Article
Cardiac & Cardiovascular Systems
Alexander Guldmann Clausen, Oliver Bundgaard Vad, Julie Husted Andersen, Morten Salling Olesen
Summary: The study identified a specific splice site variant in the SYNPO2L gene associated with an increased risk of AF, suggesting that AF may present as atrial cardiomyopathy.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Genetics & Heredity
Oliver Bundgaard Vad, Yannan Yan, Federico Denti, Gustav Ahlberg, Lena Refsgaard, Sofia Hammami Bomholtz, Joana Larupa Santos, Simon Rasmussen, Stig Haunso, Jesper Hastrup Svendsen, Ingrid Elizabeth Christophersen, Nicole Schmitt, Morten Salling Olesen, Bo Hjorth Bentzen
Summary: AF is a common sustained cardiac arrhythmia with complex pathogenesis, and rare genetic variants in the CACNA1A gene have been identified in patients with familial AF, suggesting a potential novel link between ion channel dysfunction and increased risk of AF.
FRONTIERS IN GENETICS
(2022)
Article
Genetics & Heredity
Ning Li, Ying-Jia Xu, Hong-Yu Shi, Chen-Xi Yang, Yu-Han Guo, Ruo-Gu Li, Xing-Biao Qiu, Yi-Qing Yang, Min Zhang
Summary: A Chinese pedigree with atrial fibrillation, ventricular arrhythmias, and hypertrophic cardiomyopathy was studied, leading to the identification of a novel heterozygous variation in the KLF15 gene. This variation was confirmed to be associated with autosomal dominant atrial fibrillation and was absent in unrelated healthy controls. Functional assays revealed the potential role of KLF15 in the pathogenesis of arrhythmias and cardiomyopathies, providing new insights into molecular mechanisms underlying these cardiac disorders.
Article
Medicine, General & Internal
Emile C. A. Nyns, Vincent Portero, Shanliang Deng, Tianyi Jin, Niels Harlaar, Cindy I. Bart, Thomas J. van Brakel, Meindert Palmen, Jesper Hjortnaes, Arti A. Ramkisoensing, Guo Qi Zhang, Rene H. Poelma, Balazs Ordog, Antoine A. F. de Vries, Daniel A. Pijnappels
Summary: Optogenetic cardioversion is effective for treating atrial fibrillation in aged rats and can penetrate the human atrial wall with sufficient light.
JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Medicine, General & Internal
Amalia Ioanna Moula, Iris Parrini, Cecilia Tetta, Fabiana Luca, Gianmarco Parise, Carmelo Massimiliano Rao, Emanuela Mauro, Orlando Parise, Francesco Matteucci, Michele Massimo Gulizia, Mark La Meir, Sandro Gelsomino
Summary: Atrial fibrillation (AF) is the most common arrhythmia, with its incidence increasing with age and comorbidities. Obstructive sleep apnea (OSA) is a chronic sleep disorder more commonly found in older men. Previous studies have shown a link between OSA and AF, although the prevalence of OSA in AF patients remains unknown due to underdiagnosis. This meta-analysis investigated the association between OSA and AF, using data from 54,271 patients. A strong link was found between these two disorders, with the incidence of AF being 88% higher in patients with OSA. Age and hypertension were found to independently strengthen this association, indicating that treating OSA may help reduce AF recurrence. Further research is needed to confirm these findings.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Baptiste Maille, Nathalie Lalevee, Marion Marlinge, Juliette Vahdat, Giovanna Mottola, Clara Degioanni, Lucille De Maria, Victor Klein, Franck Thuny, Frederic Franceschi, Jean-Claude Deharo, Regis Guieu, Julien Fromonot
Summary: This narrative review discusses the potential role of the adenosinergic system in the pathophysiology of atrial fibrillation (AF). It provides insights into adenosinergic system signaling and its interactions with AF. Activation of adenosine receptors can affect the occurrence and maintenance of AF, and the adenosinergic system is also associated with the modulation of the autonomic nervous system and AF risk factors.
Article
Cell Biology
Yuqing Tian, Shiying Liu, Yanan Zhang, Jiefu Yang, Peiyao Guo, Hongchao Zhang, Xue Yu, Tong Zou
Summary: This study explores the relationship between atrial fibrillation (AF) and immune infiltration, identifies new associated genes, and provides novel insights into the pathogenesis of AF based on the inflammatory response.
Article
Cardiac & Cardiovascular Systems
Jean-Baptiste Guichard, Feng Xiong, Xiao-Yan Qi, Nathalie L'Heureux, Roddy Hiram, Jiening Xiao, Patrice Naud, Jean-Claude Tardif, Antoine Da Costa, Stanley Nattel
Summary: This study assessed the specific contributions of atrial fibrillation-related atrial arrhythmia vs. associated ventricular arrhythmia to remodeling. The results showed that both atrial tachyarrhythmia and rapid ventricular response during AF produce distinct atrial remodelling, providing new insights into AF-related remodeling and ventricular rate-control considerations.
CARDIOVASCULAR RESEARCH
(2021)
Review
Cardiac & Cardiovascular Systems
Jorge G. Quintanilla, Shlomo Shpun, Jose Jalife, David Filgueiras-Rama
Summary: Modern cardiac electrophysiology has made significant advancements in understanding the mechanisms of atrial fibrillation (AF) and the debate between randomly propagating wavelets and deterministic rotors continues. Recent research supports the feasibility of targeting and ablating AF driver regions outside of pulmonary veins. New technologies and methodologies have provided platforms for clinicians to implement novel approaches in AF ablation procedures.
CARDIOVASCULAR RESEARCH
(2021)
Article
Biology
Ning Li, Yan-Jie Li, Xiao-Juan Guo, Shao-Hui Wu, Wei-Feng Jiang, Dao-Liang Zhang, Kun-Wei Wang, Li Li, Yu-Min Sun, Ying-Jia Xu, Yi-Qing Yang, Xing-Biao Qiu
Summary: A novel mutation in the TBX20 gene was found to be associated with AF, shedding light on the mechanism underlying AF and suggesting clinical significance for the individually tailored treatment of AF patients.
Article
Cardiac & Cardiovascular Systems
Funsho E. Fakuade, Vanessa Steckmeister, Fitzwilliam Seibertz, Judith Gronwald, Stefanie Kestel, Julia Menzel, Julius Ryan D. Pronto, Karim Taha, Fereshteh Haghighi, George Kensah, Charles M. Pearman, Felix Wiedmann, Arco J. Teske, Constanze Schmidt, Katharine M. Dibb, Aschraf El-Essawi, Bernhard C. Danner, Hassina Baraki, Blanche Schwappach, Ingo Kutschka, Fleur E. Mason, Niels Voigt
Summary: This study investigates the role of impaired atrial contractility and arrhythmogenic substrate in the development of postoperative atrial fibrillation (poAF).
CARDIOVASCULAR RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Jason D. Roberts, Eric Vittinghoff, Ake T. Lu, Alvaro Alonso, Biqi Wang, Colleen M. Sitlani, Pedrum Mohammadi-Shemirani, Myriam Fornage, Jelena Kornej, Jennifer A. Brody, Dan E. Arking, Honghuang Lin, Susan R. Heckbert, Ivana Prokic, Mohsen Ghanbari, Allan C. Skanes, Traci M. Bartz, Marco Perez, Kent D. Taylor, Steven A. Lubitz, Patrick T. Ellinor, Kathryn L. Lunetta, James S. Pankow, Guillaume Pare, Nona Sotoodehnia, Emelia J. Benjamin, Steve Horvath, Gregory M. Marcus
Summary: The study identified associations between epigenetic age acceleration measures and incident atrial fibrillation, indicating the importance of biological aging independent of chronological age. However, the potential underlying causal relationship remains unclear. These aging processes may be modifiable and not constrained by the immutable factor of time.
Article
Cardiac & Cardiovascular Systems
Michael Murninkas, Roni Gillis, Sigal Elyagon, Or Levi, Wesam Mulla, Amos Katz, Yoram Etzion, Gideon Gradwohl
Summary: This study developed an algorithm to clean atrial signals from ventricular mixing and objectively quantify AF substrate based on waveform complexity. The algorithm efficiently detected irregularity and atrial remodeling, facilitating standardized AF research in rodents.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Article
Multidisciplinary Sciences
Ines Assum, Julia Krause, Markus O. Scheinhardt, Christian Mueller, Elke Hammer, Christin S. Boerschel, Uwe Voelker, Lenard Conradi, Bastiaan Geelhoed, Tanja Zeller, Renate B. Schnabel, Matthias Heinig
Summary: This study integrates genomics, transcriptomics, and proteomics data to investigate the consequences of genetic variants for transcript and protein levels in atrial tissue. The authors reveal the regulatory network underlying atrial fibrillation and provide a resource for cardiac gene prioritization.
NATURE COMMUNICATIONS
(2022)
Article
Cardiac & Cardiovascular Systems
Ulrich Schotten, Seungyup Lee, Stef Zeemering, Albert L. Waldo
Summary: Determining the sequence of activation in atrial fibrillation (AF) is vital for understanding its electrophysiological mechanism(s), but the complex nature of electrograms has posed challenges. Different approaches have led to varied interpretations of AF mechanisms, with a lack of a comprehensive consensus. Traditional views propose multiple wavelets, various types of re-entry, but a universally accepted paradigm for AF mechanisms is still missing.
Article
Genetics & Heredity
Simon G. Williams, Dominic Byrne, Bernard D. Keavney
Summary: This study examined the genetic etiology of congenital heart disease using UK Biobank exomes, identifying important variants associated with GATA6. Despite limitations in detailed familial phenotype information, significant associations were derived through careful selection of case and control cohorts.
JOURNAL OF HUMAN GENETICS
(2022)
Review
Chemistry, Analytical
Jian-Dong Huang, Jinling Wang, Elaine Ramsey, Gerard Leavey, Timothy J. A. Chico, Joan Condell
Summary: Cardiovascular disease is the leading cause of death worldwide. The use of artificial intelligence to analyze data from wearable devices and other sensors can provide earlier and more accurate prediction and diagnosis of heart disease. Combining artificial intelligence with sensing devices in digital health technologies can help prevent cardiovascular disease and reduce its morbidity and mortality.
Article
Multidisciplinary Sciences
Celine Souilhol, Blanca Tardajos Ayllon, Xiuying Li, Mannekomba R. Diagbouga, Ziqi Zhou, Lindsay Canham, Hannah Roddie, Daniela Pirri, Emily Chambers, Mark J. Dunning, Mark Ariaans, Jin Li, Yun Fang, Helle F. Jorgensen, Michael Simons, Rob Krams, Johannes Waltenberger, Maria Fragiadaki, Victoria Ridger, Sarah De Val, Sheila E. Francis, Timothy J. A. Chico, Jovana Serbanovic-Canic, Paul C. Evans
Summary: This study demonstrates the role of the JAG1-NOTCH4 signaling pathway in sensing disturbed blood flow and promoting atherosclerosis susceptibility by regulating endothelial cell heterogeneity.
Article
Biochemistry & Molecular Biology
Rachel A. Oldershaw, Gavin Richardson, Phillippa Carling, W. Andrew Owens, David J. Lundy, Annette Meeson
Summary: This study compared cardiac stem cell-like cells from patients with bicuspid aortic valve disease and coronary artery disease. The results showed that stem cell-like cells from bicuspid aortic valve disease displayed a prematurely aged phenotype, with lower cell doubling rate, metabolic activity, shorter telomere lengths, and higher expression of p16.
Article
Hematology
Lindsay Canham, Sam Sendac, Mannekomba R. Diagbouga, Elena Wolodimeroff, Daniela Pirri, Blanca Tardajos Ayllon, Shuang Feng, Celine Souilhol, Timothy J. A. Chico, Paul C. Evans, Jovana Serbanovic-Canic
Summary: Hemodynamic wall shear stress (WSS) exerted on the endothelium by flowing blood determines the spatial distribution of atherosclerotic lesions. Disturbed flow (DF) with low WSS promotes atherosclerosis, while unidirectional flow with high WSS is protective. This study investigates the role of EVA1A in WSS-regulated endothelial cell dysfunction.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Cell Biology
Ryan O. Snodgrass, Karan Govindpani, Karen Plant, Elisabeth C. Kugler, Changmin Doh, Thomas Dawson, Luis E. McCormack, Helen M. Arthur, Timothy J. A. Chico
Summary: Hereditary haemorrhagic telangiectasia (HHT) is caused by mutations in the BMP co-receptor endoglin, leading to arteriovenous malformations (AVMs) and various complications. Zebrafish models were used to study the vascular phenotypes associated with endoglin mutations and the effect of inhibiting Vegf signalling pathways. Inhibiting mTOR or MEK pathways prevented abnormal vasculature phenotypes, suggesting a potential therapeutic strategy in HHT. These findings highlight the importance of Vegf signalling modulation in mitigating HHT-like phenotypes.
DISEASE MODELS & MECHANISMS
(2023)
Article
Health Care Sciences & Services
William G. Dixon, Sabine N. van der Veer, Syed Mustafa Ali, Lynn Laidlaw, Richard J. B. Dobson, Cathie Sudlow, Tim Chico, Jacqueline A. L. MacArthur, Aiden Doherty
Summary: The use of data from smartphones and wearable devices has great potential for population health research, but the uptake of large-scale mobile health research has not met expectations. Digital person-generated health data are crucial for answering research questions, but there are challenges such as data inequality, selection bias, data collection tools, data harmonization, time series data analysis, and patient and public involvement. Establishing an interdisciplinary community can transform people's lives for the better.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2023)
Review
Chemistry, Analytical
Muhammad Ali Shiwani, Timothy J. A. Chico, Fabio Ciravegna, Lyudmila Mihaylova
Summary: Cardiovascular diseases cause 18 million deaths each year. Current assessment of a patient's health only occurs during infrequent clinical visits, providing limited information about their daily life health. Advances in mobile health technologies, such as wearable devices, allow for continuous monitoring of health indicators and mobility. Longitudinal, clinically relevant measurements obtained through these technologies can improve prevention, detection, and treatment of cardiovascular diseases. This review discusses the advantages and disadvantages of different methods for monitoring cardiovascular disease patients during daily life, including physical activity, indoor home, and physiological parameter monitoring.
Editorial Material
Sport Sciences
Timothy James Chico, Emmanuel Stamatakis, Fabio Ciravegna, Jessilyn Dunn, Simon Redwood, Rasha Al-lamee, Reecha Sofat, Jason Gill
BRITISH JOURNAL OF SPORTS MEDICINE
(2023)
Editorial Material
Sport Sciences
Emmanuel Stamatakis, Matthew Ahmadi, Marie H. Murphy, Timothy James Chico, Karen Milton, Borja Del Pozo Cruz, Peter T. Katzmarzyk, I-Min Lee, Jason Gill
BRITISH JOURNAL OF SPORTS MEDICINE
(2023)
Editorial Material
Sport Sciences
Jason M. R. Gill, Timothy J. Chico, Aiden Doherty, Jessilyn Dunn, Ulf Ekelund, Peter T. Katzmarzyk, Karen Milton, Marie H. Murphy, Emmanuel Stamatakis
BRITISH JOURNAL OF SPORTS MEDICINE
(2023)
Article
Chemistry, Analytical
Peter D. Winter, Timothy J. A. Chico
Summary: A digital twin is a virtual representation of a complex system, updated with data from its real counterpart. They are utilized in various industries, including medicine, to improve healthcare and prevention. However, the implementation of digital twins faces technical, scientific, social, and ethical challenges that need to be addressed.
Article
Medicine, General & Internal
Kamilla Abdullayev, Timothy J. A. Chico, Matthew Manktelow, Oliver Buckley, Joan Condell, Richard J. Van Arkel, Vanessa Diaz, Faith Matcham
Summary: Cardiovascular diseases are prevalent in the UK, but the quality of care is declining due to accessibility and resource issues. The implementation of digital technologies in cardiovascular care has the potential to relieve the burden on the NHS, but it is important to consider the perspectives of both service users and clinicians.
Editorial Material
Biochemistry & Molecular Biology
Yingjuan Liu, Mun-kit Choy, Sabu Abraham, Gennadiy Tenin, Graeme C. Black, Bernard D. Keavney
Article
Cardiac & Cardiovascular Systems
Pyotr Telyuk, Helen Hancock, Rebecca Maier, Jonathan A. Batty, Andrew Goodwin, W. Andrew Owens, Emmanuel Ogundimu, Enoch Akowuah
Summary: This study compared long-term outcomes of patients with severe aortic stenosis undergoing mini-sternotomy versus conventional sternotomy AVR, showing no significant differences in all-cause mortality, reoperation rate, MACE events, and echocardiographic data at a median follow-up of 6.1 years.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Andrew B. Harvey, Renelyn A. Woltes, Raymond N. Deepe, Hannah G. Tarolli, Jenna R. Drummond, Allison Trouten, Auva Zandi, Jeremy L. Barth, Rupak Mukherjee, Martin J. Romeo, Silvia G. Vaena, Ge Tao, Robin Muise-Helmericks, Paula S. Ramos, Russell A. Norris, Andy Wessels
Summary: This study highlights the importance of SOX9 in the regulation of epicardial cell invasion and emphasizes the role of EPDCs in regulating atrioventricular valve development and homeostasis. It also reports a novel expression profile of Cd109, a gene with previously unknown relevance in heart development.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
Review
Cardiac & Cardiovascular Systems
MariaSanta C. Mangione, Jinhua Wen, Dian J. Cao
Summary: mTOR, a mechanistic target of rapamycin, is an evolutionarily conserved pathway that plays a fundamental role in nutrient sensing, growth, metabolism, lifespan, and aging. Recent studies have highlighted the regulatory role of mTOR in innate immune responses and its involvement in the pathogenesis of cardiovascular diseases, especially in acute inflammation and atherosclerotic cardiovascular disease. This review also discusses mTOR's role in trained immunity, immune senescence, and clonal hematopoiesis, as well as its architecture and regulatory complexes.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Junlin Li, Yajun Gong, Yiren Wang, Huihui Huang, Huan Du, Lianying Cheng, Cui Ma, Yongxiang Cai, Hukui Han, Jianhong Tao, Gang Li, Panke Cheng
Summary: Myocardial ischemia-reperfusion injury is closely related to the final infarct size in acute myocardial infarction. Regulatory T cells play an important role in the inflammatory response after AMI, but different subtypes of Tregs have different effects on the injury.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Yuxin Chu, Yutao Hua, Lihao He, Jin He, Yunxi Chen, Jing Yang, Ismail Mahmoud, Fanfang Zeng, Xiaochang Zeng, Gloria A. Benavides, Victor M. Darley-Usmar, Martin E. Young, Scott W. Ballinger, Sumanth D. Prabhu, Cheng Zhang, Min Xie
Summary: This study demonstrates that administering beta-hydroxybutyrate (beta-OHB) at the time of reperfusion can reduce infarct size and preserve cardiac function by activating autophagy and preserving mitochondrial homeostasis, potentially through mTOR inhibition.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)