Review
Biochemistry & Molecular Biology
Wenyu Cui, Kaiyun Luo, Qian Xiao, Zhaoyue Sun, Yunfu Wang, Caifang Cui, Fuchun Chen, Ben Xu, Weijun Shen, Fachun Wan, Anwei Cheng
Summary: Mulberry leaf and mulberry leaf extract have various biological properties, including regulating sugar and lipid metabolism, reducing blood glucose, and increasing insulin secretion. This systematic review and meta-analysis of randomized clinical trials showed that supplementation of mulberry leaf/mulberry leaf extract significantly reduced fasting blood glucose, glycosylated hemoglobin, and fasting plasma insulin levels.
Article
Multidisciplinary Sciences
Fangli Ding, Qing Wang, Chen Xie, Meng Wang, Lu Zhang, Ming Gao, Zongling Yang, Jianrui Ma, Xiaodong Shi, Wei Chen, Shenglin Duan, Peng Yuan, Yali Li, Xishan Ma, Yimin Wu, Jia Liu, Xiaowen Feng, Qingli Cheng, Zichun Wang, Xuyan Li, Jingmei Huang
Summary: This study evaluated the effects of mulberry leaf extract (MLE) addition on the physicochemical properties and blood glucose response of white bread. The results showed that the addition of MLE had no significant effects on the properties of white bread, but slightly changed the color and bitterness. MLE addition reduced the blood glucose rise and GI value of white bread, with a dose-dependent relationship.
Article
Chemistry, Applied
Sharma Shivangi, Darshan Dorairaj, Pradeep Singh Negi, Nandini P. Shetty
Summary: The developed pectin-based films, blended with bioactive compounds, showed improved antioxidative, antimicrobial activities, and better mechanical properties. The eco-friendly nature of the films was demonstrated by water solubility and soil degradation properties, making them a promising natural alternative for extending the shelf life of fruits and vegetables.
FOOD HYDROCOLLOIDS
(2021)
Article
Nutrition & Dietetics
Masaki Takahashi, Yui Mineshita, Jumpei Yamagami, Chunyi Wang, Kyoko Fujihira, Yu Tahara, Hyeon-Ki Kim, Takashi Nakaoka, Shigenobu Shibata
Summary: This study found that taking mulberry leaf extract in the evening can improve glucose tolerance. Additionally, taking mulberry leaf extract in the morning can reduce insulin concentrations. Therefore, the timing of mulberry leaf extract intake is crucial for improving blood sugar control.
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Biology
Chae-Won Kang, Miey Park, Hae-Jeung Lee
Summary: The study found that mulberry leaves extract and 1-deoxynojirimycin improve insulin resistance in the skeletal muscle of db/db mice by activating the IRS-1/PI3K/Akt pathway, increasing muscle fiber size and glycogen content.
Article
Food Science & Technology
Yu Cao, Wei Jiang, Huixin Bai, Jie Li, Hanzhao Zhu, Lu Xu, Yao Li, Kaifeng Li, Haifeng Tang, Weixun Duan, Siwang Wang
Summary: The main active component of mulberry leaf extract (MLE), 1-deoxynojirimycin (1-DNJ), plays a significant role in preventing and treating diabetic cardiomyopathy by improving cardiac function, body weight, glucose and lipid metabolism, and reducing myocardial fibrosis.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Medicine, Research & Experimental
Anna Gryn-Rynko, Iga Holynska-Iwan, Michal Adam Janiak, Dorota Olszewska-Slonina, Ryszard Amarowicz, Radomir Graczyk
Summary: Morus alba L., a herbal plant with therapeutic properties, has been found to affect ion channels in rabbit colon epithelium, leading to changes in electrical potential. This study provides valuable insights into the pharmacological effects of white mulberry leaves.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Nutrition & Dietetics
Pariyarath Sangeetha Thondre, Helen Lightowler, Lis Ahlstrom, Andrew Gallagher
Summary: This study conducted a double-blind, randomized, placebo-controlled, crossover trial to investigate the effects of mulberry leaf extract on glycaemic and insulinaemic responses to sucrose in healthy individuals. The results showed that mulberry leaf extract significantly reduced both glycaemic and insulinaemic responses, making it a potential ingredient for maintaining healthy blood glucose levels.
NUTRITION & METABOLISM
(2021)
Review
Food Science & Technology
Isabella Supardi Parida, Soo Takasu, Kiyotaka Nakagawa
Summary: Mulberry leaves are rich in biologically active compounds, particularly mulberry leaf iminosugars (MLIs), which have been found to have various health-promoting effects. This review comprehensively summarizes existing studies on the oral pharmacokinetics and physiological significance of MLIs, suggesting their potential for therapeutic use against metabolic and chronic disorders.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Lucia Marchetti, Eleonora Truzzi, Ilaria Frosi, Adele Papetti, Silvia Cappellozza, Alessio Saviane, Federica Pellati, Davide Bertelli
Summary: There is a growing need for new options to treat diabetes at an early stage, and natural remedies have recently been reconsidered as potential candidates due to their low cost and effectiveness. Genus Morus plants contain active compounds with hypoglycaemic, hypolipidemic, and antioxidant effects. Current research on mulberry plants has mainly focused on Asian cultivation, where it has traditionally been used as a leaf infusion. This study characterised twelve Italian mulberry cultivars to expand our knowledge, and the results suggest a strong correlation between composition, genetics, and growing area. Leaf extracts showed inhibitory effects on carbohydrate digestive enzymes, likely due to the presence of 1-deoxynojirimycin, kaempferol, quercetin, and chlorogenic acid, acting synergistically. Additionally, the extracts exhibited antiglycative and carbonyl trapping capacities, potentially preventing long-term complications in diabetic patients related to advanced glycation end products (AGEs).
Article
Biochemistry & Molecular Biology
Yuting Wang, Zhongwei Yu, Jun Jiang, Yaxin Li, Shui Yu
Summary: The study explored the effects of Mulberry leaf Deoxynojirimycin (MLD) on atherosclerotic lesions in patients with coronary heart disease, finding that treatment reduced the incidence of cardiovascular events, improved antioxidant and anti-inflammatory properties, decreased serum lipid levels, and reduced carotid intima-media thickness. Serum levels of DNJ, the main component of mulberry leaf, showed a strong negative relationship with IMT values, indicating the potential benefits of MLD treatment in reducing cardiovascular risk.
JOURNAL OF FOOD BIOCHEMISTRY
(2021)
Article
Biotechnology & Applied Microbiology
Marisa Sonthisut, Ratree Wongpanya, Anan Phonphoem, Wannarat Pornsiriwong Phonphoem
Summary: LED lights significantly increased the production of DNJ in mulberry plants, with the content positively related to the alpha-glucosidase inhibitory activity.
PLANT CELL TISSUE AND ORGAN CULTURE
(2022)
Article
Agriculture, Multidisciplinary
Jia Liu, Jingqiong Wan, Wenmin Du, Dujun Wang, Chongwei Wen, Yuan Wei, Zhen Ouyang
Summary: Through gene cloning and genetic transformation, the study confirmed the involvement of MaLDC, MaCAO, MaSDR1, and MaSDR2 genes in DNJ biosynthesis in mulberry leaves. Overexpression of these genes increased DNJ content, while silencing led to decreased content, indicating their role in DNJ biosynthesis.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Chemistry, Applied
Xiangdong Xin, Xueping Jiang, Attaribo Thomas, Baoxin Niu, Minqi Zhang, Xueming Xu, Ran Zhang, Hao Li, Zhongzheng Gui
Summary: Mulberry (Morus alba L.) seeds have the highest content of 1-deoxynojirimycin (DNJ), a potential alpha-glucosidase inhibitor, compared to other tissues. Through comparative transcriptomics, it was found that variety MS02 had the highest DNJ levels (22.28 mg/g), while variety MS15 had the lowest DNJ levels (0.37 mg/g). Four enzymes, including polyphenol oxidase, tyrosine aminotransferase, aromatic-L-amino-acid decarboxylase, and tropinone reductase, were proposed to play important roles in DNJ biosynthesis.
NATURAL PRODUCT RESEARCH
(2023)
Article
Nutrition & Dietetics
Agata Walkowiak-Brodka, Natalia Piekus-Slomka, Kacper Wnuk, Bogumila Kupcewicz
Summary: Diabetes mellitus is a growing metabolic disease, and there is a need to find natural products for preventative and early-stage treatment. White mulberry leaves, known for their beneficial properties, can regulate postprandial glucose concentration. However, the quality of dietary supplements containing white mulberry is found to be low, lacking the expected health benefits. A proposed alternative method for assessing the quality of these products involves determining DNJ content using ATR-FTIR spectroscopy combined with PLS regression.
Correction
Food Science & Technology
Humna Liaqat, Eunseon Jeong, Kyeong Jin Kim, Ji Yeon Kim
FOOD SCIENCE AND BIOTECHNOLOGY
(2023)
Article
Medicine, Research & Experimental
Soo-yeon Park, Oran Kwon, Ji Yeon Kim
Summary: The study showed that Mori ramulus extract can reduce blood glucose response, increase insulin levels, and help maintain postprandial blood glucose levels through an inflammatory mechanism.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biotechnology & Applied Microbiology
Hyeonji Yang, Kwanyong Choi, Kyeong Jin Kim, Soo-yeon Park, Jin-Young Jeon, Byung-Gon Kim, Ji Yeon Kim
Summary: This study evaluated the effects of Euglena gracilis, a type of immune stimulator, on immunocompromised mice induced by cyclophosphamide. The results showed that administration of Euglena or beta-glucan significantly improved the body weight, spleen index, and natural killer (NK) cell activity of mice compared to the cyclophosphamide group. The gene expression levels of several cytokines and receptors were also increased in the Euglena and beta-glucan groups. These findings suggest that Euglena can enhance the immune system by strengthening innate immunity through immunosuppression.
JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Article
Food Science & Technology
Seunghee Kang, Eunok Lee, Heeyeon Lee, Geum-Sook Hwang, Jaekyung Lee, Ji Won Kim, Bumjo Oh, Ji Yeon Kim, Oran Kwon
Summary: The study found that supplementation with yellow yeast rice (YYR) significantly reduced total cholesterol, LDL, and apolipoprotein B100 levels in hypercholesterolemic subjects. YYR works by stimulating bile salt export pumps and inhibiting cholesterol biosynthesis, thus reducing intrahepatic cholesterol availability.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Soo-yeon Park, Min Ju Park, Ji Yeon Kim
Summary: Cardiovascular diseases are a significant global cause of illness and death. Red foods, especially red fruits and vegetables, can protect heart and vascular health and reduce the risk of heart disease and stroke.
APPLIED SCIENCES-BASEL
(2022)
Article
Food Science & Technology
Ye Ji Hyun, Soo-yeon Park, Ji Yeon Kim
Summary: This study found that fermented rice germ extracts fermented with Lactobacillus plantarum inhibited glucose uptake by suppressing the expression of GLUT2 and SGLT1 mRNA. Experimental results demonstrated that this extract significantly reduced postprandial blood glucose levels, suggesting its potential in alleviating postprandial hyperglycemia in the gastrointestinal tract.
FOOD SCIENCE AND BIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Soo-yeon Park, Yong Dae Kim, Min Seo Kim, Ki-Tae Kim, Ji Yeon Kim
Summary: Cinnamon water extract (CWE) intake improved diarrhea symptoms and changed the composition of stools and gut microbiota. It increased colonic transit time and fecal isobutyric acid and spermidine contents, while decreasing fecal indole and agmatine contents. CWE also showed significant changes in strains of Bifidobacterium longum ATCC 55813 and increased alpha diversity in the gut microbiota.
Article
Food Science & Technology
Tae gwon Park, Yu Rim Kim, Soo-yeon Park, Kwanyong Choi, Kyeong Jin Kim, Ji Yeon Kim
Summary: The potential beneficial effects of Cinnamomum cassia on the intestine were evaluated in this study. It was found that cinnamon extract can improve intestinal health, alleviate inflammatory damage, and enhance tight junction function.
FOOD SCIENCE AND BIOTECHNOLOGY
(2023)
Article
Multidisciplinary Sciences
Min Young Park, Soo-yeon Park, Anita Hartog, Els van Hoffen, Alwine Kardinaal, Joohee Kim, Hee Jung Choi, Oran Kwon, Ji Yeon Kim
Summary: This study aims to develop a safe human challenge model to study gastrointestinal inflammation and immune function. It focuses on evaluating gut stimulation induced by the oral cholera vaccine in healthy people. The study design includes the evaluation of a probiotic lysate for its efficacy in improving the mild inflammatory response induced by the vaccine or supporting the immune response in healthy subjects.
Article
Nutrition & Dietetics
Joe Eun Son, Jay-Young Jo, San Kim, Min Ju Park, Yerin Lee, Seong Shil Park, Shin Young Park, Su Myung Jung, Sung Keun Jung, Ji Yeon Kim, Sanguine Byun
Summary: Rice bran, a by-product of rice milling, is rich in bioactive molecules and has health-promoting properties in improving metabolic conditions. This study aimed to optimize the extraction conditions of rice bran extract (RBE) and validate its impact on lipid metabolism. The optimized RBE showed significant benefits in reducing weight gain, hyperlipidemia, and hepatosteatosis in mouse models. The study also discovered that the administration of optimized RBE activated AMPK and inhibited STAT3, crucial players in liver lipid metabolism. Overall, optimized RBE holds promise as a dietary intervention against hyperlipidemia and hepatosteatosis.
Article
Nutrition & Dietetics
Seunghee Kang, Inhye Lee, Soo-yeon Park, Ji Yeon Kim, Youjin Kim, Jeong-Sook Choe, Oran Kwon
Summary: This study investigated the effects of Platycodi radix beverage (PR) on blood microbiota profiles in individuals with hyperlipidemia. It found that PR intake can improve postprandial lipid clearance in individuals with high fat intake and low fruit and vegetable intake through modulation of blood microbiota signatures.
Review
Nutrition & Dietetics
Yu Rim Kim, Min Ju Park, Soo-yeon Park, Ji Yeon Kim, Iain A. Brownlee, Amany Tawfik
Summary: Seaweed supplementation appears to be a promising strategy for improving blood glucose regulation in individuals with diabetes, as evidenced by significant improvements in postprandial blood glucose, HbA1c, and HOMA-IR levels.
Article
Biochemistry & Molecular Biology
Muniba Kousar, Yu Rim Kim, Ji Yeon Kim, Joonho Park
Summary: This study evaluated the response of Triticum aestivum to hydrogen water and trace elements treated with hydrogen water. The combined treatment of Se acid and Mo oxide showed a significant positive effect on the growth and secondary metabolites of wheat. In addition, the mixture treatment inhibited the accumulation of lipids in HepG2 hepatocytes cells. This research is important for understanding the response of plants to hydrogen water and trace elements treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Yea-eun Lee, Eunok Lee, Urmi Rahman Rinik, Ji Yeon Kim, Byung Hwa Jung, Oran Kwon
Summary: This study investigated the bioavailability of six key polyphenols in Agastache rugosa (Korean mint) and found that rosmarinic acid (RA), acacetin (AC), and tilianin (TA) could be detected in human plasma after ingestion. The transport of RA occurred through the intercellular space, while AC and TA were transported through the epithelial cells. Other AC glucosides with acetyl and/or malonyl groups were rarely found in the plasma. AC glucosides with only an acetyl group appeared at the basolateral side in Caco-2 monolayers, suggesting exclusive hydrolysis of malonyl glucosides in the colon.
Review
Nutrition & Dietetics
Inhae Kang, Chai Hong Rim, Hee Sun Yang, Jeong-Sook Choe, Ji Yeon Kim, Myoungsook Lee
Summary: Isoflavone supplementation significantly affects menopausal symptoms and hormonal changes in postmenopausal women, but caution is needed in interpreting the results and further validation is required.
NUTRITION RESEARCH AND PRACTICE
(2022)
