Following Natures Lead: On the Construction of Membrane-Inserted Toxins in Lipid Bilayer Nanodiscs

Hemolytic Lectin CEL-III Heptamerizes via a Large Structural Transition from α-Helices to a β-Barrel during the Transmembrane Pore Formation Process

(2014) Hideaki Unno et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure-based pharmacophore modeling and virtual screening to identify novel inhibitors for anthrax lethal factor

(2014) Huang-Sheng Liao et al.   MEDICINAL CHEMISTRY RESEARCH

Architecture and conformational switch mechanism of the ryanodine receptor

(2014) Rouslan G. Efremov et al.   NATURE

Probing structurally altered and aggregated states of therapeutically relevant proteins using GroEL coupled to bio-layer interferometry

(2014) Subhashchandra Naik et al.   PROTEIN SCIENCE

Membrane protein stability can be compromised by detergent interactions with the extramembranous soluble domains

(2014) Zhengrong Yang et al.   PROTEIN SCIENCE

The Resolution Revolution

(2014) W. Kuhlbrandt   SCIENCE

Monitoring the Kinetics of the pH-Driven Transition of the Anthrax Toxin Prepore to the Pore by Biolayer Interferometry and Surface Plasmon Resonance

(2013) Subhashchandra Naik et al.   BIOCHEMISTRY

Assembly of anthrax toxin pore: Lethal-factor complexes into lipid nanodiscs

(2013) N. Akkaladevi et al.   PROTEIN SCIENCE

Three dimensional structure of the anthrax toxin translocon-lethal factor complex by cryo-electron microscopy

(2013) E. P. Gogol et al.   PROTEIN SCIENCE

Three-dimensional structure of Bax-mediated pores in membrane bilayers

(2013) X-P Xu et al.   Cell Death & Disease

Electrostatic Ratchet in the Protective Antigen Channel Promotes Anthrax Toxin Translocation

(2012) Sarah L. Wynia-Smith et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reconstitution of the Escherichia coli cell division ZipA–FtsZ complexes in nanodiscs as revealed by electron microscopy

(2012) Víctor M. Hernández-Rocamora et al.   JOURNAL OF STRUCTURAL BIOLOGY

Ratcheting up protein translocation with anthrax toxin

(2012) Geoffrey K. Feld et al.   PROTEIN SCIENCE

Molecular Motions as a Drug Target: Mechanistic Simulations of Anthrax Toxin Edema Factor Function Led to the Discovery of Novel Allosteric Inhibitors

(2012) Élodie Laine et al.   Toxins

Cys−Cys Cross-Linking Shows Contact between the N-Terminus of Lethal Factor and Phe427 of the Anthrax Toxin Pore

(2011) Blythe E. Janowiak et al.   BIOCHEMISTRY

Thermodynamic Measurements of Bilayer Insertion of a Single Transmembrane Helix Chaperoned by Fluorinated Surfactants

(2011) Alexander Kyrychenko et al.   JOURNAL OF MOLECULAR BIOLOGY

Aligning Nanodiscs at the Air–Water Interface, a Neutron Reflectivity Study

(2011) Maria Wadsäter et al.   LANGMUIR

Cryo-EM structure of the ribosome–SecYE complex in the membrane environment

(2011) Jens Frauenfeld et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Recreation of the terminal events in physiological integrin activation

(2010) Feng Ye et al.   JOURNAL OF CELL BIOLOGY

Three-dimensional structure of the anthrax toxin pore inserted into lipid nanodiscs and lipid vesicles

(2010) H. Katayama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effect of detergent concentration on the thermal stability of a membrane protein: The case study of bacterial reaction center solubilized by N,N-dimethyldodecylamine-N-oxide

(2009) Gerardo Palazzo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Quantitative high-throughput screening identifies inhibitors of anthrax-induced cell death

(2009) Ping Jun Zhu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Membrane protein assembly into Nanodiscs

(2009) Timothy H. Bayburt et al.   FEBS LETTERS

Capillary morphogenesis protein-2 is the major receptor mediating lethality of anthrax toxin in vivo

(2009) S. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An approach to characterizing single-subunit mutations in multimeric prepores and pores of anthrax protective antigen

(2009) Blythe E. Janowiak et al.   PROTEIN SCIENCE

Solubilization and characterization of the anthrax toxin pore in detergent micelles

(2009) Gregory Vernier et al.   PROTEIN SCIENCE

Interactions of Fluorinated Surfactants with Diphtheria Toxin T-Domain: Testing New Media for Studies of Membrane Proteins

(2008) Mykola V. Rodnin et al.   BIOPHYSICAL JOURNAL

GroEL as a molecular scaffold for structural analysis of the anthrax toxin pore

(2008) Hiroo Katayama et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY