Article
Biotechnology & Applied Microbiology
M. Yousuf Salmasi, Selene Pirola, Sumesh Sasidharan, Serena M. Fisichella, Alberto Redaelli, Omar A. Jarral, Declan P. O'Regan, Aung Ye Oo, James E. Moore, Xiao Yun Xu, Thanos Athanasiou
Summary: The study found that elevated values of WSS in ATAA patients were associated with aortic wall degradation, indicating a potential relationship between WSS and the progression of ATAA disease. Further research may help in identifying threshold values to predict acute aortic events.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Geriatrics & Gerontology
Xinyu Liang, Fei Peng, Yunchu Yao, Yuting Yang, Aihua Liu, Duanduan Chen
Summary: This study investigated the pathophysiological mechanisms of intracranial fusiform aneurysms (IFAs) based on the characteristics of aneurysm wall enhancement (AWE), hemodynamics, and morphology. The results showed significant associations between AWE and aneurysm size as well as hemodynamic parameters. Further research is needed to understand the underlying pathological mechanisms of different types of fusiform aneurysms.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
E. Hachem, P. Meliga, A. Goetz, P. Jeken Rico, J. Viquerat, A. Larcher, R. Valette, A. F. Sanches, V. Lannelongue, H. Ghraieb, R. Nemer, Y. Ozpeynirci, T. Liebig
Summary: This study aims to identify and characterize novel flow-deviator stent devices through a high-fidelity computational framework and deep reinforcement learning algorithms. The goal is to enable patient-specific treatment by accurately adjusting the functional parameters in the implanted state.
SCIENTIFIC REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
Sricharan S. S. Veeturi, Tatsat R. R. Patel, Ammad A. A. Baig, Aichi Chien, Andre Monteiro, Muhammad Waqas, Kenneth V. V. Snyder, Adnan H. H. Siddiqui, Vincent M. M. Tutino
Summary: The study shows that there is a correlation between hemodynamic simulation results and the wall type of intracranial aneurysm. High wall shear stress and normalized wall shear stress are associated with thin regions of the aneurysm wall rather than thick and normal regions.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2022)
Article
Multidisciplinary Sciences
Sricharan S. Veeturi, Hamidreza Rajabzadeh-Oghaz, Nandor K. Pinter, Muhammad Waqas, David M. Hasan, Kenneth Snyder, Adnan H. Siddiqui, Vincent M. Tutino
Summary: Vessel wall enhancement (VWE) in unruptured intracranial aneurysms has been found to be associated with aneurysm risk, with strong correlations between CRstalk and size, and moderate correlation with rupture resemblance score (RRS). Additionally, CRstalk showed weak negative correlation with normalized wall shear stress (WSS) and weak positive correlation with size ratio (SR). Local voxel-based analysis revealed a weak negative correlation between WSS and contrast-enhanced MRI signal intensity, suggesting potential non-localized effects of low-normalized WSS on enhancement-associated pathobiology.
ROYAL SOCIETY OPEN SCIENCE
(2021)
Article
Cardiac & Cardiovascular Systems
Vincenzo Tufaro, Ryo Torii, Emrah Erdogan, Pieter Kitslaar, Bon-Kwon Koo, Roby Rakhit, Grigoris Karamasis, Christos Costa, Patrick Serruys, Daniel A. Jones, Anthony Mathur, Andreas Baumbach, Jean-Paul Aben, Christos Bourantas
Summary: A user-friendly software for real-time calculation of wall shear stress (WSS) showed high accuracy and reproducibility in assessing WSS distribution. The software significantly reduced simulation time compared to conventional methods.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Clinical Neurology
Takehiro Uno, Kouichi Misaki, Kazuya Futami, Iku Nambu, Akifumi Yoshikawa, Tomoya Kamide, Naoyuki Uchiyama, Mitsutoshi Nakada
Summary: This study aimed to investigate the influences of differences in aneurysm models and identify causative hemodynamic factors for de novo bleb formation. The results showed that de novo blebs formed in areas with high pressure, low wall shear stress, and the center of divergent wall shear stress vectors. The multipoint method introduced in this study was useful for statistical analysis of hemodynamics in a limited number of aneurysms.
NEUROLOGICAL SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Siting Li, Xiaoning Sun, Mengyin Chen, Tianxiang Ma, Xiao Liu, Yuehong Zheng
Summary: This study aims to explore the effect of common hemodynamic parameters on visceral artery aneurysms (VAAs) and uses real patients' models for research. The results revealed that high-wall shear stress group had higher hemodynamic parameters compared to low-wall shear stress group, indicating their importance in the formation of VAAs.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Computer Science, Interdisciplinary Applications
Harry J. Carpenter, Mergen H. Ghayesh, Anthony C. Zander, Peter J. Psaltis
Summary: This study investigates the relationship between twelve multi-directional/topological wall shear stress (WSS) derived metrics and the formation of coronary plaques using computational fluid dynamics (CFD) and dynamic fluid-structure interaction (FSI) frameworks. The results highlight the importance of multi-directional and topological WSS metrics in atherosclerosis related mechanotransduction and near-wall transport processes. Further research is needed to explore the mechanisms of atherosclerosis and longitudinal changes in coronary dynamics.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2023)
Review
Clinical Neurology
Hamidreza Rajabzadeh-Oghaz, Adnan H. Siddiqui, Arash Asadollahi, John Kolega, Vincent M. Tutino
Summary: Hemodynamics plays a crucial role in the development of intracranial aneurysms. Studies have shown that high flow conditions can lead to wall degeneration, while low flow conditions may result in wall thickening.
NEUROSURGICAL REVIEW
(2022)
Article
Biophysics
Christian J. Mandrycky, Ashley N. Abel, Samuel Levy, Laurel M. Marsh, Fanette Chassagne, Venkat K. Chivukula, Sari E. Barczay, Cory M. Kelly, Louis J. Kim, Alberto Aliseda, Michael R. Levitt, Ying Zheng
Summary: In this study, we developed a robust workflow to generate anatomic-scale aneurysm models and compared the flow patterns induced by parent vessel curvature. We found that these flow patterns correlated with changes in wall shear stress and wall shear stress gradients, which in turn affected cell morphology and cellular protein localization. These findings highlight the potential of cellularized aneurysm models to bridge computational fluid dynamics with underlying endothelial biology.
JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME
(2023)
Article
Clinical Neurology
Xiao Mo, Hongshi Yu, Rong Chen, Zhenpeng Chen, Haiyun Li
Summary: This study introduced a novel method for calculating the energy loss of intracranial aneurysms and revealed the temporal and spatial characteristics of energy loss through hemodynamic analysis of aneurysms located at the posterior communicating segment of the internal carotid artery. The results showed that energy loss mainly occurred in the boundary layer and high-velocity inflow jet region, reaching its peak during cardiac systole and gradually decreasing during diastole until the end of the cardiac cycle.
FRONTIERS IN NEUROLOGY
(2021)
Article
Computer Science, Interdisciplinary Applications
Nimmy Thankom Philip, Srinivas Bolem, B. J. Sudhir, B. S. V. Patnaik
Summary: This study investigates the influence of morphological features and hemodynamic forces on the rupture of cerebral aneurysms. Three different shapes of aneurysms are studied: spherical, beehive, and pear-shaped. The study compares these model aneurysms with patient-specific configurations. The results show that pear-shaped aneurysms may lead to atherosclerotic lesions, while beehive-shaped aneurysms are more prone to forming secondary blebs. Spherical aneurysms exhibit a stable flow field and uniform distribution of wall stresses, indicating a hemodynamically and bio-mechanically stable condition.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2022)
Article
Clinical Neurology
Weiying Zhong, Yiming Du, Hong Kuang, Ming Liu, Feng Xue, Xue Bai, Donghai Wang, Wandong Su, Yunyan Wang
Summary: This study found that low wall shear stress, low aneurysm pressure, and increased low shear area were significantly associated with aneurysm wall enhancement on vessel wall magnetic resonance imaging in unruptured cerebral aneurysms.
FRONTIERS IN NEUROLOGY
(2022)
Article
Materials Science, Multidisciplinary
Prasanth Velvaluri, Mariya S. Pravdivtseva, Philipp Berg, Fritz Wodarg, Rodrigo Lima de Miranda, Jan-Bernd Hoevener, Olav Jansen, Eckhard Quandt
Summary: The study demonstrates a workflow for designing, fabricating, and characterizing novel thin-film FDs that can be individualized to meet patient-specific needs. Thin-film FDs are shown to overcome limitations of braided FDs and offer higher design flexibility.
ADVANCED MATERIALS TECHNOLOGIES
(2021)
Article
Neuroimaging
Edgar A. Samaniego, Mark Fisher, David Hasan, Waldo R. Guerrero, Johanna T. Fifi, Laura Bottani, Santiago Ortega-Gutierrez
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2018)
Article
Clinical Neurology
Menno R. Germans, Blessing N. R. Jaja, Airton Leonardo de Oliviera Manoel, Ashley H. Cohen, R. Loch Macdonald
JOURNAL OF NEUROSURGERY
(2018)
Article
Clinical Neurology
Yasunori Nagahama, Lauren Allan, Daichi Nakagawa, Mario Zanaty, Robert M. Starke, Nohra Chalouhi, Pascal Jabbour, Robert D. Brown, Colin P. Derdeyn, Enrique C. Leira, Joseph Broderick, Marc Chimowitz, James C. Torner, David Hasan
JOURNAL OF NEUROSURGERY
(2018)
Article
Clinical Neurology
Daizo Ishii, Luyuan Li, Mario Zanaty, Jorge A. Roa, Lauren Allan, Edgar A. Samaniego, David M. Hasan
INTERVENTIONAL NEURORADIOLOGY
(2020)
Article
Clinical Neurology
J. M. Sequeiros, J. A. Roa, R. P. Sabotin, S. Dandapat, S. Ortega-Gutierrez, E. C. Leira, C. P. Derdeyn, G. Bathla, D. M. Hasan, E. A. Samaniego
AMERICAN JOURNAL OF NEURORADIOLOGY
(2020)
Article
Clinical Neurology
S. Hadad, F. Mut, B. J. Chung, J. A. Roa, A. M. Robertson, D. M. Hasan, E. A. Samaniego, J. R. Cebral
Summary: The study found that regions of aneurysm wall enhancement tend to have lower wall shear stress than nonenhanced regions, and the association between flow conditions and aneurysm wall enhancement depends on the location of the region on the aneurysm sac.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2021)
Article
Clinical Neurology
Daizo Ishii, Mario Zanaty, Jorge A. Roa, Luyuan Li, Yongjun Lu, Ryan Sabotin, Lauren Allan, Edgar A. Samaniego, David M. Hasan
Summary: This study found that higher luminal concentrations of lipoprotein(a) in the aneurysm sac were significantly associated with increased wall enhancement of UIAs. This suggests that lipoprotein(a) may be an important factor in vascular wall changes of UIAs. Larger studies are needed to confirm these findings.
Article
Clinical Neurology
Luyuan Li, Vaelan A. Molian, Scott C. Seaman, Mario Zanaty, Matthew A. Howard, Jeremy D. Greenlee, David M. Hasan, Enrique C. Leira
Summary: In this retrospective study, the addition of hematoma evacuation during decompressive hemicraniectomy for spontaneous intracerebral hemorrhage did not significantly alter functional outcomes at 6 months, suggesting that the surgical approach may not affect patient outcomes.
Article
Clinical Neurology
Mario Zanaty, Lauren Allan, Edgar A. Samaniego, Anthony Piscopo, Eleanor Ryan, James C. Torner, David Hasan
Summary: The study suggests that using tirofiban in patients with aneurysmal subarachnoid hemorrhage can reduce the incidence of delayed cerebral ischemia.
Article
Clinical Neurology
Daizo Ishii, Mario Zanaty, Jorge A. Roa, Luyuan Li, Yongjun Lu, Lauren Allan, Edgar A. Samaniego, James C. Torner, Daniel Tranel, David M. Hasan
Summary: The study aimed to assess the correlation of POCD with GA versus MAC in treating UIAs. The results indicated that using MAC in endovascular treatments for UIAs was associated with a decrease in POCD compared to GA. Larger randomized studies are needed to confirm these findings.
INTERVENTIONAL NEURORADIOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
William S. Dodd, Dimitri Laurent, Aaron S. Dumont, David M. Hasan, Pascal M. Jabbour, Robert M. Starke, Koji Hosaka, Adam J. Polifka, Brian L. Hoh, Nohra Chalouhi
Summary: Delayed cerebral ischemia is a significant predictor of poor outcomes in patients with subarachnoid hemorrhage, with limited treatment options. Advances in basic science have improved understanding of delayed cerebral ischemia and may lead to novel treatments. Emphasizing major themes while highlighting interdependencies among pathological factors is crucial for improving outcomes.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Clinical Neurology
Suzy H. Lin, Colette Galet, Mario Zanaty, Emine Bayman, William K. Rogers, David Hasan, Lauren D. Allan
Summary: The study found that the use of melatonin in aSAH patients does not decrease the incidence of DCI, but may improve mortality rates. Larger prospective studies are needed to validate these findings.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2021)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
David Hasan
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Letter
Clinical Neurology
Regan M. Shanahan, Joseph S. Hudson, David M. Hasan
TRANSLATIONAL STROKE RESEARCH
(2023)
Review
Critical Care Medicine
Aldo A. Mendez, Edgar A. Samaniego, Sunil A. Sheth, Sudeepta Dandapat, David M. Hasan, Kaustubh S. Limaye, Bradley J. Hindman, Colin P. Derdeyn, Santiago Ortega-Gutierrez
CRITICAL CARE RESEARCH AND PRACTICE
(2018)