Article
Biology
Maria Prado, Caroline Mascoli, Hugo Giambini
Summary: The L4-L5 spinal segment is associated with lumbar back pain, which can be caused by lumbar disc herniation, intervertebral disc degeneration, or degeneration of the facet joints. This study used a finite element model to analyze the effects of conservative and aggressive percutaneous transforaminal endoscopic discectomy (PTED) and disc degeneration on the biomechanics of the spine. The results indicate that PTED and disc degeneration can change spine kinematics, leading to instability and potential negative outcomes such as facet degeneration and LBP.
COMPUTERS IN BIOLOGY AND MEDICINE
(2022)
Article
Health Care Sciences & Services
Rui Weng, Xue-Cheng Huang, Lin-Qiang Ye, Ce-Kai Yang, Zhuo-Yan Cai, Yue-Rong Xu, Jian-Chao Cui, Sheng-Hui Yi, De Liang, Zhen-Song Yao
Summary: This study investigated the biomechanical effects of the sagittal angle of the cervical facet joints on the cervical intervertebral disc and facet joint using the finite-element technique. The results showed that facet tropism leads to unbalanced stress distribution on the annulus fibres at the cervical intervertebral disc, and the side with a larger sagittal angle of the facet joint has a greater risk of disc herniation.
Article
Biotechnology & Applied Microbiology
Lin-Yu Jin, Hong-Lin Yin, Yi-Qiong Xu, Shuai Xu, Xiao-Xing Song, Yan Luo, Xin-Feng Li
Summary: The study investigated the effects of axial whole body vibration on the intervertebral disc and facet joint in a bipedal mouse model. The results showed significant damage to the intervertebral disc and facet joint, suggesting the need for further studies on the effects of whole body vibration on the lumbar segments of humans.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Marcus Raudner, Markus M. Schreiner, Tom Hilbert, Tobias Kober, Michael Weber, Anna Szelenyi, Reinhard Windhager, Vladimir Juras, Siegfried Trattnig
Summary: The study evaluated GRAPPATINI, an accelerated T-2 mapping sequence that combines undersampling and model-based reconstruction to facilitate clinical implementation of T-2 mapping of the lumbar intervertebral disc. Results showed that T2 values obtained using GRAPPATINI were significantly different for normal discs compared to bulging or herniated discs, as well as discs with and without annular tears. The study concluded that GRAPPATINI can be used as a quantitative imaging biomarker to detect disc pathologies while significantly reducing acquisition time.
EUROPEAN RADIOLOGY
(2021)
Article
Biophysics
Elizabeth Gacek, Arin M. Ellingson, Victor H. Barocas
Summary: This study investigated the mechanical characteristics of the lumbar facet capsular ligament using cadaveric lumbar spines. The results showed that the ligament experiences nonzero strain under joint pressure and attachment constraints, with the highest stretching direction being from bone to bone. Releasing the ligament resulted in shrinkage, and the collagen in the ligament may remain uncrimped even when the spine is not loaded.
JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME
(2022)
Article
Biology
Dacheng Sang, Cheng-Fei Du, Bingxuan Wu, Xin-Yi Cai, Wei Cui, Chen-Xi Yuchi, Tianhua Rong, Hongpeng Sang, Baoge Liu
Summary: This study investigated the effect of cervical disc degeneration (CDD) on the motion path of the instantaneous center of rotation (ICR) in the cervical spine. The results showed that CDD significantly affected the ICR motion paths, with shifts in the degenerated and adjacent segments. The changes observed in adjacent segments may represent compensatory mechanisms to maintain cervical spine balance.
COMPUTERS IN BIOLOGY AND MEDICINE
(2021)
Article
Orthopedics
Sachin Gupta, Rui Xiao, Matthew Fainor, Robert L. Mauck, Harvey E. Smith, Sarah E. Gullbrand
Summary: This study characterizes alterations to human facet cartilage and subchondral bone across a spectrum of degeneration and investigates correlations between disc and facet degeneration. The findings suggest that the mechanical properties of facet cartilage and the structural properties of facet subchondral bone change with increasing degenerative grade and are correlated with aspects of disc degeneration.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2023)
Review
Biotechnology & Applied Microbiology
Andre P. G. Castro
Summary: This paper provides a brief review on computational modelling for innovative treatments of spine diseases and discusses future research directions. While patient-specific treatments have become a reality in clinical practice, there are still many issues to be addressed before universal adoption. Promising indicators have been found in scaffold modelling for disc arthroplasty and vertebroplasty, supported by advancements in imaging methods.
BIOENGINEERING-BASEL
(2021)
Article
Biotechnology & Applied Microbiology
Chloe Techens, Sara Montanari, Ferenc Bereczki, Peter Endre Eltes, Aron Lazary, Luca Cristofolini
Summary: With the ageing of the population, there is a growing demand for minimally invasive spine surgeries. This study developed an in vitro model of percutaneous cement discoplasty and found that it restored disc height and reduced range of motion without increasing the risk of tissue damage.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Computer Science, Interdisciplinary Applications
Xin-feng Li, Zheng-dong Lv, Hong-ling Yin, Xiao-xing Song
Summary: This study used finite element modeling to simulate disc degeneration and its impact on adjacent segment degeneration, finding that pre-existing degenerated discs can lead to increased stress and loads on adjacent discs, endplates, and facet joints, highlighting the importance of carefully selecting fusion levels before surgery.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2021)
Article
Engineering, Biomedical
Aapo Ristaniemi, Amra Secerovic, Vincent Dischl, Francesco Crivelli, Sarah Heub, Diane Ledroit, Gilles Weder, Sibylle Grad, Stephen J. Ferguson
Summary: The physiological and degenerative levels of maximum principal strains and stresses in bovine intervertebral disc tissue were determined through finite element analysis. It was found that when applying 0.1 MPa of compression and +/- 2-3 degrees of flexion and +/- 1-2 degrees of torsion, the mechanical parameters remained at physiological levels. However, with +/- 6-8 degrees of flexion in combination with +/- 2-4 degrees of torsion, the stresses in the outer annulus fibrosus exceeded degenerative levels. These findings provide important guidelines for bioreactor experiments with bovine intervertebral discs.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2023)
Article
Clinical Neurology
Mohamed Kamal Mesregah, Michael Repajic, Paul Mgbam, Zoe Fresquez, Jeffrey C. Wang, Zorica Buser
Summary: This study evaluated the trends and patterns of cervical degenerative disc disease in different age groups of symptomatic patients. The results showed that the number and severity of degenerated intervertebral discs increased significantly with age.
EUROPEAN SPINE JOURNAL
(2022)
Article
Biotechnology & Applied Microbiology
Francois Zot, Estelle Ben-Brahim, Mathieu Severyns, Yann Ledoux, Michel Mesnard, Laetitia Caille, Cecile Swennen, Simon Teyssedou, Abdollah-Yassine Moufid, Arnaud Germaneau, Tanguy Vendeuvre
Summary: Lumbar disc arthroplasty is a surgical procedure used to treat degenerative disc disease. This study compared the mechanical response of ball-and-socket and elastic prostheses using finite element models.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Medicine, General & Internal
Yavuz Yuksel, Tarkan Ergun, Ebru Torun
Summary: This study investigated the relationship between cervical intervertebral disc degeneration and the muscle areas in the cervical region. The findings showed that in the early stages of disc degeneration, there was an increase in muscle areas, but as the degeneration progressed, there was a decrease in all muscle areas.
Article
Engineering, Biomedical
Wei Wang, Chaochao Zhou, Runsheng Guo, Thomas Cha, Guoan Li
Summary: This study investigated how variations in structural and material properties of human intervertebral discs affect biomechanical responses under simulated physiological loading conditions using a stochastic finite element model. Analysis of 500 random disc samples revealed significant variations in intradiscal pressures, IVD displacements/rotations, and stress/strain distributions under various loading conditions.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2021)