Review
Cardiac & Cardiovascular Systems
Ti Wang, Ting Xiong, Yuxue Yang, Bangyun Zuo, Xiwei Chen, Daxin Wang
Summary: Metabolic remodeling and systemic metabolic disorders play important roles in the progression and manifestation of takotsubo syndrome (TTS). Therapeutic strategies targeting substrate utilization and oxidative stress may hold promise in improving the prognosis of patients with TTS.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Physiology
Xiaomeng Shi, Hongyu Qiu
Summary: This review highlights the importance of cardiac energy metabolism in cardiac pathogenesis and physiological adaptation, and provides updated findings regarding metabolic remodeling in the heart. The study of basic metabolic profiles in different conditions contributes to understanding the significance of metabolic regulation in the heart and exploring novel therapeutic strategies for cardiac diseases.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Nikolaus Berndt, Johannes Eckstein, Iwona Wallach, Sarah Nordmeyer, Marcus Kelm, Marieluise Kirchner, Leonid Goubergrits, Marie Schafstedde, Anja Hennemuth, Milena Kraus, Tilman Grune, Philipp Mertins, Titus Kuehne, Hermann-Georg Holzhuetter
Summary: The study utilized a comprehensive kinetic model of cardiac energy metabolism to assess the energy status of the left ventricles in healthy participants and patients with aortic stenosis and mitral valve insufficiency. The results indicated that patients had increased MVATP[rest] and decreased MVATP[max], leading to a decreased myocardial ATP production reserve, despite having preserved ejection fraction. The energy status was closely associated with mechanical energy demand.
Review
Biochemistry & Molecular Biology
Xiaonan Sun, Jalen Alford, Hongyu Qiu
Summary: Mitochondrial remodeling is crucial for maintaining normal cellular function and dysregulation can lead to complex diseases. Understanding the molecular basis and regulatory network of mitochondrial remodeling is important for elucidating the pathogenesis of cardiac diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Microbiology
Julia Martien, Edna A. Trujillo, Tyler B. Jacobson, Mehmet Tatli, Alexander S. Hebert, David M. Stevenson, Joshua J. Coon, Daniel Amador-Noguez
Summary: The study on Zymomonas mobilis during N-2 fixation revealed dynamic changes in physiology and regulatory mechanisms related to nitrogen fixation, providing insights for metabolic engineering and biofuel production.
Review
Cardiac & Cardiovascular Systems
Min Jiang, Xiaoye Xie, Feng Cao, Yabin Wang
Summary: Ischemic heart disease is a condition that can lead to myocardial damage and heart failure. Mechanical forces during myocardial contraction and mitochondrial metabolism play crucial roles in heart health. Mechanical circulatory support has significant effects on metabolic adaptations of the heart.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Dongxiao Fan, Chenshu Liu, Zhongyu Zhang, Kan Huang, Tengyao Wang, Sifan Chen, Zilun Li
Summary: Resveratrol has the potential to regulate cell metabolism and protect vascular function through various pathways, particularly in high concentrations and patients with metabolic disorders.
Review
Oncology
Mingzhou Jiang, Xi Fan, Yiqing Wang, Xiaotian Sun
Summary: Oxygen is essential for cardiomyocyte metabolism, and hypoxia may lead to metabolic remodeling and heart failure. Hypoxia-inducible factors (HIFs) are implicated in regulating hypoxia-induced metabolic changes and have potential therapeutic implications for heart failure. Understanding the effects of hypoxic pathways on heart failure can provide new treatment options.
EXPERIMENTAL CELL RESEARCH
(2023)
Review
Cardiac & Cardiovascular Systems
Edoardo Bertero, Jan Dudek, Clement Cochain, Murilo Delgobo, Gustavo Ramos, Brenda Gerull, Takahiro Higuchi, Martin Vaeth, Alma Zernecke, Stefan Frantz, Ulrich Hofmann, Christoph Maack
Summary: The interplay between the cardiovascular system, metabolism, and inflammation plays a central role in the pathophysiology of cardiovascular diseases. This paper provides an overview of the interrelation between inflammation and metabolism, discusses the involvement of disrupted immuno-metabolic interface in cardiovascular disease, and presents new technologies and therapeutic approaches.
CARDIOVASCULAR RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Yuri N. Belenkov, Anton A. Ageev, Maria V. Kozhevnikova, Natalia V. Khabarova, Anastasia V. Krivova, Ekaterina O. Korobkova, Ludmila V. Popova, Alexey V. Emelyanov, Svetlana A. Appolonova, Natalia E. Moskaleva, Ksenia M. Shestakova, Elena Privalova
Summary: This study investigated the relationship between acylcarnitine levels, myocardial remodeling parameters, and clinical characteristics in patients with chronic heart failure. The results showed that medium- and long-chain acylcarnitines were positively correlated with symptoms and heart size, while C5-OH was negatively correlated with symptoms. Some patients also had acylcarnitine deficiency. These findings contribute to the assessment of clinical manifestations and myocardial remodeling severity.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Review
Immunology
Xiaoqian Sun, Yanqin Li, Qiong Deng, Yueyao Hu, Jianteng Dong, Wei Wang, Yong Wang, Chun Li
Summary: Macrophages undergo metabolic reprogramming, which influences their inflammatory function. In ischemic heart disease, the polarization and metabolic shifts of macrophages can affect the balance of inflammatory effects and determine disease progression and prognosis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Genetics & Heredity
Jixiang Du, Chao Zhang, Fuchen Liu, Xihan Liu, Dongdong Wang, Dandan Zhao, Guanghou Shui, Yuying Zhao, Chuanzhu Yan
Summary: This study aimed to elucidate the characteristic metabolic alterations and associated homeostatic regulation caused by TYMP deficiency. The results showed distinct metabolic profiles in patients with TYMP deficiency compared to those with the m.3243A > G mutation. TYMP deficiency leads to a global disruption of nucleoside metabolism and inhibits cholesterol and fatty acid metabolism. The findings suggest potential metabolite biomarkers that could be valuable clinical tools to improve the diagnosis of MNGIE. Overall, this study is important for expanding our knowledge of the biochemical outcome of TYMP deficiency in mitochondrial disorders.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2023)
Article
Oncology
Jiecheng Yang, Fangzhou Liu, Ying Wang, Lei Qu, Aifu Lin
Summary: Long non-coding RNAs (lncRNAs) play important roles in cellular programs, modulating gene transcription and kinase cascades to impact tumor initiation and progression. This review summarizes the role of lncRNAs in tumor metabolic reprogramming and immune environment remodeling, and discusses the advancements in clinical applications.
Review
Food Science & Technology
Noah Leibold, James R. Bain, Florin Despa
Summary: Type-2 diabetes is linked to an increased risk of Alzheimer's disease and the conversion to dementia from mild cognitive impairment, but the mechanisms connecting the two remain unclear. Amylin, a hormone co-secreted with insulin, is implicated in both satiation regulation and the formation of amyloid in the pancreas. It also interacts with amyloid beta pathology in Alzheimer's disease, suggesting a potential role in neuronal metabolic remodeling.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Yijun Yang, Justin Kurian, Giana Schena, Jaslyn Johnson, Hajime Kubo, Joshua G. Travers, Chunya Kang, Anna Maria Lucchese, Deborah M. Eaton, Maoting Lv, Na Li, Lorianna G. Leynes, Daohai Yu, Fengzhen Yang, Timothy A. McKinsey, Raj Kishore, Mohsin Khan, Sadia Mohsin, Steven R. Houser
Summary: The study suggests that metabolic syndrome in obese pregnant women may lead to pathological cardiac remodeling, increasing the risk of chronic heart disorders.
Article
Gastroenterology & Hepatology
Rahul S. Dalal, Sonali Palchaudhuri, Christopher K. Snider, James D. Lewis, Shivan J. Mehta, Gary R. Lichtenstein
Summary: The study found a significant positive correlation between preadmission cannabis use and inpatient opioid exposure among patients with inflammatory bowel disease. Additionally, first patient-reported pain score and preadmission opioid use were also associated with inpatient opioid exposure.
INFLAMMATORY BOWEL DISEASES
(2021)
Editorial Material
Gastroenterology & Hepatology
Rahul S. Dalal, Gary R. Lichtenstein
DIGESTIVE DISEASES AND SCIENCES
(2021)
Letter
Gastroenterology & Hepatology
Rahul S. Dalal, Emma McClure, Jenna Marcus, Rachel W. Winter, Matthew J. Hamilton, Jessica R. Allegretti
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Editorial Material
Gastroenterology & Hepatology
Rahul S. Dalal, Scott Esckilsen, Edward L. Barnes, Jordan C. Pruce, Jenna Marcus, Jessica R. Allegretti
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Abraham Segura, Rahul S. Dalal, Meghana Golla, James N. Gerson, Nadim Mahmud, James D. Lewis, Ravy K. Vajravelu
Summary: The study found that patients who underwent endoscopy after HCT did not have a higher risk of infectious adverse events compared to controls with similar immune statuses. These results may provide guidance for clinical decision-making regarding the risks and benefits of endoscopic management after HCT.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Rahul S. Dalal, Sanchit Gupta, Hannah Goodrick, Jennifer Mitri, Jessica R. Allegretti
INFLAMMATORY BOWEL DISEASES
(2022)
Article
Gastroenterology & Hepatology
Rahul S. Dalal, Emma L. McClure, Jenna Marcus, Jessica R. Allegretti
Summary: This study compared the long-term drug survival of vedolizumab, adalimumab, and infliximab in patients with ulcerative colitis (UC). The results showed that vedolizumab had better survival rates than adalimumab for both clinical response and adverse effects, and vedolizumab also had better survival rates than infliximab for adverse effects.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Rahul S. Dalal, Kanwal Bains, Jenna Marcus, Emma L. McClure, Jessica R. Allegretti
Summary: In this case series, six patients with chronic pouchitis, cuffitis, or Crohn's-like disease of the pouch were treated with tofacitinib. One patient achieved a clinical response, but all patients eventually discontinued therapy due to nonresponse or adverse events.
INFLAMMATORY BOWEL DISEASES
(2022)
Article
Gastroenterology & Hepatology
Rahul S. Dalal, Jordan C. Pruce, Jessica R. Allegretti
Summary: In this retrospective cohort study, we demonstrated that dose intensification of ustekinumab to every 4 or every 6 weeks was effective in both achieving and maintaining clinical remission for >40% of inflammatory bowel disease patients for up to 24 months.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Gastroenterology & Hepatology
Rahul S. Dalal, Puza P. Sharma, Kanwal Bains, Jordan C. Pruce, Jessica R. Allegretti
Summary: According to a retrospective cohort study, tofacitinib and ustekinumab demonstrated similar effectiveness in treating ulcerative colitis in patients who failed anti-tumor necrosis factor treatment. Adverse events observed were consistent with known safety profiles of these drugs.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Rheumatology
Rahul S. S. Dalal, Joerg Ermann, Alexander Carlin, Jennifer Mitri, Jessica R. R. Allegretti
Summary: This retrospective cohort study examined the disease activity of axial spondyloarthritis (axSpA) after initiation of anti-tumor necrosis factor (TNF) agents in patients with inflammatory bowel diseases (IBD). The study found that 52% of patients achieved symptom resolution (SR) of axSpA at 12 months after initiating anti-TNF therapy, and shorter IBD duration and adalimumab use were associated with higher odds of SR. Larger studies are needed to confirm these findings and explore additional predictors of SR and more effective therapeutics for this population.
CLINICAL RHEUMATOLOGY
(2023)
Editorial Material
Gastroenterology & Hepatology
Rahul S. Dalal, Esther Baranov, Jessica Li, Xuefei Hong, Joshua Korzenik, Matthew Hamilton, Gila Sasson
DIGESTIVE DISEASES AND SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Rahul S. Dalal, Ken Lund, Floor D. Zegers, Sonia Friedman, Jessica R. Allegretti, Bente Mertz Norgard
Summary: The use of tramadol in patients with inflammatory bowel diseases (IBDs) was associated with lower odds of infection, bowel obstruction/ileus, and mortality compared to traditional opioids (TOs). These findings suggest that tramadol may be a safer option for pain management in IBD patients.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Gastroenterology & Hepatology
Rahul Dalal, Puza Sharma, Kanwal Bains, Jordan Pruce, Jessica Allegretti
Summary: Treatment with tofacitinib was effective in achieving steroid-free clinical remission for the majority of patients with UC through 78 weeks. Adverse events, which rarely required treatment discontinuation, were consistent with the known safety profile of tofacitinib.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Gastroenterology & Hepatology
Rahul S. Dalal, Govind Kallumkal, Heidy J. Cabral, Salam Bachour, Edward L. Barnes, Jessica R. Allegretti
Summary: In this retrospective cohort study, upadacitinib induction was shown to effectively achieve steroid-free clinical remission of ulcerative colitis for most patients. Rare adverse events leading to treatment discontinuation were consistent with the known safety profile of upadacitinib.
INFLAMMATORY BOWEL DISEASES
(2023)