Journal
COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING
Volume 19, Issue 1, Pages 60-66Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10255842.2014.984701
Keywords
restenosis; streamlined cross-section; monocytes; adhesion; endovascular stent
Funding
- National Science Foundation of China [31170904, 11072023, 11172156, 30970822, 11202016]
- China Postdoctoral Science Foundation [2012M510021]
- Special Financial Grant from the China Postdoctoral Science Foundation [2013T60105]
Ask authors/readers for more resources
We proposed a new stent with streamlined cross-sectional wires, which is different from the clinical coronary stents with square or round cross-sections. We believe the new stent might have better hemodynamic performance than the clinical metal stents. To test the hypothesis, we designed an experimental study to compare the performance of the new stent with the clinical stents in terms of monocyte (U-937 cells) adhesion. The results showed that when compared with the clinical stents, the adhesion of U-937 cells were much less in the new stent. The results also showed that, when Reynolds number increased from 180 (the rest condition for the coronary arteries) to 360 (the strenuous exercise condition for the coronary arteries), the flow disturbance zones in the clinical stents became larger, while they became smaller with the new stent. The present experimental study therefore suggests that the optimization of the cross-sectional shape of stent wires ought to be taken into consideration in the design of endovascular stents.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available