Journal
COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING
Volume 12, Issue 4, Pages 415-422Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10255840802654319
Keywords
cartilage; biphasic theory; indentation testing
Funding
- VA Rehabilitation RD Service [A2592R]
- Stanford Regenerative Medicine Training Grant [R90 DK071508-02]
- NIH [EB005790-01, EB002524-04]
- Bio-X Student Fellowship
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [R01EB002524, R01EB005790] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R90DK071508] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [U54GM072970] Funding Source: NIH RePORTER
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Cartilage material properties are important for understanding joint function and diseases, but can be challenging to obtain. Three biphasic material properties (aggregate modulus, Poisson's ratio and permeability) can be determined using an analytical or finite element model combined with optimisation to find the material properties values that best reproduce an experimental creep curve. The purpose of this study was to develop an easy-to-use resource to determine biphasic cartilage material properties. A Cartilage Interpolant Response Surface was generated from interpolation of finite element simulations of creep indentation tests. Creep indentation tests were performed on five sites across a tibial plateau. A least-squares residual search of the Cartilage Interpolant Response Surface resulted in a best-fit curve for each experimental condition with corresponding material properties. These sites provided a representative range of aggregate moduli (0.48-1.58MPa), Poisson's ratio (0.00-0.05) and permeability (1.7x10-15-5.4x10-15m4/Ns) values found in human cartilage. The resource is freely available from https://simtk.org/home/va-squish.
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