Article
Medicine, General & Internal
Willemina A. van Veldhuizen, Richte C. L. Schuurmann, Frank F. A. IJpma, Rogier H. J. Kropman, George A. Antoniou, Jelmer M. Wolterink, Jean-Paul P. M. de Vries
Summary: This study uses a statistical shape model (SSM) to analyze and describe the morphology of the infra-abdominal aortic neck, identifying five important shape features. The SSM model provides an objective and quantitative description of the neck morphology in individual patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Cardiac & Cardiovascular Systems
Christiana Lowis, Aurellia Ramara Winaya, Puja Kumari, Cristobal F. Rivera, John Vlahos, Rio Hermantara, Muhammad Yogi Pratama, Bhama Ramkhelawon
Summary: Cumulative evidence supports the idea that mechanical and frictional forces have distinct effects in the aortic layers and contribute to the development of abdominal aortic aneurysms (AAA). Mechanosensory cellular hubs play a crucial role in triggering signaling cascades that lead to the degradation of the extracellular matrix (ECM), resulting in aortic rupture. This review provides an overview of the current understanding of the mechanotransduction networks in different cell types during AAA development, focusing on the mechanosensors and stressors that accumulate in the AAA sac and their effects on inflammation, oxidative stress, remodeling, and ECM degradation. Manipulating this mechano-machinery could be a promising direction for future AAA research.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
David Sanchez-Infantes, Meritxell Nus, Miquel Navas-Madronal, Joan Fite, Belen Perez, Antonio J. Barros-Membrilla, Begona Soto, Jose Martinez-Gonzalez, Mercedes Camacho, Cristina Rodriguez, Ziad Mallat, Maria Galan
Summary: The study found extensive inflammatory infiltration in the aneurysmal wall, mainly composed of T cells, macrophages, and B cells, and altered levels of ROS, IgM, IgG, CD38, GDF15, S100A4, and CD36 in the plasma and aneurysmal tissue of AAA patients compared to controls. Circulating levels of IgG, CD38, and GDF15 were positively correlated with abdominal aortic diameter, and CD38 was correlated with PWS.
Article
Biochemistry & Molecular Biology
Leander Gaarde Melin, Julie Husted Dall, Jes S. Lindholt, Lasse B. Steffensen, Hans Christian Beck, Sophie L. Elkrog, Pernille D. Clausen, Lars Melholt Rasmussen, Jane Stubbe
Summary: Supplementation of cycloastragenol can inhibit the progression of abdominal aortic aneurysm, possibly by reducing matrix metalloprotease-2 activity, preserving elastin, and reducing calcification.
Review
Cardiac & Cardiovascular Systems
Li Yin, Eric William Kent, Bowen Wang
Summary: Abdominal aortic aneurysm (AAA) is a common focal dilation of the aorta in the elderly population, which can lead to aneurysmal rupture with a mortality rate of around 80%. Despite increased screening efforts, there is currently no cure to halt the expansion of AAA, partly due to incomplete understanding of its pathogenesis. Animal models provide valuable insights into AAA pathophysiology, but no single experimental model fully captures the complexity of the disease.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Azar Hosseini, Toktam Sahranavard, Zeljko Reiner, Tannaz Jamialahmadi, Yusra Al Dhaheri, Ali H. Eid, Amirhossein Sahebkar
Summary: This article reviews different studies and summarizes potential mechanisms by which statins can have an effect on abdominal aortic aneurysm (AAA). The evidence suggests an association between treatment with statins and improvement of AAA.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Azar Hosseini, Peter E. Penson, Arrigo F. G. Cicero, Jonathan Golledge, Khalid Al-Rasadi, Tannaz Jamialahmadi, Amirhossein Sahebkar
Summary: This review critically summarized prior research on the potential benefits of phytochemicals in preventing or treating AAA, with preliminary data supporting further investigation of certain phytochemicals as potential treatments for AAA.
CURRENT MEDICINAL CHEMISTRY
(2021)
Article
Cardiac & Cardiovascular Systems
Naofumi Amioka, Toru Miyoshi, Tomoko Yonezawa, Megumi Kondo, Satoshi Akagi, Masashi Yoshida, Yukihiro Saito, Kazufumi Nakamura, Hiroshi Ito
Summary: This study found that Pemafibrate has a preventive effect on AAA rupture, reducing ROS, inflammation, and extracellular matrix degradation. The protective effect against AAA rupture is partly mediated by the antioxidative effect of catalase induced by Pemafibrate.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Sakshi Vats, Kristina Sundquist, Jan Sundquist, Naiqi Zhang, Xiao Wang, Stefan Acosta, Anders Gottsater, Ashfaque A. Memon
Summary: The study investigates the impact of genetic variations in genes related to oxidative stress, intake of antioxidant vitamins, and potential interactions on abdominal aortic aneurysm (AAA) and its rupture. Results show that a variant in NOX3 is associated with increased risk of AAA and rupture. Higher intake of antioxidant vitamins, riboflavin, and folate are associated with reduced incidence of AAA. The relationship between riboflavin and vitamin B12 intake and AAA risk is modified by sex.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Oncology
Laura Lopez-Sanz, Susana Bernal, Luna Jimenez-Castilla, Ignacio Prieto, Sara La Manna, Sergio Gomez-Lopez, Luis Miguel Blanco-Colio, Jesus Egido, Jose Luis Martin-Ventura, Carmen Gomez-Guerrero
Summary: Research has shown that overexpression of FcγR has been detected in abdominal aortic aneurysm lesions, and inhibiting FcγR signaling molecules can reduce AAA development, restore inflammatory responses and vascular wall injury, potentially serving as therapeutic targets for AAA disease.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Javier Rodriguez-Carrio, Isabel Cerro-Pardo, Jes S. Lindholt, Elena Bonzon-Kulichenko, Diego Martinez-Lopez, Raquel Roldan-Montero, Joan-Carles Escola-Gil, Jean-Baptiste Michel, Luis Miguel Blanco-Colio, Jesus Vazquez, Ana Suraez, Jose Luis Martin-Ventura
Summary: The study found that oxidative modifications could lead to dysfunctional HDL in abdominal aortic aneurysm (AAA), and antibodies against HDL-MDA have the potential to be used as stable biomarkers of oxidative stress in AAA patients. These antibodies were detected in both a mouse model and AAA patients.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Review
Medicine, General & Internal
Petroula Nana, Konstantinos Dakis, Alexandros Brodis, Konstantinos Spanos, George Kouvelos
Summary: A systematic review examined the correlation of abdominal aortic aneurysm expansion rates with serum circulating biomarkers, identifying specific biomarkers potentially useful for individualized surveillance of patients with increased AAA growth rates. Various biomarkers, including D-dimers, LDL-C, HDL-C, and genetic factors, were found to be significantly associated with AAA growth rates, suggesting a potential role for serum biomarkers in patient monitoring.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Cardiac & Cardiovascular Systems
John Anagnostakos, Brajesh K. Lal
Summary: Abdominal aortic aneurysms (AAA) are common in older adults and can lead to serious morbidity and mortality if not treated promptly. The causes include trauma, infection, and inflammatory disorders, with risk factors such as smoking, advanced age, dyslipidemia, hypertension, and coronary artery disease. The pathophysiology involves arterial insult leading to inflammation and weakening of the arterial wall, requiring monitoring of size and growth rate to prevent rupture. Management options include controlling risk factors, surgical intervention based on risk assessment, and post-operative monitoring for complications. Advancements in technology have improved the diagnosis and treatment of AAA in recent years.
PROGRESS IN CARDIOVASCULAR DISEASES
(2021)
Article
Surgery
Sydney L. Olson, Annalise M. Panthofer, William Blackwelder, Michael L. Terrin, John A. Curci, B. Timothy Baxter, Fred A. Weaver, Jon S. Matsumura
Summary: This study examines the predictors of abdominal aortic aneurysm (AAA) volume growth and finds that baseline volume, tortuosity, maximum transverse diameter (MTD), current tobacco use, angiotensin II receptor blocker use, and history of diabetes mellitus are predictive of volume growth over time.
JOURNAL OF VASCULAR SURGERY
(2022)
Article
Biochemistry & Molecular Biology
Hana Hadzikadunic, Tea Bovling Sjaelland, Jes S. Lindholt, Lasse Bach Steffensen, Hans Christian Beck, Egle Kavaliunaite, Lars Melholt Rasmussen, Jane Stubbe
Summary: In this study, the researchers investigated the effect of low-dose nicotine on the progression of elastase-induced abdominal aortic aneurysms (AAAs). They found that nicotine promotes AAA progression and reduces the activity of pro-matrix metalloproteinase 2 and MMP9 in aneurysmal tissue. However, nicotine has no effect on inflammatory response and oxidative stress. Therefore, these results do not support the use of low-dose nicotine for preventing AAA progression.