Article
Nutrition & Dietetics
Aneta Jonczy, Rafal Mazgaj, Rafal Radoslaw Starzynski, Piotr Poznanski, Mateusz Szudzik, Ewa Smuda, Marian Kamyczek, Pawel Lipinski
Summary: This study investigates the interaction between copper and iron metabolism, revealing that regulation of iron absorption in the duodenal enterocytes is based on the interaction between proteins of copper and iron metabolisms rather than systemic regulation in the context of neonatal iron deficiency anemia.
Article
Hematology
Regina R. Woloshun, Yang Yu, Xiaodong Xu, Jennifer K. Lee, Sean Zhu, Jacob S. Shine, Pearl Ebea, Bruce R. Stevens, Sadasivan Vidyasagar, James F. Collins
Summary: This study found that specific amino acids can induce the transporter DMT1 to enter the membrane of intestinal cells, thereby increasing iron absorption. Further experiments showed that the four amino acid formulation can enhance iron absorption in mice and even be effective with a high iron content solution.
Article
Genetics & Heredity
Ezgi Evcan, Sukru Gulec
Summary: The blood copper level plays an important role in intestinal iron homeostasis during iron deficiency. Our study found that the polarization of enterocyte cells and the basolateral copper level significantly influenced the gene regulation in iron-deficient conditions.
GENES AND NUTRITION
(2022)
Article
Biology
C. J. Kelly, Reid K. Couch, Vivian T. Ha, Camille M. Bodart, Judy Wu, Sydney Huff, Nicole T. Herrel, Hyunsung D. Kim, Azaad O. Zimmermann, Jessica Shattuck, Yu-Chen Pan, Matt Kaeberlein, Anthony S. Grillo
Summary: Mice lacking Complex I subunit NDUFS4 exhibit mitochondrial dysfunction and the abnormal iron homeostasis may contribute to the progression of Leigh Syndrome and other mitochondrial disorders.
Article
Multidisciplinary Sciences
Stella Ekaputri, Eun-Kyung Choi, Manuela Sabelli, Luisa Aring, Kelsie J. Green, Juoae Chang, Kai Bao, Hak Soo Choi, Shigeki Iwase, Jonghan Kime, Elena Corradini, Antonello Pietrangelo, Martin D. Burke, Young Ah Seo
Summary: This study shows that hinokitiol can serve as a surrogate transmembrane iron transporter and restore normal iron physiology in FPN1-deficient animals or primary cells from patients. It redistributes iron from the liver to red blood cells, increases hemoglobin and hematocrit, and activates the regulated ferritin proteolysis.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Food Science & Technology
Bolun Sun, Panxue Zhang, Huamao Wei, Ru Jia, Tao Huang, Chao Li, Wenge Yang
Summary: This study evaluated the therapeutic effects of hemoglobin from Tegillarca granosa on iron deficiency anemia (IDA) in mice. The results showed that hemoglobin could effectively improve blood parameters and liver morphology associated with IDA, and restore the levels of serum ferritin and soluble transferrin receptor, indicating a potential role as an alternative for iron supplementation.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Agriculture, Multidisciplinary
Xiaoyang Liu, Xuening Yu, Shijie Dou, Fawen Yin, Deyang Li, Dayong Zhou
Summary: This study successfully formed a complex of oyster-protein hydrolysates and ferrous chloride, which showed better iron absorption than ferrous sulfate and had better protective effects against iron-deficiency anemia. Three representative peptides that were absorbed intact were identified.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Medicine, General & Internal
Arif Mumtaz, Qaisar Ali Khan, Nowshad Asim, Abdul Baqi, Sumaira Iram, Abdul Majeed, Muhammad Junaid Tahir, Md Saiful Islam, Zohaib Yousaf
Summary: Celiac disease is an autoimmune enteropathy with classical gastrointestinal symptoms. This case report presents a female patient with atypical features of celiac disease, including progressive anemia, amenorrhea, and weight loss. The patient showed significant improvement after strict gluten-free diet and achieved complete resolution of symptoms at 1 year follow-up.
Article
Clinical Neurology
Hyoeun Bae, Yong Won Cho, Keun Tae Kim, Xu Li, Christopher J. Earley
Summary: The aim of this study was to determine the clinical efficacy and brain iron concentration improvement in RLS patients with IDA using 1500 mg FCM. The study found that patients in the FCM group showed significant improvement in RLS symptoms and brain iron content after a 6-week treatment. The results suggest that 1500 mg FCM effectively treats RLS symptoms in IDA patients, with improved brain iron content serving as a potential biomarker for RLS patients.
Review
Medicine, General & Internal
Marialuisa Zedde, Giacomo Portaro, Laura Ferri, Francesco Cavallieri, Manuela Napoli, Claudio Moratti, Fabrizio Piazza, Franco Valzania, Rosario Pascarella
Summary: Anemia, especially iron-deficient anemia, is associated with a higher risk of thrombotic events such as ischemic stroke and cerebral venous thrombosis. This article presents a case study discussing the diagnostic pathway of multiple thrombotic manifestations related to iron-deficient anemia.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Food Science & Technology
Jie-Hua Chen, Yiyuan Wang, Jialiang Pan, Louise Weiwei Lu, Jianfeng Yu, Bin Liu, Feng Chen, Hong Deng
Summary: This study investigates the mechanism of how GOS/FOS affect iron absorption in an iron-deficient rat model and determines the optimum dose of GOS.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Pediatrics
Min Young Park, Carole Le Henaff, Despina Sitara
Summary: The study found that α-Klotho does not directly contribute to the development of renal anemia and FGF23 suppresses erythropoiesis in CKD through a Klotho-independent mechanism. However, under physiological conditions, α-Klotho has an inhibitory effect on erythropoiesis and iron regulation.
FRONTIERS IN PEDIATRICS
(2022)
Article
Immunology
Patricia Schroeder, Marion Rivalan, Sami Zaqout, Christina Krueger, Jutta Schueler, Melissa Long, Andreas Meisel, York Winter, Angela M. Kaindl, Seija Lehnardt
Summary: The absence of MyD88 leads to morphological and cellular changes in the mouse brain, as well as alterations in specific behaviors. The data suggest a pathophysiological significance of MyD88 for mammalian CNS development, structure, and function.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Fisheries
Yan-Lin Guo, Lin Feng, Wei-Dan Jiang, Pei Wu, Yang Liu, Sheng-Yao Kuang, Shu-wei Li, Ling Tang, Lu Zhang, Haifeng Mi, Xiao-Qiu Zhou
Summary: This study discovered that iron deficiency has harmful effects on the intestinal health of on-growing grass carp, possibly leading to a decline in the physical barrier function of the intestine. Ferrous fumarate was found to be more efficient than ferrous sulfate in maintaining the intestinal barrier.
Article
Food Science & Technology
Anatoly Skalny, Yordanka Gluhcheva, Olga P. Ajsuvakova, Ekaterina Pavlova, Emilia Petrova, Pavel Rashev, Ivelin Vladov, Roza A. Shakieva, Michael Aschner, Alexey A. Tinkov
Summary: The study found that cobalt exposure could lead to accumulation of copper, iron, manganese, and zinc in tissue of immature mice, and alter serum hepcidin levels. The effect was most pronounced in 25-day-old mice.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Gabriela Maressa Machado Baesso, Amanda Vitoria Venancio, Livia Costa Varela Barca, Pepita Fernanda Peppi, Caique Aparecido Faria, Joao Pedro Cosmo Machado, Luiz David Solis Murgas, Alvaro Jose de Almeida Bicudo, Eduardo Mauricio Mendes de Lima, Andre Rodrigues da Cunha Barreto-Vianna
Summary: This study evaluated the effects of eugenol, menthol, and lidocaine as anesthetics on glucose levels and recovery times in zebrafish. The results showed that eugenol and menthol did not affect glucose levels, while lidocaine caused non-concentration-dependent hyperglycemia. Recovery times were similar for eugenol and menthol, but concentration-dependent for lidocaine. Eugenol and menthol were deemed safe and satisfactory for glucose analysis in zebrafish research, while lidocaine could introduce biases and safety concerns. Researchers should carefully consider the selection of anesthetics for reliable results in zebrafish assessments.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Xiaoxue Li, Tangsong Feng, Weiqun Lu
Summary: This study reveals that exposure to VPA induces ASD-like phenotypes and behaviors, including gene transcription changes, social interaction deficit, decreased aggression, increased anxiety behavior, and elevated cortisol levels. The aggression behavior assay is a better predictor of neurotoxicology behavior of VPA.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Garam An, Junho Park, Whasun Lim, Gwonhwa Song
Summary: In this study, we investigated the hepatotoxicity and mechanism of action of pyridaben using zebrafish and ZFL cells. Pyridaben caused liver size reduction and apoptosis, and these effects were associated with uncontrolled intracellular calcium flow and downregulation of the PI3K/Akt signaling cascade.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Md Alamgir Kabir, Md. Golam Rabbane, Marco R. Hernandez, Md Aftab Ali Shaikh, Mohammad Moniruzzaman, Xuexiu Chang
Summary: This study investigated the toxicity of high concentrations of cadmium (Cd) on intestinal immunity and microbial diversity in common carp. The results showed that high Cd concentration caused intestinal inflammation, immunosuppression, and changes in the gut microbiome, leading to detrimental effects on the intestinal homeostasis and health status of the fish.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Anuradha Batabyal, Veronica Rivi, Cristina Benatti, Johanna M. C. Blom, Fabio Tascedda, Ken Lukowiak
Summary: This study found that exposure to heat shock stressors and bacterial lipopolysaccharide can induce the Garcia effect in pond snails. Additionally, aspirin can prevent the formation of the Garcia effect. However, unexpectedly, exposure to crushed aspirin and heat shock stressors together leads to long-lasting feeding suppression and molecular changes in the snails' serotoninergic system and neuroplasticity genes.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Li-Yih Lin, Chieh-An Cheng, Sian-Tai Liu, Jiun-Lin Horng
Summary: This study reveals that ammonia exposure impairs ion regulation in zebrafish embryos by inducing oxidative stress, mitochondrial dysfunction, and cell death. The findings suggest that ammonia is toxic to aquatic animals and can lead to the death of embryos.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Antonio Durate Pagano, Natieli Machado Goncalves, William Borges Domingues, Tony Leandro Rezende da Silveira, Mateus Tavares Kutter, Antonio Sergio Varela Jr, Carine Dahl Corcini, Mariana Cavalcanti Nascimento, Luana Ferreira Viana dos Reis, Patricia Gomes Costa, Adalto Bianchini, Matheus Vieira Volcan, Mariana Harter Remia, Vinicius Farias Campos
Summary: This study analyzed the toxic effects of Roundup Transorb (R) on the endangered Neotropical annual killifish Austrolebias charrua by evaluating molecular and biochemical biomarkers. The findings showed that exposure to Roundup significantly increased the production of reactive oxygen species, lipid peroxidation, and DNA damage in the fish's blood cells. It also decreased membrane fluidity. Gene expression analysis revealed alterations in genes associated with oxidative stress and antioxidant defense. This study provides new insights into adaptive mechanisms of A. charrua in response to Roundup, and it has important implications for environmental monitoring and aquatic toxicology assessment.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Xiaochan Gao, Hongtao Ren, Yong Huang, Yimin Li, Jiaqi Shen
Summary: The influence of multi-walled carbon nanotubes (MWCNTs) on the toxicity of zinc oxide nanoparticles (ZnONPs) in the intestine of common carp was investigated. The study found that the concentration and concentration ratio of the mixture played a role in the toxicity of ZnONPs. The presence of MWCNTs significantly decreased intercellular zinc accumulation and altered the microbial community diversity and composition of the gut microbiota.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Guangchao Yang, Qian Yang, Trust Beta, Qin Liu, Zhenzhu Zhu, Fei Shen
Summary: The study found that black garlic MLDs have alleviative effects on ZEN-induced toxicity, and exert their effects through antioxidative, anti-apoptotic, and inhibitory mechanisms on ZEN absorption.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Tuul Sepp, Ciara Baines, Randel Kreitsberg, Joern Peter Scharsack, Pedro Nogueira, Thomas Lang, Jerome Fort, Elin Sild, John T. Clarke, Arvo Tuvikene, Richard Meitern
Summary: Environmental factors can cause cancer in both wild animals and humans. The use of polluted habitats provides opportunities to study cancer defense mechanisms, which can be influenced by genetic variation and natural selection. Flatfish species, specifically flounders, show higher resistance to pollution-induced cancer compared to dabs, with elevated pollutant metabolism and stronger tumor suppression mechanisms in their liver tissue. This suggests a potential hormetic upregulation of tumor suppression or stronger natural selection pressure for cancer resistance in flounders. Wild species offer valuable insights into understanding the nature and evolution of natural cancer defense mechanisms.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Regan A. Moss, Kaitlyn M. Murphy, Steven T. Gardner, Madison M. Watkins, John W. Finger Finger Jr, Meghan D. Kelley, Ruth M. Elsey, Daniel A. Warner, Mary T. Mendonca
Summary: The study explored the impact of environmentally relevant concentrations of E2 on the immune system and hormone levels of hatchling American alligators. Results showed that exposure to environmental estrogen can alter plasma hormone concentrations but have little to no impact on morphology and immune responses.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Ye Liang, Zihao Li, Jing Yuan, Yiwen Zhou, Meng Li, Haifeng Gu
Summary: This study investigated the toxicity mechanism of homo-YTX and NH3-N on the survival of abalone. The results showed that homo-YTX and NH3-N enhanced oxidative stress and lipid peroxidation reactions, inhibited energy supply, disrupted metabolic and immune physiological functions, and activated apoptosis in the gills of abalone.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2024)