Efficient generation of gene-modified human natural killer cells via alpharetroviral vectors

T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: a phase 1 dose-escalation trial

(2015) Daniel W Lee et al.   LANCET

Advantages and applications of CAR-expressing natural killer cells

(2015) Wolfgang Glienke et al.   Frontiers in Pharmacology

All-in-One inducible lentiviral vector systems based on drug controlled FLP recombinase

(2014) Tobias Maetzig et al.   BIOMATERIALS

Antibody-modified T cells: CARs take the front seat for hematologic malignancies

(2014) M. V. Maus et al.   BLOOD

Infusions of Allogeneic Natural Killer Cells as Cancer Therapy

(2014) W. Leung   CLINICAL CANCER RESEARCH

Acute myeloid leukemia impairs natural killer cells through the formation of a deficient cytotoxic immunological synapse

(2014) Zena Khaznadar et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The Nonsignaling Extracellular Spacer Domain of Chimeric Antigen Receptors Is Decisive for In Vivo Antitumor Activity

(2014) M. Hudecek et al.   Cancer Immunology Research

Are natural killer cells superior CAR drivers?

(2014) Hans Klingemann   OncoImmunology

Modification of Hematopoietic Stem/Progenitor Cells with CD19-Specific Chimeric Antigen Receptors as a Novel Approach for Cancer Immunotherapy

(2013) Satiro Nakamura De Oliveira et al.   HUMAN GENE THERAPY

A CD19/Fc fusion protein for detection of anti-CD19 chimeric antigen receptors

(2013) Satiro N De Oliveira et al.   Journal of Translational Medicine

Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation

(2013) Linda V Sinclair et al.   NATURE IMMUNOLOGY

Tumor-Primed NK Cells: Waiting for the Green Light

(2013) May Sabry et al.   Frontiers in Immunology

Clinical Grade Purification and Expansion of NK Cell Products for an Optimized Manufacturing Protocol

(2013) Ulrike Koehl et al.   Frontiers in Oncology

Pre-emptive immunotherapy with purified natural killer cells after haploidentical SCT: a prospective phase II study in two centers

(2012) M Stern et al.   BONE MARROW TRANSPLANTATION

Alpharetroviral Self-inactivating Vectors: Long-term Transgene Expression in Murine Hematopoietic Cells and Low Genotoxicity

(2012) Julia D Suerth et al.   MOLECULAR THERAPY

Membrane-Bound IL-21 Promotes Sustained Ex Vivo Proliferation of Human Natural Killer Cells

(2012) Cecele J. Denman et al.   PLoS One

Successful transfer of alloreactive haploidentical KIR ligand-mismatched natural killer cells after infusion in elderly high risk acute myeloid leukemia patients

(2011) A. Curti et al.   BLOOD

Human NK cells in acute myeloid leukaemia patients: analysis of NK cell-activating receptors and their ligands

(2011) Beatriz Sanchez-Correa et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Immune responses to transgene and retroviral vector in patients treated with ex vivo-engineered T cells

(2010) C. H. J. Lamers et al.   BLOOD

Adoptive immunotherapy with genetically engineered T cells: modification of the IgG1 Fc ‘spacer’ domain in the extracellular moiety of chimeric antigen receptors avoids ‘off-target’ activation and unintended initiation of an innate immune response

(2010) A Hombach et al.   GENE THERAPY

NKAML: A Pilot Study to Determine the Safety and Feasibility of Haploidentical Natural Killer Cell Transplantation in Childhood Acute Myeloid Leukemia

(2010) Jeffrey E. Rubnitz et al.   JOURNAL OF CLINICAL ONCOLOGY

Self-Inactivating Alpharetroviral Vectors with a Split-Packaging Design

(2010) J. D. Suerth et al.   JOURNAL OF VIROLOGY

CD137 ligand mediates opposite effects in human and mouse NK cells and impairs NK-cell reactivity against human acute myeloid leukemia cells

(2009) T. Baessler et al.   BLOOD

Construction and Preclinical Evaluation of an Anti-CD19 Chimeric Antigen Receptor

(2009) James N. Kochenderfer et al.   JOURNAL OF IMMUNOTHERAPY

Relationship between CD107a expression and cytotoxic activity

(2008) Esin Aktas et al.   CELLULAR IMMUNOLOGY