Article
Multidisciplinary Sciences
Alireza Savadipour, Robert J. Nims, Neda Rashidi, Jaquelin M. Garcia- Castorena, Ruhang Tang, Gabrielle K. Marushack, Sara J. Oswald, Wolfgang B. Liedtke, Farshid Guilak
Summary: Through AFM and FEM studies, we found that PIEZO1 and PIEZO2 mediate calcium (Ca2+) signaling in chondrocytes at moderately high levels of cellular deformation, while at the highest strains, PIEZO1 functions independently of PIEZO2. Biophysical factors that increase apparent chondrocyte membrane tension also enhance PIEZO1-driven Ca2+ signaling. We identified a threshold of membrane stretch ratio that leads to PIEZO1-induced chondrocyte mechanical injury, suggesting potential targets for osteoarthritis prevention or treatment.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Multidisciplinary Sciences
Apratim Bajpai, Rui Li, Weiqiang Chen
Summary: Aging is a chronic and complex process that results in degenerative physical and biological changes in living organisms, affecting the mechanobiological features of cells. These mechanobiological changes can lead to dysfunctions and diseases in various organ systems. Understanding the mechanobiological effects of aging is important in developing strategies to halt and reverse the aging process.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Giulio Capponi, Martina Zambito, Igor Neri, Francesco Cottone, Maurizio Mattarelli, Massimo Vassalli, Silvia Caponi, Tullio Florio
Summary: Mechanotransduction is the ability of cells to sense mechanical stimuli and convert them into biochemical signals. Mechanosensitive ion channels, especially Piezo family channels, play a crucial role in this process. This study proposes an open-hardware approach to measure the mechanosensitivity of single cells and validates the device using a neural mice cell line. The device is versatile and can be integrated with different read-out technologies.
Review
Polymer Science
Ayse Z. Sahan, Murat Baday, Chirag B. Patel
Summary: Hydrogels, as biocompatible polymers, have diverse applications in medicine, bioprinting, tissue engineering, and biomechanics. They can simulate the microenvironment of tissues and influence cancer cell behavior. However, further research is needed on the development and potential applications of biomimetic hydrogels in clinical settings.
Review
Biotechnology & Applied Microbiology
Joana Reis, Antonio Ramos
Summary: Oxidative stress plays a central role in physiological and pathological bone conditions, regulating bone cell population differentiation, activity, and fate. While the interplay between redox balance and response to mechanical stimuli is not fully understood, the potential for its use and manipulation with therapeutic goals is nearly limitless.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Biotechnology & Applied Microbiology
Shu Yang, Jing Zhang, Youhua Tan, Yan Wang
Summary: This article reviews the corneal mechano-environment and its impact on corneal diseases. Both laboratory research and clinical observations indicate the involvement of mechanical cues in the development and progression of corneal disorders, suggesting new possibilities for the development of therapeutic strategies targeting corneal mechanics.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Cell Biology
Carin Basirun, Melanie L. Ferlazzo, Nicholas R. Howell, Guo-Jun Liu, Ryan J. Middleton, Boris Martinac, S. Anand Narayanan, Kate Poole, Carmine Gentile, Joshua Chou
Summary: With increasing interest in space exploration and advancements in technology, there is a need to evaluate the impact of microgravity and radiation on the cardiovascular system. Understanding these effects can provide insights into deep space exploration and increase knowledge of the cardiovascular system and associated diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Alberto Ruffilli, Giovanni Viroli, Simona Neri, Matteo Traversari, Francesca Barile, Marco Manzetti, Elisa Assirelli, Marco Ialuna, Fabio Vita, Cesare Faldini
Summary: Low back pain, often caused by degenerative disc disease (DDD), is a common condition that can have severe consequences. This study aimed to systematically review the existing literature on the mechanobiology of the human intervertebral disc (IVD), identify the main pathways involved in DDD, and find potential therapeutic targets. The review included 15 studies that demonstrated promising results confirming the importance of mechanobiology in DDD and providing insights for possible treatment and prevention strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Shaobao Liu, Yuan Li, Yuan Hong, Ming Wang, Hao Zhang, Jinlu Ma, Kai Qu, Guoyou Huang, Tian Jian Lu
Summary: Mechanotherapy is proposed as a new option for cancer treatment, as increasing evidence suggests characteristic differences in nuclear mechanics and mechanotransduction between cancer cells and normal cells. Recent advances in understanding these differences provide insights into malignant transformation and references for developing new therapeutic approaches. This overview highlights the alterations of nuclear mechanics and mechanotransduction in cancer cells and their implications in cancer mechanotherapy.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Review
Cell Biology
Alireza Savadipour, Daniel Palmer, Erica V. Ely, Kelsey H. Collins, Jaquelin M. Garcia-Castorena, Zainab Harissa, Yu Seon Kim, Arin Oestrich, Feini Qu, Neda Rashidi, Farshid Guilak
Summary: PIEZO1 and PIEZO2 are highly expressed mechanosensitive channels with diverse functions in various tissues. They play important roles in musculoskeletal health, including maintenance of muscle and bone mass, sensing tendon stretch, and regulation of senescence and apoptosis. PIEZO2 is essential for pain and touch perception as well as proprioception. Alterations in PIEZO channel mechanosensitivity can significantly affect these functions. Therapeutic approaches focus on controlling PIEZO1 and/or PIEZO2 activity through inhibition or dietary control. Overall, these studies highlight the crucial role of PIEZO channels in musculoskeletal health and suggest promising avenues for therapeutic modulation.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Sergio Aguilera Suarez, Nadia Chandra Sekar, Ngan Nguyen, Austin Lai, Peter Thurgood, Ying Zhou, Scott Needham, Elena Pirogova, Khashayar Khoshmanesh, Sara Baratchi
Summary: The study introduces a motorized cam-driven system for cyclic stretch of aortic endothelial cells, which allows for generating customized spatiotemporal stretch profiles. Experiments demonstrate significant changes in cytoskeletal structure and morphology of cells following exposure to cyclic stretch.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Cell Biology
Hyondeog Kim, Yun Shin, Dong-Hwee Kim
Summary: Alterations in the cellular response to the space environment, including changes in cytokine and gene expression, can enhance cancer malignancy. The mechanotransduction mechanism of cancer cells in space and its impact on human health have not been fully understood, highlighting the need for further research in space mechanobiology.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Arikta Biswas, Boon Heng Ng, Vinod S. O. Prabhakaran, Chii Jou Chan
Summary: This review discusses the role of mechanical forces in follicle development and their underlying mechanisms, highlights emerging techniques for quantifying mechanical interactions and follicular dynamics, and proposes new directions for future studies. It aims to provide a timely and useful framework for understanding mechano-signalling pathways in reproductive biology and diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Abdulghani A. Khilan, Noor A. Al-Maslamani, Henning F. Horn
Summary: The LINC complex is essential for mechanotransduction in cells, allowing the nucleus to respond to mechanical stress. Cell stretchers are commonly used devices to study how cells respond to mechanical stress and the role of the LINC complexes in these processes.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Review
Cell Biology
Chi Woo Yoon, Yijia Pan, Yingxiao Wang
Summary: Immune-engineering is an emerging field that combines biomedical engineering with immunology to study and control the immune system for disease treatments. Mechanobiology plays a crucial role in regulating immune cells, providing opportunities for designing tools for immunotherapy. This review introduces recent advances in mechanobiology for immune cells, discusses different immuno-engineering strategies, and describes the opportunities and challenges of applying mechanobiology to engineer immune cells for immunotherapy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biophysics
Su-Jin Heo, Woojin M. Han, Spencer E. Szczesny, Brian D. Cosgrove, Dawn M. Elliott, David A. Lee, Randall L. Duncan, Robert L. Mauck
BIOPHYSICAL JOURNAL
(2016)
Article
Cell Biology
R. K. Tilwani, S. Vessillier, B. Pingguan-Murphy, D. A. Lee, D. L. Bader, T. T. Chowdhury
INFLAMMATION RESEARCH
(2017)
Article
Dermatology
Georgios Theocharidis, Zoe Drymoussi, Alexander P. Kao, Asa H. Barber, David A. Lee, Kristin M. Braun, John T. Connelly
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2016)
Article
Cell & Tissue Engineering
H. K. Heywood, D. A. Lee
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2017)
Article
Orthopedics
K. Sliogeryte, L. Botto, D. A. Lee, M. M. Knight
OSTEOARTHRITIS AND CARTILAGE
(2016)
Article
Computer Science, Interdisciplinary Applications
V. Elyasigomari, D. A. Lee, H. R. C. Screen, M. H. Shaheed
JOURNAL OF BIOMEDICAL INFORMATICS
(2017)
Article
Immunology
Abhishek Das, Kevin Rouault-Pierre, Shraddha Kamdar, Iria Gomez-Tourino, Kristie Wood, Ian Donaldson, Charles A. Mein, Dominique Bonnet, Adrian C. Hayday, Deena L. Gibbons
JOURNAL OF IMMUNOLOGY
(2017)
Review
Cell Biology
Stephen D. Thorpe, David A. Lee
Review
Cell Biology
Stephen D. Thorpe, David A. Lee
Article
Gastroenterology & Hepatology
Ernesto Cortes, Dariusz Lachowski, Alistair Rice, Antonios Chronopoulos, Benjamin Robinson, Stephen Thorpe, David A. Lee, Lucia A. Possamai, Haiyun Wang, David J. Pinato, Armando E. del Rio Hernandez
Article
Biochemistry & Molecular Biology
Ernesto Cortes, Muge Sarper, Benjamin Robinson, Dariusz Lachowski, Antonios Chronopoulos, Stephen D. Thorpe, David A. Lee, Armando E. del Rio Hernandez
Article
Biochemistry & Molecular Biology
Ernesto Cortes, Dariusz Lachowski, Benjamin Robinson, Muge Sarper, Jaakko S. Teppo, Stephen D. Thorpe, Tyler J. Lieberthal, Kazunari Iwamoto, David A. Lee, Mariko Okada-Hatakeyama, Markku T. Varjosalo, Armando E. del Rio Hernandez
Article
Biochemistry & Molecular Biology
Ernesto Cortes, Dariusz Lachowski, Alistair Rice, Stephen D. Thorpe, Benjamin Robinson, Gulcen Yeldag, David A. Lee, Leo Ghemtio, Krista Rombouts, Armando E. del Rio Hernandez
Article
Immunology
L. V. Clark, M. Buckland, G. Murphy, N. Taylor, V. Vleck, C. Mein, E. Wozniak, M. Smuk, P. D. White
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2017)
Article
Toxicology
Robin Mesnage, Martina Biserni, Eva Wozniak, Theodoros Xenakis, Charles A. Mein, Michael N. Antoniou
TOXICOLOGY REPORTS
(2018)