Iron status influences mitochondrial disease progression in Complex I-deficient mice

A meta-analysis and systematic review of Leigh syndrome

(2020) Xueli Chang et al.   MEDICINE

Regional metabolic signatures in the Ndufs4(KO) mouse brain implicate defective glutamate/α-ketoglutarate metabolism in mitochondrial disease

(2020) Simon C. Johnson et al.   MOLECULAR GENETICS AND METABOLISM

Genetics of mitochondrial diseases: Identifying mutations to help diagnosis

(2020) Sarah L. Stenton et al.   EBioMedicine

Brain Hepcidin Suppresses Major Pathologies in Experimental Parkinsonism

(2020) Tuo Liang et al.   iScience

Targeting NAD+ Metabolism as Interventions for Mitochondrial Disease

(2019) Chi Fung Lee et al.   Scientific Reports

Leigh Syndrome Mouse Model Can Be Rescued by Interventions that Normalize Brain Hyperoxia, but Not HIF Activation

(2019) Isha H. Jain et al.   Cell Metabolism

Influence of iron metabolism on manganese transport and toxicity

(2017) Qi Ye et al.   Metallomics

Hypoxia treatment reverses neurodegenerative disease in a mouse model of Leigh syndrome

(2017) Michele Ferrari et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Restored iron transport by a small molecule promotes absorption and hemoglobinization in animals

(2017) Anthony S. Grillo et al.   SCIENCE

Hepatic S6K1 Partially Regulates Lifespan of Mice with Mitochondrial Complex I Deficiency

(2017) Takashi K. Ito et al.   Frontiers in Genetics

Hypoxia as a therapy for mitochondrial disease

(2016) I. H. Jain et al.   SCIENCE

Iron misregulation and neurodegenerative disease in mouse models that lack iron regulatory proteins

(2015) Manik C. Ghosh et al.   NEUROBIOLOGY OF DISEASE

Healthy aging: The ultimate preventative medicine

(2015) M. Kaeberlein et al.   SCIENCE

Geroscience: Linking Aging to Chronic Disease

(2014) Brian K. Kennedy et al.   CELL

The role of iron in brain ageing and neurodegenerative disorders

(2014) Roberta J Ward et al.   LANCET NEUROLOGY

Abnormal Brain Iron Metabolism in Irp2 Deficient Mice Is Associated with Mild Neurological and Behavioral Impairments

(2014) Kimberly B. Zumbrennen-Bullough et al.   PLoS One

Mitochondrial Complex I

(2013) Judy Hirst   Annual Review of Biochemistry

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Regulation of Cation Balance in Saccharomyces cerevisiae

(2013) M. S. Cyert et al.   GENETICS

mTOR Inhibition Alleviates Mitochondrial Disease in a Mouse Model of Leigh Syndrome

(2013) S. C. Johnson et al.   SCIENCE

Mitochondria: In Sickness and in Health

(2012) Jodi Nunnari et al.   CELL

Effect of mitochondrial complex I inhibition on Fe–S cluster protein activity

(2011) Natalia P. Mena et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Transition metal homeostasis: from yeast to human disease

(2011) Mark R. Bleackley et al.   BIOMETALS

Two to Tango: Regulation of Mammalian Iron Metabolism

(2010) Matthias W. Hentze et al.   CELL

The GRACILE mutation introduced into Bcs1l causes postnatal complex III deficiency: A viable mouse model for mitochondrial hepatopathy

(2010) Per Levéen et al.   HEPATOLOGY

A Disruption in Iron-Sulfur Center Biogenesis via Inhibition of Mitochondrial Dithiol Glutaredoxin 2 May Contribute to Mitochondrial and Cellular Iron Dysregulation in Mammalian Glutathione-Depleted Dopaminergic Cells: Implications for Parkinson's Disease

(2009) Donna W. Lee et al.   ANTIOXIDANTS & REDOX SIGNALING

Mechanisms of brain iron transport: insight into neurodegeneration and CNS disorders

(2009) Eric Mills et al.   Future Medicinal Chemistry

Metal trafficking: from maintaining the metal homeostasis to future drug design

(2009) Lalla Aicha Ba et al.   Metallomics

Mice with Mitochondrial Complex I Deficiency Develop a Fatal Encephalomyopathy

(2008) Shane E. Kruse et al.   Cell Metabolism

Screening of BCS1L mutations in severe neonatal disorders suspicious for mitochondrial cause

(2008) Vineta Fellman et al.   JOURNAL OF HUMAN GENETICS