robert J. Lipinski et al.   TOXICOLOGICAL SCIENCES