System-L amino acid transporters play a key role in pancreatic β-cell signalling and function

Pancreatic  -Cell Failure Mediated by mTORC1 Hyperactivity and Autophagic Impairment

(2014) A. Bartolome et al.   DIABETES

Exendin-4 stimulates islet cell replication via the IGF1 receptor activation of mTORC1/S6K1

(2014) J. Xie et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Regulation of mTORC1 by amino acids

(2014) Liron Bar-Peled et al.   TRENDS IN CELL BIOLOGY

High expression of L-type amino acid transporter 1 as a prognostic marker in bile duct adenocarcinomas

(2014) Nobuyuki Yanagisawa et al.   Cancer Medicine

RNA Sequencing Identifies Dysregulation of the Human Pancreatic Islet Transcriptome by the Saturated Fatty Acid Palmitate

(2013) Miriam Cnop et al.   DIABETES

Proteome Analysis and Conditional Deletion of the EAAT2 Glutamate Transporter Provide Evidence against a Role of EAAT2 in Pancreatic Insulin Secretion in Mice

(2013) Yun Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Self-defeating Anabolic Program Leads to β-Cell Apoptosis in Endoplasmic Reticulum Stress-induced Diabetes via Regulation of Amino Acid Flux

(2013) Dawid Krokowski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amino acid signalling upstream of mTOR

(2013) Jenna L. Jewell et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Guidelines for the use and interpretation of assays for monitoring autophagy

(2012) Daniel J. Klionsky et al.   Autophagy

mTORC1 signaling and regulation of pancreatic β-cell mass

(2012) Manuel Blandino-Rosano et al.   CELL CYCLE

Milk protein intake, the metabolic-endocrine response, and growth in infancy: data from a randomized clinical trial

(2011) et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Androgen Receptor and Nutrient Signaling Pathways Coordinate the Demand for Increased Amino Acid Transport during Prostate Cancer Progression

(2011) Q. Wang et al.   CANCER RESEARCH

The role of mammalian target of rapamycin (mTOR) in the regulation of pancreatic β-cell mass: implications in the development of type-2 diabetes

(2011) Jianling Xie et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Metabolite profiles and the risk of developing diabetes

(2011) Thomas J Wang et al.   NATURE MEDICINE

Leucine as a pharmaconutrient to prevent and treat sarcopenia and type 2 diabetes

(2011) Marika Leenders et al.   NUTRITION REVIEWS

PERK Activation at Low Glucose Concentration Is Mediated by SERCA Pump Inhibition and Confers Preemptive Cytoprotection to Pancreatic β-Cells

(2010) Claire E. Moore et al.   MOLECULAR ENDOCRINOLOGY

Plasma Metabolomic Profiles Reflective of Glucose Homeostasis in Non-Diabetic and Type 2 Diabetic Obese African-American Women

(2010) Oliver Fiehn et al.   PLoS One

Amino acid transceptors: gate keepers of nutrient exchange and regulators of nutrient signaling

(2009) Harinder S. Hundal et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

A Branched-Chain Amino Acid-Related Metabolic Signature that Differentiates Obese and Lean Humans and Contributes to Insulin Resistance

(2009) Christopher B. Newgard et al.   Cell Metabolism

Upregulation of the Mammalian Target of Rapamycin Complex 1 Pathway by Ras Homolog Enriched in Brain in Pancreatic  -Cells Leads to Increased  -Cell Mass and Prevention of Hyperglycemia

(2009) S. Hamada et al.   DIABETES

mTORC1 Activation Regulates β-Cell Mass and Proliferation by Modulation of Cyclin D2 Synthesis and Stability

(2009) Norman Balcazar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of cAMP-Dependent Kinase as a Third in Vivo Ribosomal Protein S6 Kinase in Pancreatic β-Cells

(2009) Claire E.J. Moore et al.   JOURNAL OF MOLECULAR BIOLOGY

Inhibition of SNAT2 by Metabolic Acidosis Enhances Proteolysis in Skeletal Muscle

(2008) K. Evans et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Leucine, when ingested with glucose, synergistically stimulates insulin secretion and lowers blood glucose

(2008) Dionysia Kalogeropoulou et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Biphasic Response of Pancreatic  -Cell Mass to Ablation of Tuberous Sclerosis Complex 2 in Mice

(2008) Y. Shigeyama et al.   MOLECULAR AND CELLULAR BIOLOGY

Disruption of Tsc2 in pancreatic   cells induces   cell mass expansion and improved glucose tolerance in a TORC1-dependent manner

(2008) L. Rachdi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA