Membrane protein stability can be compromised by detergent interactions with the extramembranous soluble domains

Unravelling the folding and stability of an ABC (ATP-binding cassette) transporter

(2015) Natalie DiBartolo et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Mapping lipid and detergent molecules at the surface of membrane proteins

(2015) Richard J. Cogdell et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Steroid-based facial amphiphiles for stabilization and crystallization of membrane proteins

(2013) S. C. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Open and shut: Crystal structures of the dodecylmaltoside solubilized mechanosensitive channel of small conductance fromEscherichia coliandHelicobacter pyloriat 4.4 Å and 4.1 Å resolutions

(2013) Jeffrey Y. Lai et al.   PROTEIN SCIENCE

Rampant Exchange of the Structure and Function of Extramembrane Domains between Membrane and Water Soluble Proteins

(2013) Hyun-Jun Nam et al.   PLoS Computational Biology

Efficiency of detergents at maintaining membrane protein structures in their biologically relevant forms

(2012) David V. Tulumello et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Requirements for Efficient Correction of ΔF508 CFTR Revealed by Analyses of Evolved Sequences

(2012) Juan L. Mendoza et al.   CELL

Conformational Changes Relevant to Channel Activity and Folding within the first Nucleotide Binding Domain of the Cystic Fibrosis Transmembrane Conductance Regulator

(2012) Rhea P. Hudson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Allosteric Modulation Balances Thermodynamic Stability and Restores Function of ΔF508 CFTR

(2012) Andrei A. Aleksandrov et al.   JOURNAL OF MOLECULAR BIOLOGY

Protein–surfactant interactions: A tale of many states

(2011) Daniel Otzen   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

In VitroFolding and Assembly of theEscherichia coliATP-binding Cassette Transporter, BtuCD

(2011) Natalie D. Di Bartolo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human-mouse cystic fibrosis transmembrane conductance regulator (CFTR) chimeras identify regions that partially rescue CFTR- F508 processing and alter its gating defect

(2011) Q. Dong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The variable detergent sensitivity of proteases that are utilized for recombinant protein affinity tag removal

(2011) James M. Vergis et al.   PROTEIN EXPRESSION AND PURIFICATION

Benchmarking Membrane Protein Detergent Stability for Improving Throughput of High-Resolution X-ray Structures

(2011) Yo Sonoda et al.   STRUCTURE

High-throughput evaluation of the critical micelle concentration of detergents

(2010) Thorsten Jumpertz et al.   ANALYTICAL BIOCHEMISTRY

Amphipols, Nanodiscs, and Fluorinated Surfactants: Three Nonconventional Approaches to Studying Membrane Proteins in Aqueous Solutions

(2010) Jean-Luc Popot   Annual Review of Biochemistry

The V510D Suppressor Mutation Stabilizes ΔF508-CFTR at the Cell Surface

(2010) Tip W. Loo et al.   BIOCHEMISTRY

Lysophospholipid Micelles Sustain the Stability and Catalytic Activity of Diacylglycerol Kinase in the Absence of Lipids

(2010) Julia Koehler et al.   BIOCHEMISTRY

Restoration of domain folding and interdomain assembly by second-site suppressors of the ΔF508 mutation in CFTR

(2010) Lihua He et al.   FASEB JOURNAL

Tricks of the trade used to accelerate high-resolution structure determination of membrane proteins

(2010) Yo Sonoda et al.   FEBS LETTERS

The Cystic Fibrosis-causing Mutation ΔF508 Affects Multiple Steps in Cystic Fibrosis Transmembrane Conductance Regulator Biogenesis

(2010) Patrick H. Thibodeau et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulatory Insertion Removal Restores Maturation, Stability and Function of ΔF508 CFTR

(2010) Andrei A. Aleksandrov et al.   JOURNAL OF MOLECULAR BIOLOGY

SDS-Induced Fibrillation of α-Synuclein: An Alternative Fibrillation Pathway

(2010) Lise Giehm et al.   JOURNAL OF MOLECULAR BIOLOGY

Maltose–neopentyl glycol (MNG) amphiphiles for solubilization, stabilization and crystallization of membrane proteins

(2010) Pil Seok Chae et al.   NATURE METHODS

Structures of a minimal human CFTR first nucleotide-binding domain as a monomer, head-to-tail homodimer, and pathogenic mutant

(2010) Shane Atwell et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Thermal unfolding studies show the disease causing F508del mutation in CFTR thermodynamically destabilizes nucleotide-binding domain 1

(2010) Irina Protasevich et al.   PROTEIN SCIENCE

Integrated biophysical studies implicate partial unfolding of NBD1 of CFTR in the molecular pathogenesis of F508del cystic fibrosis

(2010) Chi Wang et al.   PROTEIN SCIENCE

Influence of solubilizing environments on membrane protein structures

(2010) Timothy A. Cross et al.   TRENDS IN BIOCHEMICAL SCIENCES

NMR evidence for differential phosphorylation-dependent interactions in WT and ΔF508 CFTR

(2009) Voula Kanelis et al.   EMBO JOURNAL

Structure and Dynamics of NBD1 from CFTR Characterized Using Crystallography and Hydrogen/Deuterium Exchange Mass Spectrometry

(2009) H.A. Lewis et al.   JOURNAL OF MOLECULAR BIOLOGY

The intact CFTR protein mediates ATPase rather than adenylate kinase activity

(2008) Mohabir Ramjeesingh et al.   BIOCHEMICAL JOURNAL

Mg2+-dependent ATP occlusion at the first nucleotide-binding domain (NBD1) of CFTR does not require the second (NBD2)

(2008) Luba Aleksandrov et al.   BIOCHEMICAL JOURNAL

Misfolding of the Cystic Fibrosis Transmembrane Conductance Regulator and Disease†

(2008) Joanne C. Cheung et al.   BIOCHEMISTRY

α-Lactalbumin is unfolded by all classes of surfactants but by different mechanisms

(2008) Daniel E. Otzen et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

Rationalizing α-helical membrane protein crystallization

(2008) Simon Newstead et al.   PROTEIN SCIENCE